|Budget Amount *help
¥88,920,000 (Direct Cost: ¥68,400,000、Indirect Cost: ¥20,520,000)
Fiscal Year 2012: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2011: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2010: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2009: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Highly elaboratedπ一space can be seen in biomolecules such as proteins, where specific chemical reactions occur in protein environment. In this study, we aimed at revealing the mechanism of such specific chemical reactions in photoreceptive roteins. By combining genetic engineering and various spectroscopic methods, we revealed the mechanism of color tuning and chemical reactions. Of particular notice is the structural study of primate color visual pigments, and the discovery ofthe positive correlation between hydrogen-bonding strength ofintemal water molecules and proton pump fUnction. We also attempted to create new fUnction in bio-π-space, and achieved a protein performing an inward proton tran sport.