| Co-Investigator(Kenkyū-buntansha) |
KAGEYAMA Haruaki 桐生大学, 医療保健学部, 准教授 (00433839)
SIBA Kanako 昭和大学, 医学部, 助教 (40551263)
TAKENOYA Fumiko 星薬科大学, 薬学部, 准教授 (30234412)
KAN Kison 昭和大学, 医学部, ポストドクター (80613083)
OGAWA Tetuo 昭和大学, 医学部, 講師 (60384210)
OOTA Eizi 昭和大学, 医学部・歯学部 (10644263)
HIRAKO Satoshi 昭和大学, 医学部, ポストドクター (90644261)
WADA Nobuhiko 昭和大学, 医学部 (30724661)
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| Budget Amount *help |
¥88,400,000 (Direct Cost: ¥68,000,000、Indirect Cost: ¥20,400,000)
Fiscal Year 2014: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2013: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2012: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2011: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2010: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
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| Outline of Final Research Achievements |
We studied a feeding inhibiting neuropeptide Galanin-like peptide (GALP) to identify distribution and localization and afferent neuronal input in brain by use of transgenic (Tg) mice. It appeared that GALP-containing neurons were localized in the hypothalamic arcuate nucleus by Tg mice which expressed GFP under the promoter of GALP gene. Also, GALP-containing neurons were innervated from several neurons distributed in both hypothalamic and extra-hypothalamic regions in mouse brain. We studied the effect of GALP on lipid metabolism in liver. After intraventricular infusion of GALP, the gene expression of several lipid metabolism-relating enzymes and also it appeared the increase of palmitoyl carnitine by a metabolome analysis. These findings were completely canceled by treatment of guanitidine which blocked the sympathetic nerve. These may indicate that GALP inhibits appetite through sympathetic nervous system and it also affects on lipid metabolism in liver and adipose tissue..
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