| Project Area | The germline: its developmental cycle and epigenome network |
|---|
| Project/Area Number |
20062001
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
MATSUI Yasuhisa (YASUHISA Matsui) 東北大学, 加齢医学研究所, 教授 (40241575)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NOCE Toshiaki 慶應義塾大学, 先導研究センター, 特任教授 (70183902)
岡村 大治 東北大学, 加齢医学研究所, 助教 (80393263)
前田 郁麻 東北大学, 加齢医学研究所, 助教 (20376560)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OKAMURA Daiji 東北大学, 加齢医学研究所, 助教 (80393263)
MAEDA Ikuma 東北大学, 加齢医学研究所, 助教 (20376560)
|
|---|
| Project Period (FY) |
2008 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥129,000,000 (Direct Cost: ¥129,000,000)
Fiscal Year 2012: ¥25,800,000 (Direct Cost: ¥25,800,000)
Fiscal Year 2011: ¥25,800,000 (Direct Cost: ¥25,800,000)
Fiscal Year 2010: ¥25,800,000 (Direct Cost: ¥25,800,000)
Fiscal Year 2009: ¥25,800,000 (Direct Cost: ¥25,800,000)
Fiscal Year 2008: ¥25,800,000 (Direct Cost: ¥25,800,000)
|
|---|
| Keywords | 始原生殖細胞 / エピジェネティクス / 遺伝子改変マウス / ES細胞 / siRNA / DNAメチル化 / 転写制御 / Vasa |
|---|
| Research Abstract |
In this research project, we have found the following three points. (1) Transcription regulators REST and Larp7 positively control survival and proliferation of primordial germ cells (PGCs), respectively, in mouse embryos. (2) The expression of PGC-specific genes is controlled by DNA demethylation of their regulatory regions. (3) Transcription regulator Max represses the expression of germ cell-specific genes in ES cells.
|
