• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Histone signaling network in DNA damage response

Planned Research

Project AreaCoupling of replication, repair and transcription, and their common mechanism of chromatin remodeling
Project/Area Number 22131004
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

IKURA TSUYOSHI  京都大学, 放射線生物研究センター, 准教授 (70335686)

Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥110,890,000 (Direct Cost: ¥85,300,000、Indirect Cost: ¥25,590,000)
Fiscal Year 2014: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2012: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2011: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2010: ¥28,860,000 (Direct Cost: ¥22,200,000、Indirect Cost: ¥6,660,000)
KeywordsTIP60ヒストンアセチル化酵素 / ヒストンアセチル化 / ヒストン交換反応 / ヒストンH2AX / クロマチンダイナミクス / DNA損傷応答 / TIP60ヒストンアセチル化酵素複合体 / アセチル化 / 高次クロマチン構造変換 / H2AX交換反応 / ヒストンシャペロン / クロマチン構造変換因子 / ADP-リボシル化 / NBS1 / MDC1 / H2AX eviction / プロテアソーム蛋白質分解系 / TIP60複合体 / ヒストンeviction / DNA損傷応答シグナル
Outline of Final Research Achievements

The eukaryotic genome is tightly packed into the chromatin, a hierarchically organized complex of DNA, histone and nonhistone proteins. Recent findings indicates that histone variant eviction/exchange has an important role in DNA repair and DNA damage response. We found that the TIP60 complex facilitates histone H2AX exchange at the sites of DNA damage. Interestingly, the phosphorylation of histone H2AX is not required for histone H2AX exchange. In this project, we investigated the physiological significance of histone H2AX exchange in DNA damage response. We found that the histone signaling network regulated by the acetylation-dependent histone H2AX exchange is cross-talked with the phosphorylation-dependent DNA damage response signaling.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (80 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (64 results) (of which Invited: 17 results) Book (1 results)

  • [Journal Article] Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage.2015

    • Author(s)
      Liu NA
    • Journal Title

      FASEB J.

      Volume: 14 Pages: 265546-265546

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reorganization of Damaged Chromatin by the Exchange of Histone Variant H2A.Z-2.2014

    • Author(s)
      Nishibuchi I
    • Journal Title

      Int J Radiat Oncol Biol Phys.

      Volume: 89 Issue: 4 Pages: 736-744

    • DOI

      10.1016/j.ijrobp.2014.03.031

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1.2014

    • Author(s)
      Machida, S., Takaku, M., Ikura, M., Sun, J., Suzuki, H., Kobayashi, W., Kinomura, A., Osakabe, A., Tachiwana, H., Horikoshi, Y., Fukuto, A., Matsuda, R., Ura, K., Tashiro, S., Ikura, T., and Kurumizaka, H.
    • Journal Title

      Scientific Rep.

      Volume: 4 Issue: 1 Pages: 4863-4863

    • DOI

      10.1038/srep04863

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] FANCD2 Binds CtIP and Regulates DNA-End Resection during DNA Interstrand Crosslink Repair.2014

    • Author(s)
      Unno J
    • Journal Title

      Cell Rep.

      Volume: 7 Issue: 4 Pages: 1039-1047

    • DOI

      10.1016/j.celrep.2014.04.005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone chaperone FACT regulates homologous recombination by chromatin remodeling through interaction with RNF20.2014

    • Author(s)
      Oliveira DV, Kato A, Nakamura K, Ikura T, Okada M, Kobayashi J, Yanagihara H, Saito Y, Tauchi H, Komatsu K
    • Journal Title

      J Cell Sci

      Volume: 127 Pages: 763-772

    • DOI

      10.1242/jcs.135855

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structural basis of a nucleosome containing histone H2A. B/H2A. Bbd that transiently associates with reorganized chromatin.2013

    • Author(s)
      Arimura Y., Kimura H., Oda T., Sato K., Osakabe A., Tachiwana H., Sato Y., Kinugasa Y., Ikura T., Sugiyama M., Sato M., Kurumizaka H.
    • Journal Title

      Sci Rep.

      Volume: 3 Issue: 1 Pages: 3510-3510

    • DOI

      10.1038/srep03510

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of the SUMO modification system is required for the accumulation of RAD51 at sites containing DNA damage2013

    • Author(s)
      Shima H, Suzuki H, Sun J, Kono K, Shi L, Kinomura A, Horikoshi Y, Ikura T, Ikura M, Kanaar R, Igarashi K, Saitoh H, Kurumizaka H, Tashiro S
    • Journal Title

      J Cell Sci

      Volume: 126 Pages: 5284-5292

    • DOI

      10.1242/jcs.133744

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of homologous recombination in the synergism between cisplatin and poly(ADP-ribose) polymerase inhibition2013

    • Author(s)
      Sakogawa K, Aoki Y, Misumi K, Hamai Y, Emi M, Hihara J, Shi L, Kono K, Horikoshi Y, Sun J, Ikura T, Okada M, Tashiro S
    • Journal Title

      Cancer Sci. 2013 Sep 5

      Volume: 104 Issue: 12 Pages: 1593-1609

    • DOI

      10.1111/cas.12281

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair2013

    • Author(s)
      J Tomida, A Itaya, T Shigechi, J Unno, E Uchida, M Ikura, Y Masuda, S Matsuda J Adachi, M Kobayashi, AR Meetei, Y Maehara, K Yamamoto K Kamiya, A Matsuura, T Matsuda. T Ikura, M Ishiai, M Takata
    • Journal Title

      Nucleic Acids Research

      Volume: VOL. 41 Issue: 14 Pages: 6930-6941

    • DOI

      10.1093/nar/gkt467

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of ribonucleotide reductase-M1 in 5-fluorouracil induced DNA damage in esophageal cancer cell lines.2013

    • Author(s)
      Aoki Y, Sakogawa K, Hihara J, Emi M, Hamai Y, Kono K, Shi L, Sun J, Kitao H, Ikura T, Niida H, Nakanishi M, Okada M, Tashiro S.
    • Journal Title

      Int J Oncol.

      Volume: 42(6) Issue: 6 Pages: 1951-60

    • DOI

      10.3892/ijo.2013.1899

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterocomplex Formation by Arp4 and β-Actin Involved in Integrity of the Brg1 Chromatin Remodeling Complex2012

    • Author(s)
      Nishimoto, N.
    • Journal Title

      J. Cell Sci.

      Volume: 125 Pages: 3870-3882

    • DOI

      10.1242/jcs.104349

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bach1-mediated suppression of p53 is inhibited by p19(ARF) independently of MDM22012

    • Author(s)
      Nishizawa H
    • Journal Title

      Cancer Science

      Volume: 10 Issue: 5 Pages: 2237-2244

    • DOI

      10.1111/j.1349-7006.2012.02244.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purification of the human SMN-GEMIN2 complex and assessment of its stimulation of RAD51-mediated DNA recombination reactions2011

    • Author(s)
      Takaku M
    • Journal Title

      Biochemistry

      Volume: 50 Pages: 6797-6805

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methionine Adenosyltransferase II Serves As a Transcriptional Corepressor of Maf Oncoprotein2011

    • Author(s)
      Katoh Y
    • Journal Title

      Mol Cell

      Volume: 41 Pages: 554-566

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot2010

    • Author(s)
      Sun J
    • Journal Title

      PLoS ONE

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Histone H2AX dynamics coordinates DNA repair with chromatin reorganization2015

    • Author(s)
      Masae Ikura
    • Organizer
      The 5th International Symposium of RIRBM, Hiroshima University
    • Place of Presentation
      広島市
    • Year and Date
      2015-03-02 – 2015-03-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] The coupling of epigenetic regulation with metabolism in cancer2015

    • Author(s)
      Tsuyoshi Ikura
    • Organizer
      The 30th RBC-NIRS International Symposium "Frontier Radiation Biology, Now and In the future."
    • Place of Presentation
      京都市
    • Year and Date
      2015-02-20 – 2015-02-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The role of the pyruvate kinase M2 (PKM2) in the Arylhydrocarbon Receptor-mediated Transcription2015

    • Author(s)
      Tsuyoshi Ikura
    • Organizer
      5th meeting of the Asian Forum for chromatin and chromosome Biology
    • Place of Presentation
      Bungalow, India.
    • Year and Date
      2015-01-13 – 2015-01-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The role of histone H2AX dynamics in DNA damage response2014

    • Author(s)
      Tsuyoshi Ikura
    • Organizer
      The 4D Nucleome 2014
    • Place of Presentation
      広島市
    • Year and Date
      2014-12-17 – 2014-12-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Nap1 is required for the homologous recombination reaction in higher-order chromatin containing histone H12014

    • Author(s)
      Shinichi Machida
    • Organizer
      The 4D Nucleome 2014
    • Place of Presentation
      広島市
    • Year and Date
      2014-12-17 – 2014-12-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Nap1は高次クロマチンでの相同組換えを促進する2014

    • Author(s)
      町田晋一
    • Organizer
      第32回 染色体ワークショップ
    • Place of Presentation
      広島市
    • Year and Date
      2014-12-15 – 2014-12-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 翻訳後修飾を介した色素性乾皮症遺伝子産物の機能制御2014

    • Author(s)
      秋田真季
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] DNA複製チェックポイント蛋白質Rad9は、PLK1依存的に分解をうける2014

    • Author(s)
      郡司 未佳
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 生細胞イメージングを用いたDNA損傷修復過程におけるヒストン修飾動態とクロマチン凝集の解析2014

    • Author(s)
      大倉健太
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] DNA損傷応答におけるヒストンアセチル化を介したクロマチン動的制御とその意義2014

    • Author(s)
      井倉 毅
    • Organizer
      平成26年度遺伝研研究会「クロマチンにおけるゲノムDNAの機能発現メカニズム」
    • Place of Presentation
      静岡県三島市
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Activation of the SUMO modification system is required for the accumulation of RAD51 at sites containing DNA damage2014

    • Author(s)
      Tsuyoshi Ikura
    • Organizer
      第5回日米修復会議
    • Place of Presentation
      徳島県鳴門市
    • Year and Date
      2014-10-28 – 2014-10-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] DNA損傷応答におけるヒストンH2AX化学修飾の時空間的制御2014

    • Author(s)
      井倉 毅
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都市
    • Year and Date
      2014-10-15 – 2014-10-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] DNA損傷応答におけるポジティブフィードバック制御を介した高次クロマチン構造の役割2014

    • Author(s)
      井倉 毅
    • Organizer
      神戸大学セミナー
    • Place of Presentation
      神戸市
    • Year and Date
      2014-06-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Chromatin dynamics in DNA damage response2014

    • Author(s)
      Masae Ikura
    • Organizer
      IIAS Research Conference 2014 Chromatin decoding
    • Place of Presentation
      京都市
    • Year and Date
      2014-05-12 – 2014-05-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] DNA損傷初期応答におけるヒストンシグナルネットワークの解明2014

    • Author(s)
      井倉 毅
    • Organizer
      新学術領域 ゲノム普遍的制御 第5回領域班会議
    • Place of Presentation
      徳島県鳴門市
    • Year and Date
      2014-05-07 – 2014-05-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] The role of chromatin dynamics in DNA damage response2014

    • Author(s)
      Tsuyoshi Ikura
    • Organizer
      International Conference, Kyoto, 2014, Replication, repair and transcription, coupling mechanisms and chromatin dynamics for genome integrity
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The role of histone H2AX dynamics in DNA damage response2014

    • Author(s)
      Masae Ikura, Ryou Matuda, Satoshi Tashiro, Tsuyoshi Ikura,
    • Organizer
      第4回 国際シンポジウム 広島大学原爆放射線医科学研究所
    • Place of Presentation
      広島市
    • Related Report
      2013 Annual Research Report
  • [Presentation] DNA損傷応答におけるヒストンH2AXのダイナミクス2013

    • Author(s)
      1. 井倉 毅
    • Organizer
      第1回ヒストンヴァリアント研究会
    • Place of Presentation
      九州大学医学部
    • Year and Date
      2013-03-08
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] クロマチンの動的変化を介したDNA損傷応答シグナルのエピジェネティクス制御機構2013

    • Author(s)
      井倉 毅
    • Organizer
      文部科学省第五回生物学・化学・情報科学融合のための戦略的先進理工学研究基盤の形成支援事業シンポジウム
    • Place of Presentation
      早稲田大学
    • Year and Date
      2013-03-06
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The role of chromatin dynamics in DNA damage-induced checkpoint activation2013

    • Author(s)
      Masae Ikura
    • Organizer
      第3回広島大学原爆放射線医科学研究所国際シンポジウム
    • Place of Presentation
      広島大学原爆放射線医科学研究所
    • Year and Date
      2013-02-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] 放射線の攻撃からゲノムを守る-我々のゲノムを守る蛋白質の巧妙かつダイナミックな防衛戦略-2013

    • Author(s)
      井倉 毅
    • Organizer
      京都大学品川セミナー
    • Place of Presentation
      京都大学品川オフィス
    • Year and Date
      2013-02-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] The role of chromatin dynamics in DNA damage response2013

    • Author(s)
      Tsuyoshi Ikura, Ryo Matuda, Satoshi Tashiro, Masae Ikura
    • Organizer
      第36回日本分子生物学会年会 ワークショップ、蛋白質翻訳後修飾を介した超分子複合体形成とゲノム機能制御
    • Place of Presentation
      神戸市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Development of a Simple Mutagenicity Test Using eGFP-MDC1-expressing cells2013

    • Author(s)
      Shun Matuda, Masae Ikura, Tsuyoshi Ikura, Tomonari Matsuda
    • Organizer
      第42回環境変異学会
    • Place of Presentation
      岡山市
    • Related Report
      2013 Annual Research Report
  • [Presentation] DNA損傷応答におけるクロマチン動的変化とその意義2013

    • Author(s)
      井倉正枝、松田涼、田代聡、井倉 毅
    • Organizer
      第56回日本放射線影響学会シンポジウム
    • Place of Presentation
      青森市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] DNA損傷応答におけるヒストンH2AXのアセチル化とリン酸化のクロストーク2013

    • Author(s)
      井倉正枝、松田涼、田代聡、井倉 毅
    • Organizer
      第86回日本生化学会シンポジウム
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 染色体DNA相同組換え修復の細胞核内局在2013

    • Author(s)
      田代聡、鈴木秀和、井倉毅、井倉正枝、胡桃坂仁志、孫継英
    • Organizer
      第86回日本生化学会シンポジウム
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 相同組換えにおける高次クロマチン構造の動的な制御2013

    • Author(s)
      町田晋一、高久誉大、井倉正枝、孫継英、鈴木秀和、小林航、越阪部晃永、立和名博昭、浦聖恵、田代聡、井倉毅、胡桃坂仁志
    • Organizer
      第86回日本生化学会シンポジウム
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] DNA損傷初期応答におけるヒストンシグナルネットワークの解明2013

    • Author(s)
      井倉 毅
    • Organizer
      新学術領  ゲノム普遍的制御 第3回領域班会議
    • Place of Presentation
      鳴門市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Molecular mechanism of etoposide induced 11q23 chromosome translocation2013

    • Author(s)
      Jiying Sun, Aiko Kinomura, Hidekazu Suzuki, Tsuyoshi Ikura, Satoshi Tashiro
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Annual Research Report
  • [Presentation] リンカーヒストンを含む高次クロマチン構造における相同組換え機構2013

    • Author(s)
      町田 晋一、高久 誉大、 井倉 正枝、 孫 継英、 鈴木 秀和、 小林 航、 木野村 愛子、 越阪部 晃永、 立和名 博昭、 浦 聖恵、 田代 聡、井倉 毅、胡桃坂 仁志
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高次クロマチンにおける相同組換えの反応機構2013

    • Author(s)
      町田晋一、高久誉大、井倉正枝、孫継英、鈴木秀和、小林航、木野村愛子、越阪部晃永、立和名博昭、浦聖恵、田代聡、井倉毅、胡桃坂仁志
    • Organizer
      第22回DNA複製・組換え・修復ワークショップ
    • Place of Presentation
      仙台市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Involvement of Recombination Repair Proteins in 11q23 Chromosome Translocation2013

    • Author(s)
      Jiying Sun, Tsuyoshi Ikura, Satoshi Tashiro
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 酸化ストレス条件におけるヒトINO80複合体の遺伝子発現制御への関与の解析2013

    • Author(s)
      高橋 裕一朗、 松田 涼、 加藤 恭丈、 五十嵐 和彦、 西嶋 仁、 柴原 慶一、 原田 昌彦
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] ピルビン酸キナーゼM2はダイオキシン受容体の活性化補助因子である2012

    • Author(s)
      松田俊
    • Organizer
      第35回分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] クロマチン高次構造上における相同組換え反応の解析2012

    • Author(s)
      町田晋一
    • Organizer
      第35回分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] 放射線誘発核内フォーカス形成制御の分子機構2012

    • Author(s)
      田代聡
    • Organizer
      第35回分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] DNA鎖間架橋応答におけるファンコニ貧血経路によるCtIPの調節2012

    • Author(s)
      海野純也
    • Organizer
      第35回分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] Involvement of Recombination Repair Proteins in 11q23 Chromosome Translocation2012

    • Author(s)
      Jiying Sun
    • Organizer
      第35回分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] DNA損傷応答におけるヒストンH2AXとH2AZのアセチル化クロストーク2012

    • Author(s)
      松田 涼
    • Organizer
      放射線影響学会
    • Place of Presentation
      東北大学
    • Year and Date
      2012-09-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] DNA損傷応答シグナルのエピジェネティクス制御機構の解明と展望2012

    • Author(s)
      井倉 毅
    • Organizer
      放射線影響学会
    • Place of Presentation
      東北大学
    • Year and Date
      2012-09-06
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ゲノム損傷におけるクロマチンの動的制御変化とエピジェネティクス制御機構2012

    • Author(s)
      井倉 毅
    • Organizer
      第80回NM-GCOEセミナー
    • Place of Presentation
      東北大学医学部
    • Year and Date
      2012-08-24
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ゲノム損傷におけるクロマチンの動的制御変化とエピジェネティクス制御機構2012

    • Author(s)
      井倉 毅
    • Organizer
      京都大学循環器内科セミナー
    • Place of Presentation
      京都大学循環器内科
    • Year and Date
      2012-07-11
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] DNA損傷応答シグナルのエピジェネティクス制御機構の解明と展望2012

    • Author(s)
      井倉 毅
    • Organizer
      早稲田大学セミナー
    • Place of Presentation
      早稲田大学
    • Year and Date
      2012-06-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] ゲノム損傷におけるクロマチンダイナミクスとエピジェネティクス制御機構2012

    • Author(s)
      井倉 毅
    • Organizer
      早稲田大学セミナー
    • Place of Presentation
      早稲田大学
    • Year and Date
      2012-06-15
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] DNA損傷初期応答におけるヒストンシグナルネットワークの解明2012

    • Author(s)
      井倉 毅
    • Organizer
      新学術領域 ゲノム普遍的制御 第3回領域班会議
    • Place of Presentation
      淡路夢舞台
    • Year and Date
      2012-05-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] The role of chromatin dynamics in DNA damage-induced checkpoint activation2012

    • Author(s)
      井倉 毅
    • Organizer
      日米DNA修復会議
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2012-04-11
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] クロマチンの動的変化を介したDNA損傷応答シグナルのエピジェネティクス制御2012

    • Author(s)
      井倉毅
    • Organizer
      第10回口腔医科学フロンティア
    • Place of Presentation
      大阪大学歯学部記念館、吹田市(招待講演)
    • Year and Date
      2012-03-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] クロマチンの動的変化を介したDNA損傷応答シグナルのエピジェネティクス制御2012

    • Author(s)
      井倉毅
    • Organizer
      第3次対がん10か年総合戦略平成16年-25年度・文部科学省がん支援活動、合同公開シンポジウム
    • Place of Presentation
      学術総合センター、一橋記念講堂、東京都(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] クロマチンの動的変化を介したDNA損傷応答シグナルのエピジェネティクス制御2012

    • Author(s)
      井倉毅
    • Organizer
      第29回染色体ワークショップ
    • Place of Presentation
      仙台市秋保温泉ホテルニュー水戸屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] The role of chromatin dynamics in DNA damage-induced checkpoint activation2012

    • Author(s)
      Tsuyoshi Ikura
    • Organizer
      広島大学原爆放射線医科学研究所創立50周年記念国際シンポジウム
    • Place of Presentation
      広島市広島国際会議場
    • Related Report
      2011 Annual Research Report
  • [Presentation] The role of histone H2AX eviction in DNA damage-induced checkpoint activation2011

    • Author(s)
      井倉毅
    • Organizer
      第34回日本分子生物学会年会ワークショップ
    • Place of Presentation
      横浜市パシフィコ横浜(招待講演)
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] リン酸化プロテオミクスを用いた新規DNA損傷初期応答キナーゼの探索2011

    • Author(s)
      足立淳
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市パシフィコ横浜
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] A new system for analyzing ionizing radiation-induced chromosome abnormalities2011

    • Author(s)
      Shi L.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市パシフィコ横浜
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] SMN-GEMIN2 complex stimulates the RAD51-mediated recombination reactions2011

    • Author(s)
      Takaku, M
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市パシフィコ横浜
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] ゲノム損傷におけるクロマチンの動的変化とエピジェネティクス制御2011

    • Author(s)
      井倉毅
    • Organizer
      第3回エピジェネティクス療法研究会
    • Place of Presentation
      東京都ホテルルポール麹町(招待講演)
    • Year and Date
      2011-11-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA損傷応答シグナルにおけるTIP60ヒストンアセチル化酵素複合体のダイナミクス2011

    • Author(s)
      井倉毅
    • Organizer
      構造エピゲノム研究会第4回ワークショップ
    • Place of Presentation
      横浜市理化学研究所(招待講演)
    • Year and Date
      2011-07-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] ゲノム疾患研究の現状と未来2011

    • Author(s)
      井倉毅
    • Organizer
      神戸大学バイオシグナル研究センター特別講義
    • Place of Presentation
      神戸大学バイオシグナル研究センター(招待講演)
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA損傷応答シグナルにおけるヒストンH2AXのダイナミクス2011

    • Author(s)
      井倉毅
    • Organizer
      第7回宮崎サイエンスキャンプ
    • Place of Presentation
      宮崎市
    • Year and Date
      2011-02-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] DNA損傷初期応答におけるヒストンシグナルネットワークの解明2011

    • Author(s)
      井倉毅
    • Organizer
      新学術領域ゲノム普遍的制御第2回領域班会議
    • Place of Presentation
      広島市広島プリンスホテル
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA損傷初期シグナルにおけるヒストンシグナルネットワークの解明2010

    • Author(s)
      井倉毅
    • Organizer
      第33回日本分子生物学会年会 第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸市(招待講演)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of chromatin dynamics in DNA damage-induced checkpoint activation.2010

    • Author(s)
      井倉毅
    • Organizer
      日本環境変異原学会第39回大会
    • Place of Presentation
      つくば市(招待講演)
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] DNA損傷応答におけるヒストンH2AXのダイナミクスとその意義2010

    • Author(s)
      井倉毅
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都市(招待講演)
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Checkpoint activation regulated by DNA damage-induced H2AX eviction2010

    • Author(s)
      井倉毅
    • Organizer
      56^<th> Annual Meeting Radiation Research Society
    • Place of Presentation
      Hawaii(招待講演)
    • Year and Date
      2010-09-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] ゲノムストレスにおけるクロマチンの動的変化とその意義

    • Author(s)
      井倉 毅
    • Organizer
      広島大学理学部セミナー
    • Place of Presentation
      広島市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 遺伝情報の発現制御-転写機構からエピジェネティクスまで-著David S.Latchman(第3章翻訳、松田俊、井倉正枝、井倉毅)2012

    • Author(s)
      井倉毅
    • Total Pages
      429
    • Publisher
      メディカル・サイエンス・インターナショナル
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi