Molecular regulation of ROS signal receptor proteins: S-guanylation proteomics

• Project Area: Signaling functions of reactive oxygen species
• Project/Area Number: 20117005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tohoku University (2012-2013); Kumamoto University (2008-2011)
• Principal Investigator: AKAIKE Takaaki 東北大学, 医学(系)研究科(研究院), 教授 (20231798)
• Co-Investigator(Kenkyū-buntansha): SAWA Tomohiro 東北大学, 医学系研究科, 准教授 (30284756) ; IWAI Sumio 鹿児島大学, 農学部, 教授 (50295276) ; IHARA Hideshi 大阪府立大学, 理学系研究科, 准教授 (60254447)
• Project Period (FY): 2008-11-13 – 2013-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥177,320,000 (Direct Cost: ¥136,400,000、Indirect Cost: ¥40,920,000); Fiscal Year 2012: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000); Fiscal Year 2011: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000); Fiscal Year 2010: ¥35,620,000 (Direct Cost: ¥27,400,000、Indirect Cost: ¥8,220,000); Fiscal Year 2009: ¥36,270,000 (Direct Cost: ¥27,900,000、Indirect Cost: ¥8,370,000); Fiscal Year 2008: ¥36,790,000 (Direct Cost: ¥28,300,000、Indirect Cost: ¥8,490,000)
• Keywords: 活性酸素 / シグナル伝達 / プロテオミクス / 酸化ストレス / 生理活性 / プロテオーム / ストレス

Research Abstract

8-Nitro-cGMP functions as a second messenger for ROS signaling via protein S-guanylation, a unique posttranslational protein thiol modification. In this study, new methodology was developed for identification of S-guanylation proteome. Several ROS sensor proteins were identified and examined for their impacts of S-guanylation on cellular functions. We further identified that metabolic regulation n of 8-nitro-cGMP via sulfhydration to form 8-SH-cGMP mediated by reactive sulfur species generated by cys tathione beta-synthase and cystathione gamma-lyase systems.

Research Products

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• [Journal Article] S-guanylation proteomics for redox-based mitochondrial signaling. (2014)
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• [Journal Article] Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress. (2014)
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• [Journal Article] Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons. Biochem J (2014)
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• [Journal Article] Nitrated cGMP: a new player in guard cell signaling (2013)
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• [Journal Article] Endogenous NItrated Nucleotide Is a Key Mediator of Autophagy and Innate Defense against Bacteria (2013)
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• [Journal Article] Regulation of redox signalling by an electrophilic cyclic nucleotide. (2013)
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• [Journal Article] Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide (2013)
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• [Journal Article] S-guanylation of human serum albumin 18 a unique posttranslational modification and results ill a novel class of antibacterial agents. (2013)
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• [Journal Article] Redox signaling by 8-nitro-cyclic guanosine monophosphate: nitric oxide- and reactive oxygen species-derived electrophilic messenger. (2013)
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• [Journal Article] Inhibition of H3K18 deacetylation of Sirt7 by Myb-binding protein 1a (Mybbp1a) (2013)
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• [Journal Article] レドックスシグナル制御と酸化ストレスバイオマーカー (2013)
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  • Journal Title: Fragrance Journal Volume: 41 Pages: 75-80
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• [Journal Article] Regulation by Mitochondrial Superoxide and NADPH Oxidase of Cellular Formation of Nitrated Cyclic GMP: Potential Implications for Ros Signalling (2012)
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• [Journal Article] Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells. (2012)
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• [Journal Article] Keap1 Degradation by Autophagy for the Maintenance of Redox Homeostasis (2012)
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• [Journal Article] Hydrogen sulfide anion regulates redox signaling via electrophile sulfation (2012)
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• [Journal Article] HGF-mediated ihibition of oxidative stress by 8-nitro-cGMP in high glucose-treated rat mesangial cells (2012)
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• [Journal Article] 新・活性酸素中毒 (2012)
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• [Journal Article] 基礎の基礎 (2012)
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• [Journal Article] ニトロ化環状ヌクレオチドによるタンパク質S-グアニル化を介する酸化ストレス適応応答の分子機序 (2012)
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• [Journal Article] Midbrain dopaminergic neurons utilize nitric oxide/cyclic GMP signaling to recruit ERK that links retinoic acid receptor stimulation to up-regulation of BDNF (2011)
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• [Journal Article] Vascular responses to 8-nitro-cyclic GMP in non-diabetic and diabetic mice. (2011)
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• [Journal Article] Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3', 5'-cyclic monophosphate formed in glia cells (2011)
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• [Journal Article] Detoxification of Methylmercury by Hydrogen Sulfide Producing Enzyme in Mammalian Cells. (2011)
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• [Journal Article] Cellular uptake mechanisms and responses to NO transferred from mono-and poly-S-nitrosated human serum albumin (2011)
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• [Journal Article] Nucleotides function as endogenous chemical sensors for oxidative stress signaling (2011)
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• [Journal Article] Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitro-nucleotides (2011)
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• [Journal Article] Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile (2011)
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• [Journal Article] Antioxidant Effect of a Nitrated Cyclic Nucleotide Functioning as an Endogenous Electrophile (2011)
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• [Journal Article] Vascular responses to 8-nitro-cyclic GMP in nondiabetic and diabetic mice (2011)
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• [Journal Article] The critical role of nitric oxide signaling, via proteinS-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response (2010)
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• [Journal Article] One-step preparation of S-nitrosated human serum albumin with high biological activities (2010)
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• [Journal Article] Cell signaling mediated by nitrated cyclic guanine nucleotide (2010)
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• [Journal Article] Regulation of Redox Signaling Involving Chemical Conjugation of Protein Thiols by Nitric Oxide and Electrophiles (2010)
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• [Journal Article] The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response (2010)
  • Author(s): Fujii, S., Sawa, T., Ihara, H., Tong, K., Ida, T., Okamoto, T., Ahtesham, A.K., Ishima, Y., Motohashi, H., Yamamoto, M., Akaike, T
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• [Journal Article] Cell signaling mediated by nitrated cyclic guanine nucleotide (2010)
  • Author(s): Akaike, T., Fujii, S., Sawa, T., Ihara, H
  • Journal Title: Nitric Oxide 23 Pages: 166-174
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• [Journal Article] Regulation of redox signaling involving chemical conjugation of protein thiols by nitric oxide and electrophiles (2010)
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• [Journal Article] The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response (2010)
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• [Journal Article] Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitro-nucleotides (2010)
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  • Journal Title: Amino Acids Volume: (in press)
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• [Journal Article] Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile (2010)
  • Author(s): Sawa T., et al
  • Journal Title: Current Topics Med Chem Volume: (in press)
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• [Journal Article] 8-Nitro-cGMPの発見と生理機能の解明 (2010)
  • Author(s): 藤井重元, 他
  • Journal Title: 化学と生物 Volume: 48 Pages: 22-27
• [Journal Article] 毒性説から脱した活性酸素研究-シグナル分子としての活躍- (2010)
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• [Journal Article] A new paradigm for antimicrobial host defense mediated by a nitrated cyclic nucleotide (2010)
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• [Journal Article] Cellular signaling mediated bvy nitrated cyclic nucleotides (2010)
  • Author(s): Akaike T., et al
  • Journal Title: Nitric Oxide (in press)
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• [Journal Article] Regulation of redox signaling involving chemical conjugation of protein thiols by nitric oxide and electrophiles (2010)
  • Author(s): Sawa T., et al
  • Journal Title: Bioconjug Chem (in press)
  • Peer Reviewed
• [Journal Article] Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitronucleotides (2010)
  • Author(s): Ahmed KA., et al
  • Journal Title: Amino Acids (in press)
  • Peer Reviewed
• [Journal Article] 毒性説から脱した活性酸素研究-シグナル分子としての活躍- (2010)
  • Author(s): 澤智裕, 他
  • Journal Title: 現代化学 469 Pages: 34-38
• [Journal Article] 8-Nitro-cGMPの発見と生理機能の解明- (2010)
  • Author(s): 藤井重元, 他
  • Journal Title: 化学と生物 48 Pages: 22-27
• [Journal Article] Cytoprotective function of heme oxygenase-1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis (2009)
  • Author(s): Zaki MH, Fujii S, Okamoto T, Islam S, Khan S, Ahmed KA, Sawa T, and Akaike T
  • Journal Title: J Immnol Volume: 182 Pages: 3746-3756
  • DOI: 10.4049/jimmunol.0803363
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• [Journal Article] Cytoprotective function of heme oxygenase-1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis (2009)
  • Author(s): Zaki, Md.H., Fujii, S., Okamoto, T., Islam, S., Khan, S., Ahtecham, K., Sawa, T., Akaike, T
  • Journal Title: J.Immunol 182 Pages: 3746-3756
  • Peer Reviewed
• [Journal Article] Cytoprotective function of heme oxygenase-1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis (2009)
  • Author(s): Zaki MH., et al
  • Journal Title: J Immnol 182 Pages: 3746-3756
  • Peer Reviewed
• [Journal Article] 活性酸素のシグナル伝達機能-その生理機能の再発見と酸化ストレス研究の新展開 (2009)
  • Author(s): 赤池孝章, 他
  • Journal Title: 実験医学増刊:病態解明に迫る活性酸素シグナルと酸化ストレス 27 Pages: 2320-2329
• [Journal Article] チオール基の修飾による活性酸素のセンサー機能制御 (2009)
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• [Journal Article] NOによる細胞内感染防御の新しい展開-New paradigm of host defense against intracellular pathogens by nitric oxide (2009)
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  • Author(s): Ishima Y, Akaike T, Kragh-Hansen U, Hiroyama S, Sawa T, Maruyama T, Kai T, and Otagiri M
  • Journal Title: J. Biol. Chem Volume: 283 Pages: 34966-34975
  • DOI: 10.1074/jbc.m807009200
  • Peer Reviewed
• [Journal Article] 8-Nitroguanosines as chemical probes of the proteinS-guanylation (2008)
  • Author(s): Saito Y, Taguchi H, Fujii S, Sawa T, Kida E, Kabuto C, Akaike T, and Arimoto H
  • Journal Title: Chem. Commun Volume: 45 Pages: 5984-5986
  • DOI: 10.1039/b810771h
  • Peer Reviewed
• [Journal Article] Nitric oxide regulation of MMP-9 activation and its relationship to modifications of the cysteine switch (2008)
  • Author(s): McCarthy SM, Bove PF, Matthews DE, Akaike T, and van der Vliet A
  • Journal Title: Biochemistry Volume: 47 Pages: 5832-5840
  • DOI: 10.1021/bi702496v
  • Peer Reviewed
• [Journal Article] Suppression of NO production and 8-nitroguanosine formation by phenol-containing endocrine-disrupting chemicals in LPS-stimulated macrophages : Involvement of estrogen receptor-dependent or -independent pathways (2008)
  • Author(s): Yoshitake J, Kato K, Yoshioka D, Sueishi Y, Sawa T, Akaike T, and Yoshimura T
  • Journal Title: Nitric Oxide Volume: 18 Pages: 223-228
  • DOI: 10.1016/j.niox.2008.01.003
  • Peer Reviewed
• [Journal Article] S-nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding (2008)
  • Author(s): Ishima Y, et.al.
  • Journal Title: Biol Chem 283 Pages: 34966-34975
  • Peer Reviewed
• [Journal Article] 8-Nitroguanosines as chemical probes of the protein S-guanylation (2008)
  • Author(s): Saito Y, et.al.
  • Journal Title: Chem Commun Pages: 5984-5986
  • Peer Reviewed
• [Journal Article] Nitric oxide regulation of MMP-9 activation and its relationship to modifications of the cysteine switch (2008)
  • Author(s): McCarthy SM, et.al.
  • Journal Title: Biochemistry 47 Pages: 5832-5840
  • Peer Reviewed
• [Journal Article] Suppression of NO production and 8-titroguanosine formation by phenol-containing endocrine-disrupting chemicals in LPS-stimulated macrophages : Involvement of estrogen receptor-dependent or-independent pathways (2008)
  • Author(s): Yoshitake J, et.al.
  • Journal Title: Nitric Oxide 18 Pages: 223-228
  • Peer Reviewed
• [Journal Article] Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model (2008)
  • Author(s): Urano T, et.al.
  • Journal Title: Arterioscler Thromb Vase Biol 28 Pages: 827-834
  • Peer Reviewed
• [Journal Article] Nitric oxide produced in Peyer's patches exhibits antiapoptotic activity contributing to an antimicrobial effect in murine salmonellosis (2008)
  • Author(s): Alam MS, et.al.
  • Journal Title: Microbiol Immunol 52 Pages: 197-208
  • Peer Reviewed
• [Journal Article] Identification of the Major Antigenic Protein of Helicobacter cinaedi and the Immunogenicity During Infections in Humans (2008)
  • Author(s): Iwashita H, et.al.
  • Journal Title: Clin Vaccine Immunol 15 Pages: 513-521
  • Peer Reviewed
• [Journal Article] Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells (2008)
  • Author(s): Kaneko K, et.al.
  • Journal Title: Cancer Lett 262 Pages: 239-247
  • Peer Reviewed
• [Journal Article] 肺の感染炎症病態におけるニトロ化ストレスとそのバイオマーカー (2008)
  • Author(s): 岡本竜哉、他
  • Journal Title: 検査と技術 36 Pages: 678-679
  • Peer Reviewed
• [Journal Article] 感染病態におけるNO・活性酸素のシグナル伝達機能 : 酸化ストレスとその適応応答の分子メカニズム (2008)
  • Author(s): 岡本竜哉、他
  • Journal Title: AIlergy From the Nose to the Lung 6 Pages: 12-17
  • Peer Reviewed
• [Journal Article] Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3', 5'-cyclic monophosphate formed in glia cells
  • Author(s): Ihara, H., Ahmed, K.A., Ida, T., Kasamatsu, S., Kunieda, K., Okamoto, T., Sawa, T., Akaike, T
  • Journal Title: Nitric Oxide in press
  • Peer Reviewed
• [Presentation] 酸化ストレスとオートファジー (2014)
  • Author(s): 赤池孝章
  • Organizer: 大阪大学蛋白質研究所セミナー
  • Place of Presentation: 大阪大学蛋白質研究所 （大阪府吹田市）
  • Invited
• [Presentation] Regulation of 8-nitro-cGMP electrophilic signal transduction (2014)
  • Author(s): Akaike T
  • Organizer: The Environmental Response IV
  • Place of Presentation: 東北大学片平さくらホール （宮城県仙台市）
  • Invited
• [Presentation] 酸化ストレス応答とポリチオールバイオロジー (2014)
  • Author(s): 赤池孝章
  • Organizer: 日本農芸化学会2014年度大会
  • Place of Presentation: 神奈川県川崎市
  • Year and Date: 2014-03-30
• [Presentation] 活性イオウ分子による活性酸素シグナル制御 (2013)
  • Author(s): 赤池孝章
  • Organizer: 第22回日本Cell Death 学会学術集会
  • Place of Presentation: 京都大学医学部芝蘭会舘 （京都府京都市）
  • Invited
• [Presentation] 活性酸素シグナル制御とポリスルフィドミクス (2013)
  • Author(s): 赤池孝章
  • Organizer: 第86回日本生化学会
  • Place of Presentation: パシフィコ横浜 （神奈川県横浜市）
  • Invited
• [Presentation] 酸化ストレスの新しい制御因子:活性イオウ分子 (2013)
  • Author(s): 赤池孝章
  • Organizer: 第236回宮城県立がんセンターセミナー
  • Place of Presentation: 宮城県名取市
  • Year and Date: 2013-09-06
• [Presentation] 活性酸素シグナル制御とポリサルファバイオロジー (2013)
  • Author(s): 赤池孝章
  • Organizer: 国立がんセンターセミナー
  • Place of Presentation: 千葉県柏市
  • Year and Date: 2013-08-09
• [Presentation] 活性酸素シグナルとオートファジー:活性酸素によるユニークな感染防御機構 (2013)
  • Author(s): 赤池孝章
  • Organizer: 大阪大学微生物病研究所アドバンスセミナー
  • Place of Presentation: 大阪府吹田市
  • Year and Date: 2013-06-06
  • Invited
• [Presentation] Redox signaling regulation by hydrogen sulfide (2012)
  • Author(s): Akaike T
  • Organizer: Joint JSPS - Karolinska Institute Symposium : Current Concepts in Regulation of Metabolism, Cell Differentiation and Function, Nobel Forum
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2012-10-23
• [Presentation] トップジャーナル七転び八起き (2012)
  • Author(s): 赤池孝章
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎ブリックホール(長崎)(招待講演)
  • Year and Date: 2012-03-27
• [Presentation] Cellular signaling mediated by nitrated cyclic nucleotides and its regulation by hydrogen sulfide (2011)
  • Author(s): Takaaki Akaike
  • Organizer: The 23^<rd> Annual Meeting of the Korean Society for Molecular and Cellular Biology
  • Place of Presentation: COEX(ソウル韓国)(招待講演)
  • Year and Date: 2011-10-06
• [Presentation] ROS and electrophilic cellular signaling regulated by hydrogen sulfide (2011)
  • Author(s): 赤池孝章, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都)(招待講演)
  • Year and Date: 2011-09-21
• [Presentation] Antimicrobial cell signaling mediated by nitrated cyclic nucleotide (2011)
  • Author(s): Takaaki Akaike
  • Organizer: 第84回日本細菌学会総会
  • Place of Presentation: 札幌コンベンションセンター(札幌)(招待講演)
  • Year and Date: 2011-09-06
• [Presentation] 内因性硫化水素イオンによるROS・親電子シグナル制御 (2011)
  • Author(s): 赤池孝章
  • Organizer: 第2回Molecular Cardiovascular Conference II
  • Place of Presentation: ホテルピアノ(北海道キロロ)(招待講演)
  • Year and Date: 2011-09-02
• [Presentation] 生体内ガス分子と活性酸素による多次元シグナルネットワーク (2011)
  • Author(s): 赤池孝章
  • Organizer: 第8回Heme Oxygenase研究フォーラム
  • Place of Presentation: 京都府立医科大学・青蓮会館(京都)(招待講演)
  • Year and Date: 2011-08-26
• [Presentation] Protein S-guanylation and its unique regulation mechnism involving cysteine metabolism (2011)
  • Author(s): Akaike T
  • Organizer: 12th International Congress on Amino Acids, Peptides and Proteins
  • Place of Presentation: Beijin, China
  • Year and Date: 2011-08-01
• [Presentation] Protein S-guanylation and its unique regulation mechanisms involving cysteine metabolism (2011)
  • Author(s): Takaaki Akaike
  • Organizer: 12th International congress on amino acids, peptides and proteins
  • Place of Presentation: Beijing International Convention Center(北京)
  • Year and Date: 2011-08-01
• [Presentation] 親電子シグナルと硫化水素.九州大学生体防御医学研究所共同利用 (2011)
  • Author(s): 赤池孝章
  • Organizer: 九州大学生体防御医学研究所共同利用研究集会
  • Place of Presentation: 九州大学生体防御医学研究所会議室(福岡)(招待講演)
  • Year and Date: 2011-07-22
• [Presentation] 内因性硫化水素イオンによる親電子シグナル制御 (2011)
  • Author(s): 赤池孝章
  • Organizer: 64回日本酸化ストレス学会学術集会
  • Place of Presentation: ルスツリゾートホテル&コンベンション(北海道留寿都)(招待講演)
  • Year and Date: 2011-07-02
• [Presentation] Cellular signaling mediated by nitrated cyclic nucleotide and regulated by hydrogen sulfide. 5th International Conference on cGMP (2011)
  • Author(s): Takaaki Akaike
  • Organizer: 第5回cGMP国際会議
  • Place of Presentation: Lowengebaude, (Halle, Germany)(招待講演)
  • Year and Date: 2011-06-23
• [Presentation] 活性酸素シグナル伝達と加齢 (2011)
  • Author(s): 赤池孝章
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 国立京都国際会館(京都)(招待講演)
  • Year and Date: 2011-05-27
• [Presentation] Electrophilic cellular signaling regulated by H_2S-medaited sulfhydration (2011)
  • Author(s): Takaaki Akaike
  • Organizer: 第11回日本NO学会総会
  • Place of Presentation: 昭和薬科大学(東京都町田市)
  • Year and Date: 2011-05-13
• [Presentation] Cellular signaling by nitrated cyclic nucleotides and regulation of its biological effects (2011)
  • Author(s): Akaike, T
  • Organizer: Gordon Research Conference on Nitric Oxide
  • Place of Presentation: Ventura,CA,USA
  • Year and Date: 2011-02-17
• [Presentation] Cellular signaling by nitrated cyclic nucleotides and regulation of its biological effects (2011)
  • Author(s): Akaike T.
  • Organizer: Gordon Research Conferemce on Nitric Oxide : Understanding the Biology and Chemistry of Its Formation, Action, and Signaling
  • Place of Presentation: Four Points Sheraton/Holiday Inn Express (Ventura, CA)
  • Year and Date: 2011-02-17
• [Presentation] Cell signaling mediated by nitrated cyclic guanine nucleotide (2011)
  • Author(s): Akaike, T
  • Organizer: International Symposium on Free Radical Research: Contribution to Medicine
  • Place of Presentation: Kyoto,Japan
  • Year and Date: 2011-01-21
• [Presentation] Cell signaling mediated by nitrated cyclic guanine nucleotide (2011)
  • Author(s): Akaike T.
  • Organizer: International Symposium on Free Radical Research : Contribution to Medicine
  • Place of Presentation: Hyatt Regency Kyoto(京都市)
  • Year and Date: 2011-01-21
• [Presentation] 核酸分子の化学修飾による活性酸素シグナルのケミカルセンシング (2010)
  • Author(s): 澤智裕, 他
  • Organizer: 第83回日本生化学会大会
  • Place of Presentation: ポートアイランド(神戸市)
  • Year and Date: 2010-12-07
• [Presentation] NOによる抗酸化応答の新展開 (2010)
  • Author(s): 澤智裕, 他
  • Organizer: 第27回臨床フリーラジカル会議
  • Place of Presentation: 京都・烟河(京都市)
  • Year and Date: 2010-12-04
• [Presentation] Glyceraldehyde 3-phosphate dehydrogenaseの基質依存的な酸化的不活性化 (2010)
  • Author(s): 小野勝彦, 他
  • Organizer: 第63回日本酸化ストレス学会学術集会
  • Place of Presentation: 神奈川県民ホール(横浜市)
  • Year and Date: 2010-06-24
• [Presentation] 細胞内における8-nitro-cGMP生成メカニズムの解析 (2010)
  • Author(s): 吉武淳, 他
  • Organizer: 第63回日本酸化ストレス学会学術集会
  • Place of Presentation: 神奈川県民ホール(横浜市)
  • Year and Date: 2010-06-24
• [Presentation] Critical roles of nitric oxide signaling via 8-nitro-cGMP-induced protein S-guanylation in antioxidant adaptive responses (2010)
  • Author(s): Fujii S, et al
  • Organizer: The 26th Kumamoto Medical Bioscience Symposium
  • Place of Presentation: 山崎記念館(熊本市)
  • Year and Date: 2010-06-19
• [Presentation] Chemical basis for mechanism of 8-nitroguanosine 3',5'-cyclic monophosohate formation in cells (2010)
  • Author(s): Ahmed K.A., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Detection of protein-bound 3-nitrotyrosine in plasma from pediatric patients with fulminant ARDS and avian influenza infection (2010)
  • Author(s): Okamoto T., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Guanine nitration and oxidative stress responses during influenza virus pneumonia in mice (2010)
  • Author(s): Khan S., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Nitration of 3',5'-cyclic guanylic acid, a bacterial signaling molecule (2010)
  • Author(s): Ono K., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Estrogen receptor-dependent or -independent suppression of NO production and 8-nitroguanosine formation by endocrine-disrupting chemicals (2010)
  • Author(s): Yoshitake J., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Proteomic identification for sulfhydryl modifications of mitochondrial proteins by 8-nitroguanosine 3',5'-cyclic monophosphate (2010)
  • Author(s): Rahaman M.M., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Activation mechanism of cGMP-dependent protein kinase by a nitrated derivative of cGMP (2010)
  • Author(s): Oyama K., et al
  • Organizer: 6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-06-16
• [Presentation] Protein S-guanylation: a new post-translational regulation for redox signaling (2010)
  • Author(s): Akaike, T
  • Organizer: The 20th World Congress of the International Society for Heart Research 2010 Kyoto
  • Place of Presentation: Kyoto,Japan
  • Year and Date: 2010-05-14
• [Presentation] Protein S-guanylation : a new post-translational regulation for redox signaling (2010)
  • Author(s): Akaike T.
  • Organizer: The 20th World Congress of the International Society for Heart Research 2010 Kyoto
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2010-05-14
• [Presentation] A New Paradigm for Antimicrobial Host Defense Mediated by NO and ROS : A Critical Role of Nitrated Nucleotides (2010)
  • Author(s): Takaaki Akaike
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2010-03-27
• [Presentation] ニトロ化環状ヌクレオチドによる蛋白質S-グアニル化を介するcGMP依存性プロテインキナーゼの活性化 (2010)
  • Author(s): 藤井重元, 他
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2010-03-27
• [Presentation] Possible association of Helicobacter cinaedi with arrhythmia and atherosclerosis (2010)
  • Author(s): 岡本竜哉, 他
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2010-03-27
• [Presentation] Helicobacter cinaedi-related cardiovascular diseases and atherosclerosis (2010)
  • Author(s): Okamoto T., et al.
  • Organizer: 第10回日韓国際微生物学シンポジウム
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2010-03-26
• [Presentation] NO・活性酸素のヌクレオチドセンサーと親電子シグナル形成 (2010)
  • Author(s): 赤池孝章
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2010-03-16
• [Presentation] ROS signaling in animal cells (2010)
  • Author(s): Takaaki Akaike
  • Organizer: 第51回日本植物生理学会年会
  • Place of Presentation: 熊本大学黒髪北キャンパス
  • Year and Date: 2010-03-16
• [Presentation] A unique signal transduction of NO and ROS iated bvy cGMP-dependent protein kinase activated via S-guanylation (2010)
  • Author(s): Ahmed KA., et al.
  • Organizer: 第26回臨床フリーラジカル会議
  • Place of Presentation: 琵琶湖ホテル(大津市)
  • Year and Date: 2010-01-29
• [Presentation] A unique activating mechanism of cGMP-dependent protein kinase by a nitrated derivative of cGMP (2009)
  • Author(s): Oyama K., et al.
  • Organizer: 5^<th> Joint Meeting of the Societies for Free Radical Research Australasia and Japan
  • Place of Presentation: University of Sydney, Sydney, Australia
  • Year and Date: 2009-12-11
• [Presentation] New NO signaling via 8-nitro-cGMP formation and protein S-guanylation (2009)
  • Author(s): Takaaki Akaike
  • Organizer: 5^<th> Joint Meeting of the Societies for Free Radical Research Australasia and Japan
  • Place of Presentation: University of Sydney, Sydney, Australia
  • Year and Date: 2009-12-11
• [Presentation] New NO signaling via 8-nitro-cGMP formation and protein S-guanylation (2009)
  • Author(s): Akaike T
  • Organizer: 5th Joint Meeting of the Societies for Free Radical Research Australasia and Japan
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2009-12-06
• [Presentation] New NO signaling via 8-nitro-cGMP formation and protein S-guanylation (2009)
  • Author(s): Akaike, T
  • Organizer: 5th Joint Meeting of the Societies for Free Radical Research Australia and Japan
  • Place of Presentation: Sydney,Australia
  • Year and Date: 2009-12-04
• [Presentation] 活性酸素による新しい翻訳後修飾と親電子シグナル (2009)
  • Author(s): 赤池孝章
  • Organizer: 大阪大学蛋白質研究所セミナー
  • Place of Presentation: 大阪大学蛋白質研究所講演
  • Year and Date: 2009-11-27
• [Presentation] An emerging pathogen, Helicobacter cinaedi : Possible association with atherosclerosis (2009)
  • Author(s): Khan S., et al.
  • Organizer: 第25回熊本医学生物科学シンポジウム
  • Place of Presentation: 熊本大学山崎記念館(熊本市)
  • Year and Date: 2009-11-12
• [Presentation] A unique activating mechanism of cGMP-dependent protein kinase by a nitrated derivative of cGMP (2009)
  • Author(s): Ahmed KA., et al.
  • Organizer: 第25回熊本医学生物科学シンポジウム
  • Place of Presentation: 熊本大学山崎記念館(熊本市)
  • Year and Date: 2009-11-12
• [Presentation] 新興感染症菌ヘリコバクター・シネディの血清診断法の確立と感染疫学への応用 (2009)
  • Author(s): 小山耕太, 他
  • Organizer: 第3回細菌学・若手コロセウム
  • Place of Presentation: シーガイアサンホテルフェニックス(宮崎市)
  • Year and Date: 2009-10-26
• [Presentation] NOと活性酸素による酸化ストレス適応応答 (2009)
  • Author(s): 赤池孝章, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] ニトロ化環状ヌクレオチドによる蛋白質S-グアニル化を介したcGMP依存性プロテインキナーゼの活性化機構 (2009)
  • Author(s): 澤智裕, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] 細胞内S-グアニル化蛋白質同定と蛋白質S-グアニル化の生理機能の解明 (2009)
  • Author(s): 藤井重元, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] 細菌シグナル分子3^', 5^'-cyclic diguanylic acidのニトロ化 (2009)
  • Author(s): 小野勝彦, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] Chemical basis of 8-nitroguanosine 3^', 5^'-cyclic monophosphate formation in cells (2009)
  • Author(s): Ahmed KA., et al.
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2009-10-21
• [Presentation] An emerging pathogen, Helicobacter cinaedi : Possible association with atherosclerosis (2009)
  • Author(s): Khan S., et al.
  • Organizer: 第3回細菌学・若手コロセウム
  • Place of Presentation: シーガイアサンホテルフェニックス(宮崎市)
  • Year and Date: 2009-10-21
• [Presentation] 活性酸素シグナル研究の新展開 (2009)
  • Author(s): 赤池孝章, 他
  • Organizer: 第13回Molecular Cardiovascular Conference
  • Place of Presentation: キロロホテルピアノ(北海道)
  • Year and Date: 2009-09-04
• [Presentation] サルモネラ感染におけるニトロ化環状ヌクレオチドを介するNO誘導性生体防御機構 (2009)
  • Author(s): 藤井重元, 他
  • Organizer: 第62回日本細菌学会九州支部総会
  • Place of Presentation: 佐賀大学医学部(佐賀市)
  • Year and Date: 2009-09-04
• [Presentation] An emerging pathogen, Helicobacter cinaedi : Possible association with atherosclerosis (2009)
  • Author(s): Khan S., et al.
  • Organizer: 第62回日本細菌学会九州支部総会
  • Place of Presentation: 佐賀大学医学部(佐賀市)
  • Year and Date: 2009-09-04
• [Presentation] 新興感染症菌ヘリコバクター・シネディの血清診断法の確立と感染疫学への応用 (2009)
  • Author(s): 小山耕太, 他
  • Organizer: 第62回日本細菌学会九州支部総会
  • Place of Presentation: 佐賀大学医学部(佐賀市)
  • Year and Date: 2009-09-04
• [Presentation] インフルエンザウイルス肺炎における8-ニトロ-cGMPの生成を介した酸化ストレス応答の分子メカニズム (2009)
  • Author(s): 岡本竜哉, 他
  • Organizer: 第46回日本ウイルス学会九州支部総会
  • Place of Presentation: 佐賀大学医学部(佐賀市)
  • Year and Date: 2009-09-04
• [Presentation] Nitric oxide and electrophilic signaling mediated via 8-nitro-cGMP (2009)
  • Author(s): Akaike, T
  • Organizer: SFRR International Free Radical School in Japan 2009
  • Place of Presentation: Niigata,Japan
  • Year and Date: 2009-09-03
• [Presentation] Nitric oxide and electrophilic signaling mediated via 8-nitro-cGMP (2009)
  • Author(s): Takaaki Akaike
  • Organizer: SFRR International Free Radical School in Japan 2009
  • Place of Presentation: 上越国際スキーリゾート
  • Year and Date: 2009-09-03
• [Presentation] 蛋白質S-グアニル化を介する酸化ストレス適応応答の分子機序 (2009)
  • Author(s): 藤井重元, 他
  • Organizer: 第62回日Heme Oxygenase研究フォーラム
  • Place of Presentation: 京都府立医科大学(東京都)
  • Year and Date: 2009-08-31
• [Presentation] インフルエンザウイルス肺炎における8-ニトロ-cGMPの生成を介した酸化ストレス応答の分子メカニズム (2009)
  • Author(s): 岡本竜哉, 他
  • Organizer: 第20回日本生体防御学会
  • Place of Presentation: 東京医科歯科大学(東京都)
  • Year and Date: 2009-07-25
• [Presentation] SNO化血液製剤の薬理活性解析と臨床応用 (2009)
  • Author(s): 丸山徹, 他
  • Organizer: レッドックス生命科学第170委員会第21回研究会
  • Place of Presentation: ホテルグリーンピア南阿蘇(熊本)
  • Year and Date: 2009-07-16
• [Presentation] 新興感染症菌ヘリコバクター・シネディと院内感染 (2009)
  • Author(s): 岡本竜哉, 他
  • Organizer: 第2回感染病態研究フロンティア
  • Place of Presentation: 江陽グランドホテル(仙台市)
  • Year and Date: 2009-07-04
• [Presentation] Impairment of NO-dependent host defense via degradation of 8-nitro-cGMP induced by group A Streptococcus (2009)
  • Author(s): Ahmed KA., et al.
  • Organizer: 第18回Lancefieldレンサ球菌研究会
  • Place of Presentation: 九州大学(福岡市)
  • Year and Date: 2009-06-26
• [Presentation] 活性酸素とNOによる親電子シグナル伝達 (2009)
  • Author(s): 赤池孝章, 他
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 九州大学(福岡市)
  • Year and Date: 2009-06-11
• [Presentation] S-グアニル化を介したprotein kinase Gの新規な活性化機構 (2009)
  • Author(s): 澤智裕, 他
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 九州大学(福岡市)
  • Year and Date: 2009-06-11
• [Presentation] 細胞内S-グアニル化蛋白質の同定とS-グアニル化制御機構の解明 (2009)
  • Author(s): 藤井重元, 他
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 九州大学(福岡市)
  • Year and Date: 2009-06-11
• [Presentation] 活性酸素による新しい翻訳後修飾とシグナル伝達と機能の解明 (2009)
  • Author(s): 赤池孝章, 他
  • Organizer: 科学技術振興調整費先端融合領域イノベーション創出拠点の形成第1回公開シンポジウム
  • Place of Presentation: 港南区民文化センクーひまわりの郷(横浜市)
  • Year and Date: 2009-06-11
• [Presentation] 8-ニトログアノシン3^', 5^'-環状1リン酸による蛋白質S-グアニル化を介する酸化ストレス適応応答の分子機構 (2009)
  • Author(s): 藤井重元, 他
  • Organizer: 第9回日本NO学会総会
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] インフルエンザウイルス肺炎における8-ニトロ-Cgmpの生成を介した酸化ストレス応答の分子メカニズム (2009)
  • Author(s): 岡本竜哉, 他
  • Organizer: 第9回日本NO学会総会
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] S-Guanylation proteomics : unique post-translational modification of thiols dependent on nitric oxide and reactive oxygen species (2009)
  • Author(s): 澤智裕, 他
  • Organizer: 第9回日本NO学会総会
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] Nitration of guanosine 3^', 5^'-cyclic monophosphate by nitric oxide and reactive oxigen species (2009)
  • Author(s): Ahmed KA., et al.
  • Organizer: 第9回日本NO学会総会
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] Host defense function of 8-nitro-cGMP during murine salmonellosis (2009)
  • Author(s): Khan S., et al.
  • Organizer: 第9回日本NO学会総会
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] 細菌シグナル分子3^', 5^'-cyclic diguanylic acidのニトロ化 (2009)
  • Author(s): 小山耕太, 他
  • Organizer: 第9回日本NO学会総会
  • Place of Presentation: グランシップ(静岡市)
  • Year and Date: 2009-05-08
• [Presentation] Protein S-guanylation induced by 8-nitro-cGMP (2008)
  • Author(s): Akaike T
  • Organizer: 5th International Conference Biology, Chemistry and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Bregenz, Austria
  • Year and Date: 2008-08-25
• [Presentation] 活性酸素シグナルとオートファジー：活性酸素によるユニークな感染防御機構
  • Author(s): 赤池孝章
  • Organizer: 大阪大学微生物病研究所アドバンスセミナー
  • Place of Presentation: 大阪大学微生物病研究所 （大阪府吹田市）
  • Invited
• [Presentation] 活性酸素シグナル制御とポリサルファバイオロジー
  • Author(s): 赤池孝章
  • Organizer: 東京理科大学セミナー
  • Place of Presentation: 東京理科大学生命医科学研究所（千葉県野田市）
  • Invited
• [Presentation] 活性酸素シグナル制御とポリサルファバイオロジー
  • Author(s): 赤池孝章
  • Organizer: 国立がんセンターセミナー
  • Place of Presentation: 国立がんセンター （千葉県柏市）
  • Invited
• [Presentation] 酸化ストレスの新しい制御因子：活性イオウ分子
  • Author(s): 赤池孝章
  • Organizer: 第236回宮城県立がんセンターセミナー
  • Place of Presentation: 宮城県立がんセンター （宮城県名取市）
  • Invited
• [Presentation] 喘息を含めた呼吸器疾患と酸化ストレス
  • Author(s): 赤池孝章
  • Organizer: 第２回東北呼吸器疾患懇談会
  • Place of Presentation: AER （宮城県仙台市）
  • Invited
• [Presentation] 環境応答とチオールバイオロジー
  • Author(s): 赤池孝章
  • Organizer: 第30回高峰カンファレンス
  • Place of Presentation: 東京會館（東京都中央区）
  • Invited
• [Book] Antioxidant adaptive response of malignant glioma related to resistance to antitumor treatment. Novel Therapeutic Concepts in Targeting Glioma (2012)
  • Author(s): Sawa T. and Akaike T
  • Publisher: In Tech
• [Book] 一酸化窒素nitric oxide/NO. 免疫の事典 (2011)
  • Author(s): 澤 智裕, 赤池孝章
  • Total Pages: 39
  • Publisher: 朝倉書店
• [Book] 活性酸素reactive oxygen species (ROS). 免疫の事典 (2011)
  • Author(s): 澤 智裕, 赤池孝章
  • Total Pages: 109
  • Publisher: 朝倉書店
• [Book] Antioxidant adaptive response of malignant glioma related to resistance to antitumor treatment. In Novel Therapeutic Concepts in Targeting Glioma (eds., Faris Farassati), p.247-262 (2011)
  • Author(s): Sawa, T., Akaike T
  • Total Pages: 15
  • Publisher: InTech (Open Access Company)
• [Book] 免疫り事典-酸化窒素nitric oxide/NO.p.39(桂義元,河本宏,小安重夫,山本一彦編) (2011)
  • Author(s): 澤智裕, 赤池孝章
  • Total Pages: 1
  • Publisher: 朝倉書店
• [Book] 免疫の事典活性酸素reactive oxygen species (ROS). p.109(桂義元,河本宏,小安重夫,山本一彦編) (2011)
  • Author(s): 澤智裕, 赤池孝章
  • Total Pages: 1
  • Publisher: 朝倉書店
• [Book] Transworld Research Network, T.C Nitric Oxide Synthase Inhibitors: From Animal Studies to Clinical Implications (Tunctan, B., Editor) (2011)
  • Author(s): Okamoto, T., Zaki, M.H., Fujii, S., Sawa, T
  • Publisher: Akaike, T(in press)
• [Book] Nitric Oxide Synthase Inhibitors : From Animal Studies to Clinical Implications (2011)
  • Author(s): Okamoto T., et al
  • Publisher: Nitric oxide-mediated host immune response and microbial pathogenesis(in press)
• [Book] 日本臨床増刊号 広範囲血液・尿化学検査,免疫学的検査-4 (2010)
  • Author(s): 岡本竜哉, 他
  • Publisher: Nitric oxide(NO)およびNO関連物質
• [Book] 活性酸素のシグナル伝達機能―その生理機能の再発見と酸化ストレス研究の新展開.実験医学増刊:病態解明に迫る活性酸素シグナルと酸化ストレス (2009)
  • Author(s): 赤池孝章
  • Publisher: 羊土社
• [Book] チオール基の修飾による活性酸素のセンサー機能制御.実験医学増刊:病態解明に迫る活性酸素シグナルと酸化ストレス (2009)
  • Author(s): 澤 智裕, 有本博一, 赤池孝章
  • Publisher: 羊土社
• [Book] 実験医学(増刊).病態解明に迫る活性酸素シグナルと酸化ストレス (2009)
  • Author(s): 谷口直之(監修)、赤池孝章、鈴木敬一郎、内田浩二(編集)
  • Total Pages: 241
  • Publisher: 羊土社
• [Book] 一酸化窒素(NO)とシグナル伝達.酸化ストレスの医学.診断と治療社(吉川敏一 監修) (2008)
  • Author(s): 澤 智裕, 赤池孝章
• [Book] 診断と治療社、酸化ストレスの医学 (2008)
  • Author(s): 澤 智裕
  • Total Pages: 384
  • Publisher: 赤池孝章
• [Book] 酸化ストレスの医学 (2008)
  • Author(s): 澤智裕、他
  • Total Pages: 384
  • Publisher: 診断と治療社
• [Remarks]
  • URL: http://www.toxicosci.med.tohoku.ac.jp
• [Remarks] 東北大学大学院医学系研究科環境保健医学分野
  • URL: http://www.toxicosci.med.tohoku.ac.jp/index.html
• [Remarks]
  • URL: http://kumadai-bisei.com/
• [Remarks]
  • URL: http://www.ros-signal.jp/
• [Remarks] を開設し、積極的に情報発信を行った
  • URL: http://www.ros-signal.jp/
• [Remarks]
  • URL: http://kumadai-bisei.com/
• [Remarks]
  • URL: http://www.ros-signal.jp/
• [Remarks]
  • URL: http://kumadai-bisei.com
• [Remarks]
  • URL: http://www.ros-signal.jp