Regulatory mechanism of Xist RNA machinery

• Project Area: Functional machinery for non-coding RNAs
• Project/Area Number: 21115005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyushu University
• Principal Investigator: SADO Takashi 九州大学, 生体防御医学研究所, 准教授 (70321601)
• Project Period (FY): 2009-07-23 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥96,460,000 (Direct Cost: ¥74,200,000、Indirect Cost: ¥22,260,000); Fiscal Year 2013: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2012: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2011: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2010: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2009: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
• Keywords: 非コードRNA / 発生・分化 / クロマチン / 遺伝学 / エピジェネティクス / ゲノム / 蛋白質 / 高分子非コードRNA / ヘテロクロマチン / X染色体

Research Abstract

In this mission, we attempted to figure out the regulatory mechanisms of Xist RNA machinery, which has been known for many years to play a pivotal role in X chromosome inactivation in female mammals. Especially, we focused on the potential role of the proteins, which has been shown to localize to the inactive X, and their interacting partners in Xist RNA-mediated chromatin silencing. The findings indicates the importance of further studies of the potential role of factors involved in replication programming in the Xist RNA machinery. In addition, we have paved the way to our further understanding of the Xist RNA machinery by deriving various cell lines from the mice we established by knocking out a protein involved in the regulation of Xist RNA deposition to the inactive X.

Research Products

• [Journal Article] Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells (2014)
  • Author(s): Shinagawa T, Takagi T, Tsukamoto D, Tomaru C, Huynh LM, Sivaraman P, Kumarevel T, Inoue K, Nakato R, Katou Y, Sado T, Takahashi S, Ogura A, Shirahige K, Ishii S
  • Journal Title: Cell Stem Cell Volume: 14(2) Issue: 2 Pages: 217-227
  • DOI: 10.1016/j.stem.2013.12.015
  • Peer Reviewed
• [Journal Article] The CENP-O complex requirement varies among different cell types (2014)
  • Author(s): Kagawa N, Hori T, Hoki Y, Hosoya O, Tsutsui K, Saga Y, Sado T, Fukagawa T
  • Journal Title: Chromosome Res Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] The CENP-O complex requirement varies among different cell types. (2014)
  • Author(s): Kagawa, N., Hori, T., Hoki, Y., Hosoya, O., Tsutsui, K., Saga, Y., Sado, T., and *Fukagawa, T.
  • Journal Title: Chrom. Research Volume: in press Issue: 3 Pages: 293-303
  • DOI: 10.1007/s10577-014-9404-1
  • Peer Reviewed / Open Access
• [Journal Article] Species-specific differences in X chromosome inactivation in mammals (2013)
  • Author(s): Sado T, Sakaguchi T
  • Journal Title: Reproduction Volume: 146(4) Issue: 4 Pages: R131-R139
  • DOI: 10.1530/rep-13-0173
  • Peer Reviewed
• [Journal Article] Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway (2013)
  • Author(s): Nozawa RS, Nagao K, Igami K, Shibata S, Shirai N, Nozaki N, Sado T, Kimura H, and Obuse C
  • Journal Title: Nat. Struct. Mol. Biol Volume: 20 Issue: 5 Pages: 566-573
  • DOI: 10.1038/nsmb.2532
  • Peer Reviewed
• [Journal Article] Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus (2013)
  • Author(s): Yamamoto Y,Watanabe T,Hoki Y, Shirane K, Li Y, Ichiiyanagi K, Kuramochi-Miyagawa S, Toyoda A, Fujiyama A, Oginuma M, Suzuki H, Sado T, Nakano T, Sasaki H
  • Journal Title: Genome Res Volume: 23 Issue: 2 Pages: 292-299
  • DOI: 10.1101/gr.137224.112
  • Peer Reviewed
• [Journal Article] Advances in understanding chromosome silencing by the long non-coding RNA Xist (2013)
  • Author(s): Sado T, Brockdorff N
  • Journal Title: Philos Trans R Soc Lond B Biol Sci Volume: 368(1609) Issue: 1609 Pages: 20110325-20110325
  • DOI: 10.1098/rstb.2011.0325
  • Peer Reviewed
• [Journal Article] Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse (2011)
  • Author(s): Hoki, Y., et al
  • Journal Title: Development Volume: 138 Issue: 13 Pages: 2649-2659
  • DOI: 10.1242/dev.061226
  • Peer Reviewed
• [Journal Article] Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus (2011)
  • Author(s): Watanabe, T., Tomizawa, S., Mitsuya, K., Totoki, Y., Yamamoto, Y., Kuramochi-Miyagawa, S., Iida, N., Hoki, Y., Murphy, P.J., Toyoda, A., Gotoh, K., Hiura, H., Arima, T., Fujiyama, A., Sado, T., Shibata, T., Nakano, T., Lin, H., Ichiyanagi, K., Soloway, P.D., Sasaki, H
  • Journal Title: Science Volume: 332 Issue: 6031 Pages: 848-52
  • DOI: 10.1126/science.1203919
  • Peer Reviewed
• [Journal Article] MitoPLD Is a Mitochondrial Protein Essential for Nuage Formation and piRNA Biogenesis in the Mouse Germline (2011)
  • Author(s): Watanabe T, et al
  • Journal Title: Dev Cell Volume: 20 Issue: 3 Pages: 364-375
  • DOI: 10.1016/j.devcel.2011.01.005
  • Peer Reviewed
• [Journal Article] Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrfl locus. (2011)
  • Author(s): Watanabe, et al.
  • Journal Title: Science Volume: (In press)
  • Peer Reviewed
• [Journal Article] Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse. (2011)
  • Author(s): Hoki, et al.
  • Journal Title: Development Volume: (In press)
  • Peer Reviewed
• [Journal Article] MitoPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline. (2011)
  • Author(s): Watanabe, et al.
  • Journal Title: Developmental Cell Volume: 20 Pages: 364-375
  • Peer Reviewed
• [Journal Article] Impeding Xist expression from the active X chromosome improves mouse somatic cell nuclear transfer (2010)
  • Author(s): Inoue, K., Kohda T., Sugimoto, M., Sado T., Ogonuki, N., Matoba, S., Shiura, H., Ikeda, R., Mochida, K., Fujii, T., Sawai, K., Otte, A.P, Tian, X.C., Yang, X., Ishino, F., Abe, K., Ogura, A
  • Journal Title: Science Volume: 330 Issue: 6003 Pages: 496-499
  • DOI: 10.1126/science.1194174
  • Peer Reviewed
• [Journal Article] Impeding Xist Expression from the Active X Chromosome Improves Mouse Somatic Cell Nuclear Transfer. (2010)
  • Author(s): Inoue, et al
  • Journal Title: Science Volume: 330 Pages: 496-499
  • Peer Reviewed
• [Journal Article] Sex-reversed somatic cell cloning in the mouse (2009)
  • Author(s): Inoue K, Ogonuki N, Mekada K, Yoshiki A, Sado T, Ogura A
  • Journal Title: J Reprod Dev Volume: 55(5) Pages: 566-569
  • NAID: 10025616710
  • Peer Reviewed
• [Journal Article] Sex-reversed somatic cell cloning in the mouse. (2009)
  • Author(s): Inoue, K., et al.
  • Journal Title: J.Reprod.Dev. 55 Pages: 566-569
  • Peer Reviewed
• [Presentation] 変異Xist RNA による不活性化クロマチンドメインの形成 (2013)
  • Author(s): 酒田祐佳
  • Organizer: エピジェネティクス研究会
  • Place of Presentation: 奈良
• [Presentation] 機能欠損を持つXist RNA は不活性X 染色体のCpG メチル化を正常に構築できない (2013)
  • Author(s): 中島達郎
  • Organizer: エピジェネティクス研究会
  • Place of Presentation: 奈良
• [Presentation] Xist RNA の5'領域はRNA を核内に保持させる (2013)
  • Author(s): 千木雄太, 他2人
  • Organizer: 第15回日本RNA学会
  • Place of Presentation: 愛媛
• [Presentation] 変異Xist RNA がもたらすX 染色体クロマチンドメインの変化 (2013)
  • Author(s): 酒田祐佳, 他3人
  • Organizer: 日本遺伝学会第85回大会
  • Place of Presentation: 神奈川
• [Presentation] 部分的機能欠損Xist RNAによるエピジェネティック制御の異常 (2013)
  • Author(s): 中島達郎, 他3人
  • Organizer: 日本遺伝学会第85回大会
  • Place of Presentation: 神奈川
• [Presentation] Silent chromatin domain formed by Xist RNA defective in silencing in the mouse embryo (2013)
  • Author(s): Sakata, Y., et al.
  • Organizer: Riboclub 2013
  • Place of Presentation: ケベック(カナダ)
• [Presentation] Defects in epijenethic regulation caused by partially dysfunctional Xist RNA (2013)
  • Author(s): Nakajima, T., et al.
  • Organizer: Riboclub 2013
  • Place of Presentation: ケベック(カナダ)
• [Presentation] A new Xist allele driven by a constitutive active promoter : implication for asymmetric expression of Xist in preimplantation mouse embryos (2013)
  • Author(s): Amakawa Y., et al.
  • Organizer: Riboclub 2013
  • Place of Presentation: ケベック(カナダ)
• [Presentation] 哺乳類X 染色体のエピジェネティクス (2013)
  • Author(s): 佐渡 敬
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 兵庫
  • Invited
• [Presentation] アリル特異的ChIP-seq法によるマウス不活性化X 染色体の解析 (2013)
  • Author(s): 長尾恒治, 他6人
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 兵庫
• [Presentation] SmcHD1 機能欠損胚におけるX 染色体不活性化 (2013)
  • Author(s): 榊原祐樹, 他2人
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 兵庫
• [Presentation] Cloning and molecular characterization of mouse Hbix1 (2013)
  • Author(s): Sakaguchi T., et al.
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 兵庫
• [Presentation] 変異Xist RNAによる不活性化クロマチンドメインの形成 (2013)
  • Author(s): 酒田祐佳
  • Organizer: エピジェネティクス研究会
  • Place of Presentation: 奈良
• [Presentation] 機能欠損を持つXist RNAは不活性X染色体のCpGメチル化を正常に構築できない (2013)
  • Author(s): 中島達郎
  • Organizer: エピジェネティクス研究会
  • Place of Presentation: 奈良
• [Presentation] Xist RNA の5'領域の配列はRNA を核内に保持させる (2013)
  • Author(s): 千木 雄太, 佐々木 裕之, 佐渡 敬
  • Organizer: 第15回日本RNA学会
  • Place of Presentation: 松山
• [Presentation] 変異Xist RNAがもたらすX染色体クロ マチンドメインの変化 (2013)
  • Author(s): 酒田 祐佳、保木 裕子、佐々木 裕之、 佐渡 敬
  • Organizer: 日本遺伝学会第85回大会
  • Place of Presentation: 神奈川
• [Presentation] 部分的機能欠損Xist RNAによるエピ ジェネティック制御異常 (2013)
  • Author(s): 中島 達郎、保木 裕子、 佐々木 裕之、佐渡 敬
  • Organizer: 日本遺伝学会第85回大会
  • Place of Presentation: 神奈川
• [Presentation] Silent chromatin domain formed by Xist RNA defective in silencing in the mouse embryo (2013)
  • Author(s): Yuka Sakata, Yuko Hoki, Hiroyuki Sasaki, and Takashi Sado
  • Organizer: Riboclub 2013
  • Place of Presentation: Quebec
• [Presentation] Defects in epigenetic regulation caused by partially dysfunctional Xist RNA (2013)
  • Author(s): Tatsuro Nakajima, Yuko Hoki, Hiroyuki Sasaki and Takashi Sado
  • Organizer: Riboclub 2013
  • Place of Presentation: Quebec
• [Presentation] A new Xist allele driven by a constitutively active promoter: implications for the asymmetric expression of Xist in preimplantation mouse embryos (2013)
  • Author(s): Yuko Amakawa, Yuka Sakata, Yuko Hoki, Tatsuo Fukagawa, Hiroyuki Sasaki, and Takashi Sado
  • Organizer: Riboclub 2013
  • Place of Presentation: Quebec
• [Presentation] アリル特異的ChIP-seq 法によるマウス不活性化X 染色体の解析 (2013)
  • Author(s): 長尾 恒治，柴田 幸子，野澤 竜介，奥田 将旭，木村 宏，佐渡 敬，小布施 力史
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 兵庫
• [Presentation] SmcHD1機能欠損マウス胚におけるX 染色体不活性化 (2013)
  • Author(s): 榊原 祐樹，佐々木 裕之，佐渡 敬
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 兵庫
• [Presentation] Cloning and molecular characterization of a mouse homolog of HBiX1 (2013)
  • Author(s): Takehisa Sakaguchi, Yuko Hoki, Chikashi Obuse, Takashi Sado
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 兵庫
• [Presentation] Xist RNA defective in chromosome silencing in the mouse (2012)
  • Author(s): 佐渡 敬
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
  • Invited
• [Presentation] Defects in X-inactivation initiated by mutant Xist RNA in the mouse embryo (2012)
  • Author(s): 佐渡 敬
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-14
  • Invited
• [Presentation] Xist RNA の作用機序解明へ向けた遺伝学的アプローチ (2012)
  • Author(s): 佐渡 敬
  • Organizer: 日本遺伝学会第84回大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-09-26
  • Invited
• [Presentation] Xist RNAの作用機序解明へ向けた遺伝学的アプローチ (2012)
  • Author(s): 佐渡 敬
  • Organizer: 日本遺伝学会第84回大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-09-26
  • Invited
• [Presentation] Xist の部分的機能欠損アレルによって不活性化を開始したX 染色体のCpG メチル化 (2012)
  • Author(s): 中島達郎
  • Organizer: 日本遺伝学会第84回大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-09-25
• [Presentation] 変異型Xist RNA による不活性化クロマチンドメインの形成 (2012)
  • Author(s): 酒田祐佳
  • Organizer: 日本遺伝学会第84回大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-09-25
• [Presentation] Xistの部分的機能欠損アレルによって不活性化を開始したX染色体のCpGメチル化 (2012)
  • Author(s): 中島達郎
  • Organizer: 日本遺伝学会第84回大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-09-25
• [Presentation] 変異型Xist RNAによる不活性化クロマチンドメインの形成 (2012)
  • Author(s): 酒田祐佳
  • Organizer: 日本遺伝学会第84回大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-09-25
• [Presentation] Epigenetic Regulation of the Mammalian X chromosome (2012)
  • Author(s): 佐渡 敬
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 北海道
  • Year and Date: 2012-09-21
  • Invited
• [Presentation] Epigenetic Regulation of the Mammalian X chromosome (2012)
  • Author(s): 佐渡 敬
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
  • Invited
• [Presentation] 変異型Xist RNA が招くX 染色体不活性化の異常 (2012)
  • Author(s): 佐渡 敬
  • Organizer: 第14回日本RNA学会年会
  • Place of Presentation: 宮城
  • Year and Date: 2012-07-18
• [Presentation] 変異型Xist RNAが招くX染色体不活性化の異常 (2012)
  • Author(s): 佐渡 敬
  • Organizer: 第14回日本RNA学会年会
  • Place of Presentation: 仙台
  • Year and Date: 2012-07-18
• [Presentation] ヒト不活性化X 染色体に局在する新規タンパク質のマウスホモログの単離と解析 (2011)
  • Author(s): 坂口武久, 他4名
  • Organizer: 第5回日本エピジェネティクス研究会年会
  • Place of Presentation: 熊本
• [Presentation] Xist RNA の5'領域のX 染色体不活性化における役割 (2011)
  • Author(s): 酒田祐佳, 他4名
  • Organizer: 第5回日本エピジェネティクス研究会年会
  • Place of Presentation: 熊本
• [Presentation] Incomplete X-inactivation Initiated by a Hypomorphic Xist Allele in the Mouse (2011)
  • Author(s): T. Sado, et al
  • Organizer: The 16th annual meeting of the RNA society and the RNA society of Japan 13th annual meeting
  • Place of Presentation: 京都
• [Presentation] X-inactivation initiated by Xist RNA defective in silencing in the mouse embryo (2011)
  • Author(s): T. Sado
  • Organizer: 3rd X-inactivation Conference
  • Place of Presentation: オックスフォード(UK)
• [Presentation] X-inactivation in female mice deficient for macroH2A1 and macroH2A2 (2011)
  • Author(s): T. Sakaguchi, et al
  • Organizer: 3rd X-inactivation Conference
  • Place of Presentation: オックスフォード(UK)
• [Presentation] X-inactivation triggeredby Xist RNA deleted for the 5' Sequencein the mouse embryo (2011)
  • Author(s): Y. Sakata, et al
  • Organizer: 3rd X-inactivation Conference
  • Place of Presentation: オックスフォード(UK)
• [Presentation] マウス雌生殖細胞におけるX 染色体の再活性化 (2011)
  • Author(s): 佐渡 敬
  • Organizer: 日本遺伝学会第83回大会
  • Place of Presentation: 京都
• [Presentation] Xist RNA の5'領域のX染色体不活性化における役割 (2011)
  • Author(s): 酒田祐佳, 他4名
  • Organizer: 日本遺伝学会第83回大会
  • Place of Presentation: 京都
• [Presentation] ヒト不活性化X染色体に局在する新規タンパク質のマウスホモログの単離と解析 (2011)
  • Author(s): 坂口武久, 他4名
  • Organizer: 第5回日本エピジェネティクス研究会年会
  • Place of Presentation: 熊本
• [Presentation] Xist RNAの5'領域のX染色体不活性化における役割 (2011)
  • Author(s): 酒田祐佳, 他4名
  • Organizer: 第5回日本エピジェネティクス研究会年会
  • Place of Presentation: 熊本
• [Presentation] Incomplete X-inactivation Initiated by a Hypomorphic Xist Allele in the Mouse (2011)
  • Author(s): T.Sado, et al
  • Organizer: The 16th annual meeting of the RNA society and the RNA society of Japan 13th annual meeting
  • Place of Presentation: Kyoto
• [Presentation] X-inactivation initiated by Xist RNA defective in silencing in the mouse embryo (2011)
  • Author(s): T.Sado
  • Organizer: 3rd X-inactivation Conference
  • Place of Presentation: England(招待講演)
• [Presentation] X-inactivation in female mice deficient for macroH2A1 and macroH2A2 (2011)
  • Author(s): T.Sakaguchi, et al
  • Organizer: 3rd X-inactivation Conference
  • Place of Presentation: England
• [Presentation] X-inactivation triggered by Xist RNA deleted for the 5' Sequence in the mouse embryo (2011)
  • Author(s): Y.Sakata, et al
  • Organizer: 3rd X-inactivation Conference
  • Place of Presentation: England
• [Presentation] マウス雌生殖細胞におけるX染色体の再活性化 (2011)
  • Author(s): 佐渡敬
  • Organizer: 日本遺伝学会第83回大会
  • Place of Presentation: 京都(招待講演)
• [Presentation] Xist RNAの5'領域のX染色体不活性化における役割 (2011)
  • Author(s): 酒田祐佳, 他4名
  • Organizer: 日本遺伝学会第83回大会
  • Place of Presentation: 京都
• [Presentation] A partial loss of function mutation in the mechanism of X chromosome inactivation (2010)
  • Author(s): Hoki, Y., et al.
  • Organizer: Keystone Symposium (A8)
  • Place of Presentation: タオス(USA)
• [Presentation] Prolonged expression of Xist retards X chromosome reactivation in mouse germ line (2010)
  • Author(s): Amakawa, Y., et al.
  • Organizer: Keystone Symposium (A8)
  • Place of Presentation: タオス(USA)
• [Presentation] A Partial Loss of Function Mutation in the Mechanism of X Chromosome Inactivation (2010)
  • Author(s): Sado, T
  • Organizer: The 19th CDB Meeting
  • Place of Presentation: 兵庫
• [Presentation] Xist RNAの5'領域のX染色体不活化における役割 (2010)
  • Author(s): 酒田祐佳, 他4名
  • Organizer: 第4回 日本エピジェネティクス研究会
  • Place of Presentation: 鳥取
• [Presentation] 胚体外組織における父由来X 染色体のインプリント (2010)
  • Author(s): 尼川裕子, 他4名
  • Organizer: 第4回 日本エピジェネティクス研究会
  • Place of Presentation: 鳥取
• [Presentation] X 染色体不活性化の部分的機能欠損変異の解析 (2010)
  • Author(s): 佐渡 敬, 他6名
  • Organizer: 第12回 日本RNA学会年会
  • Place of Presentation: 東京
• [Presentation] Xist RNA の作用機序の理解へ向けて (2010)
  • Author(s): 佐渡 敬
  • Organizer: 日本遺伝学会 第82回大会
  • Place of Presentation: 北海道
• [Presentation] Xist RNAの5'領域のX染色体不活化における役割 (2010)
  • Author(s): 酒田祐佳, 他4名
  • Organizer: 日本遺伝学会 第82回大会
  • Place of Presentation: 北海道
• [Presentation] Xist RNA の機能不全が招くX 染色体不活性化の異常 (2010)
  • Author(s): 佐渡 敬
  • Organizer: 第33回日本分子生物学会年会, 第83回日本生化学会大会
  • Place of Presentation: 兵庫
• [Presentation] Xist RNAの5'領域のX染色体不活化における役割. (2010)
  • Author(s): 酒田祐佳, 他4名
  • Organizer: 第33回日本分子生物学会年会, 第83回日本生化学会大会
  • Place of Presentation: 兵庫
• [Presentation] Xist RNAの5'領域のX染色体不活化における役割 (2010)
  • Author(s): 酒田祐佳, 他4名
  • Organizer: 第4回日本エピジェネティクス研究会
  • Place of Presentation: 鳥取
• [Presentation] 胚体外組織における父由来X染色体のインプリント (2010)
  • Author(s): 尼川裕子, 他4名
  • Organizer: 第4回日本エピジェネティクス研究会
  • Place of Presentation: 鳥取
• [Presentation] X染色体不活性化の部分的機能欠損変異の解析 (2010)
  • Author(s): 佐渡敬, 他6名
  • Organizer: 第12回日本RNA学会年会
  • Place of Presentation: 東京
• [Presentation] Xist RNAの作用機序の理解へ向けて (2010)
  • Author(s): 佐渡敬
  • Organizer: 日本遺伝学会 第82回大会
  • Place of Presentation: 北海道
• [Presentation] Xist RNAの機能不全が招くX染色体不活性化の異常 (2010)
  • Author(s): 佐渡敬
  • Organizer: 第33回日本分子生物学会年会,第83回日本生化学会大会
  • Place of Presentation: 兵庫
• [Presentation] Xist RNAの5'領域のX染色体不活化における役割 (2010)
  • Author(s): 酒田祐佳, 他4名
  • Organizer: 第33回日本分子生物学会年会,第83回日本生化学会大会
  • Place of Presentation: 兵庫
• [Presentation] A partial loss of function mutation in the mechanism of X chromosome inactivation (2010)
  • Author(s): Hoki, Y., et al.
  • Organizer: Keystone Symposium (A8)
  • Place of Presentation: Taos, NM (USA)
• [Presentation] Prolonged expression of Xist retards X chromosome reactivation in mouse germ line. (2010)
  • Author(s): Amakawa, Y., er al.
  • Organizer: Keystone Symposium (A8)
  • Place of Presentation: Taos, NM (USA)
• [Presentation] X染色体の不活性化の分子機構 (2009)
  • Author(s): 佐渡 敬
  • Organizer: 第138回染色体研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-13
• [Presentation] Toward the understanding of molecular events underlying X-inactivation (2009)
  • Author(s): Sado, T
  • Organizer: The 24th Naito Conference on Nuclear Dynamics and RNA[II]
  • Place of Presentation: 北海道
  • Invited
• [Presentation] マウスのメス生殖細胞におけるXist発現消失時期の遅延はX染色体再活性化を遅らせる (2009)
  • Author(s): 尼川裕子, 他3名
  • Organizer: 日本遺伝学会第81回大会
  • Place of Presentation: 長野
• [Presentation] X染色体不活性化機構の部分的機能欠損変異 (2009)
  • Author(s): 保木裕子, 他3名
  • Organizer: 日本遺伝学会第81回大会
  • Place of Presentation: 長野
• [Presentation] 哺乳類のメス生殖細胞における不活性X染色体の再活性化 (2009)
  • Author(s): 佐渡 敬
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 兵庫
• [Presentation] A partial loss of function mutation in the mechanism of X chromosome inactivation (2009)
  • Author(s): 保木裕子, 他3名
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 兵庫
• [Presentation] Prolonged expression of Xist retards X chromosome reactivation in mouse germ line (2009)
  • Author(s): 尼川裕子, 他3名
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川
• [Presentation] Toward the understanding of molecular events underlying X-inactivation (2009)
  • Author(s): Sado, T.
  • Organizer: The 24th Naito Conference on Nuclear Dynamics and RNA[II]
  • Place of Presentation: 札幌
• [Presentation] マウスのメス生殖細胞におけるXist発現消失時期の遅延はX染色体再活性化を遅らせる (2009)
  • Author(s): 尼川裕子, 他3名
  • Organizer: 日本遺伝学会第81回大会
  • Place of Presentation: 松本
• [Presentation] X染色体の不活性化の分子機構の部分的機能欠損変異 (2009)
  • Author(s): 保木裕子, 他3名
  • Organizer: 日本遺伝学会第81回大会
  • Place of Presentation: 松本
• [Presentation] 哺乳類のメス生殖細胞における不活性X染色体の再活性化 (2009)
  • Author(s): 佐渡敬
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] A partial loss of function mutation in the mechanism of X chromosome (2009)
  • Author(s): 保川裕子, 他3名
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Prolonged expression of Xist retards X chromosome reactivation in mouse germ line. (2009)
  • Author(s): 尼川裕子, 他3名
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Book] 卵子学 (森崇英総編集) 第IV-14章: 卵子とX 染色体 (2011)
  • Author(s): 佐渡 敬
• [Book] 卵子学第IV-14章:卵子とX染色体(森崇英総編集) (2011)
  • Author(s): 佐渡敬
  • Total Pages: 13
  • Publisher: 京都大学学術出版会