| Budget Amount *help |
¥111,670,000 (Direct Cost: ¥85,900,000、Indirect Cost: ¥25,770,000)
Fiscal Year 2014: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2013: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2012: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2011: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2010: ¥21,710,000 (Direct Cost: ¥16,700,000、Indirect Cost: ¥5,010,000)
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| Outline of Final Research Achievements |
To elucidate the mechaism of selective neuronal degeneration of Huntington disease, we analyzed aggregate interacting proteins including FUS/TLS,NF-YA,and p62 using knockout mice and showed their in vivo functions.Investigating sodium channel beta4 subunit using knockout mouse, we demonstrated the resurgent current is regulated by beta4 in medium spiny neurons(MSNs) and during this study, we found the MSNs have unmyelinated fibers, which was first clearly demonstrated in this study.We established the methods to analyze the gene expressions of selected neurons by FACS and found new genes which changed in HD MSNs.
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