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Regulation of germ line function and development by genome imprinting

Planned Research

Project AreaThe germline: its developmental cycle and epigenome network
Project/Area Number 20062009
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo University of Agriculture

Principal Investigator

KONO Tomohiro  東京農業大学, 応用生物科学部, 教授 (80153485)

Co-Investigator(Renkei-kenkyūsha) OBATA Yayoi  東京農業大学, 応用生物科学部, 准教授 (70312907)
OGAWA Hidehiko  東京農業大学, 応用生物科学部, 准教授 (20339089)
Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥108,500,000 (Direct Cost: ¥108,500,000)
Fiscal Year 2012: ¥21,700,000 (Direct Cost: ¥21,700,000)
Fiscal Year 2011: ¥21,700,000 (Direct Cost: ¥21,700,000)
Fiscal Year 2010: ¥21,700,000 (Direct Cost: ¥21,700,000)
Fiscal Year 2009: ¥21,700,000 (Direct Cost: ¥21,700,000)
Fiscal Year 2008: ¥21,700,000 (Direct Cost: ¥21,700,000)
Keywordsゲノムインプリント / 二母性胚 / 遺伝子発現 / 個体発生 / 非翻訳RNA / ゲノムインプリンティング / 単為発生 / BACクローン / TGマウス / メチル化転移酵素 / 非コードRNA / メチローム / メチル基転移酵素 / マイクロアレイ
Research Abstract

We showed novel findings that imprint gene clusters, including the non-cording RNAs, in the Igf2-H19 domain of the chromosome 7 and the Dlk1-Dio3 domain of the chromosome 12, play a decisive role for embryogenesis and placentation. In addition, we provided comprehensive and single resolution DNA methylome data of germ cells, and also we showed particular functions of maternal genome on embryogenesis in cloned embryos and trophoblastic stem cells.

Report

(7 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (122 results)

All 2013 2012 2011 2010 2009 2008 2007 2004 Other

All Journal Article (45 results) (of which Peer Reviewed: 39 results) Presentation (60 results) Book (4 results) Remarks (2 results) Patent(Industrial Property Rights) (11 results) (of which Overseas: 6 results)

  • [Journal Article] Mouse oocyte methylomes at base resolution reveal genome- wide accumulation of non-CpG methylation and role of DNA methyltransferases2013

    • Author(s)
      Shirane K, Toh H, Kobayashi H, Miura F, Chiba H, Ito T, Kono T, Sasaki H
    • Journal Title

      PLoS Genet

      Volume: 9(4) Issue: 4 Pages: 303-306

    • DOI

      10.1371/journal.pgen.1003439

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The transcriptomic architecture of mouse Sertoli cell clone embryos reveals temporal.spatial-specific reprogramming2013

    • Author(s)
      Cao F, Fukuda A, Watanabe H, Kono T
    • Journal Title

      Reproduction

      Volume: 145(3) Pages: 277-288

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The transcriptomic architecture of mouse Sertoli cell clone embryos reveals temporal-spatial-specific reprogramming2013

    • Author(s)
      Cao, Feng
    • Journal Title

      Reproduction

      Volume: 145 Pages: 277-188

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EIF1A expression in Sertoli cell nuclear transfer embryos during preimplantation development2013

    • Author(s)
      Cao, Feng
    • Journal Title

      Journal of Mammalian Ova Research

      Volume: 30 Pages: 41-45

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks2012

    • Author(s)
      Kobayashi H, Sakurai T, Imai M, Takahashi N, Fukuda A, Yayoi O, Sato S, Nakabayashi K, Hata K, Sotomaru Y, Suzuki Y, Kono T
    • Journal Title

      PLoS Genet

      Volume: 8(1) Issue: 1 Pages: e1002440-e1002440

    • DOI

      10.1371/journal.pgen.1002440

    • NAID

      120005300482

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Porcine nuclei in early growing stage do not possess meiotic competence in matured oocytes2012

    • Author(s)
      Ogawa H, Matsuzaki T, Yamamoto A, Kashiwazaki N, Kono T
    • Journal Title

      Theriogenology

      Volume: 78(3) Issue: 3 Pages: 560-566

    • DOI

      10.1016/j.theriogenology.2012.03.001

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imprinted DNA methylation reprogramming during early mouse embryogenesis at the Gpr1-Zdbf2 locus is linked to long cis-intergenic transcription2012

    • Author(s)
      Kobayashi H, Sakurai T, Sato S, Nakabayashi K, Hata K, Kono T
    • Journal Title

      FEBS Lett

      Volume: 23;586(6) Issue: 6 Pages: 827-833

    • DOI

      10.1016/j.febslet.2012.01.059

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells2012

    • Author(s)
      Stadtfeld M, Apostolou E, Akutsu H, Fukuda A, Follett P, Natesan S, Kono T, Shioda T, Hochedlinger K
    • Journal Title

      Nature

      Volume: 13;465(7295) Issue: 7295 Pages: 175-181

    • DOI

      10.1038/nature09017

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Porcine nuclei in early growing stage do not possess meiotic competence in matured oocytes.2012

    • Author(s)
      Ogawa, Hidehiko
    • Journal Title

      Theriogenology

      Volume: 78 Pages: 560-566

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks2012

    • Author(s)
      Kobayashi, Hisato
    • Journal Title

      PLoS GENETICS

      Volume: 8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ゲノムインプリンティングと個体発生制御2012

    • Author(s)
      高橋望
    • Journal Title

      細胞工学

      Volume: 31 Pages: 464-469

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Epigenetically immature oocytes lead to loss of imprinting during embryogenesis2011

    • Author(s)
      Obata Y, Hiura H, Fukuda A, Komiyama J, Hatada I, Kono T
    • Journal Title

      J Reprod Dev

      Volume: 57(3) Pages: 327-334

    • NAID

      10029050351

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetically immature oocytes lead to loss of imprinting during embryogenesis2011

    • Author(s)
      Obata, Yayoi
    • Journal Title

      The Journal of Reproduction and Development

      Volume: 57 Pages: 327-334

    • NAID

      10029050351

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Longevity in mice without a father2010

    • Author(s)
      Kawahara M, Kono T
    • Journal Title

      Hum Reprod

      Volume: 25(2) Issue: 2 Pages: 457-461

    • DOI

      10.1093/humrep/dep400

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Restoration of Dlk1 and Rtl1 is necessary but insufficient to rescue lethality in intergenic differentially methylated region (IG-DMR)- deficient mice2010

    • Author(s)
      Takahashi N, Kobayashi R, Kono T
    • Journal Title

      J Biol Chem

      Volume: 285(34) Issue: 34 Pages: 26121-26125

    • DOI

      10.1074/jbc.m109.075325

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of inappropriately reprogrammed genes by large-scale transcriptome analysis of individual cloned mouse blastocysts2010

    • Author(s)
      Fukuda A, Cao F, Morita S, Yamada K, Jincho Y, Tane S, Sotomaru Y, Kono T
    • Journal Title

      PLoS One

      Volume: 30;5(6) Issue: 6 Pages: e11274-e11274

    • DOI

      10.1371/journal.pone.0011274

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of inappropriately reprogrammed genes by large-scale transcriptome analysis of individual cloned mouse blastocysts.2010

    • Author(s)
      Fukuda, Atsushi, Kono, Tomohiro
    • Journal Title

      PLoS One 5

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Restoration of Dlk1 and Rtl1 is necessary but insufficient to rescue of the lethality in IG-DMR deficient mice.2010

    • Author(s)
      Takahashi, Nozomi.Kono, Tomohiro
    • Journal Title

      J Biol Chem 285

      Pages: 26121-26125

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells.2010

    • Author(s)
      Stadtfeld, Matthias, Kono, Tomohiro
    • Journal Title

      Nature 465

      Pages: 175-181

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Longevity in mice without a father.2010

    • Author(s)
      Kawahara, Manabu, Kono, Tomohiro.
    • Journal Title

      Human Reprod 25

      Pages: 457-461

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Identification of inappropriately reprogrammed genes by large-scale transcriptome analysis of individual cloned mouse blastocysts.2010

    • Author(s)
      Fukuda, Atsushi.
    • Journal Title

      PLoS One

      Volume: 30

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Restoration of Dlk1 and Rtl1 is necessary but insufficient to rescue of the lethality in IG-DMR deficient mice.2010

    • Author(s)
      Takahashi, Nozomi.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 285 Pages: 26121-26125

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells.2010

    • Author(s)
      Stadtfeld, Matthias.
    • Journal Title

      Nature

      Volume: 465 Pages: 175-181

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 卵子形成とエピジェネティクス2010

    • Author(s)
      河野友宏
    • Journal Title

      HORMONE FRONTIER IN GYNECOLOGY

      Volume: 5 Pages: 335-340

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Involvement of Insulin-like Growth Factor 2 in Angiogenic Factor Transcription in Bi-maternal Mouse Conceptuses.2010

    • Author(s)
      Kawahara, Manabu.
    • Journal Title

      Journal of Reproduction and Development 56

      Pages: 79-85

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Longevity in mice without a father.2010

    • Author(s)
      Kawahara, Manabu.
    • Journal Title

      Human Reproduction 25

      Pages: 457-461

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the mouse paternally expressed imprinted gene Zdbf2 on chromosome 1 and its imprinted human homolog ZDBF2 on chromosome 22009

    • Author(s)
      Kobayashi H, Yamada K, Morita S, Hiura H, Fukuda A, Kagami M, Ogata T, Hata K, Sotomaru Y, Kono T
    • Journal Title

      Genomics

      Volume: 93(5) Issue: 5 Pages: 461-47

    • DOI

      10.1016/j.ygeno.2008.12.012

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of Gtl2, imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin- dependent defects in mice2009

    • Author(s)
      Takahashi N, Okamoto A, Kobayashi R, Shirai M, Obata Y, Ogawa H, Sotomaru Y, Kono T
    • Journal Title

      Hum Mol Genet

      Volume: 15;18(10) Pages: 1879-1888

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Defining contributions of paternally methylated imprinted genes at the Igf2-H19 and Dlk1-Gtl2 domains to mouse placentation by transcriptomic analysis2009

    • Author(s)
      Kawahara M, Morita S, Takahashi N, Kono T
    • Journal Title

      J Biol Chem

      Volume: 284(26) Pages: 17751-17765

    • NAID

      120006377532

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Developmental ability of trophoblast stem cells in uniparental mouse embryos2009

    • Author(s)
      Ogawa H, Shindo N, Kumagai T, Usami Y, Shikanai M, Jonwn K, Fukuda A, Kawahara M, Sotomaru Y, Tanaka S, Arima T, Kono T
    • Journal Title

      Placenta

      Volume: 30(5) Issue: 5 Pages: 448-456

    • DOI

      10.1016/j.placenta.2009.02.006

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Defining contributions of paternally methylated imprinted genes at the Igf2-H19 and Dlk1-Gtl2 domains to mouse placentation by transcriptomic analysis.2009

    • Author(s)
      Kawahara, Manabu, Kono Tomohiro
    • Journal Title

      J Biol Chem 284

      Pages: 17751-17765

    • NAID

      120006377532

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Deletion of Gtl2, imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin-dependent defects in mice.2009

    • Author(s)
      Takahashi, Nozomi, Obata, Yayoi, Kono, Tomohiro, et al.
    • Journal Title

      Human Mol Genet 18

      Pages: 1879-1888

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Defining contributions of patemally methylated imprinted genes at the IGF2-H19 and DLKI-GT12 domains to mouse placentation by transcriptomic analysis.2009

    • Author(s)
      Kawahara, M.
    • Journal Title

      Journal of Biological Chemistry 284

      Pages: 17751-17765

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Large-scale production of growing oocytes in vitro from neonatal mouse ovaries.2009

    • Author(s)
      Honoda, Arata.
    • Journal Title

      The International Journal of Developmental Biology 53

      Pages: 605-613

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 「かぐやシスターズ」の誕生からみえてきた父母ゲノムの役割2009

    • Author(s)
      河野友宏
    • Journal Title

      Biophilia 5

      Pages: 34-48

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ほ乳類の単為発生2009

    • Author(s)
      河野友宏
    • Journal Title

      最新医学 64

      Pages: 104-116

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Genetic modification for bimaternal embryo development2009

    • Author(s)
      Kono, Tomohiro
    • Journal Title

      Reproduction, Fertility and Development 21

      Pages: 31-36

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the mouse paternally expressed imprinted gene Zdbf2 on chromosome 1 and its imprinted human homolog ZDBF2 on chromosome 22009

    • Author(s)
      Kobayashi, Hisato., Kono, Tomohiro, 他8名
    • Journal Title

      Genomics 93

      Pages: 461-472

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developmental ability of trophoblast stem cells in uniparental mouse embryos2009

    • Author(s)
      Ogawa, Hidehiko., Kono, Tomohiro, 他8名
    • Journal Title

      Placenta 30

      Pages: 448-456

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of Gt12, imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin-dependent defects in mice2009

    • Author(s)
      Takahashi, Nozomi., Obata, Yayoi., Ogawa, Hidehiko., Kono, Tomohiro, 他4名
    • Journal Title

      Human Molecular Genetics 18

      Pages: 1879-1888

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defining contributions of paternally methylated imprinted genes at the IGF2-H19 and DLKJ-GT12 domains to mouse placentation by transcriptomic analysis2009

    • Author(s)
      Kawahara, Manabu., Kono, Tomohiro, 他2名
    • Journal Title

      Journal of Biological Chemistry (Published online on April 20)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protocol for the production of viable bimaternal mouse embryos2008

    • Author(s)
      Kawahara M, Obata Y, Sotomaru Y, Shimozawa N, Bao S, Tsukadaira T, Fukuda A, Kono T
    • Journal Title

      Nat Protoc

      Volume: 3(2) Issue: 2 Pages: 197-209

    • DOI

      10.1038/nprot.2007.531

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protocol for the production of viable bimaternal mouse embryos2008

    • Author(s)
      Kawahara, Manabu., Kono Tomohiro, 他6名
    • Journal Title

      Nature protocols 3

      Pages: 197-209

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 二母性マウスの開発2008

    • Author(s)
      河野友宏
    • Journal Title

      細胞工学 27

      Pages: 812-819

    • Related Report
      2008 Annual Research Report
  • [Journal Article] ゲノムインプリンティングと二母性マウスの開発2008

    • Author(s)
      川原学
    • Journal Title

      化学と生物 46

      Pages: 452-459

    • Related Report
      2008 Annual Research Report
  • [Presentation] Amplification-free whole-genome shotgun bisulfite sequencing of mouse primordial germ cells (ポスター発表)2013

    • Author(s)
      小林久人
    • Organizer
      Epigenetics & Chromatin : Interactions and Processes 2013
    • Place of Presentation
      ハーバードメディカルセンター、ボストン・アメリカ
    • Year and Date
      2013-03-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス卵母細胞の成熟過程におけるミトコンドリアの動態2012

    • Author(s)
      若井拓哉
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] 着床前クローン胚発生において異常発現遺伝子の染色体マップ2012

    • Author(s)
      曹峰,福田篤,渡辺大士,河野友宏
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] マウス始原生殖細胞におけるDNAメチローム解析2012

    • Author(s)
      小林久人
    • Organizer
      第105回日本繁殖生物学会大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2012-09-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス雄核発生胚由来栄養膜幹細胞から分化した細胞の特性2012

    • Author(s)
      武弓竜一
    • Organizer
      第105回日本繁殖生物学会大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2012-09-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウスセルトリ細胞クローン胚におけるMsn及びX1r3aの発現解析2012

    • Author(s)
      渡辺大士
    • Organizer
      第105回日本繁殖生物学会大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2012-09-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] 母性因子RNF12はマウスにおける体細胞核のリプログラミングを阻害する2012

    • Author(s)
      福田篤
    • Organizer
      第105回日本繁殖生物学会大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2012-09-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス卵子の減数分裂におけるH3K27me3の伝達機構2012

    • Author(s)
      若井拓哉
    • Organizer
      第53回日本哺乳動物卵子学会
    • Place of Presentation
      大阪千里ライフサイエンスセンター
    • Year and Date
      2012-05-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dnmt3a2/Dnmt3L過剰発現マウス卵母細胞におけるインブリント遺伝子メチル化解析2012

    • Author(s)
      原聡史
    • Organizer
      第53回日本哺乳動物卵子学会
    • Place of Presentation
      大阪千里ライフサイエンスセンター
    • Year and Date
      2012-05-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウスにおける新規父方特異的メチル化DNA領域の探索2012

    • Author(s)
      坂下陽彦
    • Organizer
      第53回日本哺乳動物卵子学会
    • Place of Presentation
      大阪千里ライフサイエンスセンター
    • Year and Date
      2012-05-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス配偶子における全ゲノム包括的 DNAメチローム解析2011

    • Author(s)
      小林久人,河野友宏
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] DNAメチローム解析による生殖系列のリプログラミング評価2011

    • Author(s)
      河野友宏
    • Organizer
      第56回日本生殖医学会学術講演会・総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 生殖細胞形成過程におけるインプリント遺伝子のDNAメチル化機構2011

    • Author(s)
      尾畑やよい
    • Organizer
      特定領域研究第4回シンポジウム
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス雌核発生胚の胚盤胞期胚における内部細胞塊および栄養外胚葉における網羅的遺伝子発現解析2011

    • Author(s)
      小川英彦,後藤詩織,岸靖典,曹峰,河野友宏
    • Organizer
      第104回日本繁殖生物学会大会
    • Place of Presentation
      いわて県民情報交流センター
    • Year and Date
      2011-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス雌核発生胚の胚盤胞期胚における内部細胞塊および栄養外胚葉における網羅的遺伝子発現解析2011

    • Author(s)
      小川英彦
    • Organizer
      第104回日本繁殖生物学会大会
    • Place of Presentation
      いわて県民情報交流センター・アイーナ
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNMT3A2/DNMT3Lの異所的発現がマウスインプリント遺伝子に及ぼす影響2011

    • Author(s)
      原聡史
    • Organizer
      第104回日本繁殖生物学会大会
    • Place of Presentation
      いわて県民情報交流センター・アイーナ
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 核移植による栄養膜幹細胞ゲノムの全能性再獲得能の評価2011

    • Author(s)
      渡邊紘之
    • Organizer
      第52回日本哺乳動物卵子学会
    • Place of Presentation
      国際医療福祉大学本校
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス胚盤胞期胚の内部細胞塊と栄養外胚葉における網羅的遺伝子発現解析2011

    • Author(s)
      小川英彦
    • Organizer
      第52回日本哺乳動物卵子学会
    • Place of Presentation
      国際医療福祉大学本校
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Methylomes and transcriptomes in mouse germ cells2011

    • Author(s)
      Tomohiro Kono
    • Organizer
      Fertility 2011
    • Place of Presentation
      Dublin, Ireland
    • Year and Date
      2011-01-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Methylomes and transcriptomes in mouse germ cells.2011

    • Author(s)
      Kono, Tomohiro.
    • Organizer
      Fertility 2011
    • Place of Presentation
      アイルランド
    • Year and Date
      2011-01-07
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Bisulphite Shotgun Sequencing法によるマウス生殖細胞の包括的 DNAメチル化解析2010

    • Author(s)
      小林久人,桜井隆順,福田篤,高橋望,尾畑やよい,中林一彦,秦健一郎,外丸佑介,鈴木穣,河野友宏
    • Organizer
      第33回分子生物学会(BMB2010)
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Bisulphite Shotgun Sequencing法によるマウス生殖細胞の包括的DNAメチル化解析2010

    • Author(s)
      小林久人
    • Organizer
      第33回日本分子生物学会年会(BMB2010)
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 着床前マウスクローン胚におけるトランスクリプトーム解析2010

    • Author(s)
      曹 峰,福田 篤,岸 靖典,河野 友宏
    • Organizer
      第33回分子生物学会(MB2010)
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] The ncRNAs in the Dlk1-Dio3 domain function as tumor suppressor.2010

    • Author(s)
      Takahashi, Nozomi.
    • Organizer
      International Symposium on "Epigenome Network, Development and Reprogramming of Germ Cells"
    • Place of Presentation
      九州大学医学部
    • Year and Date
      2010-11-22
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] The ncRNAs in the Dlk1-Dio3 domain function as tumor suppressor2010

    • Author(s)
      Takahashi, Nozomi.
    • Organizer
      International Symposium on "Epigenome Network, Development and Reprogramming of Germ Cells"
    • Place of Presentation
      九州大学医学部百年講堂(福岡市)
    • Year and Date
      2010-11-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] ウシ胚盤胞期胚における内部細胞塊と栄養外胚葉の網羅的遺伝子発現解析2010

    • Author(s)
      長友啓明
    • Organizer
      第103回日本繁殖生物学会大会
    • Place of Presentation
      北里大学獣医学部(十和田市)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス非成長期卵母細胞におけるDNAメチル基転移酵素の発現誘導2010

    • Author(s)
      原聡史
    • Organizer
      第103回日本繁殖生物学会大会
    • Place of Presentation
      北里大学獣医学部(十和田市)
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] XX型雌マウスとXY型雄マウス由来卵母細胞における網羅的遺伝子発現解析2010

    • Author(s)
      尾畑やよい
    • Organizer
      第51回日本哺乳動物卵子学会
    • Place of Presentation
      新潟県・朱鷺メッセ
    • Year and Date
      2010-05-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 二母性マウス胚由来胎盤における網羅的遺伝子発現解析2009

    • Author(s)
      川原学,森田慎之助,高橋望,河野友宏
    • Organizer
      第102回日本繁殖生物学会
    • Place of Presentation
      近畿大学農学部
    • Year and Date
      2009-09-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 二母性マウスの長命性について2009

    • Author(s)
      河野友宏
    • Organizer
      第102回日本繁殖生物学会
    • Place of Presentation
      近畿大学農学部
    • Year and Date
      2009-09-12
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 胚形成過程におけるゲノムインプリンティングの維持と消失2009

    • Author(s)
      尾畑やよい
    • Organizer
      第102回日本繁殖生物学会
    • Place of Presentation
      近畿大学農学部
    • Year and Date
      2009-09-12
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] インプリント遺伝子Rt11/asRt11の発現制御機構の解明2009

    • Author(s)
      小林亮太
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      近畿大学
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウスクローン胚盤胞におけるドナー細胞特異的な遺伝子発現プロファイル2009

    • Author(s)
      福田篤
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      近畿大学
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 二母性マウスの長命性について2009

    • Author(s)
      河野友宏
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      近畿大学
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胚形成過程におけるゲノムインプリンティングの維持と消失2009

    • Author(s)
      尾畑やよい
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      近畿大学
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 雄核発生胚および雌核発生胚における胚体外組織への分化能の解明2009

    • Author(s)
      小川英彦
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      近畿大学
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 二母性マウス胚由来胎盤における網羅的遺伝子発現解析2009

    • Author(s)
      川原学
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      近畿大学
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 非コードインプリント遺伝子Gtl2欠損マウスの親特異的な致死性と分子制御機構2009

    • Author(s)
      高橋望,小林亮太,岡本晶,山口瑛人,河野友宏
    • Organizer
      第102回日本繁殖生物学会
    • Place of Presentation
      近畿大学農学部
    • Year and Date
      2009-09-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 非コードインプリント遺伝子Glt2欠損マウスの親特異的な致死性と分子制御機構2009

    • Author(s)
      高橋望
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      近畿大学
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] The regulation of imprinted gene2009

    • Author(s)
      Tomohiro Kono
    • Organizer
      From imprinting to the Epigenome in 25 years
    • Place of Presentation
      University of Cambridge, England
    • Year and Date
      2009-09-06
    • Related Report
      2012 Final Research Report
  • [Presentation] The regulation of imprinted gene.2009

    • Author(s)
      Kono, Tomohiro.
    • Organizer
      From imprinting to the Epigenome in 25 years.
    • Place of Presentation
      英国ケンブリッジ大学
    • Year and Date
      2009-09-06
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] The regulation of imprinted gene2009

    • Author(s)
      Kono, Tomohiro.
    • Organizer
      From imprinting to the Epigenome in 25 years
    • Place of Presentation
      ケンブリッジ大学(イギリス国ケンブリッジシャー州)
    • Year and Date
      2009-09-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Global gene expression analysis of mouse single cloned blastocysts2009

    • Author(s)
      Fukuda, Atsushi.
    • Organizer
      42nd Annual Meeting of the Society for the Study of Reproduction
    • Place of Presentation
      Pittsburgh,Pennsylvania (United States of America)
    • Year and Date
      2009-07-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] マルチプレックスリアルタイムPCRを利用した単一胚盤胞における多数遺伝子の発現評価系の構築2009

    • Author(s)
      福田篤
    • Organizer
      日本哺乳動物卵子学会
    • Place of Presentation
      東京都市センターホテル(東京)
    • Year and Date
      2009-05-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス二母性胚の発生に対する父性メチル化制御インプリント遺伝子の発現アレルの影響2009

    • Author(s)
      川原学
    • Organizer
      日本哺乳動物卵子学会
    • Place of Presentation
      東京都市センターホテル(東京)
    • Year and Date
      2009-05-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Genetic modification for bi-maternal embryo development2009

    • Author(s)
      Tomohiro Kono
    • Organizer
      35th Annual Conference of the International Embryo Transfer Society
    • Place of Presentation
      SanDiego, USA
    • Year and Date
      2009-01-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Genetic modification for bi-maternal embryo development2009

    • Author(s)
      Kono, Tomohiro
    • Organizer
      Annual Conference of the International Embryo Transfer Society
    • Place of Presentation
      SanDiego, USA
    • Year and Date
      2009-01-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 単為発生胚を用いた新規インプリント遺伝子の探索 : マウス1番染色体のZdbf2遺伝子は父由来アレル特異的に発現するインプリント遺伝子である2008

    • Author(s)
      小林久人、河野友宏
    • Organizer
      日本分子生物学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 非コードインプリント遺伝子 Gtl2欠損マウスにおける親の特異的な致死性および遺伝子発現異常2008

    • Author(s)
      高橋望,岡本晶,小林亮太,白井求,小川英彦,尾畑やよい,河野友宏
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 非コードインプリント遺伝子Glt2欠損マウスにおける親の特異的な致死性および遺伝子発現異常2008

    • Author(s)
      高橋望、小川英彦、尾畑やよい、河野友宏
    • Organizer
      日本分子生物学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 非翻訳インプリント遺伝子Glt2欠損マウスにおける致死性および器官形成異常2008

    • Author(s)
      岡本晶、小川英彦、尾畑やよい、河野友宏
    • Organizer
      日本分子生物学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 単為発生胚を用いた新規インプリント遺伝子の探索 : マウス1番染色体のZdbfZ遺伝子は父由来アレル特異的に発現するインプリント遺伝子である2008

    • Author(s)
      小林久人、河野友宏
    • Organizer
      日本繁殖生物学会大会
    • Place of Presentation
      九州大学
    • Year and Date
      2008-09-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] マイクロアレイ法を用いた単一マウスクローン胚盤胞の網羅的遺伝子発現解析2008

    • Author(s)
      曹峰、河野友宏
    • Organizer
      日本繁殖生物学会大会
    • Place of Presentation
      九州大学
    • Year and Date
      2008-09-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Non-codingRNAインプリント遺伝子Glt2欠損マウスにおけるRtl1遺伝子の発現解析2008

    • Author(s)
      小林亮太、河野友宏
    • Organizer
      日本繁殖生物学会大会
    • Place of Presentation
      九州大学
    • Year and Date
      2008-09-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Generation of viable bimaternal mice lacking a paternal genome2008

    • Author(s)
      Tomohiro Kono
    • Organizer
      World Congress on Reproductive Biology
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2008-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Deletion of the maternally expressed imprinted gene, Gtl2, resulted in parental-specific lethality in mice2008

    • Author(s)
      Nozomi Takahashi, Akira Okamoto, Motomu Shirai, Ryota Kobayashi, Tomohiro Kono
    • Organizer
      World Congress on Reproductive Biology
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2008-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Generation of viable bimaternal mice lacking a paternal genome.2008

    • Author(s)
      Kono, Tomohiro.
    • Organizer
      World Congress on Reproductive Biology
    • Place of Presentation
      米国ハワイ
    • Year and Date
      2008-05-24
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Generation of viable bimaternal mice lacking a paternal genome2008

    • Author(s)
      Kono, Tomohiro
    • Organizer
      World Congress on Reproductive Biology
    • Place of Presentation
      Hawaii,USA
    • Year and Date
      2008-05-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Deletion of the maternally expressed imprinted gene, Glt2, resulted in parental-specific lethality in mice2008

    • Author(s)
      Takahashi, Nozomi., Kono, Tomohiro
    • Organizer
      World Congress on Reproductive Biology
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2008-05-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Glt2遺伝子欠損マウスにおける器官形成異常2008

    • Author(s)
      岡本晶、河野友宏
    • Organizer
      日本哺乳動物卵子学会大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Book] 卵子発育とゲノムインプリンティング,「卵子学」2011

    • Author(s)
      河野友宏, 他
    • Publisher
      京都大学学術出版会
    • Related Report
      2012 Final Research Report
  • [Book] 卵子学2011

    • Author(s)
      河野友宏
    • Publisher
      京都大学学術出版会
    • Related Report
      2011 Annual Research Report
  • [Book] 生命の誕生に向けて<第二版>生殖補助医療(ART)胚培養の理論と実際2011

    • Author(s)
      河野友宏
    • Publisher
      近代出版
    • Related Report
      2010 Annual Research Report 2010 Self-evaluation Report
  • [Book] 生殖系列細胞のプログラム, 「生命の誕生にむけて」2010

    • Author(s)
      河野友宏,他
    • Publisher
      近大出版
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://nodai-konolab.net/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://nodai-konolab.net/

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 核移植卵、単為発生胚および単為発生非ヒト哺乳動物の作出方法2012

    • Inventor(s)
      河野友宏、川原学
    • Industrial Property Rights Holder
      学校法人東京農業大学
    • Acquisition Date
      2012-09-07
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] METHOD OF CONSTRUCTING NUCLEUS-IMPLANTED EGG,PARTHENOGENETIC EMBRYO AND PARTHENOGENETIC MAMMAL2010

    • Inventor(s)
      河野友宏、尾畑やよい、川原学
    • Industrial Property Rights Holder
      学校法人東京農業大学
    • Acquisition Date
      2010-02-09
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 特許権2010

    • Inventor(s)
      河野友宏, 尾畑やよい, 川原学
    • Industrial Property Rights Holder
      学校法人東京農業大学
    • Filing Date
      2010-02-09
    • Related Report
      2010 Self-evaluation Report
    • Overseas
  • [Patent(Industrial Property Rights)] METHOD OF CONSTRUCTING NUCLEAR-TRANSPLANTED EGG,PARTHENOGENETIC EMBRYO AND PARTHENOGENETIC MAMMAL2009

    • Inventor(s)
      河野友宏、尾畑やよい
    • Industrial Property Rights Holder
      学校法人東京農業大学
    • Acquisition Date
      2009-02-25
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 核移植卵、単為発生胚および単為発生哺乳動物の作出方法2009

    • Inventor(s)
      河野友宏、尾畑やよい
    • Industrial Property Rights Holder
      学校法人東京農業大学
    • Acquisition Date
      2009-03-13
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 特許権2009

    • Inventor(s)
      河野友宏, 尾畑やよい
    • Industrial Property Rights Holder
      学校法人東京農業大学
    • Filing Date
      2009-03-13
    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 特許権2009

    • Inventor(s)
      河野友宏, 尾畑やよい
    • Industrial Property Rights Holder
      学校法人東京農業大学
    • Filing Date
      2009-02-25
    • Related Report
      2010 Self-evaluation Report
    • Overseas
  • [Patent(Industrial Property Rights)] METHOD OF CONSTRUCTING NUCLEUS-IMPLANTED EGG,PARTHENOGENETIC EMBRYO AND PARTHENOGENETIC MAMMAL2008

    • Inventor(s)
      河野友宏、尾畑やよい、川原学
    • Industrial Property Rights Holder
      学校法人東京農業大学
    • Filing Date
      2008-06-18
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 核移植卵、単為発生胚および単為発生非ヒト哺乳動物の作出方法2007

    • Inventor(s)
      河野友宏、川原学
    • Industrial Property Rights Holder
      学校法人東京農業大学
    • Industrial Property Number
      2007-171707
    • Filing Date
      2007-06-29
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] METHOD OF CONSTRUCTING NUCLEAR-TRANSPLANTED EGG,PARTHENOGENETIC EMBRYO AND PARTHENOGENETIC MAMMAL2004

    • Inventor(s)
      河野友宏、尾畑やよい
    • Industrial Property Rights Holder
      学校法人東京農業大学
    • Filing Date
      2004-08-04
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 核移植卵、単為発生胚および単為発生哺乳動物の作出方法2004

    • Inventor(s)
      河野友宏、尾畑やよい
    • Industrial Property Rights Holder
      学校法人東京農業大学
    • Industrial Property Number
      2005-512613
    • Filing Date
      2004-08-04
    • Related Report
      2012 Final Research Report

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Published: 2008-04-01   Modified: 2019-07-29  

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