Analysis of the interaction between cancer stem cells and their microenvironment.

• Project Area: Integrative Research on Cancer Microenvironment Network
• Project/Area Number: 22112004
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: AIYAMA Tetsu 東京大学, 分子細胞生物学研究所, 教授 (70150745)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥322,790,000 (Direct Cost: ¥248,300,000、Indirect Cost: ¥74,490,000); Fiscal Year 2014: ¥60,060,000 (Direct Cost: ¥46,200,000、Indirect Cost: ¥13,860,000); Fiscal Year 2013: ¥62,790,000 (Direct Cost: ¥48,300,000、Indirect Cost: ¥14,490,000); Fiscal Year 2012: ¥65,650,000 (Direct Cost: ¥50,500,000、Indirect Cost: ¥15,150,000); Fiscal Year 2011: ¥65,130,000 (Direct Cost: ¥50,100,000、Indirect Cost: ¥15,030,000); Fiscal Year 2010: ¥69,160,000 (Direct Cost: ¥53,200,000、Indirect Cost: ¥15,960,000)
• Keywords: 微小環境 / がん / がん幹細胞 / 造腫瘍性 / non-coding RNA / hydroxymethyl化 / Lgr5 / GATA6 / Asef / 神経膠芽腫 / 大腸がん / 分子標的 / 低酸素 / ncRNA / RNAiライブラリー / Wntシグナル

Outline of Final Research Achievements

We have identified and characterized genes involved in the tumorigenicity of glioblastoma and colon cancer cells and obtained the following results:
1) PCDH10, PCDH17, PTPRD, SOX9, LGR5, ALK, Pleiotrophin and TET1 play important roles in the tumorigenicity of glioblastoma cells.2) Endothelial DLL4 induces Notch3-Asef pathway-mediated cell migration.3) TET1-mediated production of 5-hydroxymethylcytosine (5hmC) is required for the tumorigenicity of glioblastoma cells. 5hmC recruites the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates transcription of cancer-related genes.

Research Products

• [Journal Article] Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction. (2015)
  • Author(s): Meng F, Meliton A, Moldobaeva N, Mutlu G, Kawasaki Y, Akiyama T, Birukova AA.
  • Journal Title: Am J Physiol Lung Cell Mol Physiol Volume: 308 Issue: 5 Pages: 452-463
  • DOI: 10.1152/ajplung.00170.2014
  • Peer Reviewed
• [Journal Article] Asef controls vascular endothelial permeability and barrier recovery in the lung. (2015)
  • Author(s): Tian X, Tian Y, Gawlak G, Meng F, Kawasaki Y, Akiyama T, Birukova AA.
  • Journal Title: Mol Biol Cell. Volume: 26 Issue: 4 Pages: 636-650
  • DOI: 10.1091/mbc.e14-02-0725
  • Peer Reviewed
• [Journal Article] Heterogeneous nuclear ribonucleoprotein K upregulates the kinetochore complex component NUF2 and promotes the tumorigenicity of colon cancer cells (2015)
  • Author(s): Hironobu Sugimasa, Kenzui Taniue, Akiko Kurimoto, Yasuko Takeda, Yoshihiro Kawasaki, Tetsu Akiyama
  • Journal Title: Biochemical and Biophysical Research Communications Volume: Volume 459, Issue 1 Issue: 1 Pages: 29-35
  • DOI: 10.1016/j.bbrc.2015.02.043
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] SOX9-mediated upregulation of LGR5 is important for glioblastoma tumorigenicity. (2015)
  • Author(s): Hiraoka K, Hayashi T, Kaneko R, Nasu-Nishimura Y, Koyama-Nasu R, Kawasaki Y, Akiyama T.
  • Journal Title: Biochem Biophys Res Commun. Volume: 460 Issue: 2 Pages: 4097-4109
  • DOI: 10.1016/j.bbrc.2015.03.012
  • Peer Reviewed
• [Journal Article] HGF-induced Asef-IQGAP1 Complex Controls Cytoskeletal Remodeling and Endothelial Barrier. (2015)
  • Author(s): Tian Y, Gawlak G, Shah AS, Higginbotham K, Tian X, Kawasaki Y, Akiyama T, Sacks DB, Birukova AA.
  • Journal Title: J Biol Chem. Volume: 290 Issue: 7 Pages: 4097-4109
  • DOI: 10.1074/jbc.m114.620377
  • Peer Reviewed
• [Journal Article] Somatic copy number alterations associated with Japanese or endometriosis in ovarian clear cell adenocarcinoma. (2015)
  • Author(s): Okamoto A, Sehouli J, Yanaihara N, Hirata Y, Braicu I, Kim BG, Takakura S, Saito M, Yanagida S, Takenaka M, Yamaguchi N, Morikawa A, Tanabe H, Yamada K, Yoshihara K, Enomoto T, Itamochi H, Kigawa J, Matsumura N, Konishi I, Aida S, Aoki Y, Ishii N, Ochiai K, Akiyama T, Urashima M.
  • Journal Title: PLoS One Volume: 10 Issue: 2 Pages: 1-13
  • DOI: 10.1371/journal.pone.0116977
  • Peer Reviewed / Open Access
• [Journal Article] Thr160 of Axin1 is critical for the formation and function of the β-catenin destruction complex. (2015)
  • Author(s): Koyama-Nasu R, Hayashi T, Nasu-Nishimura Y, Akiyama T, Yamanaka R
  • Journal Title: Biochem Biophys Res Commun. Volume: 459 Issue: 3 Pages: 411-415
  • DOI: 10.1016/j.bbrc.2015.02.118
  • Peer Reviewed
• [Journal Article] Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton. (2015)
  • Author(s): Taki Sakai, Yotaro Matsumoto, Minoru Ishikawa, Kazuyuki Sugita, Yuichi Hashimoto, Nobuhiko Wakai, Akio Kitao, Era Morishita, Chikashi Toyoshima, Tomoatsu Hayashi, Tetsu Akiyama
  • Journal Title: Bioorg Med Chem. Volume: 23 Issue: 2 Pages: 328-339
  • DOI: 10.1016/j.bmc.2014.11.027
  • Peer Reviewed / Open Access
• [Journal Article] Requirement of DLG1 for cardiovascular development and tissue elongation 1 during cochlear, enteric, and skeletal development: possible role in convergent extension. (2015)
  • Author(s): Akiko Iizuka-Kogo, Takao Senda, Tetsu Akiyama, Atsushi Shimomura, Ryuji Nomura, Yoshimi Hasegawa, Ken-ichi Yamamura, Hiroshi Kogo, Nobuhiko Sawai, Toshiyuki Matsuzaki
  • Journal Title: PLoS ONE Volume: 10 Issue: 4 Pages: e0123965-e0123965
  • DOI: 10.1371/journal.pone.0123965
  • Peer Reviewed / Open Access
• [Journal Article] Susceptibility to proteases of anti-Tn-antigen MLS128 binding glycoproteins expressed in human colon cancer cells (2015)
  • Author(s): Oura, F., Yajima, Y., Nakata, M., Taniue, K., Akiyama, T., Nakada, H., Yamamoto, K., Fujita-Yamaguchi, Y
  • Journal Title: BioScience Trends Volume: 9 Issue: 1 Pages: 49-55
  • DOI: 10.5582/bst.2014.01127
  • NAID: 130005054681
  • ISSN: 1881-7815, 1881-7823
  • Peer Reviewed
• [Journal Article] 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-Methylosome complex (2014)
  • Author(s): Hiroki Takai, Tetsu Akiyama et al.
  • Journal Title: Cell Reports Volume: 9 Issue: 1 Pages: 48
  • DOI: 10.1016/j.celrep.2014.08.071
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The miR-363-GATA6-Lgr5 pathway is critical for colorectal tumorigenesis (2014)
  • Author(s): Tsuji S
  • Journal Title: Nat. Commun. Volume: 5 Issue: 1 Pages: 3150-3150
  • DOI: 10.1038/ncomms4150
  • Peer Reviewed / Open Access
• [Journal Article] PCDH10 is required for the tumorigenicity of glioblastoma cells (2014)
  • Author(s): Kanae Echizen, Mitsutoshi Nakada , Tomoatsu Hayashi, Hemragul Sabit, Takuya Furuta, Miyuki Nakai, Ryo Koyama-Nasu, Yukiko Nishimura, Kenzui Taniue, Yasuyuki Morishita, Shinji Hirano, Kenta Terai, Tomoki Todo, Yasushi Ino, Akitake Mukasa, Shunsaku Takayanagi, Ryohei Ohtani, Nobuhito Saito, Tetsu Akiyama
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 444 Issue: 1 Pages: 13
  • DOI: 10.1016/j.bbrc.2013.12.138
  • Peer Reviewed / Open Access
• [Journal Article] Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia (2014)
  • Author(s): Takanori Onouchi, Katsunori Kobayashi, Kazuyoshi Sakai, Atsushi Shimomura, Ron Smits, Chiho Sumi-Ichinose, Masafumi Kurosumi Keizo Takao, Ryuji Nomura, Akiko Iizuka-Kogo, Hidenori Suzuki,Kazunao Kondo, Tetsu Akiyama Tsuyoshi Miyakawa Riccardo Fodde and Takao Senda, Riccardo Fodde, Takao
  • Journal Title: Molecular Brain Volume: 7 Issue: 1 Pages: 21-21
  • DOI: 10.1186/1756-6606-7-21
  • Peer Reviewed / Open Access
• [Journal Article] The miR-1-NOTCH3-Asef Pathway Is Important for Colorectal Tumor Cell Migration (2013)
  • Author(s): Shiori Furukawa,Yoshihiro Kawasaki, Masaya Miyamoto, Masaya Hiyoshi,Joji Kitayama, Tetsu Akiyama
  • Journal Title: PLoS ONE Volume: 8 Issue: 11 Pages: e80609-e80609
  • DOI: 10.1371/journal.pone.0080609
  • Peer Reviewed / Open Access
• [Journal Article] Crystal structure of the guanylate kinase domain from Discs large homolog 1 (DLG1/SAP97) (2013)
  • Author(s): Shinji Mori, Yuta Tezuka, Akihiko Arakawa, Noriko Handa, Mikako Shirouzu, Tetsu Akiyama, Shigeyuki Yokoyama
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 435 Issue: 3 Pages: 334-338
  • DOI: 10.1016/j.bbrc.2013.04.056
  • Peer Reviewed
• [Journal Article] Alendronate attenuates eosinophilic airway inflammation associated with suppression of Th2 cytokines, Th17 cytokines, and eotaxin-2. (2013)
  • Author(s): Oh Sasaki, Mitsuru Imamura, Yusuke Yamazumi, Hiroaki Harada, Taku Matsumoto, Katsuhide Okunishi, Kazuyuki Nakagome, Ryoichi Tanaka, Tetsu Akiyama, Kazuhiko Yamamoto and Makoto Dohi
  • Journal Title: J. Immunol Volume: 191 Issue: 6 Pages: 2879-2889
  • DOI: 10.4049/jimmunol.1300460
  • Peer Reviewed
• [Journal Article] The critical role of cyclin D2 in cell cycle progression and tumorigenicity of glioblastoma stem cells (2013)
  • Author(s): R Koyama-Nasu, Y Nasu-Nishimura, T Todo, Y Ino, N Saito, H Aburatani, K Funato, K Echizen, H Sugano, R Haruta, M Matsui, R Takahashi, E Manabe, T Oda and T Akiyama
  • Journal Title: Oncogene Volume: 32 Issue: 33 Pages: 3840
  • DOI: 10.1038/onc.2012.399
  • URL: https://pure.teikyo.jp/en/publications/e70c2970-6caa-4438-92cd-ad93bd0eb776
  • Peer Reviewed
• [Journal Article] The pleiotrophin-ALK axis is required for tumorigenicity of glioblastoma stem cells (2013)
  • Author(s): R Koyama-Nasu, R Haruta, Y Nasu-Nishimura, K Taniue, Y Katou, K Shirahige, T Todo, Y Ino, A Mukasa, N Saito, M Matsui, R Takahashi, A Hoshino-Okubo, H Sugano, E Manabe, K Funato and T Akiyam
  • Journal Title: Oncogene Volume: 33 Issue: 17 Pages: 2236
  • DOI: 10.1038/onc.2013.168
  • URL: https://pure.teikyo.jp/en/publications/135c04b7-5122-4cd6-97db-1d91999d9fe9
  • Peer Reviewed / Open Access
• [Journal Article] Differences in the localization of the APC-Asef/Asef2 complex between APC wild-type and mutant cells (2013)
  • Author(s): Yoshihiro Kawasaki, Shiori Furukawa, Rina Sato, Tetsu Akiyama
  • Journal Title: Cancer Sci. Volume: 8 Issue: 8 Pages: 1135-1138
  • DOI: 10.1111/cas.12180
  • Peer Reviewed
• [Journal Article] Epub ahead of print (2013)
  • Author(s): Toki H, Inoue M, Motegi H, Minowa O, Kanda H, Yamamoto N, Ikeda A, Karashima Y, Matsui J, Kaneda H, Miura I, Suzuki T, Wakana S, Masuya H, Gondo Y, Shiroishi T, Akiyama T, Yao R, Noda T
  • Journal Title: Cancer Sci Volume: PMID: 23551873 Issue: 7 Pages: 937-944
  • DOI: 10.1111/cas.12161
  • Peer Reviewed
• [Journal Article] Decreased apoptosis and persistence of the common nephric duct during the development of an aberrant vesicoureteral junction in dlg1 gene-targeted mice (2013)
  • Author(s): Akiko Iizuka-Kogo, Tetsu Akiyama, Takao Senda
  • Journal Title: Anat Rec. Volume: 296 Issue: 12 Pages: 1936-1942
  • DOI: 10.1002/ar.22814
  • Peer Reviewed
• [Journal Article] ASBEL, an ANA/BTG3 antisense transcript required for tumorigenicity of ovarian carcinoma (2013)
  • Author(s): Yanagida S, Taniue K, Yamamoto T. (9名)
  • Journal Title: Sci Rep Volume: Vol.3 Issue: 1 Pages: 1305-1305
  • DOI: 10.1038/srep01305
  • Peer Reviewed
• [Journal Article] Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway (2011)
  • Author(s): Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A,Aburatani H, Nakamura T, Akiyama T
  • Journal Title: Nat Commun Volume: 2 Issue: 1 Pages: 548-548
  • DOI: 10.1038/ncomms1551
  • Peer Reviewed
• [Journal Article] A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis (2011)
  • Author(s): Taniue K.
  • Journal Title: EMBO Rep. Volume: 12 Pages: 682-689
  • Peer Reviewed
• [Journal Article] Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of sam68 (2011)
  • Author(s): Morishita EC
  • Journal Title: Structure Volume: 19 Pages: 1496-508
  • Peer Reviewed
• [Journal Article] The tyrosine phosphatase PTPRD suppresses colon cancer cell migration in coordination with CD44 (2011)
  • Author(s): Funato K
  • Journal Title: Exp.Therap.Med. Volume: 2 Pages: 457-463
  • Peer Reviewed
• [Journal Article] The tyrosine phosphatase PTPRD suppresses colon cancer cell migration in coordination with CD44. (2011)
  • Author(s): Funato K.
  • Journal Title: Exp.Therap.Med Volume: 2 Pages: 457-463
  • Peer Reviewed
• [Journal Article] A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis. (2011)
  • Author(s): Taniue K
  • Journal Title: EMBO Rep Volume: (in press(掲載確定))
  • Peer Reviewed
• [Journal Article] The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis. (2010)
  • Author(s): Kawasaki Y.
  • Journal Title: J.Biol.Chem Volume: 285 Pages: 1199-1207
  • Peer Reviewed
• [Journal Article] The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas. (2010)
  • Author(s): Niimi R.
  • Journal Title: Oncol Rep Volume: 23 Pages: 631-638
  • Peer Reviewed
• [Journal Article] The PX-RICS/14-3-3ζ/θ complex couples N-cadherin/b-catenin with Dynein/Dynactin to mediate its export from the endoplasmic reticulum. (2010)
  • Author(s): Nakamura T.
  • Journal Title: J.Biol.Chem Volume: 285 Pages: 16145-16154
  • Peer Reviewed
• [Journal Article] Sunspot, a link between Wingless signaling and endoreplication in Drosophila. (2010)
  • Author(s): Taniue K.
  • Journal Title: Development Volume: 137 Pages: 1755-64
  • Peer Reviewed
• [Journal Article] Involvement of LKB1 in Epithelial-Mesenchymal Transition (EMT) of Human Lung Cancer Cells. (2010)
  • Author(s): B.C.Roy
  • Journal Title: Lung Cancer Volume: 70 Pages: 136-145
  • Peer Reviewed
• [Journal Article] High expression of Pitx-1 in the ICAT-deficient metanephros leads to developmental arrest. (2010)
  • Author(s): Hasegarwa, Y
  • Journal Title: Acta.Histochem.Cytochem Volume: 43 Pages: 51-59
  • Peer Reviewed
• [Presentation] 5-Hydroxymethylcytosine Plays a Critical Role in Glioblastomagenesis by Recruiting the CHTOP-Methylosome Complex (2015)
  • Author(s): Hiroki Takai, Tetsu Akiyama
  • Organizer: Keystone Symposia: Epigenetics and Cancer
  • Place of Presentation: Colorado, USA
  • Year and Date: 2015-01-25 – 2015-01-30
• [Presentation] MYU, a novel target lncRNA for Wnt/c-Myc signaling, mediates CDK6 induction to promote cell cycle progression (2015)
  • Author(s): Yoshihiro Kawasaki, Tetsu Akiyama
  • Organizer: Joint International Symposium on TGF-β Family and Cancer: TGF-β Family and Cancer: Signal Network in Tumor Micoroenvironment
  • Place of Presentation: つくば国際会議場(茨城県つくば市)
  • Year and Date: 2015-01-12 – 2015-01-13
• [Presentation] ASBEL, an ANA/BTG3 antisense transcript required for tumorigenicity of ovarian carcinoma (2014)
  • Author(s): Kenzui Taniue, Satoshi Yanagida, Hironobu Sugimasa, Yasuko Takeda, Tadashi Yamamoto, Aikou Okamoto, Tetsu Akiyama
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] 5hmC plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex (2014)
  • Author(s): 高井 弘基、秋山 徹
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] 大腸がん幹細胞における新規長鎖非コードRNAの機能解析 (2014)
  • Author(s): 松村厚佑、宮本昌弥、川崎善博、斎藤晋祐、日吉雅也、北山丈二、秋山徹
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] GATA6を介した細胞癌化におけるReg4とLgr5の協調作用 (2014)
  • Author(s): 川崎善博、辻真之介、宮本昌弥、平岡巧士、松村厚佑、奥野ます美、須田咲希子、日吉雅也、北山丈二、秋山徹
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] Mex-3B, an RNA-binding protein, regulates lung cancer cell migration (2014)
  • Author(s): Yusuke Yamazumi, Tetsu Akiyama
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 大腸がんの造腫瘍性に関与する新規long ncRNA の機能解析 (2014)
  • Author(s): 谷上 賢瑞、秋山 徹
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] TET1 as a molecular target for glioblastoma therapy (神経膠芽腫治療の標的としてのTET1) (2014)
  • Author(s): 高井 弘基、秋山 徹
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Cooperation between Reg4 and Lgr5 in GATA6-mediated colorectal tumorigenesis (2014)
  • Author(s): 川崎 善博、辻 真之介、宮本 昌也、平岡 巧士、松村 厚佑、奥 野 ます美、須田 咲希子、日吉 雅也、北山 丈二、秋山 徹
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] The role of the novel long non-coding RNA in human colorectal cancer stem cells (2014)
  • Author(s): 松村厚佑、宮本昌弥、川崎善博、斉藤晋祐、日吉雅也、北山丈二、秋山徹
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Long non-coding RNA ASBEL required for tumorigenicity of colon cancer (2014)
  • Author(s): Kenzui Taniue, Tetsu Akiyama
  • Organizer: Long Noncoding RNAs: Marching toward Mechanism
  • Place of Presentation: アメリカ合衆国サンタフェ
  • Year and Date: 2014-02-27 – 2014-03-04
• [Presentation] 神経膠芽腫の発症における5-hydroxymethylcytosineの役割 / Role of 5-hydroxymethylcytosine in the tumorigenicity of glioblastoma cells (2013)
  • Author(s): 高井 弘基、秋山 徹
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2013-10-03 – 2013-10-05
• [Presentation] ASBEL, an ANA/BTG3 antisense transcript required for tumorigenicity of ovarian carcinoma (2013)
  • Author(s): Kenzui Taniue, Tetsu Akiyama
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2013-10-03 – 2013-10-05
• [Presentation] The role of miR-363-GATA6-Lgr5 pathway in colorectal tumorigenesis (2013)
  • Author(s): 川崎 善博、辻 真之介、古川 史織、谷上 賢瑞、林 寛敦、日吉 雅也 、北山 丈二 、秋山 徹
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2013-10-03 – 2013-10-05
• [Presentation] RNA結合タンパク質D8はc-junの転写後制御を介してAPC (Min/+)マウスにおける腫瘍形成を制御する (2013)
  • Author(s): 山角 祐介、渡邊 紘介、小田 健昭、佐藤 裕美、秋山 徹
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2013-10-03 – 2013-10-05
• [Presentation] Functional analysis of a novel long ncRNA involved in the tumorigenicity of colorectal cancer (2013)
  • Author(s): Kenzui Taniue,Akiko Kurimoto,Hironobu Sugimasa, Emiko Nasu, Takeshi Nagashima,Mariko Okada-Hatakeyama,Tetsu Akiyama
  • Organizer: AACR
  • Place of Presentation: アメリカ合衆国ワシントンDC
  • Year and Date: 2013-04-06 – 2013-04-10
• [Presentation] SIRT2,a promising molecular target for glioblastoma therapy (2013)
  • Author(s): Kanae Echizen, Kosuke Funato, Yukiko Nasu-Nishimura, Ryo Koyama-Nasu, Tomoki Todo, Yasushi Ino, Nobuhito Saito, Tetsu Akiyama
  • Organizer: 第9回日米合同癌学会
  • Place of Presentation: ハイアット リージェンシー、マウイ
• [Presentation] The miR-1-Notch3-Asef pathway is important for colorectal tumor cell migration (2013)
  • Author(s): Shiori Furukawa, Yoshihiro Kawasaki, Masaya Hiyoshi, Joji Kitayama, Tetsu Akiyama
  • Organizer: 第9回日米合同癌学会
  • Place of Presentation: ハイアット リージェンシー、マウイ
• [Presentation] miR-1-Notch3-Asef経路は大腸癌細胞の運動 能亢進に重要である (2012)
  • Author(s): 川崎 善博, 古川 史織, 秋山 徹
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: ロイトン札幌
• [Presentation] The cancer stem cell marker CD133 is required for desmosome formation (2012)
  • Author(s): 那須 亮、髙橋 理那、柳田 聡、西村 教子、尾山 大明、秦 裕子、春田 諒、眞鍋 瑛美、大久保 明美、尾見 裕子、矢内原 臨、岡本 愛光、田中 忠男、秋山 徹
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌
• [Presentation] Identification of a link between Wnt / β-catenin signaling and the cell fusion pathwa (2012)
  • Author(s): Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A, Aburatani H, Nakamura T, Akiyama T.
  • Organizer: EMBO Conference 30 Years of Wnt Signaling
  • Place of Presentation: オランダ
• [Presentation] Regulation of cell fusion through Wnt signaling~Novel insight into cell fusion biology~ (2012)
  • Author(s): 松浦 憲、地神貴史、谷上賢瑞、森下保幸、足達俊吾、千田隆夫、野中 綾、油谷浩幸、中村 勉、秋山 徹
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡
• [Presentation] 大腸がんの造腫瘍性に関与する新規long ncRNAの機能解析 (2012)
  • Author(s): 谷上 賢瑞, 栗本 晶子, 杉政 宏信, 長嶋 剛史, 岡田 眞里子, 秋山 徹
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡
• [Presentation] The SOX2-pleiotrophin-ALK axis is required for tumorigenicity of glioblastoma stem cells (2012)
  • Author(s): 那須 亮、春田 諒、西村 教子、谷上 賢端、加藤 由起、白髭 克彦、藤堂 具紀、稲生 靖、武笠 晃丈、齊藤 延人、松井 真弓、髙橋 理那、大久保 明美、菅野 陽元、真鍋瑛美、船戸 洸佑、秋山 徹
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡