Elucidation of the molecular mechanisms regulating inflammatory memory

• Project Area: Integrated elucidation of inflammatory tissue-resilience and tissue damage-entropy;Creation of innovative science for resolution of inflammation
• Project/Area Number: 21H05121
• Research Category: Grant-in-Aid for Transformative Research Areas (B)
• Allocation Type: Single-year Grants
• Review Section: Transformative Research Areas, Section (III)
• Research Institution: Chiba University
• Principal Investigator: Hirahara Kiyoshi 千葉大学, 大学院医学研究院, 教授 (00707193)
• Project Period (FY): 2021-08-23 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥40,950,000 (Direct Cost: ¥31,500,000、Indirect Cost: ¥9,450,000); Fiscal Year 2023: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000); Fiscal Year 2022: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000); Fiscal Year 2021: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
• Keywords: 炎症組織記憶 / 組織常在性記憶CD4+ T細胞 / 神経-炎症性組織レジリエンス連関 / iBALT / Proof of concept

Outline of Research at the Start

組織常在性記憶CD4+ T細胞が、肺の炎症記憶を制御し組織障害エントロピーの一端を担う細胞集団であることが示唆されるが、組織常在性記憶CD4+ T細胞の分化・維持に関する分子機構は、現在のところ全く不明である。そこで、本計画研究では、炎症記憶の制御機構を解明し、慢性気道炎症疾患の再燃や増悪のリスクを増加させる“組織障害エントロピー”の一端を明らかにするために、組織常在性記憶CD4+ T細胞の分化・維持機構に焦点をあて、1細胞レベル、クロマチンレベルおよび生体レベルの解析、患者での解析を進める。

Outline of Final Research Achievements

In order to elucidate the molecular mechanisms of inflammatory memory and to identify 'tissue damage entropy' that increase the risk of relapse or exacerbation of chronic airway inflammatory diseases, we analyzed the inflammatory memory at the single-cell, chromatin and biological levels, as well as in patients. We identified the mechanism of severe disease on viral infection and the mechanism of chronic inflammation pathogenesis associated with increased "tissue damage entropy" via the "neuro-immune interaction".

Academic Significance and Societal Importance of the Research Achievements

本研究の大きな成果の一つは、「免疫系」と「神経系」の相互連関によって形成される組織障害エントロピーに関して、その本質を細胞・分子・クロマチンレベルで明らかにしたことである。これは、今後の炎症収束学の創生へつながる学術的意義が大きい成果である。本研究領域の研究を通じてヒトの生体内において炎症記憶の制御機構を解き明かすことは、難治性疾患の病態制御へとつながり、社会貢献上のインパクトも大きい。

Research Products

• [Journal Article] The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells (2023)
  • Author(s): Kumagai Jin、Kiuchi Masahiro、Kokubo Kota、Yagyu Hiroyuki、Nemoto Masahiro、Tsuji Kaori、Nagahata Ken、Sasaki Atsushi、Hishiya Takahisa、Onoue Miki、Shinmi Rie、Sonobe Yuri、Iinuma Tomohisa、Yonekura Syuji、Shinga Jun、Hanazawa Toyoyuki、Koseki Haruhiko、Nakayama Toshinori、Yokote Koutaro、Hirahara Kiyoshi
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 120 Issue: 49 Pages: 2302903120-2302903120
  • DOI: 10.1073/pnas.2302903120
  • Peer Reviewed / Open Access
• [Journal Article] Single-cell RNA sequencing of peripheral blood mononuclear cells from Kimura disease patient successfully treated with dupilumab (2023)
  • Author(s): Suga Kensuke、Kiuchi Masahiro、Kageyama Takahiro、Kokubo Kota、Tanaka Shigeru、Iwata Arifumi、Suzuki Kotaro、Hirahara Kiyoshi、Nakajima Hiroshi
  • Journal Title: Allergology International Volume: 72 Issue: 4 Pages: 610-613
  • DOI: 10.1016/j.alit.2023.06.002
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Differences in the expression of multidrug resistance proteins in chronic rhinosinusitis according to endotype (2023)
  • Author(s): Iinuma Tomohisa、Yonekura Syuji、Hirahara Kiyoshi、Kurita Junya、Yoneda Riyo、Arai Tomoyuki、Sonobe Yuri、Shinmi Rie、Okamoto Yoshitaka、Hanazawa Toyoyuki
  • Journal Title: Allergology International Volume: 72 Issue: 4 Pages: 564-572
  • DOI: 10.1016/j.alit.2023.03.008
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases (2023)
  • Author(s): Onodera Atsushi、Kokubo Kota、Okano Mikiko、Onoue Miki、Kiuchi Masahiro、Iwamura Chiaki、Iinuma Tomohisa、Kimura Motoko Y.、Ebihara Nobuyuki、Hanazawa Toyoyuki、Nakayama Toshinori、Hirahara Kiyoshi
  • Journal Title: Pharmacology & Therapeutics Volume: 247 Pages: 108445-108445
  • DOI: 10.1016/j.pharmthera.2023.108445
  • Peer Reviewed / Open Access
• [Journal Article] The roles of tertiary lymphoid structures in chronic diseases (2023)
  • Author(s): Sato Yuki、Silina Karina、van den Broek Maries、Hirahara Kiyoshi、Yanagita Motoko
  • Journal Title: Nature Reviews Nephrology Volume: 19 Issue: 8 Pages: 525-537
  • DOI: 10.1038/s41581-023-00706-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characterization of eosinophils and natural killer cells in nasal polyps and peripheral blood in eosinophilic chronic rhinosinusitis patients (2023)
  • Author(s): Tsuji Kaori、Aoki Ami、Onodera Atsushi、Kiuchi Masahiro、Kokubo Kota、Morimoto Yuki、Iinuma Tomohisa、Hanazawa Toyoyuki、Nakayama Toshinori、Hirahara Kiyoshi
  • Journal Title: Allergology International Volume: 72 Issue: 2 Pages: 335-338
  • DOI: 10.1016/j.alit.2022.11.009
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism (2023)
  • Author(s): Kokubo Kota、Hirahara Kiyoshi、Kiuchi Masahiro、Tsuji Kaori、Shimada Yuki、Sonobe Yuri、Shinmi Rie、Hishiya Takahisa、Iwamura Chiaki、Onodera Atsushi、Nakayama Toshinori
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 120 Issue: 2
  • DOI: 10.1073/pnas.2218345120
  • Peer Reviewed / Open Access
• [Journal Article] The new preparation method for paraffin-embedded samples applying scanning electron microscopy revealed characteristic features in asthma-induced mice (2022)
  • Author(s): Wakai Ken、Azuma Kazuhiko、Iwamura Chiaki、Maimaiti Maihulan、Mikami Kosuke、Yoneda Kei、Sakamoto Shinichi、Ikehara Sanae、Yamaguchi Takashi、Hirahara Kiyoshi、Ichikawa Tomohiko、Nakayama Toshinori、Ikehara Yuzuru
  • Journal Title: Scientific Reports Volume: 12(1) Issue: 1 Pages: 9046-9046
  • DOI: 10.1038/s41598-022-12666-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity (2022)
  • Author(s): Iwamura Chiaki、Hirahara Kiyoshi、Kiuchi Masahiro、Ikehara Sanae、Azuma Kazuhiko、Shimada Tadanaga、Kuriyama Sachiko、Ohki Syota、Yamamoto Emiri、Inaba Yosuke、Shiko Yuki、Aoki Ami、Kokubo Kota、et al.
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 119 Issue: 33 Pages: 2203437119-2203437119
  • DOI: 10.1073/pnas.2203437119
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Single-cell immunoprofiling after immunotherapy for allergic rhinitis reveals functional suppression of pathogenic TH2 cells and clonal conversion (2022)
  • Author(s): Iinuma Tomohisa、Kiuchi Masahiro、Hirahara Kiyoshi、Kurita Junya、Kokubo Kota、Yagyu Hiroyuki、Yoneda Riyo、Arai Tomoyuki、Sonobe Yuri、Fukuyo Masaki、Kaneda Atsushi、Yonekura Syuji、Nakayama Toshinori、Okamoto Yoshitaka、Hanazawa Toyoyuki
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 150 Issue: 4 Pages: 850-860.e5
  • DOI: 10.1016/j.jaci.2022.06.024
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis (2022)
  • Author(s): Fujimoto Masanori、Yokoyama Masataka、Kiuchi Masahiro、Hosokawa Hiroyuki、Nakayama Akitoshi、Hashimoto Naoko、Sakuma Ikki、Nagano Hidekazu、Yamagata Kazuyuki、Kudo Fujimi、Manabe Ichiro、Lee Eunyoung、Hatano Ryo、Onodera Atsushi、Hirahara Kiyoshi、Yokote Koutaro、Miki Takashi、Nakayama Toshinori、Tanaka Tomoaki
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 1-21
  • DOI: 10.1038/s41467-022-33171-6
  • Peer Reviewed / Open Access
• [Journal Article] Interleukin-33-activated neuropeptide CGRP-producing memory Th2 cells cooperate with somatosensory neurons to induce conjunctival itch (2022)
  • Author(s): Okano Mikiko、Hirahara Kiyoshi、Kiuchi Masahiro、Onoue Miki、Iwamura Chiaki、Kokubo Kota、Hishiya Takahisa、Morimoto Yuki、Ikehara Yuzuru、Murakami Akira、Ebihara Nobuyuki、Nakayama Toshinori
  • Journal Title: Immunity Volume: 55 Issue: 12 Pages: 2352-2368.e7
  • DOI: 10.1016/j.immuni.2022.09.016
  • Peer Reviewed / Open Access
• [Journal Article] Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis (2022)
  • Author(s): Kokubo Kota、Onodera Atsushi、Kiuchi Masahiro、Tsuji Kaori、Hirahara Kiyoshi、Nakayama Toshinori
  • Journal Title: Frontiers in Immunology Volume: 13 Pages: 945063-945063
  • DOI: 10.3389/fimmu.2022.945063
  • Peer Reviewed / Open Access
• [Journal Article] アレルギー疾患の病態形成における記憶型病原性Th2細胞の役割 (2022)
  • Author(s): 1.平原潔、尾上美樹、横山美樹子、中山俊憲
  • Journal Title: アレルギー Volume: 71(4) Pages: 297-300
• [Journal Article] 病原性免疫記憶による慢性炎症性肺疾患の病態形成機構 (2022)
  • Author(s): 柳生洋行、平原潔、中山俊憲
  • Journal Title: 医学のあゆみ 基盤病態としての慢性炎症 Volume: 282(1) Pages: 19-25
• [Journal Article] 局所免疫応答における組織常在性メモリーT細胞 (2022)
  • Author(s): 小久保幸太、平原潔
  • Journal Title: 臨床免疫・アレルギー科 Volume: 78(4) Pages: 438-443
• [Journal Article] CD4陽性T細胞と肺の線維化 (2022)
  • Author(s): 平原潔、小久保幸太、中山俊憲
  • Journal Title: 医学のあゆみ Volume: 283(1) Pages: 4-9
• [Journal Article] Nematode ascarosides attenuate mammalian type 2 inflammatory responses (2022)
  • Author(s): Shinoda Kenta、Choe Andrea、Hirahara Kiyoshi、Kiuchi Masahiro、Kokubo Kota、Ichikawa Tomomi、Hoki Jason S.、Suzuki Akane S.、Bose Neelanjan、Appleton Judith A.、Aroian Raffi V.、Schroeder Frank C.、Sternberg Paul W.、Nakayama Toshinori
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 119(9) Issue: 9
  • DOI: 10.1073/pnas.2108686119
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Role of CD4+ Resident Memory T Cells in Local Immunity in the Mucosal Tissue - Protection Versus Pathology - (2021)
  • Author(s): Kiyoshi Hirahara、Kota Kokubo、Ami Aoki、Masahiro Kiuchi、Toshinori Nakayama
  • Journal Title: Frontiers in Immunology Volume: - Pages: 616309-616309
  • DOI: 10.3389/fimmu.2021.616309
  • Peer Reviewed / Open Access
• [Journal Article] CD4+ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69-Myl9 system (2021)
  • Author(s): Nakayama Toshinori、Hirahara Kiyoshi、Kimura Motoko Y、Iwamura Chiaki、Kiuchi Masahiro、Kokubo Kota、Onodera Atsushi、Hashimoto Kahoko、Motohashi Shinichiro
  • Journal Title: International Immunology Volume: 33(12) Issue: 12 Pages: 699-704
  • DOI: 10.1093/intimm/dxab053
  • Peer Reviewed / Open Access
• [Journal Article] Trithorax複合体を構成するCxxc1はCD4+T細胞分化におけるepigenetic licensingをつかさどる (2021)
  • Author(s): 木内 政宏、平原 潔、中山 俊憲
  • Journal Title: 臨床免疫・アレルギー科 Volume: 76(6) Pages: 688-693
  • NAID: 40022755458
• [Presentation] “神経-免疫連関”と慢性炎症の病態形成 - 病原性CD4+ T (pathogenic T: Tpath)細胞による病的な痒みの誘導機構 - (2024)
  • Author(s): 平原潔
  • Organizer: シンポジウム 第101回日本生理学会大会
  • Invited
• [Presentation] 「組織炎症記憶」の蓄積がもたらす慢性炎症の難治化とその制御」 (2024)
  • Author(s): 平原潔
  • Organizer: 第2回STROMA (Stromal cell neTwork in chROnic inflamMAtion and disease)
  • Invited
• [Presentation] 慢性炎症下における病原性記憶T細胞を起点とした難治性病態形成の分子・細胞機構 (2024)
  • Author(s): 平原潔
  • Organizer: 第48回皮膚科免疫セミナー
  • Invited
• [Presentation] Pathological tissue inflammatory memories shape the intractable pathology of chronic lung inflammation. (2024)
  • Author(s): Hirahara, K.
  • Organizer: 10th Global Network Forum on Infection and Immunity
  • Invited
• [Presentation] Development of next-generation mucosal vaccines by controlling “pathogenic” immune memory. (2024)
  • Author(s): Hirahara, K.
  • Organizer: (Lecture) Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop
  • Invited
• [Presentation] A novel subpopulation of fibroblasts involved in the formation of inducible bronchus-associated lymphoid tissue (iBALT). (2024)
  • Author(s): Hishiya, T., Kiuchi, M., Nakayama, T., Ohotori, S., and Hirahara, K.
  • Organizer: Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop
• [Presentation] Physiological acid exposure in the esophagus activates esophageal immune system. (2024)
  • Author(s): Kurosugi, A., Iwamura, C., Kaneko, T., and Hirahara, K.
  • Organizer: Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop
• [Presentation] The effect of tissue hypoxia on the immune system in chronic inflammation. (2024)
  • Author(s): Sasaki, A., Kiuchi, M., Yagyu, H., Suzuki, T., Nakayama, T., and Hirahara, K.
  • Organizer: Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop
• [Presentation] Repetitive exposure to aspergillus antigen induces type 17 inflammation accompanied by alveolar epithelial cell differentiation. (2024)
  • Author(s): Tsuji, K., Aoki, A., Kiuchi, M., Nemoto, M., Nakayama, T., and Hirahara, K.
  • Organizer: Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop
• [Presentation] Diverse characteristics of pulmonary neuroendocrine cells reversed in chronic airway inflammation. (2024)
  • Author(s): Nemoto, M., Kiuchi, M., Tsuji, K., Nakayama, T., and Hirahara, K.
  • Organizer: Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop
• [Presentation] Lipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic type 2 adaptive immunity via the PPARg-ST2 axis. (2024)
  • Author(s): Yagyu, H., Kiuchi, M., Kokubo, K., Sasaki, A., Onodera, A., Iwamura, C., Kaneko, T., Nakayama, T., and Hirahara, K.
  • Organizer: Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop
• [Presentation] The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells. (2024)
  • Author(s): Kumagai, J., Kiuchi, M., Kokubo, K., Yagyu, H., Nemoto, M., Tsuji. K., Nagahata, K., Sasaki, A., Hishiya, T., Onoue, M., Shinmi, R., Sonobe, Y., Iinuma, T., Yonekura, S., Shinga, J., Hanazawa, T., Koseki, H., Nakayama, T., Yokote, K., and Hirahara, K.
  • Organizer: Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop
• [Presentation] Inflammation driven fibrosis and tissue repair. (2024)
  • Author(s): Hirahara, K.
  • Organizer: (Overview talk) The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research / Invited
• [Presentation] Memory-type pathogenic Th2 (Tpath2) cells in airway inflammation. (2024)
  • Author(s): Hirahara, K., and Nakayama, T.
  • Organizer: (Symposium) The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research / Invited
• [Presentation] Inflamed tissue-derived unsaturated fatty acids induce memory-type pathogenic Th2 cells via the PPARg-ST2 axis. (2024)
  • Author(s): Yagyu, H., Kiuchi, M., Kokubo, K., Sasaki, A., Kaneko, T., Nakayama, T., and Hirahara, K.
  • Organizer: The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research
• [Presentation] A novel subpopulation of fibroblasts involved in the formation of induciblebronchus-associated lymphoid tissue (iBALT). (2024)
  • Author(s): Hishiya, T., Kiuchi, M., Nakayama, T., and Hirahara, K.
  • Organizer: The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research
• [Presentation] Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism. (2024)
  • Author(s): Kokubo, K., Hirahara, K., Kiuchi, M., Tsuji, K., Sonobe, Y., Shinmi, R., Hishiya, T., Iwamura, C., Onodera, A., and Nakayama, T.
  • Organizer: The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research
• [Presentation] Diverse characteristics of pulmonary neuroendocrine cells revealed in chronic airway inflammation. (2024)
  • Author(s): Nemoto, M., Kiuchi, M., Tsuji, K., Nakayama, T., and Hirahara, K.
  • Organizer: The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research
• [Presentation] The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells. (2024)
  • Author(s): Kiuchi, M., Kokubo, K., Yagyu, H., Nemoto, M., Tsuji, K., Hishiya, T., Onoue, M., Shinmi, R., Sonobe, Y., Nakayama, T., and Hirahara, K.
  • Organizer: The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research
• [Presentation] Characterization of eosinophils and natural killer cells in nasal polyps and peripheral blood in eosinophilic chronic rhinosinusitis patients. (2024)
  • Author(s): Tsuji, K., Aoki, A., Onodera, A., Kiuchi, M., Kokubo, K., Morimoto, Y., Iinuma, T., Hanazawa, T., Nakayama, T., and Hirahara, K.
  • Organizer: The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research
• [Presentation] Suppression of type I interferon signaling in myeloid cells by autoantibodies in severe COVID-19 patients. (2024)
  • Author(s): Sasaki, A., Aoki, A., Iwamura, C., Kiuchi, M., Tsuji, K., Hishiya, T., Hirasawa, R., Kokubo, K., Onodera, A., Suzuki, T., Nakayama, T., and Hirahara, K.
  • Organizer: The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research
• [Presentation] Amphiregulin-producing T helper 2 cells facilitate esophageal fibrosis of eosinophilic esophagitis. (2024)
  • Author(s): Kaneko, T., Iwamura, C., Kurosugi, A., Kiuchi, M., Nakayama, T., and Hirahara, K.
  • Organizer: The 52nd Annual Meeting of The Japanese Society for Immunology
  • Int'l Joint Research
• [Presentation] Pathological tissue inflammatory memories. (2024)
  • Author(s): Hirahara, K.
  • Organizer: 5th CSI/JSI/KAI Joint Symposium on Immunology “Frontier in Immunology Research in the Aftermath of the Pandemic”
  • Int'l Joint Research / Invited
• [Presentation] Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism. (2024)
  • Author(s): Kokubo, K., Kiuchi, M., Hirahara, K., and Nakayama, T.
  • Organizer: 5th CSI/JSI/KAI Joint Symposium on Immunology “Frontier in Immunology Research in the Aftermath of the Pandemic”
  • Int'l Joint Research
• [Presentation] 慢性アレルギー炎症難治化における病原性T細胞を中心とした細胞間ネットワークの役割 (2023)
  • Author(s): 平原潔
  • Organizer: セッション 第10回JCRベーシックリサーチカンファレンス
  • Invited
• [Presentation] 喘息病態におけるTertiary Lymphoid Structureの病的役割&~治療ターゲットとしての組織炎症記憶~ (2023)
  • Author(s): 平原潔
  • Organizer: Scientific Exchange Meeting in Kyoto
  • Invited
• [Presentation] 記憶T細胞を起点とした「神経免疫連関」による病的かゆみの病態形成機構 (2023)
  • Author(s): 平原潔
  • Organizer: シンポジウム 第96回日本生化学会大会
  • Invited
• [Presentation] Pathological tissue inflammatory memories - Immune-neuro interaction shapes the transformation of inflamed tissue -. (2023)
  • Author(s): Hirahara, K.
  • Organizer: The 32nd Hot Spring Harbor International Symposium Recent Advances in Cell Biology and Immunology
  • Invited
• [Presentation] 眼瞼結膜における「神経-免疫連関」を介したかゆみの病態形成機構 (2023)
  • Author(s): 平原潔
  • Organizer: シンポジウム 第72回日本アレルギー学会学術大会
  • Invited
• [Presentation] 治療学研究へのいざない - SARS-CoV2感染の重症化機構から慢性炎症疾患の難治性病態まで- (2023)
  • Author(s): 平原潔
  • Organizer: 石巻赤十字病院 感染症セミナー
  • Invited
• [Presentation] 組織炎症記憶による慢性炎症の病態形成機構 (2023)
  • Author(s): 平原潔
  • Organizer: シンポジウム 第53回日本腎臓学会西部学術大会
  • Invited
• [Presentation] 病原性記憶T細胞の多様性とアレルギー性炎症の難治性病態について－組織線維化から病的かゆみまで－ (2023)
  • Author(s): 平原潔
  • Organizer: 特別公演 Online Science Club
  • Invited
• [Presentation] 免疫細胞の組織への常在化と慢性炎症の難治化－組織常在性記憶T細胞と異所性リンパ組織の病的役割－ (2023)
  • Author(s): 平原潔
  • Organizer: 講演 第49回佐島シンポジウム
  • Invited
• [Presentation] 病原性T細胞と異所性リンパ組織の相互作用による病態形成機構について (2023)
  • Author(s): 平原潔
  • Organizer: シンポジウム 第4回日本喘息学会総会学術大会
  • Invited
• [Presentation] 「治療学研究へのいざない - 病原性T細胞の機能的多様性が誘導する様々な難治病態 -」 (2023)
  • Author(s): 平原潔
  • Organizer: 特別講演 第71回文月会
  • Invited
• [Presentation] 慢性炎症難治化における細胞間ネットワーク－病原性T細胞と好酸球のcross-talkによる組織線維化機構－ (2023)
  • Author(s): 平原潔
  • Organizer: 溜池カンファレンス2023
  • Invited
• [Presentation] 『治療学研究へのいざない - 病原性T細胞の機能的多様性が誘導する様々な難治病態 - 』 (2023)
  • Author(s): 平原潔
  • Organizer: 特別講演 第113回新潟内分泌代謝同好会
  • Invited
• [Presentation] COVID-19における血管内皮障害・血小板活性化のメカニズム (2023)
  • Author(s): 平原潔
  • Organizer: 第65回日本小児神経学会
  • Invited
• [Presentation] ST2+ memory Th2 cells shape the intractable pathogenesis of chronic inflammation -Interleukin-33-neuropeptide CGRP axis induces conjunctival itch - (2023)
  • Author(s): Hirahara, K.
  • Organizer: The Laboratory of Immunology Weekly Seminar Series, NEI, NIH, 4/7/2023, @Zoom
  • Int'l Joint Research / Invited
• [Presentation] Immune-neuro interaction shapes the pathology of intractable allergic diseases. (2023)
  • Author(s): Hirahara, K.
  • Organizer: シンポジウム International Symposium for Future Mucosal Vaccines: Safeguards and Innovations against Infectious Diseases
  • Invited
• [Presentation] 慢性炎症難治化における細胞間ネットワーク －病原性T細胞と好酸球のcross-talkによる組織線維化機構－ (2023)
  • Author(s): 平原潔
  • Organizer: 講演 Mepolizumab Severe Asthma National Conference in Tokyo
  • Invited
• [Presentation] 病原性T細胞とアレルギー（アドバンス） (2023)
  • Author(s): 平原潔
  • Organizer: 講演 第9回総合アレルギー講習会-Total Allergistをめざして-
  • Invited
• [Presentation] Development of next-generation mucosal vaccines free from adverse reaction by controlling “pathogenic” immune memory (2023)
  • Author(s): Hirahara, K.
  • Organizer: cSIMVa Workshop
  • Int'l Joint Research / Invited
• [Presentation] The effect of tissue hypoxia on the immune system in chronic inflammatory lung diseases Presenter (2023)
  • Author(s): Sasaki, A., Kiuchi, M., Yagyu, H., Tsuji, K., Suzuki, T., Nakayama, T., and Hirahara, K.
  • Organizer: International Symposium for Future Mucosal Vaccines: Safeguards and Innovations against Infectious Diseases
  • Int'l Joint Research
• [Presentation] Expanding Pulmonary Neuroendocrine Cells Show Heterogeneity in Chronic Airway Inflammation. (2023)
  • Author(s): Nemoto, M., Kiuchi, M., Tsuji, K., Nakayama, T., and Hirahara, K.
  • Organizer: International Symposium for Future Mucosal Vaccines:Safeguards and Innovations against Infectious Diseases
  • Int'l Joint Research
• [Presentation] Unsaturated fatty acids promote pathogenic type 2 adaptive immunity via PPARg-ST2 axis (2023)
  • Author(s): Yagyu, H., Kiuchi, M., Kokubo, K., Sasaki, A., Onodera, A., Iwamura, C., Kaneko, T., Nakayama T., and Hirahara, K.
  • Organizer: International Symposium for Future Mucosal Vaccines: Safeguards and Innovations against Infectious Diseases
  • Int'l Joint Research
• [Presentation] Roles of TET and TDG in DNA demethylation in the immune system (2023)
  • Author(s): Onodera, A., Tanaka, H., Hirahara, K., Nakayama, T., and Rao, A
  • Organizer: International Symposium for Future Mucosal Vaccines: Safeguards and Innovations against Infectious Diseases
  • Int'l Joint Research
• [Presentation] Role of amphiregulin-producing pathogenic T helper 2 cells in the fibrotic responses in eosinophilic esophagitis (2023)
  • Author(s): Kaneko, T., Iwamura, C., Kiuchi, M., Kurosugi, A., Hirahara, K., and Nakayama, T.
  • Organizer: International Symposium for Future Mucosal Vaccines: Safeguards and Innovations against Infectious Diseases
  • Int'l Joint Research
• [Presentation] 慢性炎症肺におけるinflammatory nicheを介した難治性病態形成機構 (2022)
  • Author(s): 平原潔
  • Organizer: シンポジウム 第62回日本呼吸器学会学術講演会
  • Invited
• [Presentation] 病原性Th2 (pathogenic Th2; Tpath2)細胞の生体内における多様な役割 (2022)
  • Author(s): 平原潔
  • Organizer: シンポジウム 第50回日本臨床免疫学会総会
  • Invited
• [Presentation] 気管支喘息と好塩基球 (2022)
  • Author(s): 平原潔
  • Organizer: 第40回呼吸器・免疫シンポジウム
  • Invited
• [Presentation] Pathological inflammatory memories (2022)
  • Author(s): 平原潔
  • Organizer: リエゾンラボ研究会 HIGOプログラム最先端研究セミナー
  • Invited
• [Presentation] 病原性Th2(pathogenic Th2;Tpath2)細胞による細胞外マトリックス沈着誘導を介した気道線維化の発症メカニズム (2022)
  • Author(s): 平原潔
  • Organizer: シンポジウム 第95回日本生化学会大会
  • Invited
• [Presentation] 病原性CD4 T細胞の多様性に基づいたアレルギー疾患の難治性病態形成機構の理解 (2022)
  • Author(s): 平原潔
  • Organizer: 第11回神奈川気道炎症病態研究会
  • Invited
• [Presentation] 「若手研究者による破壊的イノベーションの創出」-若手研究者支援制度である創発的研究支援事業について考える- Creation of Disruptive Innovation by Young Researchers by FOREST, a long-term support system for young researchers (2022)
  • Author(s): 岡崎朋彦、平原潔
  • Organizer: フォーラム 第45回日本分子生物学会年会
  • Invited
• [Presentation] 治療学研究へのいざない - 病原性T細胞の機能的多様性と難治性病態 - (2022)
  • Author(s): 平原潔
  • Organizer: 講演 新潟大学医学部 第二内科同窓会 集談会
  • Invited
• [Presentation] Pathological inflammatory memories - Immune-neuro interaction shapes the transformation of inflamed tissue - (2022)
  • Author(s): Hirahara, K.
  • Organizer: シンポジウム 第51回日本免疫学会学術集会
  • Int'l Joint Research / Invited
• [Presentation] Multiple inflammatory cytokines shape the pathogenicity of memory CD4+ T cells during chronic allergic inflammation (2022)
  • Author(s): Hirahara, K.
  • Organizer: 第51回日本免疫学会学術集会Clinical Seminar 12
  • Int'l Joint Research / Invited
• [Presentation] Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity (2022)
  • Author(s): Iwamura, C., Hirahara, K., Nemoto, M., Tsuji, K., Onoue, M., Kurosugi, A., Sasaki, A., and Nakayama, T.
  • Organizer: 第51回日本免疫学会学術集会
  • Int'l Joint Research
• [Presentation] Nematode ascarosides attenuate mammalian type 2 inflammatory responses (2022)
  • Author(s): Kiuchi, M., Kokubo, K., Onodera, A., Hirahara, K., and Nakayama, T.
  • Organizer: 第51回日本免疫学会学術集会
  • Int'l Joint Research
• [Presentation] 病原性Th2細胞による難治性アレルギー性気道炎症の病態制御 (2021)
  • Author(s): 中山 俊憲、市川 智巳、小久保 幸太、木内 政宏、青木 亜美、平原 潔
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] 病原性ヘルパー細胞によるアレルギー性炎症の難治性病態形成機構について (2021)
  • Author(s): 平原 潔、中山 俊憲
  • Organizer: 第70回日本アレルギー学会学術大会
  • Invited
• [Presentation] 慢性アレルギー性結膜炎におけるIL-33-ST2-CGRP経路を介した記憶型Th2細胞の役割 (2021)
  • Author(s): 横山 美樹子、尾上 美樹、木内 政宏、平原 潔、池原 譲、海老原 伸行、中山 俊憲
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] ベンラリズマブによる好酸球性炎症組織局所での抗体依存性細胞傷害活性についての検討 (2021)
  • Author(s): 青木 亜美、辻 香織、小久保 幸太、木内 政宏、平原 潔、中山 俊憲
  • Organizer: 第70回日本アレルギー学会学術大会
• [Book] 臨床免疫・アレルギー科 第80巻第2号 (2023)
  • Author(s): 尾上美樹、岡野美樹子、木内政宏、海老原伸行、中山俊憲、平原潔
  • Total Pages: 259
  • Publisher: 科学評論社
• [Remarks] 千葉大学大学院医学研究院 免疫発生学HP
  • URL: https://www.m.chiba-u.jp/dept/meneki/
• [Remarks] 千葉大学大学院医学研究院 免疫発生学HP
  • URL: https://www.m.chiba-u.ac.jp/class/meneki/jisseki/index.html