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Molecular regulation of ROS signal receptor proteins: S-guanylation proteomics

Planned Research

Project AreaSignaling functions of reactive oxygen species
Project/Area Number 20117005
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTohoku University (2012-2013)
Kumamoto University (2008-2011)

Principal Investigator

AKAIKE Takaaki  東北大学, 医学(系)研究科(研究院), 教授 (20231798)

Co-Investigator(Kenkyū-buntansha) SAWA Tomohiro  東北大学, 医学系研究科, 准教授 (30284756)
IWAI Sumio  鹿児島大学, 農学部, 教授 (50295276)
IHARA Hideshi  大阪府立大学, 理学系研究科, 准教授 (60254447)
Project Period (FY) 2008-11-13 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥177,320,000 (Direct Cost: ¥136,400,000、Indirect Cost: ¥40,920,000)
Fiscal Year 2012: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
Fiscal Year 2011: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
Fiscal Year 2010: ¥35,620,000 (Direct Cost: ¥27,400,000、Indirect Cost: ¥8,220,000)
Fiscal Year 2009: ¥36,270,000 (Direct Cost: ¥27,900,000、Indirect Cost: ¥8,370,000)
Fiscal Year 2008: ¥36,790,000 (Direct Cost: ¥28,300,000、Indirect Cost: ¥8,490,000)
Keywords活性酸素 / シグナル伝達 / プロテオミクス / 酸化ストレス / 生理活性 / プロテオーム / ストレス
Research Abstract

8-Nitro-cGMP functions as a second messenger for ROS signaling via protein S-guanylation, a unique posttranslational protein thiol modification. In this study, new methodology was developed for identification of S-guanylation proteome. Several ROS sensor proteins were identified and examined for their impacts of S-guanylation on cellular functions. We further identified that metabolic regulation n of 8-nitro-cGMP via sulfhydration to form 8-SH-cGMP mediated by reactive sulfur species generated by cys tathione beta-synthase and cystathione gamma-lyase systems.

Report

(7 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (203 results)

All 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article (88 results) (of which Peer Reviewed: 70 results,  Open Access: 5 results) Presentation (91 results) (of which Invited: 12 results) Book (15 results) Remarks (9 results)

  • [Journal Article] Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.2014

    • Author(s)
      Ida T, Sawa T, Ihara H, Tsucr iya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S. Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N O, Xian M, Fukuto J M, Akaike T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: (印刷中) Issue: 21 Pages: 7606-7611

    • DOI

      10.1073/pnas.1321232111

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses.2014

    • Author(s)
      Khan S, Rahman H N A, Okamoto T, Matsunaga T, Fujiwara Y, Sawa T, Yoshitake J, Ono K, Ahmed K A, Rahaman M d M, Oyama K, Takeya M, Ida T, Kitamura Y, Fujii S, Akaike T.
    • Journal Title

      Sci. Rep.

      Volume: (印刷中) Issue: 1 Pages: 4680-4680

    • DOI

      10.1038/srep04680

    • NAID

      120005649608

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.2014

    • Author(s)
      Yoshizawa T, Karim Md. F, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Kakeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
    • Journal Title

      Cell Metab.

      Volume: 9 Issue: 4 Pages: 712-721

    • DOI

      10.1016/j.cmet.2014.03.006

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] S-Guanylation proteomics for redox-based mitochondrial signaling.2014

    • Author(s)
      Rahaman MM, Sawa T, Ahtesh am AK, Khan S, Inoue H, Irie A. Fujii S, and Akaike T.
    • Journal Title

      Antioxid. Redox Signal.

      Volume: 20 Issue: 2 Pages: 295-307

    • DOI

      10.1089/ars.2012.4606

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Angiopoietin-like protein 2 accelerates carcinogenesis by activating chronic inflammation and oxidative stress2014

    • Author(s)
      Aoi J, Endo M, Kadomatsu T, Miyata K, Ogata A, Horiguchi H, Odagiri H, Masuda T, Fukushima S, Jinnin M, Hirakawa S, Sawa T, Akaike T, Ihn H and Oike Y
    • Journal Title

      Mol. Cancer Res

      Volume: 12 Issue: 2 Pages: 239-249

    • DOI

      10.1158/1541-7786.mcr-13-0336

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons.2014

    • Author(s)
      Kasamats S, Watanabe Y, Sawa T, Akaike T, Ihara H.
    • Journal Title

      Biochem. J.

      Volume: 459 Issue: 2 Pages: 251-263

    • DOI

      10.1042/bj20131262

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S-nitrosylated a-l-acid glycoprotein kills drug-resistant bacteria and aids survival in sepsis2013

    • Author(s)
      Watanabe K, Ishima Y, Akaike T, Sawa T, Kuroda T, Ogawa W, Watanabe H, Suenaga A, Kai T, Otagiri M, and Maruyama T.
    • Journal Title

      FASEB J

      Volume: 27 Issue: 1 Pages: 391-398

    • DOI

      10.1096/fj.12-217794

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide/soluble guanylyl cyclase signaling mediates depolarization-induced protection of rat mesencephalic dopaminergic neurons from MPP+ cytotoxicity2013

    • Author(s)
      Kurauchi Y, Hisatsune A, Isohama Y, Sawa T, Akaike T and Katsuki H.
    • Journal Title

      Neurosci.

      Volume: 231 Pages: 206-215

    • DOI

      10.1016/j.neuroscience.2012.11.044

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitrated cyclic GMP modulates guard cell signaling in Arabidopsis2013

    • Author(s)
      Joudoi T, Hatakeyama T, Maeda T, Akaike T, Sawa T and Iwai S.
    • Journal Title

      Plant Cell

      Volume: 25 Issue: 2 Pages: 558-571

    • DOI

      10.1105/tpc.112.105049

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescent probes for live cell imaging of endogenous guanine nitration2013

    • Author(s)
      Saito Y, Ito C, Fujii S, Sawa T, Akaike T and Arimoto H.
    • Journal Title

      Chembiochem.

      Volume: 14 Issue: 9 Pages: 1068-1071

    • DOI

      10.1002/cbic.201300129

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria.2013

    • Author(s)
      Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, Arimoto H.
    • Journal Title

      Mol. Cell

      Volume: 52 Issue: 6 Pages: 794-804

    • DOI

      10.1016/j.molcel.2013.10.024

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of redox signaling by an electrophilic cyclic nucleotide.2013

    • Author(s)
      Akaike T, Nishida M and Fujii S.
    • Journal Title

      J. Biochem.

      Volume: 153 Issue: 2 Pages: 131-138

    • DOI

      10.1093/jb/mvs145

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide.2013

    • Author(s)
      Sawa T, Ihara H, Ida T, Fujii S, Nishida M and Akaike T.
    • Journal Title

      Nitric Oxide

      Volume: 34 Pages: 10-18

    • DOI

      10.1016/j.niox.2013.04.004

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redox signaling by 8-nitro-cyclic guanosine monophosphate : nitric oxide- and reactive oxygen species-derived electrophilic messenger2013

    • Author(s)
      Fujii S and Akaike T.
    • Journal Title

      Antioxid. Redox Signal.

      Volume: 19 Issue: 11 Pages: 1236-1246

    • DOI

      10.1089/ars.2012.5067

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of H3K18 deacetylation of SIRT7 by Myb-binding protein la (Mybbpla)2013

    • Author(s)
      Karim Md F, Yoshizawa T, Sato Y, Sawa T, Tomizawa K, A kaike T and Yamagata K.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 441 Issue: 1 Pages: 157-163

    • DOI

      10.1016/j.bbrc.2013.10.020

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] レドックスシグナル制御と酸化ストレスバイオマーカー2013

    • Author(s)
      赤池孝章、藤井重元
    • Journal Title

      精神科救急

      Volume: 16 Pages: 69-72

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 活性酸素シグナルの調節機構 ROS毒性説から脱却した新たな概念2013

    • Author(s)
      居原秀、井田智章、赤池孝章
    • Journal Title

      Fragrance Journal

      Volume: 41 Pages: 75-80

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 概論:活性酸素のシグナル伝達機能?その生理機能の再発見と酸化ストレス研究の新展開2013

    • Author(s)
      赤池孝章
    • Journal Title

      実験医学(増刊)

      Volume: 30 Pages: 22-29

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 細胞の酸化ストレスを量る 親電子化合物8-nitro-cGMPの定量を例に.見つける、量る、可視化する!質量分析実験ガイド2013

    • Author(s)
      澤 智裕、居原 秀、赤池孝章
    • Journal Title

      実験医学別冊

      Volume: - Pages: 151-158

    • Related Report
      2012 Annual Research Report
  • [Journal Article] NOシグナリング研究の最前線2013

    • Author(s)
      澤 智裕、赤池孝章
    • Journal Title

      Heart View

      Volume: 17 Pages: 88-92

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 活性酸素とガス状分子のシグナルネットワーク2013

    • Author(s)
      澤 智裕、赤池孝章
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 776-780

    • Related Report
      2012 Annual Research Report
  • [Journal Article] はじめに -活性酸素と分子状酸素のバイオセンサーと生体応答-2013

    • Author(s)
      赤池孝章、末松誠
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 727-727

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Nitric oxide promotes recycling of 8-nitro-cGMP, a cytoprotectivemediator, into intact cGMP in cells2012

    • Author(s)
      Yohei Saito, Tomohiro Sawa, Jun Yoshitake, Chiaki Ito, Shigemoto Fujii, Takaaki Akaike and Hirokazu Arimoto
    • Journal Title

      Moi BioSyst

      Volume: 8 Issue: 11 Pages: 2909-2915

    • DOI

      10.1039/c2mb25189b

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP : potential implications for ROS signalling2012

    • Author(s)
      Ahmed KA., et al
    • Journal Title

      Biochem J

      Volume: 441 Issue: 2 Pages: 719-730

    • DOI

      10.1042/bj20111130

    • NAID

      120004875062

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anks4b, a novel target of HNF4α interacts with GRP78 and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells2012

    • Author(s)
      Sato Y, Hatta M, Karim MF, Sawa T, Wei F-Y, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, and Yamagata K
    • Journal Title

      J. Biol. Chem

      Volume: 287 Issue: 27 Pages: 23236-23245

    • DOI

      10.1074/jbc.m112.368779

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] S-Guanylation of human serum albumin is a unique posttranslational modification and results in a novel class of antibacterial agents2012

    • Author(s)
      Ishima Y, Hoshino H, Shinagawa T, Watanabe K, Akaike T, Sawa T, Kragh-Hansen U, Kai T, Watanabe H, Maruyama T, and Otagiri M
    • Journal Title

      J. Pharm. Sci

      Volume: 101 Issue: 9 Pages: 3222-3229

    • DOI

      10.1002/jps.23143

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Keap1 degradation by autophagy for the maintenance of redox homeostasis2012

    • Author(s)
      Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, and Yamamoto M
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 109 Issue: 34 Pages: 13561-13566

    • DOI

      10.1073/pnas.1121572109

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration.2012

    • Author(s)
      Nishida M., et al
    • Journal Title

      Nature Chen. Biol.

      Volume: 8 Issue: 8 Pages: 714-724

    • DOI

      10.1038/nchembio.1018

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] HGF-mediated inhibition of oxidative stress by 8-nitro-cGMP in high glucose-treated rat mesangial cells2012

    • Author(s)
      Guoguo S, Akaike T, Tao J, Qi C, Nong Z, and Hui L
    • Journal Title

      Free Radic. Res

      Volume: 46 Issue: 10 Pages: 1238-1248

    • DOI

      10.3109/10715762.2012.701292

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新・活性酸素中毒2012

    • Author(s)
      赤池孝章
    • Journal Title

      ファルマシア

      Volume: 48 Pages: 1-1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 基礎の基礎2012

    • Author(s)
      赤池孝章
    • Journal Title

      細胞工学

      Volume: 31 Pages: 134-137

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ニトロ化環状ヌクレオチドによるタンパク質S-グアニル化を介する酸化ストレス適応応答の分子機序2012

    • Author(s)
      藤井重元、赤池孝章
    • Journal Title

      生化学

      Volume: 84 Pages: 124-128

    • NAID

      10030346449

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Midbrain dopaminergic neurons utilize nitric oxide/cyclic GMP signaling to recruit ERK that links retinoic acid receptor stimulation to up-regulation of BDNF2011

    • Author(s)
      Kurauchi Y., et al
    • Journal Title

      J Neurochem

      Volume: 116 Issue: 3 Pages: 323-333

    • DOI

      10.1111/j.1471-4159.2010.06916.x

    • Related Report
      2013 Final Research Report 2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular responses to 8-nitro-cyclic GMP in non-diabetic and diabetic mice2011

    • Author(s)
      Tokutomi Y., et al
    • Journal Title

      Br J Pharmabol

      Volume: 162 Issue: 8 Pages: 1884-1893

    • DOI

      10.1111/j.1476-5381.2011.01201.x

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frontiers in nitric oxide and redox signaling2011

    • Author(s)
      Akaike T., et al
    • Journal Title

      Nitric Oxide

      Volume: 25 Issue: 2 Pages: 57-58

    • DOI

      10.1016/j.niox.2011.04.015

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detoxification of methylmercury by hydrogen sulfide-producing enzyme in Mammalian cells2011

    • Author(s)
      Yoshida E, Toyama T (equalcontributor), Shinkai Y, Sawa T, Akaike T, Kumagai Y
    • Journal Title

      Chemical Research in Toxicology

      Volume: 24 Issue: 10 Pages: 1633-1635

    • DOI

      10.1021/tx200394g

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular uptake mechanisms and responses to NO transferred from mono- and poly-S-nitrosated human serum albumin2011

    • Author(s)
      Yu Ishima., et al
    • Journal Title

      Free Radical Research

      Volume: 45 Issue: 10 Pages: 1196-1206

    • DOI

      10.3109/10715762.2011.606814

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitro-nucleotides2011

    • Author(s)
      Ahmed KA., et al
    • Journal Title

      Amino Acids

      Volume: 41 Issue: 1 Pages: 123-130

    • DOI

      10.1007/s00726-010-0535-1

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile2011

    • Author(s)
      Sawa T, Ihara H, and Akaike T
    • Journal Title

      Current Topics Med. Chem

      Volume: 11 Issue: 14 Pages: 1854-1860

    • DOI

      10.2174/156802611796235080

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant Effect of a Nitrated Cyclic Nucleotide Functioning as an Endogenous Electrophile2011

    • Author(s)
      Sawa T., et al
    • Journal Title

      Curr Top Med Chem.

      Volume: 11 Pages: 1854-1860

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 喫煙と酸化ストレス:Oxidative stress induced by cigarette smoking2011

    • Author(s)
      岡本竜哉, 他
    • Journal Title

      最新精神医学

      Volume: 16 Pages: 431-439

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 活性酸素・一酸化窒素によるニトロ化シグナルと抗炎症作用2011

    • Author(s)
      澤智裕, 他
    • Journal Title

      感染・炎症・免疫

      Volume: 41 Pages: 12-19

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
  • [Journal Article] Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3',5'-cyclic monophosphate formed in glia cells2011

    • Author(s)
      Ihara H., et al
    • Journal Title

      Nitric Oxide

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular responses to 8-nitro-cyclic GMP in nondiabetic and diabetic mice2011

    • Author(s)
      Tokutomi Y., et al
    • Journal Title

      Br J Pharmacol

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nucleotides function as endogenous chemical sensors for oxidative stress signaling2010

    • Author(s)
      Ihara H., et al
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 48 Issue: 1 Pages: 33-39

    • DOI

      10.3164/jcbn.11-003FR

    • NAID

      130004879228

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2013 Final Research Report 2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The critical role of nitric oxide signaling, via proteinS-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response2010

    • Author(s)
      Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahmed KA, Ishima Y, Motohashi H, Yamamoto M, and Akaike T
    • Journal Title

      J. Biol. Chem

      Volume: 285 Issue: 31 Pages: 23970-23984

    • DOI

      10.1074/jbc.m110.145441

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-step preparation of S-nitrosated human serum albumin with high biological activities2010

    • Author(s)
      Ishima Y, Hiroyama S, Kragh-Hansen U, Maruyama T, Sawa T, Akaike T, Kai T and Otagiri M
    • Journal Title

      Nitric Oxide

      Volume: 23 Issue: 2 Pages: 121-127

    • DOI

      10.1016/j.niox.2010.05.002

    • NAID

      120002971552

    • Related Report
      2013 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell signaling mediated by nitrated cyclic guanine nucleotide2010

    • Author(s)
      Akaike T, Fujii S, Sawa T, and Ihara H
    • Journal Title

      Nitric Oxide

      Volume: 23 Issue: 3 Pages: 166-174

    • DOI

      10.1016/j.niox.2010.06.006

    • NAID

      120002772115

    • Related Report
      2013 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of redox signaling involving chemical conjugation of protein thiols by nitric oxide and electrophiles2010

    • Author(s)
      Sawa T, Arimoto H, and Akaike T
    • Journal Title

      Bioconjugate Chem

      Volume: 21 Issue: 7 Pages: 1121-1129

    • DOI

      10.1021/bc900396u

    • Related Report
      2013 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response2010

    • Author(s)
      Fujii, S., Sawa, T., Ihara, H., Tong, K., Ida, T., Okamoto, T., Ahtesham, A.K., Ishima, Y., Motohashi, H., Yamamoto, M., Akaike, T
    • Journal Title

      J.Biol.Chem 285

      Pages: 23970-23984

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Cell signaling mediated by nitrated cyclic guanine nucleotide2010

    • Author(s)
      Akaike, T., Fujii, S., Sawa, T., Ihara, H
    • Journal Title

      Nitric Oxide 23

      Pages: 166-174

    • NAID

      120002772115

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Regulation of redox signaling involving chemical conjugation of protein thiols by nitric oxide and electrophiles2010

    • Author(s)
      Sawa, T., Arimoto, H., Akaike, T
    • Journal Title

      Bioconjugate Chem 21

      Pages: 1121-1129

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] A new paradigm for antimicrobial host defense mediated by a nitrated cyclic nucleotide2010

    • Author(s)
      Okamoto T., et al
    • Journal Title

      J Clin Biochem Nutr

      Volume: 46 Pages: 14-19

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response2010

    • Author(s)
      Fujii S., et al
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 23970-23984

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitro-nucleotides2010

    • Author(s)
      Ahmed K.A., et al
    • Journal Title

      Amino Acids

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile2010

    • Author(s)
      Sawa T., et al
    • Journal Title

      Current Topics Med Chem

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 呼吸器疾患における酸化ストレスと制御シグナルの分子基盤: Molecular mechanisms of nitric oxide- and reactive oxygen species-mediated signalings in the respiratory diseases2010

    • Author(s)
      岡本竜哉, 他
    • Journal Title

      呼吸

      Volume: 29 Pages: 859-866

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 8-Nitro-cGMPの発見と生理機能の解明2010

    • Author(s)
      藤井重元, 他
    • Journal Title

      化学と生物

      Volume: 48 Pages: 22-27

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 毒性説から脱した活性酸素研究-シグナル分子としての活躍-2010

    • Author(s)
      澤智裕, 他
    • Journal Title

      現代化学

      Volume: 469 Pages: 34-38

    • NAID

      40016994933

    • Related Report
      2010 Annual Research Report
  • [Journal Article] A new paradigm for antimicrobial host defense mediated by a nitrated cyclic nucleotide2010

    • Author(s)
      Okamoto T., et al
    • Journal Title

      J Clin Biochem Nutr 46

      Pages: 14-19

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular signaling mediated bvy nitrated cyclic nucleotides2010

    • Author(s)
      Akaike T., et al
    • Journal Title

      Nitric Oxide (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of redox signaling involving chemical conjugation of protein thiols by nitric oxide and electrophiles2010

    • Author(s)
      Sawa T., et al
    • Journal Title

      Bioconjug Chem (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitronucleotides2010

    • Author(s)
      Ahmed KA., et al
    • Journal Title

      Amino Acids (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 毒性説から脱した活性酸素研究-シグナル分子としての活躍-2010

    • Author(s)
      澤智裕, 他
    • Journal Title

      現代化学 469

      Pages: 34-38

    • NAID

      40016994933

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 8-Nitro-cGMPの発見と生理機能の解明-2010

    • Author(s)
      藤井重元, 他
    • Journal Title

      化学と生物 48

      Pages: 22-27

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Cytoprotective function of heme oxygenase-1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis2009

    • Author(s)
      Zaki MH, Fujii S, Okamoto T, Islam S, Khan S, Ahmed KA, Sawa T, and Akaike T
    • Journal Title

      J. Immnol

      Volume: 182 Issue: 6 Pages: 3746-3756

    • DOI

      10.4049/jimmunol.0803363

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytoprotective function of heme oxygenase-1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis2009

    • Author(s)
      Zaki, Md.H., Fujii, S., Okamoto, T., Islam, S., Khan, S., Ahtecham, K., Sawa, T., Akaike, T
    • Journal Title

      J.Immunol 182

      Pages: 3746-3756

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Cytoprotective function of heme oxygenase-1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis2009

    • Author(s)
      Zaki MH., et al
    • Journal Title

      J Immnol 182

      Pages: 3746-3756

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 活性酸素のシグナル伝達機能-その生理機能の再発見と酸化ストレス研究の新展開2009

    • Author(s)
      赤池孝章, 他
    • Journal Title

      実験医学増刊:病態解明に迫る活性酸素シグナルと酸化ストレス 27

      Pages: 2320-2329

    • Related Report
      2009 Annual Research Report
  • [Journal Article] チオール基の修飾による活性酸素のセンサー機能制御2009

    • Author(s)
      澤智裕, 他
    • Journal Title

      実験医学増刊:病態解明に迫る活性酸素シグナルと酸化ストレス 27

      Pages: 2341-2347

    • Related Report
      2009 Annual Research Report
  • [Journal Article] NOによる細胞内感染防御の新しい展開-New paradigm of host defense against intracellular pathogens by nitric oxide2009

    • Author(s)
      赤池孝章, 他
    • Journal Title

      日本ハンセン病学会雑誌 78

      Pages: 41-47

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 活性酸素・NOによる感染防御シグナルの新展開-Antimicrobial signaling mediated by reactive oxygen species and NO2009

    • Author(s)
      岡本竜哉, 他
    • Journal Title

      細胞 41

      Pages: 51-55

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Cytoprotective function of heme oxygenase-1 induced by a nitrate(cyclic nucleotide formed during murine salmonellosis2009

    • Author(s)
      Zalci MI-I, et.al.
    • Journal Title

      J Immunol 182

      Pages: 3746-3756

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S-Nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding2008

    • Author(s)
      Ishima Y, Akaike T, Kragh-Hansen U, Hiroyama S, Sawa T, Maruyama T, Kai T, and Otagiri M
    • Journal Title

      J. Biol. Chem

      Volume: 283 Issue: 50 Pages: 34966-34975

    • DOI

      10.1074/jbc.m807009200

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 8-Nitroguanosines as chemical probes of the proteinS-guanylation2008

    • Author(s)
      Saito Y, Taguchi H, Fujii S, Sawa T, Kida E, Kabuto C, Akaike T, and Arimoto H
    • Journal Title

      Chem. Commun

      Volume: 45 Issue: 45 Pages: 5984-5986

    • DOI

      10.1039/b810771h

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide regulation of MMP-9 activation and its relationship to modifications of the cysteine switch2008

    • Author(s)
      McCarthy SM, Bove PF, Matthews DE, Akaike T, and van der Vliet A
    • Journal Title

      Biochemistry

      Volume: 47 Issue: 21 Pages: 5832-5840

    • DOI

      10.1021/bi702496v

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of NO production and 8-nitroguanosine formation by phenol-containing endocrine-disrupting chemicals in LPS-stimulated macrophages : Involvement of estrogen receptor-dependent or -independent pathways2008

    • Author(s)
      Yoshitake J, Kato K, Yoshioka D, Sueishi Y, Sawa T, Akaike T, and Yoshimura T
    • Journal Title

      Nitric Oxide

      Volume: 18 Issue: 3 Pages: 223-228

    • DOI

      10.1016/j.niox.2008.01.003

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] S-nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding2008

    • Author(s)
      Ishima Y, et.al.
    • Journal Title

      Biol Chem 283

      Pages: 34966-34975

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 8-Nitroguanosines as chemical probes of the protein S-guanylation2008

    • Author(s)
      Saito Y, et.al.
    • Journal Title

      Chem Commun

      Pages: 5984-5986

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide regulation of MMP-9 activation and its relationship to modifications of the cysteine switch2008

    • Author(s)
      McCarthy SM, et.al.
    • Journal Title

      Biochemistry 47

      Pages: 5832-5840

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of NO production and 8-titroguanosine formation by phenol-containing endocrine-disrupting chemicals in LPS-stimulated macrophages : Involvement of estrogen receptor-dependent or-independent pathways2008

    • Author(s)
      Yoshitake J, et.al.
    • Journal Title

      Nitric Oxide 18

      Pages: 223-228

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model2008

    • Author(s)
      Urano T, et.al.
    • Journal Title

      Arterioscler Thromb Vase Biol 28

      Pages: 827-834

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide produced in Peyer's patches exhibits antiapoptotic activity contributing to an antimicrobial effect in murine salmonellosis2008

    • Author(s)
      Alam MS, et.al.
    • Journal Title

      Microbiol Immunol 52

      Pages: 197-208

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the Major Antigenic Protein of Helicobacter cinaedi and the Immunogenicity During Infections in Humans2008

    • Author(s)
      Iwashita H, et.al.
    • Journal Title

      Clin Vaccine Immunol 15

      Pages: 513-521

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells2008

    • Author(s)
      Kaneko K, et.al.
    • Journal Title

      Cancer Lett 262

      Pages: 239-247

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肺の感染炎症病態におけるニトロ化ストレスとそのバイオマーカー2008

    • Author(s)
      岡本竜哉、他
    • Journal Title

      検査と技術 36

      Pages: 678-679

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 感染病態におけるNO・活性酸素のシグナル伝達機能 : 酸化ストレスとその適応応答の分子メカニズム2008

    • Author(s)
      岡本竜哉、他
    • Journal Title

      AIlergy From the Nose to the Lung 6

      Pages: 12-17

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3', 5'-cyclic monophosphate formed in glia cells

    • Author(s)
      Ihara, H., Ahmed, K.A., Ida, T., Kasamatsu, S., Kunieda, K., Okamoto, T., Sawa, T., Akaike, T
    • Journal Title

      Nitric Oxide in press

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Presentation] 酸化ストレス応答とポリチオールバイオロジー2014

    • Author(s)
      赤池孝章
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      神奈川県川崎市
    • Year and Date
      2014-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 酸化ストレスとオートファジー2014

    • Author(s)
      赤池孝章
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学蛋白質研究所 (大阪府吹田市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Regulation of 8-nitro-cGMP electrophilic signal transduction2014

    • Author(s)
      Akaike T
    • Organizer
      The Environmental Response IV
    • Place of Presentation
      東北大学片平さくらホール (宮城県仙台市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 酸化ストレス応答とポリチオールバイオロジー2014

    • Author(s)
      赤池孝章
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学生田キャンパス (神奈川県川崎市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 酸化ストレスの新しい制御因子:活性イオウ分子2013

    • Author(s)
      赤池孝章
    • Organizer
      第236回宮城県立がんセンターセミナー
    • Place of Presentation
      宮城県名取市
    • Year and Date
      2013-09-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 活性酸素シグナル制御とポリサルファバイオロジー2013

    • Author(s)
      赤池孝章
    • Organizer
      国立がんセンターセミナー
    • Place of Presentation
      千葉県柏市
    • Year and Date
      2013-08-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 活性酸素シグナルとオートファジー:活性酸素によるユニークな感染防御機構2013

    • Author(s)
      赤池孝章
    • Organizer
      大阪大学微生物病研究所アドバンスセミナー
    • Place of Presentation
      大阪府吹田市
    • Year and Date
      2013-06-06
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 活性イオウ分子による活性酸素シグナル制御2013

    • Author(s)
      赤池孝章
    • Organizer
      第22回日本Cell Death 学会学術集会
    • Place of Presentation
      京都大学医学部芝蘭会舘 (京都府京都市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 活性酸素シグナル制御とポリスルフィドミクス2013

    • Author(s)
      赤池孝章
    • Organizer
      第86回日本生化学会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Redox signaling regulation by hydrogen sulfide2012

    • Author(s)
      Akaike T
    • Organizer
      Joint JSPS - Karolinska Institute Symposium : Current Concepts in Regulation of Metabolism, Cell Differentiation and Function, Nobel Forum
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2012-10-23
    • Related Report
      2013 Final Research Report
  • [Presentation] トップジャーナル七転び八起き2012

    • Author(s)
      赤池孝章
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール(長崎)(招待講演)
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cellular signaling mediated by nitrated cyclic nucleotides and its regulation by hydrogen sulfide2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      The 23^<rd> Annual Meeting of the Korean Society for Molecular and Cellular Biology
    • Place of Presentation
      COEX(ソウル韓国)(招待講演)
    • Year and Date
      2011-10-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] ROS and electrophilic cellular signaling regulated by hydrogen sulfide2011

    • Author(s)
      赤池孝章, 他
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都)(招待講演)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Antimicrobial cell signaling mediated by nitrated cyclic nucleotide2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      第84回日本細菌学会総会
    • Place of Presentation
      札幌コンベンションセンター(札幌)(招待講演)
    • Year and Date
      2011-09-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 内因性硫化水素イオンによるROS・親電子シグナル制御2011

    • Author(s)
      赤池孝章
    • Organizer
      第2回Molecular Cardiovascular Conference II
    • Place of Presentation
      ホテルピアノ(北海道キロロ)(招待講演)
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生体内ガス分子と活性酸素による多次元シグナルネットワーク2011

    • Author(s)
      赤池孝章
    • Organizer
      第8回Heme Oxygenase研究フォーラム
    • Place of Presentation
      京都府立医科大学・青蓮会館(京都)(招待講演)
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Protein S-guanylation and its unique regulation mechnism involving cysteine metabolism2011

    • Author(s)
      Akaike T
    • Organizer
      12th International Congress on Amino Acids, Peptides and Proteins
    • Place of Presentation
      Beijin, China
    • Year and Date
      2011-08-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Protein S-guanylation and its unique regulation mechanisms involving cysteine metabolism2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      12th International congress on amino acids, peptides and proteins
    • Place of Presentation
      Beijing International Convention Center(北京)
    • Year and Date
      2011-08-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 親電子シグナルと硫化水素.九州大学生体防御医学研究所共同利用2011

    • Author(s)
      赤池孝章
    • Organizer
      九州大学生体防御医学研究所共同利用研究集会
    • Place of Presentation
      九州大学生体防御医学研究所会議室(福岡)(招待講演)
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 内因性硫化水素イオンによる親電子シグナル制御2011

    • Author(s)
      赤池孝章
    • Organizer
      64回日本酸化ストレス学会学術集会
    • Place of Presentation
      ルスツリゾートホテル&コンベンション(北海道留寿都)(招待講演)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cellular signaling mediated by nitrated cyclic nucleotide and regulated by hydrogen sulfide. 5th International Conference on cGMP2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      第5回cGMP国際会議
    • Place of Presentation
      Lowengebaude, (Halle, Germany)(招待講演)
    • Year and Date
      2011-06-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 活性酸素シグナル伝達と加齢2011

    • Author(s)
      赤池孝章
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      国立京都国際会館(京都)(招待講演)
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Electrophilic cellular signaling regulated by H_2S-medaited sulfhydration2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      第11回日本NO学会総会
    • Place of Presentation
      昭和薬科大学(東京都町田市)
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cellular signaling by nitrated cyclic nucleotides and regulation of its biological effects2011

    • Author(s)
      Akaike, T
    • Organizer
      Gordon Research Conference on Nitric Oxide
    • Place of Presentation
      Ventura,CA,USA
    • Year and Date
      2011-02-17
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Cellular signaling by nitrated cyclic nucleotides and regulation of its biological effects2011

    • Author(s)
      Akaike T.
    • Organizer
      Gordon Research Conferemce on Nitric Oxide : Understanding the Biology and Chemistry of Its Formation, Action, and Signaling
    • Place of Presentation
      Four Points Sheraton/Holiday Inn Express (Ventura, CA)
    • Year and Date
      2011-02-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cell signaling mediated by nitrated cyclic guanine nucleotide2011

    • Author(s)
      Akaike, T
    • Organizer
      International Symposium on Free Radical Research: Contribution to Medicine
    • Place of Presentation
      Kyoto,Japan
    • Year and Date
      2011-01-21
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Cell signaling mediated by nitrated cyclic guanine nucleotide2011

    • Author(s)
      Akaike T.
    • Organizer
      International Symposium on Free Radical Research : Contribution to Medicine
    • Place of Presentation
      Hyatt Regency Kyoto(京都市)
    • Year and Date
      2011-01-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 核酸分子の化学修飾による活性酸素シグナルのケミカルセンシング2010

    • Author(s)
      澤智裕, 他
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      ポートアイランド(神戸市)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] NOによる抗酸化応答の新展開2010

    • Author(s)
      澤智裕, 他
    • Organizer
      第27回臨床フリーラジカル会議
    • Place of Presentation
      京都・烟河(京都市)
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Glyceraldehyde 3-phosphate dehydrogenaseの基質依存的な酸化的不活性化2010

    • Author(s)
      小野勝彦, 他
    • Organizer
      第63回日本酸化ストレス学会学術集会
    • Place of Presentation
      神奈川県民ホール(横浜市)
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細胞内における8-nitro-cGMP生成メカニズムの解析2010

    • Author(s)
      吉武淳, 他
    • Organizer
      第63回日本酸化ストレス学会学術集会
    • Place of Presentation
      神奈川県民ホール(横浜市)
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Critical roles of nitric oxide signaling via 8-nitro-cGMP-induced protein S-guanylation in antioxidant adaptive responses2010

    • Author(s)
      Fujii S, et al
    • Organizer
      The 26th Kumamoto Medical Bioscience Symposium
    • Place of Presentation
      山崎記念館(熊本市)
    • Year and Date
      2010-06-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chemical basis for mechanism of 8-nitroguanosine 3',5'-cyclic monophosohate formation in cells2010

    • Author(s)
      Ahmed K.A., et al
    • Organizer
      6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Detection of protein-bound 3-nitrotyrosine in plasma from pediatric patients with fulminant ARDS and avian influenza infection2010

    • Author(s)
      Okamoto T., et al
    • Organizer
      6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Guanine nitration and oxidative stress responses during influenza virus pneumonia in mice2010

    • Author(s)
      Khan S., et al
    • Organizer
      6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nitration of 3',5'-cyclic guanylic acid, a bacterial signaling molecule2010

    • Author(s)
      Ono K., et al
    • Organizer
      6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Estrogen receptor-dependent or -independent suppression of NO production and 8-nitroguanosine formation by endocrine-disrupting chemicals2010

    • Author(s)
      Yoshitake J., et al
    • Organizer
      6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Proteomic identification for sulfhydryl modifications of mitochondrial proteins by 8-nitroguanosine 3',5'-cyclic monophosphate2010

    • Author(s)
      Rahaman M.M., et al
    • Organizer
      6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Activation mechanism of cGMP-dependent protein kinase by a nitrated derivative of cGMP2010

    • Author(s)
      Oyama K., et al
    • Organizer
      6th International Conference on Biology, Chemistry and Therapeutic applications of NO 2010
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Protein S-guanylation: a new post-translational regulation for redox signaling2010

    • Author(s)
      Akaike, T
    • Organizer
      The 20th World Congress of the International Society for Heart Research 2010 Kyoto
    • Place of Presentation
      Kyoto,Japan
    • Year and Date
      2010-05-14
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Protein S-guanylation : a new post-translational regulation for redox signaling2010

    • Author(s)
      Akaike T.
    • Organizer
      The 20th World Congress of the International Society for Heart Research 2010 Kyoto
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-05-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] A New Paradigm for Antimicrobial Host Defense Mediated by NO and ROS : A Critical Role of Nitrated Nucleotides2010

    • Author(s)
      Takaaki Akaike
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] ニトロ化環状ヌクレオチドによる蛋白質S-グアニル化を介するcGMP依存性プロテインキナーゼの活性化2010

    • Author(s)
      藤井重元, 他
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Possible association of Helicobacter cinaedi with arrhythmia and atherosclerosis2010

    • Author(s)
      岡本竜哉, 他
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Helicobacter cinaedi-related cardiovascular diseases and atherosclerosis2010

    • Author(s)
      Okamoto T., et al.
    • Organizer
      第10回日韓国際微生物学シンポジウム
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] NO・活性酸素のヌクレオチドセンサーと親電子シグナル形成2010

    • Author(s)
      赤池孝章
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] ROS signaling in animal cells2010

    • Author(s)
      Takaaki Akaike
    • Organizer
      第51回日本植物生理学会年会
    • Place of Presentation
      熊本大学黒髪北キャンパス
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] A unique signal transduction of NO and ROS iated bvy cGMP-dependent protein kinase activated via S-guanylation2010

    • Author(s)
      Ahmed KA., et al.
    • Organizer
      第26回臨床フリーラジカル会議
    • Place of Presentation
      琵琶湖ホテル(大津市)
    • Year and Date
      2010-01-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] A unique activating mechanism of cGMP-dependent protein kinase by a nitrated derivative of cGMP2009

    • Author(s)
      Oyama K., et al.
    • Organizer
      5^<th> Joint Meeting of the Societies for Free Radical Research Australasia and Japan
    • Place of Presentation
      University of Sydney, Sydney, Australia
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] New NO signaling via 8-nitro-cGMP formation and protein S-guanylation2009

    • Author(s)
      Takaaki Akaike
    • Organizer
      5^<th> Joint Meeting of the Societies for Free Radical Research Australasia and Japan
    • Place of Presentation
      University of Sydney, Sydney, Australia
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] New NO signaling via 8-nitro-cGMP formation and protein S-guanylation2009

    • Author(s)
      Akaike T
    • Organizer
      5th Joint Meeting of the Societies for Free Radical Research Australasia and Japan
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2009-12-06
    • Related Report
      2013 Final Research Report
  • [Presentation] New NO signaling via 8-nitro-cGMP formation and protein S-guanylation2009

    • Author(s)
      Akaike, T
    • Organizer
      5th Joint Meeting of the Societies for Free Radical Research Australia and Japan
    • Place of Presentation
      Sydney,Australia
    • Year and Date
      2009-12-04
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 活性酸素による新しい翻訳後修飾と親電子シグナル2009

    • Author(s)
      赤池孝章
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学蛋白質研究所講演
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] An emerging pathogen, Helicobacter cinaedi : Possible association with atherosclerosis2009

    • Author(s)
      Khan S., et al.
    • Organizer
      第25回熊本医学生物科学シンポジウム
    • Place of Presentation
      熊本大学山崎記念館(熊本市)
    • Year and Date
      2009-11-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] A unique activating mechanism of cGMP-dependent protein kinase by a nitrated derivative of cGMP2009

    • Author(s)
      Ahmed KA., et al.
    • Organizer
      第25回熊本医学生物科学シンポジウム
    • Place of Presentation
      熊本大学山崎記念館(熊本市)
    • Year and Date
      2009-11-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新興感染症菌ヘリコバクター・シネディの血清診断法の確立と感染疫学への応用2009

    • Author(s)
      小山耕太, 他
    • Organizer
      第3回細菌学・若手コロセウム
    • Place of Presentation
      シーガイアサンホテルフェニックス(宮崎市)
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] NOと活性酸素による酸化ストレス適応応答2009

    • Author(s)
      赤池孝章, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] ニトロ化環状ヌクレオチドによる蛋白質S-グアニル化を介したcGMP依存性プロテインキナーゼの活性化機構2009

    • Author(s)
      澤智裕, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞内S-グアニル化蛋白質同定と蛋白質S-グアニル化の生理機能の解明2009

    • Author(s)
      藤井重元, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細菌シグナル分子3^', 5^'-cyclic diguanylic acidのニトロ化2009

    • Author(s)
      小野勝彦, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Chemical basis of 8-nitroguanosine 3^', 5^'-cyclic monophosphate formation in cells2009

    • Author(s)
      Ahmed KA., et al.
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] An emerging pathogen, Helicobacter cinaedi : Possible association with atherosclerosis2009

    • Author(s)
      Khan S., et al.
    • Organizer
      第3回細菌学・若手コロセウム
    • Place of Presentation
      シーガイアサンホテルフェニックス(宮崎市)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 活性酸素シグナル研究の新展開2009

    • Author(s)
      赤池孝章, 他
    • Organizer
      第13回Molecular Cardiovascular Conference
    • Place of Presentation
      キロロホテルピアノ(北海道)
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] サルモネラ感染におけるニトロ化環状ヌクレオチドを介するNO誘導性生体防御機構2009

    • Author(s)
      藤井重元, 他
    • Organizer
      第62回日本細菌学会九州支部総会
    • Place of Presentation
      佐賀大学医学部(佐賀市)
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] An emerging pathogen, Helicobacter cinaedi : Possible association with atherosclerosis2009

    • Author(s)
      Khan S., et al.
    • Organizer
      第62回日本細菌学会九州支部総会
    • Place of Presentation
      佐賀大学医学部(佐賀市)
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新興感染症菌ヘリコバクター・シネディの血清診断法の確立と感染疫学への応用2009

    • Author(s)
      小山耕太, 他
    • Organizer
      第62回日本細菌学会九州支部総会
    • Place of Presentation
      佐賀大学医学部(佐賀市)
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] インフルエンザウイルス肺炎における8-ニトロ-cGMPの生成を介した酸化ストレス応答の分子メカニズム2009

    • Author(s)
      岡本竜哉, 他
    • Organizer
      第46回日本ウイルス学会九州支部総会
    • Place of Presentation
      佐賀大学医学部(佐賀市)
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nitric oxide and electrophilic signaling mediated via 8-nitro-cGMP2009

    • Author(s)
      Akaike, T
    • Organizer
      SFRR International Free Radical School in Japan 2009
    • Place of Presentation
      Niigata,Japan
    • Year and Date
      2009-09-03
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Nitric oxide and electrophilic signaling mediated via 8-nitro-cGMP2009

    • Author(s)
      Takaaki Akaike
    • Organizer
      SFRR International Free Radical School in Japan 2009
    • Place of Presentation
      上越国際スキーリゾート
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 蛋白質S-グアニル化を介する酸化ストレス適応応答の分子機序2009

    • Author(s)
      藤井重元, 他
    • Organizer
      第62回日Heme Oxygenase研究フォーラム
    • Place of Presentation
      京都府立医科大学(東京都)
    • Year and Date
      2009-08-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] インフルエンザウイルス肺炎における8-ニトロ-cGMPの生成を介した酸化ストレス応答の分子メカニズム2009

    • Author(s)
      岡本竜哉, 他
    • Organizer
      第20回日本生体防御学会
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] SNO化血液製剤の薬理活性解析と臨床応用2009

    • Author(s)
      丸山徹, 他
    • Organizer
      レッドックス生命科学第170委員会第21回研究会
    • Place of Presentation
      ホテルグリーンピア南阿蘇(熊本)
    • Year and Date
      2009-07-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新興感染症菌ヘリコバクター・シネディと院内感染2009

    • Author(s)
      岡本竜哉, 他
    • Organizer
      第2回感染病態研究フロンティア
    • Place of Presentation
      江陽グランドホテル(仙台市)
    • Year and Date
      2009-07-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Impairment of NO-dependent host defense via degradation of 8-nitro-cGMP induced by group A Streptococcus2009

    • Author(s)
      Ahmed KA., et al.
    • Organizer
      第18回Lancefieldレンサ球菌研究会
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 活性酸素とNOによる親電子シグナル伝達2009

    • Author(s)
      赤池孝章, 他
    • Organizer
      第62回日本酸化ストレス学会学術集会
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] S-グアニル化を介したprotein kinase Gの新規な活性化機構2009

    • Author(s)
      澤智裕, 他
    • Organizer
      第62回日本酸化ストレス学会学術集会
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞内S-グアニル化蛋白質の同定とS-グアニル化制御機構の解明2009

    • Author(s)
      藤井重元, 他
    • Organizer
      第62回日本酸化ストレス学会学術集会
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 活性酸素による新しい翻訳後修飾とシグナル伝達と機能の解明2009

    • Author(s)
      赤池孝章, 他
    • Organizer
      科学技術振興調整費先端融合領域イノベーション創出拠点の形成第1回公開シンポジウム
    • Place of Presentation
      港南区民文化センクーひまわりの郷(横浜市)
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 8-ニトログアノシン3^', 5^'-環状1リン酸による蛋白質S-グアニル化を介する酸化ストレス適応応答の分子機構2009

    • Author(s)
      藤井重元, 他
    • Organizer
      第9回日本NO学会総会
    • Place of Presentation
      グランシップ(静岡市)
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] インフルエンザウイルス肺炎における8-ニトロ-Cgmpの生成を介した酸化ストレス応答の分子メカニズム2009

    • Author(s)
      岡本竜哉, 他
    • Organizer
      第9回日本NO学会総会
    • Place of Presentation
      グランシップ(静岡市)
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] S-Guanylation proteomics : unique post-translational modification of thiols dependent on nitric oxide and reactive oxygen species2009

    • Author(s)
      澤智裕, 他
    • Organizer
      第9回日本NO学会総会
    • Place of Presentation
      グランシップ(静岡市)
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nitration of guanosine 3^', 5^'-cyclic monophosphate by nitric oxide and reactive oxigen species2009

    • Author(s)
      Ahmed KA., et al.
    • Organizer
      第9回日本NO学会総会
    • Place of Presentation
      グランシップ(静岡市)
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Host defense function of 8-nitro-cGMP during murine salmonellosis2009

    • Author(s)
      Khan S., et al.
    • Organizer
      第9回日本NO学会総会
    • Place of Presentation
      グランシップ(静岡市)
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細菌シグナル分子3^', 5^'-cyclic diguanylic acidのニトロ化2009

    • Author(s)
      小山耕太, 他
    • Organizer
      第9回日本NO学会総会
    • Place of Presentation
      グランシップ(静岡市)
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Protein S-guanylation induced by 8-nitro-cGMP2008

    • Author(s)
      Akaike T
    • Organizer
      5th International Conference Biology, Chemistry and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Bregenz, Austria
    • Year and Date
      2008-08-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 活性酸素シグナルとオートファジー:活性酸素によるユニークな感染防御機構

    • Author(s)
      赤池孝章
    • Organizer
      大阪大学微生物病研究所アドバンスセミナー
    • Place of Presentation
      大阪大学微生物病研究所 (大阪府吹田市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 活性酸素シグナル制御とポリサルファバイオロジー

    • Author(s)
      赤池孝章
    • Organizer
      東京理科大学セミナー
    • Place of Presentation
      東京理科大学生命医科学研究所(千葉県野田市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 活性酸素シグナル制御とポリサルファバイオロジー

    • Author(s)
      赤池孝章
    • Organizer
      国立がんセンターセミナー
    • Place of Presentation
      国立がんセンター (千葉県柏市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 酸化ストレスの新しい制御因子:活性イオウ分子

    • Author(s)
      赤池孝章
    • Organizer
      第236回宮城県立がんセンターセミナー
    • Place of Presentation
      宮城県立がんセンター (宮城県名取市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 喘息を含めた呼吸器疾患と酸化ストレス

    • Author(s)
      赤池孝章
    • Organizer
      第2回東北呼吸器疾患懇談会
    • Place of Presentation
      AER (宮城県仙台市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 環境応答とチオールバイオロジー

    • Author(s)
      赤池孝章
    • Organizer
      第30回高峰カンファレンス
    • Place of Presentation
      東京會館(東京都中央区)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] Antioxidant adaptive response of malignant glioma related to resistance to antitumor treatment. Novel Therapeutic Concepts in Targeting Glioma2012

    • Author(s)
      Sawa T. and Akaike T
    • Publisher
      In Tech
    • Related Report
      2013 Final Research Report
  • [Book] 一酸化窒素nitric oxide/NO. 免疫の事典2011

    • Author(s)
      澤 智裕, 赤池孝章
    • Total Pages
      39
    • Publisher
      朝倉書店
    • Related Report
      2013 Final Research Report
  • [Book] 活性酸素reactive oxygen species (ROS). 免疫の事典2011

    • Author(s)
      澤 智裕, 赤池孝章
    • Total Pages
      109
    • Publisher
      朝倉書店
    • Related Report
      2013 Final Research Report
  • [Book] Antioxidant adaptive response of malignant glioma related to resistance to antitumor treatment. In Novel Therapeutic Concepts in Targeting Glioma (eds., Faris Farassati), p.247-2622011

    • Author(s)
      Sawa, T., Akaike T
    • Total Pages
      15
    • Publisher
      InTech (Open Access Company)
    • Related Report
      2011 Annual Research Report
  • [Book] 免疫り事典-酸化窒素nitric oxide/NO.p.39(桂義元,河本宏,小安重夫,山本一彦編)2011

    • Author(s)
      澤智裕, 赤池孝章
    • Total Pages
      1
    • Publisher
      朝倉書店
    • Related Report
      2011 Annual Research Report
  • [Book] 免疫の事典活性酸素reactive oxygen species (ROS). p.109(桂義元,河本宏,小安重夫,山本一彦編)2011

    • Author(s)
      澤智裕, 赤池孝章
    • Total Pages
      1
    • Publisher
      朝倉書店
    • Related Report
      2011 Annual Research Report
  • [Book] Transworld Research Network, T.C Nitric Oxide Synthase Inhibitors: From Animal Studies to Clinical Implications (Tunctan, B., Editor)2011

    • Author(s)
      Okamoto, T., Zaki, M.H., Fujii, S., Sawa, T
    • Publisher
      Akaike, T(in press)
    • Related Report
      2010 Self-evaluation Report
  • [Book] Nitric Oxide Synthase Inhibitors : From Animal Studies to Clinical Implications2011

    • Author(s)
      Okamoto T., et al
    • Publisher
      Nitric oxide-mediated host immune response and microbial pathogenesis(in press)
    • Related Report
      2010 Annual Research Report
  • [Book] 日本臨床増刊号 広範囲血液・尿化学検査,免疫学的検査-42010

    • Author(s)
      岡本竜哉, 他
    • Publisher
      Nitric oxide(NO)およびNO関連物質
    • Related Report
      2010 Annual Research Report
  • [Book] 活性酸素のシグナル伝達機能―その生理機能の再発見と酸化ストレス研究の新展開.実験医学増刊:病態解明に迫る活性酸素シグナルと酸化ストレス2009

    • Author(s)
      赤池孝章
    • Publisher
      羊土社
    • Related Report
      2013 Final Research Report
  • [Book] チオール基の修飾による活性酸素のセンサー機能制御.実験医学増刊:病態解明に迫る活性酸素シグナルと酸化ストレス2009

    • Author(s)
      澤 智裕, 有本博一, 赤池孝章
    • Publisher
      羊土社
    • Related Report
      2013 Final Research Report
  • [Book] 実験医学(増刊).病態解明に迫る活性酸素シグナルと酸化ストレス2009

    • Author(s)
      谷口直之(監修)、赤池孝章、鈴木敬一郎、内田浩二(編集)
    • Total Pages
      241
    • Publisher
      羊土社
    • Related Report
      2010 Self-evaluation Report
  • [Book] 一酸化窒素(NO)とシグナル伝達.酸化ストレスの医学.診断と治療社(吉川敏一 監修)2008

    • Author(s)
      澤 智裕, 赤池孝章
    • Related Report
      2013 Final Research Report
  • [Book] 診断と治療社、酸化ストレスの医学2008

    • Author(s)
      澤 智裕
    • Total Pages
      384
    • Publisher
      赤池孝章
    • Related Report
      2010 Self-evaluation Report
  • [Book] 酸化ストレスの医学2008

    • Author(s)
      澤智裕、他
    • Total Pages
      384
    • Publisher
      診断と治療社
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.toxicosci.med.tohoku.ac.jp

    • Related Report
      2013 Final Research Report
  • [Remarks] 東北大学大学院医学系研究科環境保健医学分野

    • URL

      http://www.toxicosci.med.tohoku.ac.jp/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://kumadai-bisei.com/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.ros-signal.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks] を開設し、積極的に情報発信を行った

    • URL

      http://www.ros-signal.jp/

    • Related Report
      2010 Self-evaluation Report
  • [Remarks]

    • URL

      http://kumadai-bisei.com/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.ros-signal.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://kumadai-bisei.com

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.ros-signal.jp

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2019-07-29  

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