Functional role of pathogen sensors and their endogenous ligands in the metabolic syndrome

• Project Area: Homeostatic inflammation: Molecular basis and dysregulation
• Project/Area Number: 21117007
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: OGAWA Yoshihiro 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (70291424)
• Co-Investigator(Kenkyū-buntansha): SATA Masataka 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (80345214)
• Project Period (FY): 2009-07-23 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥214,240,000 (Direct Cost: ¥164,800,000、Indirect Cost: ¥49,440,000); Fiscal Year 2013: ¥38,870,000 (Direct Cost: ¥29,900,000、Indirect Cost: ¥8,970,000); Fiscal Year 2012: ¥38,870,000 (Direct Cost: ¥29,900,000、Indirect Cost: ¥8,970,000); Fiscal Year 2011: ¥41,730,000 (Direct Cost: ¥32,100,000、Indirect Cost: ¥9,630,000); Fiscal Year 2010: ¥40,690,000 (Direct Cost: ¥31,300,000、Indirect Cost: ¥9,390,000); Fiscal Year 2009: ¥54,080,000 (Direct Cost: ¥41,600,000、Indirect Cost: ¥12,480,000)
• Keywords: メタボリックシンドローム / 病原体センサー / 内因性リガンド / マクロファージ / 脂肪酸 / crown-like structure / NASH / 肥満 / TLR9 / 遊離核酸 / 脂肪組織 / Mincle / 動脈硬化 / 血管新生 / 飽和脂肪酸 / TLR4 / HMGB-1 / ATF3 / 冠動脈疾患

Research Abstract

In this study, we investigated novel molecular mechanisms underlying the metabolic syndrome, especially focusing on "homeostatic inflammation" that consists of pathogen sensors and their endogenous ligands. We have already demonstrated that the saturated fatty acid-TLR4 pathway plays an important role in the pathophysiology of obesity-induced adipose tissue inflammation. In addition, our data show that ATF4 and ATF3, metabolic stress-induced transcription factors, positively and negatively regulate the TLR4 pathway, respectively. Moreover, Mincle, a pathogen sensor that selectively expressed in macrophages from obese adipose tissue, is a novel regulator of adipose tissue inflammation.

Research Products

• [Journal Article] Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages. (2014)
  • Author(s): Iwasaki Y, Suganami T, Hachiya R, Shirakawa I, Kim-Saijo M, Tanaka M, Hamaguchi M, Takai-Igarashi T, Nakai M, Miyamoto Y, Ogawa Y.
  • Journal Title: Diabetes Volume: 63 Issue: 1 Pages: 152-61
  • DOI: 10.2337/db13-0757
  • Peer Reviewed
• [Journal Article] Endothelial PGC-1α mediates vascular dysfunction in diabetes (2014)
  • Author(s): N. Sawada, A. Jiang, F. Takizawa, A. Safdar, A. Manika, Y. Tesmenitsky, K.-T. Kang, J. Bischoff, H. Kalwa, J.L. Sartoretto, Y. Kamei, L.E. Benjamin, H. Watada, Y. Ogawa, Y. Higashikuni, C.W. Kessinger, F.A. Jaffer, T. Michel, M. Sata, K. Croce, R. Tanaka, Z Arany
  • Journal Title: Cell Metab Volume: 19 Issue: 2 Pages: 246-58
  • DOI: 10.1016/j.cmet.2013.12.014
  • Peer Reviewed / Open Access
• [Journal Article] Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A (2013)
  • Author(s): N. Yamakawa, U. Ohto, S. Akashi-Takamura, K. Takahashi, SI. Saitoh, N. Tanimura, T. Suganami, Y. Ogawa, T. Shibata, T. Shimizu, K. Miyake
  • Journal Title: Int. Immunol. Volume: 25 Issue: 1 Pages: 45-52
  • DOI: 10.1093/intimm/dxs084
  • Peer Reviewed
• [Journal Article] Association between body weight at weaning and remodeling in the subcutaneous adipose tissue of obese adult mice with undernourishment in utero (2013)
  • Author(s): Y.K. Kohmura, N. Kanayama, K. Muramatsu, N. Tamura, C. Yaguchi, T. Uchida, K. Suzuki, K. Sugihara, S. Aoe, T. Sasaki, T. Suganami, Y. Ogawa, H. Itoh
  • Journal Title: Reprod. Sci. Volume: 20 Issue: 7 Pages: 813-827
  • DOI: 10.1177/1933719112466300
  • Peer Reviewed
• [Journal Article] Hepatic crown-like structure : a unique histological feature in non-alcoholic steatohepatitis in mice and humans (2013)
  • Author(s): M. Itoh, H. Kato, T. Suganami, K. Konuma, Y. Marumoto, S. Terai, H. Sakugawa, S. Kanai, M. Hamaguchi, T. Fukaishi, S. Aoe, K. Akiyoshi, Y. Komohara, M. Takeya, I. Sakaida, Y. Ogawa
  • Journal Title: PLoS ONE Volume: 8 Issue: 12 Pages: e82163-e82163
  • DOI: 10.1371/journal.pone.0082163
  • Peer Reviewed
• [Journal Article] Exendin-4, a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injury (2013)
  • Author(s): Y. Hirata, H. Kurobe, C. Nishio, K. Tanaka, D. Fukuda, E. Uematsu, S. Nishimoto, T. Soeki, N. Harada, H. Sakaue, T. Kitagawa, M. Shimabukuro, N. Nakaya, M. Sata
  • Journal Title: Eur. J. Pharmacol. Volume: 699 Issue: 1-3 Pages: 106-111
  • DOI: 10.1016/j.ejphar.2012.11.057
  • Peer Reviewed
• [Journal Article] Beneficial effect of a synthetic prostacyclin agonist, ONO-1301, in rat autoimmune myocarditis model (2013)
  • Author(s): Y. Hirata, H. Kurobe, E. Uematsu, S. Yagi, T. Soeki, H. Yamada, D. Fukuda, M. Shimabukuro, M. Nakayama, K. Matsumoto, Y. Sakai, T. Kitagawa, M. Sata
  • Journal Title: Eur. J. Pharmacol. Volume: 699 Issue: 1-3 Pages: 81-87
  • DOI: 10.1016/j.ejphar.2012.11.045
  • Peer Reviewed
• [Journal Article] HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9 (2013)
  • Author(s): Y. Hirata, H. Kurobe, M. Higashida, D. Fukuda, M. Shimabukuro, Y. Higashikuni, T. Kitagawa, M. Sata
  • Journal Title: Atherosclerosis Volume: 231 Issue: 2 Pages: 227-233
  • DOI: 10.1016/j.atherosclerosis.2013.09.010
  • Peer Reviewed
• [Journal Article] Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis (2013)
  • Author(s): M. Shimabukuro, Y. Hirata, M. Tabata, M. Dagvasumberel, H. Sato, H. Kurobe, D. Fukuda, T. Soeki, T. Kitagawa, S. Takanashi, M. Sata
  • Journal Title: Arterioscler. Thromb. Vasc. Biol. Volume: 33 Issue: 5 Pages: 1077-1084
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  • Peer Reviewed
• [Journal Article] A novel role for adipose ephrin-B1 in inflammatory response (2013)
  • Author(s): Mori T, Maeda N, Inoue K, Sekimoto R, Tsushima Y, Matsuda K, Yamaoka M, Suganami T, Nishizawa H, Ogawa Y, Funahashi T, Shimomura I
  • Journal Title: PLoS ONE Volume: 8 Issue: 10 Pages: e76199-e76199
  • DOI: 10.1371/journal.pone.0076199
  • Peer Reviewed
• [Journal Article] Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling (2013)
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  • Journal Title: Circulation Volume: 128 Pages: 60-71
  • Peer Reviewed
• [Journal Article] The Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation (2012)
  • Author(s): Y. Watanabe, T. Nakamura, S. Ishikawa, S. Fujisaka, I. Usui, K. Tsuneyama, Y. Ichihara, T. Wada, Y. Hirata, T. Suganami, H. Izaki, S. Akira, K. Miyake, H. Kanayama, M. Shimabukuro, M. Sata, T. Sasaoka, Y. Ogawa, K. Tobe, K. Takatsu, Y. Nagai
  • Journal Title: Diabetes Volume: 61 Issue: 5 Pages: 1199-1209
  • DOI: 10.2337/db11-1182
  • Peer Reviewed
• [Journal Article] Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver (2012)
  • Author(s): T. Ehara, Y. Kamei, M. Takahashi, X. Yuan, S. Kanai, E. Tamura, M. Tanaka, T. Yamazaki, S. Miura, O. Ezaki, T. Suganami, M. Okano, Y. Ogawa
  • Journal Title: Diabetes Volume: 61 Pages: 2442-2450
  • Peer Reviewed
• [Journal Article] Highly purified eicosapentaenoic acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia (2012)
  • Author(s): N. Satoh-Asahara, A. Shimatsu, Y. Sasaki, H. Nakaoka, A. Himeno, M. Tochiya, S. Kono, T. Takaya, K. Ono, H. Wada, T. Suganami, K. Hasegawa, Y. Ogawa
  • Journal Title: Diabetes Care Volume: 35 Issue: 12 Pages: 2631-2639
  • DOI: 10.2337/dc12-0269
  • Peer Reviewed
• [Journal Article] Adipose tissue inflammation and ectopic lipid accumulation. (review) (2012)
  • Author(s): T. Suganami, M. Tanaka, Y. Ogawa
  • Journal Title: Endocr. J. Volume: 59 Pages: 849-857
  • Peer Reviewed
• [Journal Article] The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response (2012)
  • Author(s): Y. Higashikuni, J. Sainz, K. Nakamura, M. Takaoka, S. Enomoto, H. Iwata, T. Kimie, M. Sahara, Y. Hirata, R. Nagai, M. Sata
  • Journal Title: Arterioscler. Thromb. Vasc. Biol. Volume: 32 Issue: 11 Pages: 654-661
  • DOI: 10.1161/atvbaha.110.211755
  • Peer Reviewed
• [Journal Article] 脂肪酸の質的・量的変化がもたらす慢性炎症とメタボリックシンドローム (2012)
  • Author(s): 伊藤美智子、菅波孝祥、小川佳宏
  • Journal Title: 実験医学 Volume: 30 Pages: 418-422
• [Journal Article] Adipose tissue inflammation and ectopic lipid accumulation (2012)
  • Author(s): Suganami T, Tanaka M, Ogawa Y
  • Journal Title: Endocr J Volume: 59 Pages: 849-857
  • NAID: 10031123130
  • Peer Reviewed
• [Journal Article] Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: A 3-dimensional cardiac computed tomography imaging study in Japanese subjects (2012)
  • Author(s): Dagvasumberel M, Shimabukuro M, Nishiuchi T, Ueno J, Takao S, Fukuda D, Hirata Y, Kurobe H, Soeki T, Iwase T, Kusunose K, Niki T, Yamaguchi K, Taketani Y, Yagi S, Tomita N, Yamada H, Wakatsuki T, Harada M, Kitagawa T, Sata M
  • Journal Title: Cardiovasc Diabetol Volume: 11 Issue: 1 Pages: 106-106
  • DOI: 10.1186/1475-2840-11-106
  • Peer Reviewed
• [Journal Article] The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response (2012)
  • Author(s): Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Kimie T, Sahara M, Hirata Y, Nagai R, Sata M
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 32 Issue: 3 Pages: 654-661
  • DOI: 10.1161/atvbaha.111.240341
  • Peer Reviewed
• [Journal Article] The Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation (2012)
  • Author(s): Watanabe, Y., et al
  • Journal Title: Diabetes Volume: (In press)
  • Peer Reviewed
• [Journal Article] Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans (2011)
  • Author(s): M. Ichioka, T. Suganami, N. Tsuda, I. Shirakawa, Y. Hirata, N. Satoh-Asahara, Y. Shimoda, M. Tanaka, M. Kim-Saijo, Y. Miyamoto, Y. Kamei, M. Sata, Y. Ogawa
  • Journal Title: Diabetes Volume: 60 Issue: 3 Pages: 819-826
  • DOI: 10.2337/db10-0864
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• [Journal Article] The Japan Obesity Metabolic Syndrome Study (JOMS) Group. Urinary cystatin C as a potential risk marker for cardiovascular disease and chronic kidney disease in patients with obesity and metabolic syndrome (2011)
  • Author(s): N. Satoh-Asahara, T. Sugamami, T. Majima, K. Kotani, Y. Kato, R. Araki, K. Koyama, T. Okajima, M. Tanabe, M. Oishi, A. Himeno, S. Kono, A. Sugawara, M. Hattori, Y. Ogawa, A. Shimatsu
  • Journal Title: Clin. J. Am. Soc. Nephrol. Volume: 6 Issue: 2 Pages: 265-273
  • DOI: 10.2215/cjn.04830610
  • Peer Reviewed
• [Journal Article] Role of central leptin signaling in the starvation-induced alteration of B cell development (2011)
  • Author(s): M. Tanaka, T. Suganami, M. Kim-Saijo, C. Toda, M. Tsuiji, K. Ochi, Y. Kamei, Y. Minokoshi, Y. Ogawa
  • Journal Title: J. Neurosci. Volume: 31 Issue: 23 Pages: 8373-8380
  • DOI: 10.1523/jneurosci.6562-10.2011
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• [Journal Article] Melanocortin-4 receptor-deficient mice as a novel mouse model of non-alcoholic steatohepatitis (2011)
  • Author(s): M. Itoh, T. Suganami, N. Nakagawa, M. Tanaka, Y. Yamamoto, Y. Kamei, S. Terai, I. Sakaida, Y. Ogawa
  • Journal Title: Am. J. Pathol. Volume: 179 Issue: 5 Pages: 2454-2463
  • DOI: 10.1016/j.ajpath.2011.07.014
  • Peer Reviewed
• [Journal Article] Adipose tissue remodeling as homeostatic inflammation (2011)
  • Author(s): Itoh M, Suganami T, Hachiya R, Ogawa Y
  • Journal Title: International Journal of Inflammation Volume: 2011 Pages: 720926-720926
  • DOI: 10.4061/2011/720926
  • Peer Reviewed
• [Journal Article] Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue (2011)
  • Author(s): Y. Hirata, M. Tabata, H. Kurobe, T. Motoki, M. Akaike, C. Nishio, M. Higashida, H. Mikasa, Y. Nakaya, S. Takanashi, T. Igarashi, T. Kitagawa, M. Sata
  • Journal Title: J. Am. Coll. Cardiol. Volume: 58 Issue: 3 Pages: 248-255
  • DOI: 10.1016/j.jacc.2011.01.048
  • Peer Reviewed
• [Journal Article] Augmented angiogenesis in adventitia promotes growth of atherosclerotic plaque in apolipoprotein E-deficient mice (2011)
  • Author(s): K. Tanaka, D. Nagata, Y. Hirata, Y. Tabata, R. Nagai, M. Sata
  • Journal Title: Atherosclerosis Volume: 215 Issue: 2 Pages: 366-373
  • DOI: 10.1016/j.atherosclerosis.2011.01.016
  • Peer Reviewed
• [Journal Article] Synergistic protection against vascular inflammation with a calcium channel blocker and a statin (2011)
  • Author(s): Hirata, Y, et al
  • Journal Title: Hypertens.Res. Volume: 34 Issue: 4 Pages: 441-442
  • DOI: 10.1038/hr.2010.275
  • Peer Reviewed
• [Journal Article] Enhanced Inflammation in Epicardial Fat in Patients With Coronary Artery Disease (2011)
  • Author(s): Hirata, Y, et al
  • Journal Title: International Heart Journal Volume: 52 Issue: 3 Pages: 139-142
  • DOI: 10.1536/ihj.52.139
  • NAID: 130000770910
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed
• [Journal Article] Chronic inflammation and atherosclerosis : A critical role for renin angiotensin system that is activated by lifestyle-related diseases (2011)
  • Author(s): Sata, M, et al
  • Journal Title: Inflammation and Regeneration Volume: 31 Issue: 3 Pages: 245-255
  • DOI: 10.2492/inflammregen.31.245
  • NAID: 130004943792
  • ISSN: 1880-8190, 1880-9693
  • Peer Reviewed
• [Journal Article] Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue (2011)
  • Author(s): Hirata, Y, et al
  • Journal Title: J Am Coll Cardiol Volume: 58 Pages: 248-255
  • Peer Reviewed
• [Journal Article] Role of central leptin signaling in renal macrophage infiltration (2010)
  • Author(s): M. Tanaka, T. Suganami, S. Sugita, Y. Shimoda, M. Kasahara, S. Aoe, M. Takeya, S. Takeda, Y. Kamei, Y. Ogawa
  • Journal Title: Endocr. J. Volume: 57 Pages: 61-72
  • NAID: 10029583411
  • Peer Reviewed
• [Journal Article] Unbalanced M1/M2 phenotype of peripheral blood monocytes in obese diabetic patients : effect of pioglitazone (2010)
  • Author(s): N. Satoh, A. Shimatsu, A. Himeno, Y. Sasaki, H. Yamakage, K. Yamada, T. Suganami, Y. Ogawa
  • Journal Title: Diabetes Care Volume: 33 Issue: 1 Pages: e7-e7
  • DOI: 10.2337/dc09-1315
  • Peer Reviewed
• [Journal Article] Insulin-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor in adipocytes in vitro (2010)
  • Author(s): T. Yamamoto, T. Suganami, M. Kiso-Narita, PA. Scherle, Y. Kamei1, M. Isobe, S. Higashiyama, Y. Ogawa
  • Journal Title: Obesity Volume: 18 Issue: 10 Pages: 1888-1894
  • DOI: 10.1038/oby.2010.2
  • Peer Reviewed
• [Journal Article] Adipose tissue macrophages : their role in adipose tissue remodeling. (review) (2010)
  • Author(s): T. Suganami, Y. Ogawa
  • Journal Title: J. Leukoc. Biol. Volume: 88 Issue: 1 Pages: 33-39
  • DOI: 10.1189/jlb.0210072
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• [Journal Article] Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages (2010)
  • Author(s): K. Yamashiro, T. Sasano, K. Tojo, I. Namekata, J. Kurokawa, N. Sawada, T. Suganami, Y. Kamei, H. Tanaka, N. Tajima, K. Utsunomiya, Y. Ogawa, T. Furukawa
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 398 Pages: 284-289
  • Peer Reviewed
• [Journal Article] Anti-obesity effect of eicosapentaenoic acid in high-fat/high-sucrose diet-induced obesity : importance of hepatic lipogenesis (2010)
  • Author(s): A. Sato, H. Kawano, T. Notsu, M. Ohta, M. Nakakuki, K. Mizuguchi, M. Itoh, T. Suganami, Y. Ogawa
  • Journal Title: Diabetes Volume: 59 Issue: 10 Pages: 2495-2504
  • DOI: 10.2337/db09-1554
  • Peer Reviewed
• [Journal Article] Endovascular injury induces rapid phenotypic changes in perivascular adipose tissue (2010)
  • Author(s): M. Takaoka, H. Suzuki, S. Shioda, K. Sekikawa, Y. Saito, R. Nagai, M. Sata
  • Journal Title: Arterioscler. Thromb. Vasc. Biol. Volume: 30 Issue: 8 Pages: 1576-1582
  • DOI: 10.1161/atvbaha.110.207175
  • Peer Reviewed
• [Journal Article] Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages (2010)
  • Author(s): H. Iwata, I. Manabe, K. Fujiu, T. Yamamoto, N. Takeda, K. Eguchi, A. Furuya, M. Kuro-o, M. Sata, R. Nagai
  • Journal Title: Circulation Volume: 122 Issue: 20 Pages: 2048-2057
  • DOI: 10.1161/circulationaha.110.965202
  • Peer Reviewed
• [Journal Article] Adipose tissue macrophages : their role in adipose tissue remodeling (2010)
  • Author(s): T.Suganami, et al
  • Journal Title: J.Leukoc.Biol. Volume: 88 Pages: 33-39
  • Peer Reviewed
• [Journal Article] Unbalanced M1/M2 phenotype of peripheral blood monocytes in obese diabetic patients : effect of pioglitazone (2010)
  • Author(s): N.Satoh, et al
  • Journal Title: Diabetes Volume: 33
  • Peer Reviewed
• [Journal Article] Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages (2010)
  • Author(s): K.Yatnashiro, et al
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 398 Pages: 284-289
  • Peer Reviewed
• [Journal Article] Role of central leptin signaling in renal macrophage infiltration (2010)
  • Author(s): M.Tanaka, et al
  • Journal Title: Endocr.J. Volume: 57 Pages: 61-72
  • Peer Reviewed
• [Journal Article] Long-term patency of small-diameter vascular graft made from fibroin, asilk-based biodegradable material (2010)
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  • Journal Title: J Vase Surg. Volume: 51 Pages: 155-164
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• [Journal Article] When EPC says : I2 shall limit neointima formation! (2010)
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  • Journal Title: Arterioscler.Thromb.Vase.Biol. Volume: 30 Pages: 457-458
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• [Journal Article] Crucial role of renin-angiotensin system in the pathogenesis of atheroscle rosis (2010)
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• [Journal Article] Ezetimibe ameliorates metabolic disorder and microalbuminuria in patients with hypercholesterolemia (2010)
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• [Journal Article] Is PIGF a plaque growth factor? (2010)
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• [Journal Article] Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability (2010)
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• [Journal Article] eNOS-independent protective action of statin against angiotensin II-induced atrial remodeling via reduced oxidant injury (2010)
  • Author(s): S.Yagi, et al
  • Journal Title: Hypertension. Volume: 55 Pages: 918-923
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• [Journal Article] Impact of primitive cells in intracoronary thrombi on lesion prognosis : Temporal analysis of cellular constituents of thrombotic material obtained from patients with acute coronary syndrome (2010)
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  • Journal Title: Heart. Volume: 96 Pages: 748-755
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• [Journal Article] Congenital ventricular aneurysm manifesting as monofocal premature ventricular contractions (2010)
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• [Journal Article] Effects of additional administration of low-dose indapamide on patients with hypertension treated with angiotensin II receptor blocker (2010)
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• [Journal Article] A phoshodiesterase-5 inhibitor vardenafil enhances angiogenesis through a protein kinase G-dependent hypoxia-inducible factor-1/vascular endothelial growth factor pathway (2010)
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  • Journal Title: Arterioscler Thromb Vase Bio Volume: 30 Pages: 1315-1324
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• [Journal Article] Cardiac magnetic resonance imaging and 2-dimensional speckle tracking echocardiography in secondary cardiac amyloidosis (2010)
  • Author(s): K.Kusunose, et al
  • Journal Title: Circ J. Volume: 74 Pages: 1494-1496
  • Peer Reviewed
• [Journal Article] Endovascular injury induces rapid phenotypic changes in perivascular adipose tissue (2010)
  • Author(s): M.Takaoka, et al
  • Journal Title: Arterioscler Thromb Vase Biol. Volume: 30 Pages: 1576-1582
  • Peer Reviewed
• [Journal Article] Heparin cofactor II protects against angiotensin II-induced cardiac remode ling via attenuation of oxidative stress in mice (2010)
  • Author(s): Y.Sumitomo-Ueda, et al
  • Journal Title: Hypertension. Volume: 56 Pages: 430-436
  • Peer Reviewed
• [Journal Article] Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function (2010)
  • Author(s): S.Yoshida, et al
  • Journal Title: Atherosclerosis. Volume: 212 Pages: 310-315
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• [Journal Article] Diagnostic utility of cardiac magnetic resonance for detection of cardiac involvement in female carriers of Duchenne muscular dystrophy (2010)
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  • Journal Title: Heart Asia. Volume: 2 Pages: 52-55
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• [Journal Article] The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function (2010)
  • Author(s): Y.Higashikuni, et al
  • Journal Title: Thromb Vase Biol. Volume: 30 Pages: 2128-2135
  • Peer Reviewed
• [Journal Article] Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages (2010)
  • Author(s): H.Iwata, et al
  • Journal Title: Circulation. Volume: 122 Pages: 2048-2057
  • Peer Reviewed
• [Journal Article] Moderate intake of red wine improves ischemia-induced neovascularization in diabetic mice-Roles of endothelial progenitor cells and nitric oxide (2010)
  • Author(s): PH.Huang, et al
  • Journal Title: Atherosclerosis. Volume: 212 Pages: 426-435
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• [Journal Article] Bosentan ameliorated exercise-induced pulmonary arterial hypertension complicated with systemic sclerosis (2010)
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  • Journal Title: Intern Med. Volume: 49 Pages: 2309-2312
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• [Journal Article] The angiotensin receptor blocker, telmisartan, reduces and stabilizes ather osclerosis in ApoE and AT1aR double deficient mice (2010)
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  • Journal Title: Biomed Pharmacother. Volume: 64 Pages: 712-717
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• [Journal Article] Unbalanced M1/M2 phenotype of peripheral blood monocytes in obese diabetic patients : effect of pioglitazone (2010)
  • Author(s): N.Satoh, et al.
  • Journal Title: Diabetes Care 33
  • Peer Reviewed
• [Journal Article] Role of central leptin signaling in renal macrophage infiltration under unilateral ureteral obstruction (2010)
  • Author(s): M.Tanaka, et al.
  • Journal Title: Endocr.J. 57 Pages: 61-72
  • Peer Reviewed
• [Journal Article] Insulin-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor in adipocytes in vitro : role of a disintegrin and metalloproteinas e 17 (2010)
  • Author(s): T.Yamamoto, et al.
  • Journal Title: Obesity (Jan20. [Epub ahead of print])
  • Peer Reviewed
• [Journal Article] Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated fatty acid/Toll-like receptor 4 signaling and macrophage activation in obese adipose tissue (2009)
  • Author(s): T. Suganami, X. Yuan, Y. Shimoda, K. Uchio-Yamada, N. Nakagawa, I. Shirakawa, T. Usami, T. Tsukahara, K. Nakayama, Y. Miyamoto, K. Yasuda, J. Matsuda, Y. Kamei, S. Kitajima, Y. Ogawa
  • Journal Title: Circ. Res. Volume: 105 Issue: 1 Pages: 25-32
  • DOI: 10.1161/circresaha.109.196261
  • Peer Reviewed
• [Journal Article] Highly purified eicosapentaenoic acid reduces cardio-ankle vascular index in association with decrease in serum amyloid A-LDL in metabolic syndrome (2009)
  • Author(s): N. Satoh, A. Shimatsu, K. Kotani, A. Himeno, T. Majima, K. Yamada, T. Suganami, Y. Ogawa
  • Journal Title: Hypertens. Res. Volume: 32 Issue: 11 Pages: 1004-1008
  • DOI: 10.1038/hr.2009.145
  • NAID: 10026124410
  • Peer Reviewed
• [Journal Article] Periadventitial adipose tissue plays a critical role in vascular remodeling (2009)
  • Author(s): M. Takaoka, D. Nagata, S. Kihara, S. Shimomura, Y. Kimura, Y. Tabata, Y. Saito, R. Nagai, M. Sata
  • Journal Title: Circ. Res. Volume: 105 Issue: 9 Pages: 906-911
  • DOI: 10.1161/circresaha.109.199653
  • Peer Reviewed
• [Journal Article] Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated fatty acid/Toll-like receptor 4 signaling and macrophage activation in obese adipose tissue (2009)
  • Author(s): T.Suganami, et al.
  • Journal Title: Circ.Res. 105 Pages: 25-32
  • Peer Reviewed
• [Journal Article] Clinical utility of single-beat E/e' obtained by simultaneous recording of flow and tissue Doppler velocities in atrial fibrillation with preserved systolic function (2009)
  • Author(s): K.Kusunose, et al.
  • Journal Title: J.Am.Coll.Cardiol.Img. 2 Pages: 1147-1156
  • Peer Reviewed
• [Journal Article] Inhibition of renin-angiotensin system attenuates periadventitial inflammation and reduces atherosclerotic lesion formation (2009)
  • Author(s): D.Fukuda, et al.
  • Journal Title: Biomed.Pharmacother. 63 Pages: 754-761
  • Peer Reviewed
• [Journal Article] Periadventitial adipose tissue plays a critical role in vascular remodeling (2009)
  • Author(s): M.Takaoka, et al.
  • Journal Title: Circ Res. 105 Pages: 906-911
  • Peer Reviewed
• [Presentation] Role of parenchymal-stromal cell interaction in metabolic diseases (2014)
  • Author(s): Y. Ogawa
  • Organizer: 2014 Keystone Symposia on Molecular and Cellular Biology: Innate Immunity, Metabolism and Vascular Injury
  • Place of Presentation: Whistler, Canada
• [Presentation] Epicardial adipose tissue plays a role in the pathogenesis of atherosclerosis (2014)
  • Author(s): M. Sata
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Kyoto, Japan
• [Presentation] Role of Mincle, a novel pathogen sensor in macrophages, in obesity-induced adipose tissue inflammation and fibrosis (2014)
  • Author(s): Ikeda K, Tanaka M, Suganami T, Komiya C, Ochi K, Shirakawa I, Hamaguchi M, Ogawa Y
  • Organizer: 2014 Keystone Symposia Conference, Obesity: A Multisystems Perspective
  • Place of Presentation: Vancouver, Canada
• [Presentation] Regulation of metabolic genes by DNA methylation (2013)
  • Author(s): Y. Ogawa
  • Organizer: 8th World Congress on Developmental Origins of Health and Disease
  • Place of Presentation: SUTEC, Singapore
• [Presentation] Chronic inflammation and ectopic fat accumulation in the metabolic syndrome (2013)
  • Author(s): Y. Ogawa
  • Organizer: 2013 International Conference on Diabetes and Metabolism (ICDM2013) & 5th Scientific Meeting of the Asian Association for the Study of Diabetes (5th AASD Scientific Meeting)
  • Place of Presentation: Seoul, Korea
• [Presentation] ATF4 Plays Critical Roles in Saturated Fatty Acid induced Il-6 Expression in Macropheges (2013)
  • Author(s): Iwasaki Y, Suganami T, Hachiya R, Shirakawa I, Hamaguchi M, Ogawa Y
  • Organizer: The Endocrine Society's 95th Annual Meeting & Expo
  • Place of Presentation: San Francisco, USA
• [Presentation] 慢性炎症と異所性脂肪蓄積 (2013)
  • Author(s): 小川佳宏
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本、日本
  • Invited
• [Presentation] 生活習慣病の基盤病態としての慢性炎症 (2013)
  • Author(s): 小川佳宏
  • Organizer: 第28回日本糖尿病合併症学会
  • Place of Presentation: 旭川、日本
  • Invited
• [Presentation] NLRP3 Inflammasome Activation Through the Heart-Brain Interaction Contributes to Adaptive Cardiac Hypertrophy in Response to Pressure Overload (2013)
  • Author(s): Higashikuni Y, Nagai R, Sata M, Komuro I
  • Organizer: AHA Scientific Sessions 2013
  • Place of Presentation: Dallas, USA
• [Presentation] Macrophage Toll-like Receptor 9 Signaling Contributes to the Development of Insulin Resistance through the Promotion of Inflammation in Adipose Tissue (2013)
  • Author(s): Nishimoto S, Fukuda D, Shimabukuro M, Yagi S, Soeki T, Sakaue H, Nakaya Y, Sata M
  • Organizer: AHA Scientific Sessions 2013
  • Place of Presentation: Dallas, USA
• [Presentation] Chronic inflammation, a molecular basis underlying the metabolic syndrome (2012)
  • Author(s): Y. Ogawa
  • Organizer: 2012 Shanghai Symposium on Obesity & Diabetes
  • Place of Presentation: Shanghai, China
  • Year and Date: 2012-04-07
• [Presentation] Chronic inflammation and ectopic fat accumulation in the metabolic syndrome (2012)
  • Author(s): Y. Ogawa
  • Organizer: The 2012 Spring Conference of the Korean Association of Immunologists
  • Place of Presentation: Seoul, Korea
• [Presentation] Epicardial adipose tissue plays a role in the pathogenesis of Atherosclerosis (2012)
  • Author(s): M. Sata
  • Organizer: APSC Subspecialty Congress-Intervention and Imaging 2012
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Inflammation in atherosclerosis and adipose tissue (2012)
  • Author(s): M. Sata
  • Organizer: The 12th Biennial International Endotoxin & Innate Immunity Society (IEIIS) Meeting 2012
  • Place of Presentation: Tokyo, Japan
• [Presentation] Chronic Inflammation and Ectopic Fat Accumulation in the Metabolic Syndrome (2012)
  • Author(s): Ogawa Y
  • Organizer: The 2012 Spring Conference of the Korean Association of Immunologists
  • Place of Presentation: Seoul, Korea
  • Invited
• [Presentation] Chronic Inflammation, A Molecular Basis Underlying the Metabolic Syndrome (2012)
  • Author(s): Ogawa Y
  • Organizer: 2012 Shanghai Symposium on Obesity & Diabetes
  • Place of Presentation: Shanghai ,China
  • Invited
• [Presentation] Chronic inflammataion and ectopic fat accumulation in the metabolic syndrome (2012)
  • Author(s): Ogawa Y, Suganami T
  • Organizer: 20th International Symposium on Molecular Cell Biology of Macrophages 2012
  • Place of Presentation: Tokyo, Japan
  • Invited
• [Presentation] Locally applied suramin inhibits angiogenesis in adventitia and arterial lesion progression in apolipoprotein E-deficient mice (2012)
  • Author(s): Tanaka K, Hirata Y, Tabata Y, Ouchi Y, Sata M
  • Organizer: ESC Congress 2012
  • Place of Presentation: Munich, Germany
• [Presentation] Adipose tissue remodeling homeostatic inflammation (2011)
  • Author(s): Ogawa, Y
  • Organizer: 2011 Seoul Symposium on obesity & Diabetes
  • Place of Presentation: Seoul
  • Year and Date: 2011-04-09
• [Presentation] Homeostatic inflammation : a molecular basis underlying metabolic diseases (2011)
  • Author(s): Y. Ogawa
  • Organizer: International Symposium on Inflammation and Disease
  • Place of Presentation: Academia Sinica, Taiwan
• [Presentation] Epigenetic regulation of metabolic diseases (2011)
  • Author(s): Y. Ogawa
  • Organizer: The Endocrine Society's 93rd Annual Meeting & Expo (ENDO 2011)
  • Place of Presentation: Boston, USA
• [Presentation] メタボリックシンドロームの臓器相関における脂肪組織マクロファージの意義 (2011)
  • Author(s): 菅波孝祥, 他
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸
• [Presentation] 脂肪組織の慢性炎症 (2011)
  • Author(s): 菅波孝祥, 他
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
• [Presentation] メタボリックシンドロームと慢性炎症 (2011)
  • Author(s): 小川佳宏
  • Organizer: 第11回日本抗加齢医学総会
  • Place of Presentation: 京都
• [Presentation] 病原体センサーと慢性炎症 (2011)
  • Author(s): 菅波孝祥, 他
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路
• [Presentation] Role of saturated fatty acids in adipose tissue inflammation (2011)
  • Author(s): 菅波孝祥, 他
  • Organizer: 第19回日本血管生物医学会学術集会
  • Place of Presentation: 東京
• [Presentation] Chronic inflammation, a molecular basis underlying the metabolic syndrome (2011)
  • Author(s): 小川佳宏
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Obesity and adipose tissue inflammation (2011)
  • Author(s): 菅波孝祥, 他
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] HMGB1/TLR9 pathway plays a critical role in chronic inflammation and vascular remodeling after endovascular injury (2011)
  • Author(s): Higashida, M., et al
  • Organizer: ESC Congress 2011
  • Place of Presentation: Paris
• [Presentation] 心臓周囲脂肪におけるインフラマゾームの病態的意義 (2011)
  • Author(s): 佐藤寛美, 他
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路
• [Presentation] HMGB1 Signal via TLR9 Plays Critical Role in Vascular Remodeling (2011)
  • Author(s): Higashida, M., et al
  • Organizer: AHA Scientific Sessions 2011
  • Place of Presentation: Orlando
• [Presentation] Orally administered eicosapentaenoic acid reduces and stabilizes atherosclerotic lesions (2010)
  • Author(s): M.Sata
  • Organizer: 第42回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-07-16
• [Presentation] Adipose tissue remodeling as homeostatic inflammation (2010)
  • Author(s): Y. Ogawa
  • Organizer: The 8th International Diabetes Federation-Western Pacific Region (IDF-WPR) Congress
  • Place of Presentation: Busan, Korea
• [Presentation] Vascular injury and repair : beyond the endothelium (2010)
  • Author(s): M. Sata
  • Organizer: ESC CONGRESS 2010
  • Place of Presentation: Stockholm,Sweden
• [Presentation] 肥満と慢性炎症 (2010)
  • Author(s): 小川佳宏
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋
• [Presentation] Adipose tissue remodeling and homeostatic inflammation (2010)
  • Author(s): Y.Ogawa
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] Vascular injury anr repair : beyond the endothelium (2010)
  • Author(s): M.Sata
  • Organizer: ESC CONGRESS 2010
  • Place of Presentation: Stockholm, Sweden
• [Presentation] Atherosclerosis, Angiogenesis and Sex hormones (2010)
  • Author(s): 佐田政隆
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Role of saturated fatty acid/TLR4 signaling in macrophages in obesity-induced adipose tissue inflammation (2009)
  • Author(s): T.Suganami, et al.
  • Organizer: The 17th International Symposium on Molecular Cell Biology of Macrophages 2009
  • Place of Presentation: Kanazawa, Japan
• [Presentation] Adipose tissue remodeling (2009)
  • Author(s): Y.Ogawa
  • Organizer: The 2009 Pennington Scientific Symposia Series. US-Japan Nutrition and Metabolism Panel Annual Symposium
  • Place of Presentation: Baton Rouge
• [Presentation] Endovascular injury induces rapid phenotypic changes in perivascular adipose tissue (2009)
  • Author(s): M.Takaoka, et al.
  • Organizer: American Heart Association 2009
  • Place of Presentation: Orland
• [Book] 日本人なら知っておきたい「異所性脂肪」の恐怖 (2012)
  • Author(s): 小川佳宏
  • Total Pages: 173
  • Publisher: ワニブックス
• [Remarks]
  • URL: http://www.tmd.ac.jp/grad/cme/index.html
• [Remarks]
  • URL: http://square.umin.ac.jp/TOKUSHIM/
• [Remarks] 東京医科歯科大学大学院医歯学総合研究科分子内分泌代謝学分野
  • URL: http://www.tmd.ac.jp/grad/cme/index.html
• [Remarks] 徳島大学大学院ヘルスバイオサイエンス研究部循環器内科学
  • URL: http://square.umin.ac.jp/~TOKUSHIM/
• [Remarks] 非アルコール性脂肪性肝炎（NASH）の重症度を反映する病理組織マーカーの同定
  • URL: http://www.tmd.ac.jp/archive-tmdu/kouhou/20131212.pdf#search='%E5%B0%8F%E5%B7%9D%E4%BD%B3%E5%AE%8F+NASH'
• [Remarks] 東京医科歯科大学大学院医歯学総合研究科分子内分泌代謝学分野
  • URL: http://www.tmd.ac.jp/grad/cme/index.html
• [Remarks] 徳島大学大学院ヘルスバイオサイエンス研究部循環器内科学
  • URL: http://square.umin.ac.jp/TOKUSHIM/index.htm
• [Remarks]
  • URL: http://www.tmd.ac.jp/mri/prm/index.html
• [Remarks]
  • URL: http://square.umin.ac.jp/TOKUSHIM/index.htm
• [Remarks]
  • URL: http://www.tmd.ac.jp/mri/prm/index.html
• [Remarks]
  • URL: http://square.umin.ac.jp/TOKUSHIM/index.htm
• [Patent(Industrial Property Rights)] 脂肪細胞の炎症性変化を抑制する物質のスクリーニング系及びそれを用いたスクリーニング方法 (2011)
  • Inventor(s): 小川佳宏、菅波孝祥
  • Industrial Property Rights Holder: 国立大学法人東京医科歯科大学
  • Industrial Property Rights Type: 特許
  • Acquisition Date: 2011-11-18