| Budget Amount *help |
¥78,000,000 (Direct Cost: ¥60,000,000、Indirect Cost: ¥18,000,000)
Fiscal Year 2014: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2013: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2012: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2011: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2010: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
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| Outline of Final Research Achievements |
Tumor microenvironment has been suggested to play important roles in malignant progression and be associated with poor prognosis. Because many tumor microenvironmental factors are shared among various cancers, materials specific to the factors may be useful for developing versatile therapeutic strategies. In this study, we focused on hypoxia, one of the main characteristics of tumor microenvironment, and searched factors closely associated with hypoxia-inducible transcription factor HIF in vivo. First, we noninvasively monitored the cancer cell response to hypoxia, inflammation, and angiogenesis to understand the status of cancer cells in vivo by using multi-bioluminescence imaging systems, which we had newly established. Second, we isolated a highly lung metastatic subline from a non-metastatic osteosarcoma cell line and searched factors responsible for lung metastasis. We successfully identified some candidate factors and are investigating their involvement in lung metastasis.
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