Mechanisms for dendritic cell responses against host-derived molecules

• Project Area: Homeostatic inflammation: Molecular basis and dysregulation
• Project/Area Number: 21117003
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University (2011-2013); The Institute of Physical and Chemical Research (2009-2010)
• Principal Investigator: KAISHO Tsuneyasu 大阪大学, 免疫学フロンティア研究センター, 招へい教授 (60224325)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Takashi 独立行政法人理化学研究所, 統合生命医科学研究センター 炎症制御研究チーム, チームリーダー (00415225) ; HOSHINO Katsuaki 香川大学, 医学部 免疫学, 教授 (50324843)
• Project Period (FY): 2009-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥142,220,000 (Direct Cost: ¥109,400,000、Indirect Cost: ¥32,820,000); Fiscal Year 2013: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000); Fiscal Year 2012: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000); Fiscal Year 2011: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000); Fiscal Year 2010: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000); Fiscal Year 2009: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
• Keywords: 樹状細胞 / 自然免疫 / サイトカイン / シグナル伝達 / 病原体センサー / 炎症 / Toll様受容体 / 免疫アジュバント / I型インターフェロン / 樹状細胞サブセット

Outline of Final Research Achievements

Innate immune sensors detect not only pathogen- but also host-derived factors such as nucleic acids and cause inflammatory responses. Dendritic cells or macrophages play critical roles in this inflammation, which we call homeostatic inflammation. This study clarified molecular mechanisms regulating the production of type I interferons or proinflammatory cytokines induced by nucleic acid sensors and keeping appropriate responses. This study also generated gene-manipulating mice which should be useful for clarifying the critical roles of dendritic cell subsets in homeostatic inflammation.

Research Products

• [Journal Article] Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells. (2015)
  • Author(s): H. Sasaki, D. Kurotaki, N. Osato, H. Sato, I. Sasaki, S. Koizumi, H. Wang, C. Kaneda, A. Nishiyama, T. Kaisho, H. Aburatani, H. C. Morse III, K. Ozato, T. Tamura.
  • Journal Title: Blood Volume: 125(2) Issue: 2 Pages: 358-369
  • DOI: 10.1182/blood-2014-02-557983
  • Peer Reviewed / Open Access
• [Journal Article] Transcriptional Control of dendritic cell differentiation. (2014)
  • Author(s): I. Sasaki, T. Kaisho
  • Journal Title: Curr. Top. Microbiol. Immunol. Volume: 381 Pages: 257-278
  • DOI: 10.1007/82_2014_378
  • ISBN: 9783319073941, 9783319073958
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Homeostatic inflammation in innate immunity. (2014)
  • Author(s): K. Miyake, T. Kaisho
  • Journal Title: Curr.Opin. Immunol. Volume: 30 Pages: 85-90
  • DOI: 10.1016/j.coi.2014.08.003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria. (2014)
  • Author(s): H. Zhao, T. Aoshi, S. Kawai, Y. Mori, A. Konishi, M. Ozkan, Y. Fujita, Y. Haseda, M. Shimizu, M. Kohyama, K. Kobiyama, K. Eto, J. Nabekura, T. Horii, T. Ishino, M. Yuda, H. Hemmi, T. Kaisho, S. Akira, M. Kinoshita, K. Tohyama, Y. Yoshioka, K. J. Ishii, C. Coban
  • Journal Title: Cell Host Microbe Volume: 15 Issue: 5 Pages: 551-563
  • DOI: 10.1016/j.chom.2014.04.008
  • Peer Reviewed / Open Access
• [Journal Article] Single-Cell Imaging of Caspase-1 Dynamics Reveals an All-or-None Inflammasome Signaling Response. (2014)
  • Author(s): Liu, T., Yamaguchi, Y., Shirasaki, Y., Shikada, K., Yamagishi, M., Hoshino, K., Kaisho, T., Takemoto, K., Suzuki, T., Kuranaga, E., Ohara, O., Miura, M.
  • Journal Title: Cell Reports Volume: 8 Issue: 4 Pages: 974-982
  • DOI: 10.1016/j.celrep.2014.07.012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages. (2014)
  • Author(s): Y. Sato, H. Hara, T. Okuno, N. Ozaki, S. Suzuki, T. Yokomizo, T. Kaisho, H. Yoshida.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 451 Issue: 2 Pages: 215-221
  • DOI: 10.1016/j.bbrc.2014.07.096
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Homeostasis of thymus-derived Foxp3+ regulatory T cells is controlled by ultraviolet B exposure in the skin. (2014)
  • Author(s): S. Yamazaki, A. Nishioka, S. Kasuya, N. Ohkura, H. Hemmi, T. Kaisho, O. Taguchi, S. Sakaguchi, A. Morita
  • Journal Title: J Immunol Volume: 193(11) Issue: 11 Pages: 5488-97
  • DOI: 10.4049/jimmunol.1400985
  • Peer Reviewed
• [Journal Article] Limitation of immune tolerance-inducing thymic epithelial cell development by Spi-B-mediated negative feedback regulation. (2014)
  • Author(s): N. Akiyama, M. Shinzawa, M. Miyauchi, H. Yanai, R. Tateishi, Y. Shimo, D. Ohshima, K. Matsuo, I. Sasaki, K.Hoshino, G. Wu, S. Yagi, J. Inoue, T. Kaisho, T. Akiyama
  • Journal Title: J. Exp. Med Volume: 211 Issue: 5 Pages: 2425-2438
  • DOI: 10.1084/jem.20140825
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] HSP70 mediates degradation of the p65 subunit of nuclear factor κB to inhibit inflammatory signaling (2014)
  • Author(s): T. Tanaka, A. Shibazaki, R. Ono, T. Kaisho
  • Journal Title: Sci. Signal Volume: 7(356) Issue: 356
  • DOI: 10.1126/scisignal.2005533
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Innate immunity and allergy. (2013)
  • Author(s): T. Kaisho
  • Journal Title: Allergy Volume: 62(7) Pages: 789-796
  • NAID: 110009635084
• [Journal Article] Enhanced Apoptosis by Disruption of the STAT3-I κ B-ζ Signaling Pathway in Epithelial Cells Induces Sjogren' S Syndrome-like Autoimmune Disease. (2013)
  • Author(s): 大熊敦史
  • Journal Title: Immunity Volume: 38 Issue: 3 Pages: 450-460
  • DOI: 10.1016/j.immuni.2012.11.016
  • Peer Reviewed
• [Journal Article] Double-stranded RNA of small intestinal commensal but not pathogenic bacteria triggers TLR3-mediated IFN-β production by dendritic cells. (2013)
  • Author(s): T. Kawashima
  • Journal Title: Immunity Volume: in press
  • Peer Reviewed
• [Journal Article] Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1. (2013)
  • Author(s): C. Yamazaki
  • Journal Title: J Immunol Volume: in press
  • Peer Reviewed
• [Journal Article] Invariant NKT cells induce plasmacytoid DC cross-talk with conventional DCs for efficient memory CD8+ T cell induction. (2013)
  • Author(s): K. Shimizu
  • Journal Title: J. Immunol Volume: in press
  • Peer Reviewed
• [Journal Article] Treml4, an Ig Superfamily Member, Mediates Presentation of Several Antigens to T Cells In Vivo, Including Protective Immunity to HER2 Protein (2012)
  • Author(s): Hiroaki Hemmi, Neeha Zaidi, Bei Wang, Ines Matos, Christopher Fiorese, Ashira Lubkin, Lori Zbytnuik, Koji Suda, Kenneth Zhang, Masaki Noda, Tsuneyasu Kaisho, Ralph M. Steinman, and Juliana Idoyaga
  • Journal Title: J Immunol Volume: 188 Issue: 3 Pages: 1147-1155
  • DOI: 10.4049/jimmunol.1102541
  • Peer Reviewed
• [Journal Article] Differential MyD88/IRAK4 requirements for cross-priming and tumor rejection induced by hsp70-model Ag fusion protein. (2012)
  • Author(s): MizukamiS, KajiwaraC, TanakaM, KaishoT, Udono H.
  • Journal Title: Cancer Science Volume: 103 Issue: 5 Pages: 851-859
  • DOI: 10.1111/j.1349-7006.2012.02233.x
  • Peer Reviewed
• [Journal Article] The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells (2012)
  • Author(s): Kanaya, T., Hase, K., Takahashi, D., Fukuda, S., Hoshino, K., Sasaki, I., Hemmi, H., Knoop, K. A., Kumar, N., Sato, M., Katsuno, T., Yokosuka, O., Toyooka, K., Nakai, K., Sakamoto, A., Kitahara, Y., Jinnohara, T., McSorley, S. J., Kaisho, T., Williams, I. R., and Ohno, H.
  • Journal Title: Nat Immunol Volume: 13 Issue: 8 Pages: 729-736
  • DOI: 10.1038/ni.2352
  • Peer Reviewed
• [Journal Article] Spi-B is critical for plasmacytoid dendritic cell function and development (2012)
  • Author(s): Sasaki, K. Hoshino, T. Sugiyama, C. Yamazaki, T. Yano, A. Iizuka, H. Hemmi, T. Tanaka, M. Saito, M. Sugiyama, Y. Fukuda, T. Ohta, K. Sato, A. Ainai, T. Suzuki, H. Hasegawa, N. Toyama-Sorimachi, H. Kohara, T. Nagasawa, T. Kaisho
  • Journal Title: Blood Volume: 120 Issue: 24 Pages: 4733-4743
  • DOI: 10.1182/blood-2012-06-436527
  • Peer Reviewed
• [Journal Article] Lactococcus lactis subsp. cremoris FC triggers IFN-γ production from NK and T cells via IL-12 and IL-18 (2012)
  • Author(s): A. Kosaka, H. Yan, S. Ohashi, Y. Gotoh, A. Sato, H. Tsutsui, T. Kaisho, T. Toda, Tsuji NM
  • Journal Title: Int Immunopharmacol Volume: 14(4) Issue: 4 Pages: 729-33
  • DOI: 10.1016/j.intimp.2012.10.007
  • Peer Reviewed
• [Journal Article] Pathogen sensors and chemokine receptors in dendritic cell subsets (2012)
  • Author(s): T. Kaisho
  • Journal Title: Vaccine Volume: 30 Issue: 52 Pages: 7652-7657
  • DOI: 10.1016/j.vaccine.2012.10.043
  • Peer Reviewed
• [Journal Article] A chemokine system in CD8 positive dendritic cells (2012)
  • Author(s): H.Hemmi
  • Journal Title: Cytometry Research Volume: 22 Pages: 31-35
  • Peer Reviewed
• [Journal Article] 樹状細胞サブセットの機能と生理的意義 (2012)
  • Author(s): 佐々木泉
  • Journal Title: 炎症と免疫 Volume: 20 Pages: 21-26
• [Journal Article] PDLIM2 inhibits T helper cell development and granulomatous inflammation through degradation of STAT3 (2011)
  • Author(s): T.Tanaka
  • Journal Title: J.Immunol Volume: 188 Issue: 202 Pages: 141-151
  • DOI: 10.1126/scisignal.2001637
  • Peer Reviewed
• [Journal Article] Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo (2011)
  • Author(s): H.Takagi
  • Journal Title: Immunity Volume: 35 Issue: 6 Pages: 958-971
  • DOI: 10.1016/j.immuni.2011.10.014
  • Peer Reviewed
• [Journal Article] 樹状細胞サブセット機能を制御する分子機構 (2011)
  • Author(s): 改正恒康
  • Journal Title: アレルギー Volume: 60 Pages: 559-565
  • NAID: 110008661490
• [Journal Article] 免疫アジュバントの特性とTh細胞分化誘導 (2011)
  • Author(s): 大田友和
  • Journal Title: 臨床免疫・アレルギー科 Volume: 188 Pages: 1147-1155
• [Journal Article] Molecular mechanisms for plasmacytoid dendritic cell function and development (2010)
  • Author(s): T.Kaisho
  • Journal Title: Vaccine Volume: 28 Pages: 8046-8047
  • Peer Reviewed
• [Journal Article] Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice (2010)
  • Author(s): T.Matsuda
  • Journal Title: J.Clin.Invest. Volume: 120 Pages: 115-126
  • Peer Reviewed
• [Journal Article] Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation (2010)
  • Author(s): K.Gotoh
  • Journal Title: J.Exp.Med. Volume: 207 Pages: 721-730
  • Peer Reviewed
• [Journal Article] Cutting edge : Critical role of IκB Kinase α in TLR7/9-Induced type I interferon production by conventional dendritic cells (2010)
  • Author(s): K.Hoshino
  • Journal Title: J.Immunol Volume: 184 Pages: 3341-3345
  • Peer Reviewed
• [Journal Article] Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice (2010)
  • Author(s): C.Yamazaki
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 397 Pages: 756-761
  • Peer Reviewed
• [Journal Article] Statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, function as inhibitors of cellular and molecular components involved in type I interferon production (2010)
  • Author(s): H.Amuro
  • Journal Title: Arthritis Rheum Volume: 62 Pages: 2073-2085
  • Peer Reviewed
• [Journal Article] Inhibitor of IkappaB kinase activity, BAY11-7082, interferes with the interferon regulatory factor 7 nuclear translocation and type I IFN production by plasmacytoid dendritic cells. (2010)
  • Author(s): R.Miyamoto
  • Journal Title: Arthritis Research Therap Volume: 12
  • Peer Reviewed
• [Journal Article] 樹状細胞による獲得免疫の制御 (2010)
  • Author(s): 佐々木泉
  • Journal Title: 侵襲と免疫 Volume: 19 Pages: 11-16
• [Journal Article] TLRシグナルによるI型インターフェロンの産生 (2010)
  • Author(s): 星野克明
  • Journal Title: 臨床免疫・アレルギー科 Volume: 54 Pages: 465-471
• [Journal Article] 核酸認識Toll様受容体刺激による樹状細胞からのI型インターフェロン産生誘導機構 (2010)
  • Author(s): 改正恒康
  • Journal Title: 医学のあゆみ Volume: 234 Pages: 357-363
• [Journal Article] 核酸に対する樹状細胞応答の制御機構 (2010)
  • Author(s): 改正恒康
  • Journal Title: 炎症と免疫 Volume: 18 Pages: 234-237
• [Journal Article] Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation (2010)
  • Author(s): K.Gotoh
  • Journal Title: J.Exp.Med. (in press)
  • Peer Reviewed
• [Journal Article] Critical role of IκB Kinase α in TLR7/9-Induced type I interferon production by conventional dendritic cells (2010)
  • Author(s): 星野克明
  • Journal Title: J.Immunol. (in press)
  • Peer Reviewed
• [Journal Article] Statins, inhibitors of HMG-GoA reductase, function as inhibitors for cellular and molecular components involved in type I IFN production (2010)
  • Author(s): H.Amuro
  • Journal Title: Arthritis Rheum (in press)
  • Peer Reviewed
• [Journal Article] The study of innate immunity in Japan : a historical perspective (2009)
  • Author(s): T.Kaisho
  • Journal Title: Int.Immunol. 21 Pages: 313-316
  • Peer Reviewed
• [Journal Article] Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production (2009)
  • Author(s): Y.Tsukamoto
  • Journal Title: Mol.Immunol. 46 Pages: 1278-1288
  • Peer Reviewed
• [Journal Article] Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effects in mouse sepsis model (2009)
  • Author(s): K.Takashima
  • Journal Title: British J Pharmacology 157 Pages: 1250-1262
  • Peer Reviewed
• [Journal Article] Id2-, RORγt-, and LTβR-independent initiation of lymphoid organ ogenesis in ocular immunity (2009)
  • Author(s): T.Nagatake
  • Journal Title: J.Exp.Med 206 Pages: 2351-2364
  • Peer Reviewed
• [Journal Article] Ablation of C/EBPbeta alleviates ER stress and pancreatic betacell failure through the GRP78 chaperone in mice (2009)
  • Author(s): T.Matsuda
  • Journal Title: J.Clin.Invest. 120 Pages: 115-126
  • Peer Reviewed
• [Journal Article] 樹状細胞における pattern recognition receptor とI型インターフェロンの役割 (2009)
  • Author(s): 星野克明
  • Journal Title: 炎症と免疫 18 Pages: 38-43
• [Journal Article] Toll-like receptor による核酸認識と応答機構 (2009)
  • Author(s): 佐々木泉
  • Journal Title: ファルマシア 46 Pages: 27-31
• [Journal Article] 核酸系免疫アジュバントの特性と作用機構 (2009)
  • Author(s): 改正恒康
  • Journal Title: アレルギー 59 Pages: 14-19
  • NAID: 110007539072
• [Presentation] Intestinal Immune Homeostasis Regulated by Dendritic Cells. (2015)
  • Author(s): 改正恒康
  • Organizer: The 3rd Homeostatic Inflammation International Symposium
  • Place of Presentation: 東京大学医科学研究所（東京都、港区）
  • Year and Date: 2015-01-31
  • Invited
• [Presentation] Roles of ArginaseⅠ in Cholera toxin-induced production of proinflammatory cytokines. (2014)
  • Author(s): I. Sasaki, S. Fukuda, T. Orimo, H. Hemmi, T. Kaisho.
  • Organizer: 第43回日本免疫学会総会;学術集会記録43:99, 2014
  • Place of Presentation: 京都国際会館（京都府、京都市）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Homeostasis of thymus-derived Foxp3+ regulatory T cells is controlled by ultraviolet B exposure in the skin. (2014)
  • Author(s): S. Yamazaki, A. Nishioka, T. Kaisho, O. Taguchi, S. Sakaguchi, A.Morita.
  • Organizer: 第43回日本免疫学会総会;学術集会記録43:176, 2014
  • Place of Presentation: 京都国際会館（京都府、京都市）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] XCL1 and XCR1 are involved in intestinal immne homeostasis by dendritic cells. (2014)
  • Author(s): 1T. Ohta, S. Okura, H. Hemmi, M. Sugiyama, I. Sasaki, C. Yamazaki, K. Hoshino, T. Kaisho.
  • Organizer: 第43回日本免疫学会総会;学術集会記録43:203, 2014
  • Place of Presentation: 京都国際会館（京都府、京都市）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Resistance to a helminthic infection is dependent on mast cell activation mediated by ATP in Spi-B-deficient mice. (2014)
  • Author(s): C. Shimokawa, T. Kanaya, K. Ishiwata, Y. Kurashima, H. Kiyono, T. Kaisho, H. Ohno.
  • Organizer: 第43回日本免疫学会総会;学術集会記録43:213, 2014
  • Place of Presentation: 京都国際会館（京都府、京都市）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] 樹状細胞を介した新規の生体恒常性維持機構 (2014)
  • Author(s): 改正恒康
  • Organizer: 第50回高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 和歌山県立医科大学（和歌山県、和歌山市）
  • Year and Date: 2014-12-05
  • Invited
• [Presentation] Regulatory mechanisms for inflammatory cytokine production by metabolic pathways. (2014)
  • Author(s): 改正恒康
  • Organizer: 第87回日本生化学会大会 The 87th Annual Meeting of the Japanese Biochemical Society
  • Place of Presentation: 京都国際会館（京都府、京都市）
  • Year and Date: 2014-10-16
  • Invited
• [Presentation] In vivo roles of XCR1-expressing dendritic cells. (2013)
  • Author(s): T.Kaisho
  • Organizer: The 42th Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: 幕張メッセ（千葉県、千葉市）
  • Year and Date: 2013-12-11 – 2013-12-13
  • Invited
• [Presentation] The transcription factor IRF8 is required for basophil development. (2013)
  • Author(s): H. Sasaki, D. Kurotaki, N. Osato, I. Sasaki, C. Kaneda, A. Nishiyama, T.Kaisho, H. C. III. Morse, K. Ozato, T. Tamura.
  • Organizer: 第42回日本免疫学会総会;学術集会記録42:80, 2013
  • Place of Presentation: 幕張メッセ（千葉県、千葉市）
  • Year and Date: 2013-12-11 – 2013-12-13
• [Presentation] Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective IFN-β. (2013)
  • Author(s): T. Kawashima, H Yan, Z. Guo, J. Carreras, R. Uchiyama, R. Fukui, T. Kaisho, S. Akira, K. Miyake, H. Tsutsui, T. Saito, N.M.Tsuji.
  • Organizer: 第42回日本免疫学会総会;学術集会記録42:123, 2013
  • Place of Presentation: 幕張メッセ（千葉県、千葉市）
  • Year and Date: 2013-12-11 – 2013-12-13
• [Presentation] A novel mechanism to generate the intestinal intraepithelial T lymphocytes by XCR-expressing dendric cells. (2013)
  • Author(s): T. Ohta, H. Hemmi, C. Yamazaki, M. Sugiyama, I. Sasaki, K. Hoshino, T. Kaisho.
  • Organizer: 第42回日本免疫学会総会;学術集会記録42:124, 2013
  • Place of Presentation: 幕張メッセ（千葉県、千葉市）
  • Year and Date: 2013-12-11 – 2013-12-13
• [Presentation] Function of XCR1-expressing dendric cells in oral tolerance. (2013)
  • Author(s): H. Hemmi, M. Sugiyama, T. Ohta, I. Sasaki, C. Yamazaki, T. Tanaka, K. Hoshino, T. Kaisho.
  • Organizer: 第42回日本免疫学会総会;学術集会記録42:163, 2013
  • Place of Presentation: 幕張メッセ（千葉県、千葉市）
  • Year and Date: 2013-12-11 – 2013-12-13
• [Presentation] Long-term memory T cell response induced by adjuvant role of iNKT cells. (2013)
  • Author(s): K. Shimizu, Y. Sato, J. Shinga, M. Asakura, T. Kaisho.
  • Organizer: 第42回日本免疫学会総会;学術集会記録42:163, 2013
  • Place of Presentation: 幕張メッセ（千葉県、千葉市）
  • Year and Date: 2013-12-11 – 2013-12-13
• [Presentation] Lactococcus lactis subsp. cremoris FC triggers IFN -γ production from NK and T cells via IL-12 and IL-18. (2013)
  • Author(s): Kosaka, H. Yan, H. Tsutsui, T. Kaisho, N. Tsuji.
  • Organizer: 第42回日本免疫学会総会;学術集会記録42:165, 2013
  • Place of Presentation: 幕張メッセ（千葉県、千葉市）
  • Year and Date: 2013-12-11 – 2013-12-13
• [Presentation] The role of M cells in intestinal helminthic infection. (2013)
  • Author(s): C. Shimokawa, T. Kanaya, T. Kaisho.
  • Organizer: 第42回日本免疫学会総会;学術集会記録42:211, 2013
  • Place of Presentation: 幕張メッセ（千葉県、千葉市）
  • Year and Date: 2013-12-11 – 2013-12-13
• [Presentation] Critical in vivo roles of dendritic cells expressing a chemokine receptor, XCR1. (2013)
  • Author(s): T.Kaisho
  • Organizer: The 2013 Fall Conference of the Korean Association of Immunologists
  • Place of Presentation: Seoul（Korea）
  • Year and Date: 2013-11-07 – 2013-11-08
  • Invited
• [Presentation] Molecular mechanisms for dendritic cell subset functions. (2013)
  • Author(s): T. Kaisho.
  • Organizer: Agricultural Biotechnology Symposium ‘Immune Modulation and Bioconvergence
  • Place of Presentation: Seoul（Korea）
  • Year and Date: 2013-11-06
• [Presentation] Enhanced apoptosis by disruption of the STAT3-IκBζ signaling pathway in epithelial cells induces Sjoegren”s syndrome-like autoimmune diseases. (2013)
  • Author(s): A. Okuma, K. Hoshino, T. Kaisho, T. Muta.
  • Organizer: The 15th International Congress of Immunology
  • Place of Presentation: Milan（Italy）
  • Year and Date: 2013-08-22 – 2013-08-27
• [Presentation] In vivo roles of XC chemokine receptor 1-expressing dendritic cells. (2013)
  • Author(s): T. Ohta, H. Hemmi, C. Yamazaki, M. Sugiyama, I. Sasaki, K. Hoshino, T. Kaisho.
  • Organizer: The 15th International Congress of Immunology
  • Place of Presentation: Milan（Italy）
  • Year and Date: 2013-08-22 – 2013-08-27
• [Presentation] In vivo roles of dendritic cells expressing a chemokine receptor, XCR1. (2013)
  • Author(s): T. Kaisho.
  • Organizer: France-Japan Joint Forum “Frontiers in Innate Immunity''
  • Place of Presentation: Strasbourg（France）
  • Year and Date: 2013-06-05 – 2013-06-08
  • Invited
• [Presentation] IL-27 affects helper T cell response via regulation of PGE2 production by macrophages. (2013)
  • Author(s): Y. Sato, H. Hara, S. Suzuki, T. Kaisho and H. Yoshida.
  • Organizer: The Joint international Meeting of The 78th Meeting of the Japanese Society of Interferon and Cytokine Research and The 21st International Symposium on Molecular Cell Biology of Macrophage
  • Place of Presentation: 都市センターホテル（東京都、千代田区）
  • Year and Date: 2013-05-20 – 2013-05-21
• [Presentation] Critical roles of dendritic cells expressing a chemokine receptor XCR1. (2013)
  • Author(s): T. Kaisho, H. Hemmi, M. Sugiyama, T. Ohta.
  • Organizer: The Joint international Meeting of The 78th Meeting of the Japanese Society of Interferon and Cytokine Research and The 21st International Symposium on Molecular Cell Biology of Macrophage
  • Place of Presentation: 都市センターホテル（東京都、千代田区）
  • Year and Date: 2013-05-20 – 2013-05-21
  • Invited
• [Presentation] Visualization of Inflammasome activation: monitoring caspase-1 activity in living cells by a genetically-encoded probe SCAT1. (2012)
  • Author(s): Ting Liu
  • Organizer: 第 35回日本分子生物学会年会
  • Place of Presentation: マリンメッセ福岡（福岡県）
  • Year and Date: 2012-12-11
• [Presentation] The Ets transcription factor Spi-B is essential for M-cell differentiation. (2012)
  • Author(s): T. Kanaya
  • Organizer: 第 41回日本免疫学会総会学術集会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県）
  • Year and Date: 2012-12-05
• [Presentation] Spi-B is critical for plasmacytoid dendric cell development in bone marrow (2012)
  • Author(s): I. Sasaki
  • Organizer: 第 41回日本免疫学会総会学術集会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県）
  • Year and Date: 2012-12-05
• [Presentation] Analysis of in vivo function of XC chemokine receptor-expressing dendric cells. (2012)
  • Author(s): M. Sugiyama
  • Organizer: 第 41回日本免疫学会総会学術集会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県）
  • Year and Date: 2012-12-05
• [Presentation] Long-term memory T cell response induced by adjuvant role of iNKT cells. (2012)
  • Author(s): K. Shimizu
  • Organizer: 第 41回日本免疫学会総会学術集会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県）
  • Year and Date: 2012-12-05
• [Presentation] IL-27 affects immune responses via regulation of prostaglandin E2 production by macrophages (2012)
  • Author(s): Y. Sato
  • Organizer: 第 41回日本免疫学会総会学術集会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県）
  • Year and Date: 2012-12-05
• [Presentation] A non-synonymous SNP(single nucleotide polymorphism) of PDLIM4 is associated with susceptibility of rheumatoid arthritis and Graves diseases (2012)
  • Author(s): T. Tanaka
  • Organizer: 第 41回日本免疫学会総会学術集会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県）
  • Year and Date: 2012-12-05
• [Presentation] I κΒ-ζ-deficiency in Epithelial Cells Elicits Sjogren’s Syndrome-like Autoimmune Disease. (2012)
  • Author(s): A. Okuma
  • Organizer: 第 41回日本免疫学会総会学術集会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県）
  • Year and Date: 2012-12-05
• [Presentation] Dendritic cell subsets in inflammation (2012)
  • Author(s): T. Kaisho
  • Organizer: The 12th Biennial International Endotoxin Innate Immunity Society (IEIIS) Meeting
  • Place of Presentation: 学術総合センター（東京千代田区）
  • Year and Date: 2012-10-23
  • Invited
• [Presentation] Function and differentiation of M cells, a unique subset of intestinal epithelial cells specialized for mucosal antigen (2012)
  • Author(s): T. Kanaya
  • Organizer: The 12th Biennial International Endotoxin Innate Immunity Society (IEIIS) Meeting
  • Place of Presentation: 学術総合センター（東京千代田区）
  • Year and Date: 2012-10-23
• [Presentation] In vivo roles of XC chemokine receptor 1-expressing dendritic cells. (2012)
  • Author(s): M. Sugiyama
  • Organizer: The 12th Biennial International Endotoxin Innate Immunity Society (IEIIS) Meeting
  • Place of Presentation: 学術総合センター（東京千代田区）
  • Year and Date: 2012-10-23
• [Presentation] Roles of an Ets family transcription factor, Spi-B, in plasmacytoid dendritic cell development in the bone marrow. (2012)
  • Author(s): I. Sasaki
  • Organizer: The 12th Biennial International Endotoxin Innate Immunity Society (IEIIS) Meeting
  • Place of Presentation: 学術総合センター（東京千代田区）
  • Year and Date: 2012-10-23
• [Presentation] IκB-ζ-deficient Mice Develop Sj#246;gren’s Syndrome-like Chronic Inflammation Caused by Dysregulation of Epithelial Homeostasis. (2012)
  • Author(s): A. Okuma
  • Organizer: The 12th Biennial International Endotoxin Innate Immunity Society (IEIIS) Meeting
  • Place of Presentation: 学術総合センター（東京千代田区）
  • Year and Date: 2012-10-23
• [Presentation] Spi-B is critical for plasmacytoid dendric cell development in bone marrow (2012)
  • Author(s): T. Kanaya
  • Organizer: 12th International Symposium On Dendritic Cells
  • Place of Presentation: Daege, Korea
  • Year and Date: 2012-10-07
• [Presentation] Critical role of Siglec-H in the function of plasmacytoid dendritic cells for the regulation of inflammation and T cell immunity in vivo. (2012)
  • Author(s): R. Murakami
  • Organizer: 12th International Symposium On Dendritic Cells
  • Place of Presentation: Daege, Korea
  • Year and Date: 2012-10-07
• [Presentation] Ablation of a dendritic cell subset expressing XC chemokine receptor 1 in vivo. (2012)
  • Author(s): H. Hemmi
  • Organizer: 12th International Symposium On Dendritic Cells
  • Place of Presentation: Daege, Korea
  • Year and Date: 2012-10-07
• [Presentation] Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo. (2012)
  • Author(s): H. Takagi
  • Organizer: 12th International Symposium On Dendritic Cells
  • Place of Presentation: Daege, Korea
  • Year and Date: 2012-10-07
• [Presentation] M cells, a unique subset of intestinal epithelial cells specialized for mucosal antigen (2012)
  • Author(s): T. Kanaya
  • Organizer: The Awaji International Forum on Infection and Immunity
  • Place of Presentation: ウェスティンホテル（兵庫県）
  • Year and Date: 2012-09-11
• [Presentation] In vivo ablation of XC chemokine receptor 1-expressing dendritic cell subset (2012)
  • Author(s): M. Sugiyama
  • Organizer: 20th International Symposium on Molecular Cell Biology of Macrophages 2012
  • Place of Presentation: 東京大学山上会館（東京大学）
  • Year and Date: 2012-06-15
• [Presentation] 自然免疫～感染の検知システム (2011)
  • Author(s): 改正恒康
  • Organizer: 免疫ふしぎ未来
  • Place of Presentation: 日本科学未来館(東京)
  • Year and Date: 2011-08-21
• [Presentation] 樹状細胞機能制御の分子基盤 (2011)
  • Author(s): 改正恒康
  • Organizer: 免疫サマースクール
  • Place of Presentation: ラフォーレ蔵王(宮城県)
  • Year and Date: 2011-08-01
• [Presentation] Dendritic cell sensing and responses for nucleic acid adjuvants (2011)
  • Author(s): T.Kaisho
  • Organizer: KSBMB
  • Place of Presentation: COEX, Inter Continental Seoul(韓国)(招待講演)
  • Year and Date: 2011-05-18
• [Presentation] Dendritic cell sensing and responses for nucleic acid adjuvants (2011)
  • Author(s): T.Kaisho
  • Organizer: IVI seminar
  • Place of Presentation: International Vaccine Institute(韓国)
  • Year and Date: 2011-05-18
• [Presentation] 核酸系免疫アジュバントに対する樹状細胞サブセットの応答機構 (2011)
  • Author(s): 改正恒康
  • Organizer: 第29回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 大分
  • Year and Date: 2011-02-10
• [Presentation] Evaluation of SCAT1 : a genetically-encoded probe for detecting activation of caspase-1 in living cells (2011)
  • Author(s): K.Shikada
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] HSP70はPDLIMによるNF-κBシグナルの負の制御に必須である/HSP70 is essential for PDLIM2-mediated termination of NF-κB signaling (2011)
  • Author(s): 田中貴志
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] PDLIM4によるSTATシグナルの負の制御機構/PDLIM4 negatively regulates STAT signaling by recruiting protein tyrosine phosphatases (2011)
  • Author(s): 平島健志
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] 形質細胞様樹状細胞による炎症反応とT細胞免疫応答の制御/Crucial role of plasmacytoid dendritic cells in the regulation of inflammation and T Cell immunity in vivo (2011)
  • Author(s): H.Takagi
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] Malissen. Siglec-Hによる形質細胞様樹状細胞の機能制御/Critical role of siglec-H in the function of plasmacytoid dendritic cells for the regulation of inflammation and T Cell immunity in vivo (2011)
  • Author(s): K.Sato
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] ケモカイン受容体Xcr1発現樹状細胞のin vivoにおける機能的意義/Critical roles of murine XC chemokine receptor 1-expressing DC subset in vivo (2011)
  • Author(s): C.Yamazaki
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] TLR3を介した乳酸菌2本鎖RNAのIFN-β産生誘導/Double-stranded RNA of lactic acid bacteria triggers TLR3-mediated IFN-β production by dendritic cells (2011)
  • Author(s): T.Kawashima
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] BDCA3+DCの発現するケモカインレセプターXCR1とNK細胞活性化能の解析/Importance of chemokines system between human BDCA3+ dendritic cells and NK cells in innate cytotoxic response (2011)
  • Author(s): 伊藤量基
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] 樹状細胞サブセット機能を制御する分子機構 (2010)
  • Author(s): 改正恒康
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-25
• [Presentation] Molecular mechanisms for Dendritic cell responses against nucleic acid adjuvants (2010)
  • Author(s): T.Kaisho
  • Organizer: LIAI-RCAI Joint Workshop
  • Place of Presentation: 横浜
  • Year and Date: 2010-11-12
• [Presentation] 核酸アジュバントによる樹状細胞サブセット活性化を制御する分子機構-マウスからヒトへ- (2010)
  • Author(s): 改正恒康
  • Organizer: 北海道大学院薬学研究院大学院特別講義
  • Place of Presentation: 札幌
  • Year and Date: 2010-11-09
• [Presentation] 核酸アジュバントによる樹状細胞活性化の分子メカニズム (2010)
  • Author(s): 改正恒康
  • Organizer: ワクチンフォーラム2010
  • Place of Presentation: 東京
  • Year and Date: 2010-09-14
• [Presentation] How dendritic cells sense and respond to nucleic acid adjuvants (2010)
  • Author(s): T.Kaisho
  • Organizer: RCAI International Summer Program 2010
  • Place of Presentation: 横浜
  • Year and Date: 2010-08-19
• [Presentation] How dendritic cells respond to nucleic acid adjivants (2010)
  • Author(s): T.Kaisho
  • Organizer: The 9th International Veterinary Immunology Symposium
  • Place of Presentation: 東京
  • Year and Date: 2010-08-17
• [Presentation] 樹状細胞機能を制御する分子基盤-マウスからヒトへ- (2010)
  • Author(s): 改正恒康
  • Organizer: 林原生物化学研究所セミナー
  • Place of Presentation: 岡山
  • Year and Date: 2010-07-09
• [Presentation] Molecular mechanisms for dendritic cell heterogeneity (2010)
  • Author(s): T.Kaisho
  • Organizer: NZ-RIKEN-CHIBA Joint Workshop
  • Place of Presentation: 横浜
  • Year and Date: 2010-06-14
• [Presentation] 遺伝子改変マウスによる樹状細胞機能制御機構の解明 (2010)
  • Author(s): 改正恒康
  • Organizer: 第53回未来医療セミナー
  • Place of Presentation: 大阪
  • Year and Date: 2010-04-23
• [Presentation] 核酸に対する樹状細胞応答の制御機構 (2010)
  • Author(s): 改正恒康
  • Organizer: 新学術領域「自然炎症」第1回公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-01-13
• [Presentation] Critical role of DOCK2 in type I IFN induction in plasmacytoid dendritic cells. (2010)
  • Author(s): K.Gotoh
  • Organizer: The 14th International Congress of Immunology
  • Place of Presentation: 神戸
• [Presentation] PDLIM2 regulates Th17-mediated responses through degradation of STAT3 transcription factor (2010)
  • Author(s): T.Tanaka
  • Organizer: The 14th International Congress of Immunology
  • Place of Presentation: 神戸
• [Presentation] An Ets family member, Spi-B, transactivates type I interferon promoters through the cooperation with IRF-7 (2010)
  • Author(s): K.Hoshino
  • Organizer: The 14th International Congress of Immunology
  • Place of Presentation: 神戸
• [Presentation] Critical roles of an Ets family member, Spi-B, in pDC maturation (2010)
  • Author(s): I.Sasaki
  • Organizer: The 14th International Congress of Immunology
  • Place of Presentation: 神戸
• [Presentation] Lactic acid bacteria induce Toll-like receptor 3-mediated IFN-beta production by dendritic cells in vitro and in vivo (2010)
  • Author(s): T.Kawashima
  • Organizer: The 14th International Congress of Immunology
  • Place of Presentation: 神戸
• [Presentation] Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice (2010)
  • Author(s): C.Yamazaki
  • Organizer: The 11th International Symposium on Dendritic Cells, DC2010
  • Place of Presentation: Lugano, Switzerland
• [Presentation] Statins, inhibitors of HMG-CoA reductase, function as inhibitors for cellular and molecular components involved in type I IFN production (2010)
  • Author(s): T.Ito
  • Organizer: The 11th International Symposium on Dendritic Cells, DC2010
  • Place of Presentation: Lugano, Switzerland
• [Presentation] Inhibitor of IkB kinase activity, BAY11-7082, interferes with the IRF7 nuclear translocation and type I IFN production by plasmacytoid dendritic cells (2010)
  • Author(s): R.Amakawa
  • Organizer: The 11th International Symposium on Dendritic Cells, DC2010
  • Place of Presentation: Lugano, Switzerland
• [Presentation] 核酸成分による樹状細胞からのI型インターフェロン産生機構とその病理的意義 (2009)
  • Author(s): 改正恒康
  • Organizer: 第37回日本臨床免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2009-11-13
• [Presentation] 形質細胞様樹状細胞のワクチン開発における意義 (2009)
  • Author(s): 改正恒康
  • Organizer: 第13回日本ワクチン学会
  • Place of Presentation: 札幌
  • Year and Date: 2009-09-26
• [Presentation] 形質細胞様樹状細胞機能における転写因子Spi-Bの役割/Critical role of Spi-B in plasmacytoid dendritic cell function (2009)
  • Author(s): I.Sasaki
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] PDLIM2はTh17細胞分化を負に制御する/PDLIM2 is a negative regulator for Th17 differentiation (2009)
  • Author(s): T.Tanaka
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] 乳酸菌は樹状細胞エンドソーム内TLRを介してIFN-βを誘導する/Lactic acid bacteria induces IFN-beta secretion by dendritic cells through Toll-like receptors in endosomes (2009)
  • Author(s): T.Kawashima
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Book] Principles of innate immunity, in Sixth Edition Rheumatology vol.1 (2013)
  • Author(s): T. Kaisho, S. Akira.
  • Publisher: MOSBY, ELSEVIER
• [Book] I型インターフェロン. In サイトカインのすべて (2012)
  • Author(s): 改正恒康
  • Publisher: 化学評論社
• [Book] 分子病態の解明と治療への展開 (2012)
  • Author(s): 改正恒康
  • Publisher: 南山堂
• [Book] Principles of innate immunity, in Fifth Edition Rheumatology vol.1 (2011)
  • Author(s): T.Kaisho
  • Publisher: ELSEVIER
• [Book] Principles of innate immunity, in Fifth Edition Rheumatology vol.1 (2011)
  • Author(s): T.Kaisho
  • Publisher: MOSBY, ELSEVIER
• [Book] 総合アレルギー学 (2010)
  • Author(s): 改正恒康
  • Publisher: 南山堂
• [Remarks] 改正研究室 研究業績2013年
  • URL: http://immreg.ifrec.osaka-u.ac.jp/www/
• [Remarks] 改正研究室 研究業績2013，2014年
  • URL: http://www.wakayama-med.ac.jp/med/seitai/
• [Remarks] 自然炎症―内因性リガンドによって誘導される自然炎症の分子基盤とその破綻
  • URL: http://shizen-enshow.jp/
• [Remarks] 改正研究室 研究業績 2012年
  • URL: http://immreg.ifrec.osaka-u.ac.jp/www/publication/2012/06/2012.html
• [Remarks] 自然炎症ー内因性リガンドによって誘導される自然炎症の分子基盤とその破綻
  • URL: http://shizen-enshow.jp/index.html
• [Remarks]
  • URL: http://www.riken.jp/hosdef/index.html
• [Remarks] 研究チームHP
  • URL: http://www.riken.jp/hosdef/index.html
• [Patent(Industrial Property Rights)] 創傷治療剤及びそのスクリーニング方法 (2009)
  • Inventor(s): 田中貴志, 改正恒康
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Filing Date: 2009-11-05
• [Patent(Industrial Property Rights)] 創傷治療剤及びそのスクリーニング方法 (2009)
  • Inventor(s): 田中貴志, 改正恒康
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Filing Date: 2009-11-05
  • Overseas