| Budget Amount *help |
¥109,720,000 (Direct Cost: ¥84,400,000、Indirect Cost: ¥25,320,000)
Fiscal Year 2014: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2012: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2011: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2010: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
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| Outline of Final Research Achievements |
To understand medically important immune response and infection route, it is essential to structure biologicallyvisualize the mutual recognition mechanism in atomic level of immune cell surface receptor as the defense forefront toward cancer cells and pathogens. In this study, as important signal control complexes in immune diseases and infectious diseases, we focused on HVEM signal control complex of co-signaling molecule CD160 on T cells, the complex of NKR-P1 / CD161 receptor expressed in human Th17 cells with ligand LLT1, measles virus surface protein invasion complexes, glycolipid recognition immunoreceptor Mincle and MCL. Structural features extracted from the three-dimensional structures and physicochemical analyses of these complexes promoted advance field "structural molecular medicine".
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