• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Clarification of underlying factors involved in the establishment of sex differences

Planned Research

Project AreaMolecular mechanisms for establishment of sex differences.
Project/Area Number 22132004
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionHamamatsu University School of Medicine (2011-2014)
National Research Institute for Child Health and Development (2010)

Principal Investigator

OGATA TSUTOMU  浜松医科大学, 医学部, 教授 (40169173)

Co-Investigator(Kenkyū-buntansha) FUKAMI Maki  (独)国立成育医療研究センター研究所, 分子内分泌研究部, 部長 (40265872)
TSUTSUI Kazuyoshi  早稲田大学, 教育・総合科学学術院, 教授 (20163842)
Co-Investigator(Renkei-kenkyūsha) KAGAMI Masayo  (独)国立成育医療研究センター研究所, 分子内分泌研究部, 室長 (70399484)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥181,740,000 (Direct Cost: ¥139,800,000、Indirect Cost: ¥41,940,000)
Fiscal Year 2014: ¥33,540,000 (Direct Cost: ¥25,800,000、Indirect Cost: ¥7,740,000)
Fiscal Year 2013: ¥35,490,000 (Direct Cost: ¥27,300,000、Indirect Cost: ¥8,190,000)
Fiscal Year 2012: ¥37,440,000 (Direct Cost: ¥28,800,000、Indirect Cost: ¥8,640,000)
Fiscal Year 2011: ¥37,050,000 (Direct Cost: ¥28,500,000、Indirect Cost: ¥8,550,000)
Fiscal Year 2010: ¥38,220,000 (Direct Cost: ¥29,400,000、Indirect Cost: ¥8,820,000)
Keywords性差構築 / ヒト疾患解析 / 性分化疾患 / 遺伝的制御 / 内分泌制御 / 性差 / ヒト疾患 / ゲノム / エピゲノム / 遺伝子機能 / MAMLD1 / ゲノム・エピゲノム解析 / 高密度アレイCGH解析 / 次世代シークエンサー解析 / 新規遺伝子 / POR / アロマターゼ過剰症 / 遺伝子型-表現型解析 / プロモーター
Outline of Final Research Achievements

Sex difference is established by genetic and endocrine regulations. We studied a large number (~1,000) of patient samples by next generation sequencing and array CGH analysis, and identified BHLHA9 as the novel genetic factor as well as the relevance of oligogenecity, and MAMLD1 and PROKR1 as the novel endocrine factors as well as the presence of an alternative androgen production route called backdoor pathway. We also clarified the essential role of gnih and other genes for the production of brain steroids (e.g., 7α-hydroxypregnenolone and estrogens) in the establishment of sex difference in reproductive, aggressive, and autonomous behaviors

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (355 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (202 results) (of which Peer Reviewed: 196 results,  Acknowledgement Compliant: 13 results,  Open Access: 19 results) Presentation (124 results) (of which Invited: 35 results) Book (18 results) Remarks (11 results)

  • [Journal Article] Hemodynamic assessment in a child with renovascular hypertension using time-resolved three-dimensional cine phase-contrast MRI2015

    • Author(s)
      Ishikawa T*, Takehara Y, Yamashita S, Iwashima S, Sugiyama M, Wakayama T, Johnson K, Wieben O, Sakahara H, Ogata T
    • Journal Title

      J Magn Reson Imaging

      Volume: 41(1) Issue: 1 Pages: 165-168

    • DOI

      10.1002/jmri.24522

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A 45,X/46,XY DSD (Disorder of Sexual Development) case with an extremely uneven distribution of 46,XY cells between lymphocytes and gonads2015

    • Author(s)
      Nomura R, Miyai K, Okada M, Kajiwara M, Ono M, Ogata T, Onishi I, Sato M, Sekine M, Akashi T, Mizutani S, Kashimada K
    • Journal Title

      Clinical Pediatric Endocrinology

      Volume: 24 Issue: 1 Pages: 11-14

    • DOI

      10.1297/cpe.24.11

    • NAID

      130004853607

    • ISSN
      0918-5739, 1347-7358
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Silver-Russell syndrome without body asymmetry in three patients with duplications of maternally derived chromosome 11p15 involving CDKN1C2015

    • Author(s)
      Nakashima S, Kato F, Kosho T, Nagasaki K, Kikuchi T, Kagami M, Fukami M, Ogata T
    • Journal Title

      J Hum Genet

      Volume: 60(2) Issue: 2 Pages: 91-95

    • DOI

      10.1038/jhg.2014.100

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Detecting copy number variations in whole exome sequencing data using exome hidden markov model - an expectation of “exome-first” approach.2015

    • Author(s)
      Miyatake S, Koshimizu E, Fujita A, Fukai R, Imagawa E, Ohba C, Kuki I, Makita Y, Ogata T, Nakashima M, Tsurusaki Y, Miyake N, Saitsu H, Matsumoto N
    • Journal Title

      J Hum Genet

      Volume: 1 Issue: 4 Pages: 124-124

    • DOI

      10.1038/jhg.2014.124

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Copy-number variations in Y chromosomal azoospermia factor regions identified by multiplex ligation-dependent probe amplification2015

    • Author(s)
      Saito K, Miyado M, Kobori Y, Tanaka Y, Ishikawa H, Yoshida A, Katsumi M, Saito H, Kubota T, Okada H, Ogata T, Fukami M
    • Journal Title

      J Hum Genet

      Volume: 60(3) Issue: 3 Pages: 127-31

    • DOI

      10.1038/jhg.2014.115

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive clinical studies in 34 patients with molecularly defined UPD(14)pat and related conditions (Kagami-Ogata syndrome)2015

    • Author(s)
      Kagami M, Kurosawa K, Miyazaki O, Ishino F, Matsuoka K, Ogata T
    • Journal Title

      Eur J Hum Genet

      Volume: 2 Issue: 11 Pages: 1-8

    • DOI

      10.1038/ejhg.2015.13

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Novel splice site mutation in MAMLD1 in a patient with hypospadias.2015

    • Author(s)
      10.1038/ejhg.2015.13
    • Journal Title

      Sex Dev

      Volume: 3 Issue: 3 Pages: 1-1

    • DOI

      10.1159/000380842

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Molecular basis of non-syndromic hypospadias: Systematic mutation screening and genome-wide copy-number analysis of 62 patients.2015

    • Author(s)
      Kon M, Suzu ki E, Dung VC, Hasegawa Y, Mitsui T, Muroya K, Ueoka K, Igarashi N, Nagasaki K, Oto Y, Hamajima T, Yoshino K, Igarashi M, Kato-Fukui Y, Nakabayashi K, Hayashi K, Hata K, Matsubara Y, Moriya K, Ogata T, Nonomura K, Fukami M
    • Journal Title

      Hum Reprod

      Volume: 30(3) Issue: 3 Pages: 499-506

    • DOI

      10.1093/humrep/deu364

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Impact of a novel homozygous mutation in nicotinamide nucleotide transhydrogenase on mitochondrial DNA integrity in a case of familial glucocorticoid deficiency.2015

    • Author(s)
      Fujisawa Y, Napoli E, Wong S, Song G, Yamaguchi R, Matsui T, Nagasaki K, Ogata T, Giulivi C
    • Journal Title

      BBA clinical

      Volume: 3 Pages: 70-78

    • DOI

      10.1016/j.bbacli.2014.12.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] SOX3 overdosage permits normal sex development in females with random X inactivation2015

    • Author(s)
      Igarashi M, Mikami H, Katsumi M, Miyado M, Izumi Y, Ogata T, Fukami M
    • Journal Title

      Sex Dev

      Volume: 3 Issue: 3 Pages: 1-1

    • DOI

      10.1159/000377653

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Microhomology-Mediated Microduplication in the Y Chromosomal Azoospermia Factor a (AZFa) Region in a Male with Mild Asthenozoospermia.2015

    • Author(s)
      Katsumi M, Ishikawa H, Tanaka Y, Saito K, Kobori Y, Okada H, Saito H, Nakabayashi K, Matsubara Y, Ogata T, Fukami M, Miyado M
    • Journal Title

      Cytogenet Genome Res

      Volume: 3 Issue: 4 Pages: 1-1

    • DOI

      10.1159/000377649

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lack of genomic rearrangements involving the aromatase gene CYP19A1 in breast cancer.2014

    • Author(s)
      Fukami M*, Suzuki J, Nakabayashi K, Tsunashima R, Ogata T, Shozu M, Noguchi S
    • Journal Title

      Breast Cancer

      Volume: 21 (3) Issue: 3 Pages: 382-385

    • DOI

      10.1007/s12282-013-0471-5

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IMAGe syndrome: clinical and genetic implications based on Iinvestigations in three Japanese patients.2014

    • Author(s)
      Kato F, Hamajima T, Hasegawa T, Amano N, Horikawa R, Nishimura G, Nakashima S, Fuke T, Sano S, Fukami M, Ogata T
    • Journal Title

      Clin Endocrinol

      Volume: 80 (5) Issue: 5 Pages: 706-713

    • DOI

      10.1111/cen.12379

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of the human imprintome and suggests a germline methylation independent establishment of imprinting.2014

    • Author(s)
      Court F, Tayama C, Romanelli V, Martin-Trujillo A, Iglesias-Platas I, Okamura K, Sugahara N, Simon C, Moore H, Harness J, Keirstead H, Vicente Sanchez-Mut J, Kaneki E, Lapunzina P, Soejima H, Wake N, Esteller M, Ogata T, Hata K, Nakabayashi K, Monk D*
    • Journal Title

      Genome Res

      Volume: in press Issue: 4 Pages: 554-569

    • DOI

      10.1101/gr.164913.113

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification and Functional Characterization of Two Novel NPR2 Mutations in Japanese Patients with Short Stature.2014

    • Author(s)
      Amano N, Mukai T, Ito Y, Narumi S, Tanaka T, Yokoya S, Ogata T, Hasegawa T*
    • Journal Title

      J Clin Endocrinol Metab

      Volume: Epub ahead of print Issue: 4 Pages: E713-E718

    • DOI

      10.1210/jc.2013-3525

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TBX1 Mutation Identified by Exome Sequencing in a Japanese Family with 22q11.2 Deletion Syndrome-like Craniofacial Features and Hypocalcemia.2014

    • Author(s)
      Ogata T*, Niihori T, Tanaka N, Kawai M, Nagashima T, Funayama R, Nakayama K, Nakashim S, Kato F, Fukami M, Aoki Y, Matsubara Y
    • Journal Title

      PLoS One

      Volume: 9 Issue: 3 Pages: e91598-e91598

    • DOI

      10.1371/journal.pone.0091598

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A missense single-nucleotide polymorphism in the sialic acid acetyl esterase gene is associated with anti–PIT-1 antibody syndrome.2014

    • Author(s)
      Yamamoto M, Iguchi G, Bando H, Fukuoka H, Suda K, Takahashi M, Nishizawa H, Matsumoto R, Tojo K, Mokubo A, Ogata T, Takahashi Y
    • Journal Title

      Endocr J

      Volume: 61 (6) Pages: 641-644

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutation Spectrum and Phenotypic Variation in Nine Patients with SOX2 abnormalities2014

    • Author(s)
      Suzuki J, Azuma N, Dateki S, Soneda S, Muroya K, Yamamoto Y, Saito R, Sano S, Nagai T, Wada H, Endo A, Urakami T, Ogata T, Fukami M
    • Journal Title

      J Hum Genet

      Volume: 59 (6) Issue: 6 Pages: 353-356

    • DOI

      10.1038/jhg.2014.34

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Uniparental disomy of chromosome 8 leading to homozygosity of a CYP11B1 mutation in a patient with congenital adrenal hyperplasia: Implication for a rare etiology of an autosomal recessive disorder.2014

    • Author(s)
      Matsubara K, Kataoka N, Ogita S, Sano S, Ogata T, Fukami M*, Katsumata N
    • Journal Title

      Endocr J

      Volume: 61 (6) Pages: 629-633

    • NAID

      130004770452

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Early vitamin K deficiency bleeding in a neonate associated with maternal Crohn's disease2014

    • Author(s)
      Ohishi A, Nakashima S, Ogata T, Iijima S
    • Journal Title

      J Perinatol

      Volume: 34(8) Issue: 8 Pages: 636-639

    • DOI

      10.1038/jp.2014.64

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rationale and study design of the Japan environment and children’s study (JECS)2014

    • Author(s)
      Kawamoto T, Nitta H, Murata K, Toda E, Tsukamoto N, Hasegawa M, Yamagata Z, Kayama F, Kshi R, Ohya Y, Saito H, Sago H, Okuyama M, Ogata T, Yokoya S, Koresawa Y, Shibata Y, Nakayama S, Michikawa T, Takeuchi A, Saitoh H
    • Journal Title

      BMC Public Health

      Volume: 14 Issue: 1 Pages: 25-25

    • DOI

      10.1186/1471-2458-14-25

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions (DMRs) to aberrant methylation in Beckwith-Wiedemann syndrome with epimutations2014

    • Author(s)
      Maeda T, Higashimoto K, Jozaki K, Hitomi H, Nakabayashi K, Makita Y, Tonoki H, Okamoto N, Takada F, Ohashi H, Migita M, Kosaki R, Matsubara K, Ogata T, Matsuo M, Hamasaki Y, Ohtsuka Y, Nishioka K, Joh K, Mukai T, Hata K, Soejima H
    • Journal Title

      Genet Med

      Volume: 16(12) Issue: 12 Pages: 903-912

    • DOI

      10.1038/gim.2014.46

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide copy number analysis and systematic mutation screening in 58 patients with hypogonadotropic hypogonadism2014

    • Author(s)
      Izumi Y, Suzuki E, Kanzaki S, Yatsuga S, Kinjo S, Igarashi M, Maruyama T, Sano S, Horikawa R, Sato N, Nakabayashi K, Hata K, Umezawa A, Ogata T, Yoshimura Y, Fukami M
    • Journal Title

      Fertil Steril

      Volume: 102(4) Issue: 4 Pages: 1130-1136

    • DOI

      10.1016/j.fertnstert.2014.06.017

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinical and molecular studies in four patients with SRY-positive 46,XX testicular disorders of sex development: implications for variable sex development and genomic rearrangements.2014

    • Author(s)
      Nakashima S, Oishi A, Takada F, Kawamura H, Igarashi M, Fukami M, Ogata T
    • Journal Title

      J Hum Genet

      Volume: 59(10) Issue: 10 Pages: 549-553

    • DOI

      10.1038/jhg.2014.70

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Japanese founder duplications/triplications involving BHLHA9 are associated with split-hand/foot malformation with or without long bone deficiency and Gollop-Wolfgang complex.2014

    • Author(s)
      Nagata E, Kano H, Kato F, Yamaguchi R, Nakashima S, Takayama S, Kosaki R, Tonoki H, Mizuno S, Watanabe S, Yoshiura KI, Kosho T, Hasegawa T, Kimizuka M, Suzuki A, Shimizu K, Ohashi H, Haga N, Numabe H, Horii E, Nagai T, Yoshihashi H, Nishimura G, Toda T, et al.
    • Journal Title

      Orphanet J Rare Dis

      Volume: 9 Issue: 1 Pages: 125-125

    • DOI

      10.1186/s13023-014-0125-5

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epimutations of the IG-DMR and the MEG3-DMR at the 14q32.2 imprinted region in two patients with Silver-Russell syndrome-compatible phenotype2014

    • Author(s)
      Kagami M, Mizuno S, Matsubars K, Nakabayashi K, Sano S, Fuke T, Fukami M, Ogata T
    • Journal Title

      Eur J Hum Genet

      Volume: 11 Issue: 8 Pages: 1-6

    • DOI

      10.1038/ejhg.2014.234

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hypogonadotropic hypogonadism in a female patient previously diagnosed as having Waardenburg syndrome due to a SOX10 mutation2014

    • Author(s)
      Izumi Y, Musha I, Suzuki E, Iso M, Jinno T, Horikawa R, Amemiya S, Ogata T, Fukami M, Ohtake A
    • Journal Title

      Endocrine

      Volume: 10 Issue: 2 Pages: 1-1

    • DOI

      10.1007/s12020-014-0434-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A missense single-nucleotide polymorphism in the sialic acid acetylesterase (<i>SIAE</i>) gene is associated with anti&ndash;PIT-1 antibody syndrome2014

    • Author(s)
      Yamamoto M, Iguchi G, Bando H, Fukuoka H, Suda K, Takahashi M, Nishizawa H, Matsumoto R, Tojo K, Mokubo A, Ogata T, Takahashi Y
    • Journal Title

      Endocrine Journal

      Volume: 61 Issue: 6 Pages: 641-644

    • DOI

      10.1507/endocrj.EJ13-0539

    • NAID

      130004770453

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutation Spectrum and Phenotypic Variation in Nine Patients with SOX2 abnormalities.2014

    • Author(s)
      Fukami M*, Suzuki J, Azuma N, Dateki S, Soneda S, Muroya K, Yamamoto Y, Saito R, Sano S, Nagai T, Wada H, Endo A, Urakami T, Ogata T:
    • Journal Title

      J Hum Genet

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A missense single-nucleotide polymorphism in the sialic acid acetyl esterase gene is associated with anti-PIT-1 antibody syndrome.2014

    • Author(s)
      Yamamoto M, Iguchi G, Bando H, Fukuoka H, Suda K, Takahashi M, Nishizawa H, Matsumoto R, Tojo K, Mokubo A, Ogata T, Takahashi Y*
    • Journal Title

      Endocr J

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disorder of sex development in an infant with molecularly confirmed 46,XY, +der(10)t(10;21)(q21.1;q21.3), -21.2014

    • Author(s)
      Yagasaki H*, Nakane T, Saito T, Koizumi K, Kobayashi K, Ogata T
    • Journal Title

      Am J Med Genet A

      Volume: 164 Issue: 3 Pages: 841-843

    • DOI

      10.1002/ajmg.a.36354

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal Genetic testing for a microdeletion at chromosome 14q32.2 imprinted region leading to upd(14)pat-like phenotype.2014

    • Author(s)
      Sasaki A, Sumie M, Eada S, Kosaki R, Kurosawa K, Fukami M, Sago H, Ogata T, Kagami M*
    • Journal Title

      Am J Med Genet A

      Volume: 164A Issue: 1 Pages: 264-266

    • DOI

      10.1002/ajmg.a.36185

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A. Caraty, Differential expressions of RFamide-related peptide, a mammalian gonadotropin-inhibitory hormone ortholog, and kisspeptin in the hypothalamus of Abadeh ecotype does during breeding and anestrous seasons2014

    • Author(s)
      M. R. J. Shirazi, M. J. Zamiri, M. S. Salehi, S. Moradi, A. Tamadon, M. R. Namavar, A. Akhlaghi, K. Tsutsui
    • Journal Title

      J. Neuroendocrinol

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular basis for the activation of gonadotropin-inhibitory hormone gene transcription by corticosterone2014

    • Author(s)
      Y. L. Son, T. Ubuka, M. Narihiro, Y. Fukuda, I. Hasunuma, K. Yamamoto, D. D. Belsham, K. Tsutsui
    • Journal Title

      Endocrinology

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis2014

    • Author(s)
      Takayoshi Ubuka, Shogo Haraguchi, Yasuko Tobari, Misato Narihiro, Kei Ishikawa, Takanori Hayashi, Nobuhiro Harada , Kazuyoshi Tsutsui
    • Journal Title

      Nature Communications

      Volume: 5 Issue: 1 Pages: 3061-3061

    • DOI

      10.1038/ncomms4061

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Breakthrough in neuroendocrinology by discovering novel neuropeptides and neurosteroids: 1) Discovery of gonadotropin-inhibitory hormone (GnIH) across vertebrates2014

    • Author(s)
      K. Tsutsui, T. Ubuka, Review
    • Journal Title

      Gen. Comp. Endocrinol

      Volume: in press Pages: 4-10

    • DOI

      10.1016/j.ygcen.2014.03.006

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Breakthrough in neuroendocrinology by discovering novel neuropeptides and neurosteroids: 2) Discovery of neurosteroids and pineal neurosteroids2014

    • Author(s)
      K. Tsutsui, S. Haraguchi, Review
    • Journal Title

      Gen. Comp. Endocrinol

      Volume: in press Pages: 11-22

    • DOI

      10.1016/j.ygcen.2014.03.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone inhibits aggressive behavior of male quail by increasing neuroestrogen synthesis in the brain beyond its optimum concentration2014

    • Author(s)
      T. Ubuka, K. Tsutsui, Review
    • Journal Title

      Gen. Comp. Endocrinol

      Volume: in press Pages: 49-54

    • DOI

      10.1016/j.ygcen.2014.03.014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthesis and biological action of pineal allopregnanolone.2014

    • Author(s)
      K. Tsutsui, S. Haraguchi, Review
    • Journal Title

      Front. Neurosci

      Volume: 5 Pages: 1-10

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular evolution and function of 26RFa/QRFP and its cognate receptor2014

    • Author(s)
      K. Ukena, T. Osugi, J. Leprince, H. Vaudry, K. Tsutsui, Review
    • Journal Title

      J. Mol. Endocrinol

      Volume: in press Issue: 3 Pages: T119-T131

    • DOI

      10.1530/jme-13-0207

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central and direct regulation of testicular activity by gonadotropin-inhibitory hormone and its receptor2014

    • Author(s)
      T. Ubuka, Y. L. Son, Y. Tobari, M. Narihiro, G. E. Bentley, L. Kriegsfeld, K. Tsutsui
    • Journal Title

      Front. Endocrinol. (Lausanne)

      Volume: VOL.5 Pages: 1-10

    • DOI

      10.3389/fendo.2014.00008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 化学掲示板‐女性ホルモンの量がオスの攻撃性を調整していた!2014

    • Author(s)
      筒井和義 総説
    • Journal Title

      (1月18日日本経済新聞掲載)筒井和義教授(早稲田大学教育・総合科学学術院/先端生命医科学センター)に聞く、化学

      Volume: 69 Pages: 73-73

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aromatase excess syndrome in a family with upstream deletion of CYP19A12013

    • Author(s)
      Shihara D, Miyado M, Nakabayashi K, Shozu M, Nagasaki K, Ogata T, Fukami M*
    • Journal Title

      Clin Endocrinol,

      Volume: Epub ahead of print Issue: 2 Pages: 314-316

    • DOI

      10.1111/cen.12329

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] De novo frameshift mutation in fibroblast growth factor 8 in a male patient with gonadotropin deficiency2013

    • Author(s)
      Suzuki E, Yatsuga S, Igarashi M, Miyado M, Nakabayashi K, Hayashi K, Hata K, Umezawa A, Yamada G, Ogata T, Fukami M*
    • Journal Title

      Horm Res Paediatr ,

      Volume: 81 Issue: 2 Pages: 139-144

    • DOI

      10.1159/000355380

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel de novo point mutation of OCT-binding site in the IGF2/H19-imprinting control region in a patient with Beckwith-Wiedemann syndrome.2013

    • Author(s)
      Higashimoto K, Jozaki K, Kosho T, Matsubara K, Sato T, Yamada D, Yatsuki H, Maeda T, Ohtsuka Y, Nishioka K, Joh K, Koseki H, Ogata T, SoejimaH*
    • Journal Title

      Clin Genet

      Volume: in press Issue: 6 Pages: 539-544

    • DOI

      10.1111/cge.12318

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Backdoor pathway for dihydrotestosterone biosynthesis: implications for normal and abnormal human sex development.2013

    • Author(s)
      Fukami M, Homma K, Hasegawa T, Ogata T*
    • Journal Title

      Dev Dyn ,

      Volume: 4 Issue: 4 Pages: 320-329

    • DOI

      10.1002/dvdy.23892

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions (DMRs) to aberrant methylation in Beckwith-Wiedemann syndrome with epimutations.2013

    • Author(s)
      Maeda T, Higashimoto K, Jozaki K, Yatsuki H, Nakabayashi K, Makita Y, Tonoki H, Okamoto N, Takada F, Ohashi H, Migita M, Kosaki R, Matsubara K, Ogata T, Matsuo M, Hamasaki Y, Ohtsuka Y, Nishioka K, Joh K, Mukai T, Hata K, Soejima H*
    • Journal Title

      Genet Med

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic basis of aromatase excess syndrome: recombination- and replication-mediated rearrangements leading to CYP19A1 overexpression.2013

    • Author(s)
      Fukami M*, Tsuchiya T, Vollbach H, Brown KA, Abe S, Ohtsu S, Wabitsch M, Gurger H, Sompson ER, Emezawa A, Nakabayashi K, Bulun SE, Shozu M, Ogata T
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 98 Issue: 12 Pages: E2013-E2021

    • DOI

      10.1210/jc.2013-2520

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compound heterozygous deletions in pseudoautosomal region 1 in an infant with mild manifestsations of Langer mesomelic dysplasia.2013

    • Author(s)
      Tsuchiya T, Shibata M, Numabe H, Jinnno T, Nakabayashi K, Nishimura G, Nagai T, Ogata T, Fukami M*
    • Journal Title

      Am J Med Genet A

      Volume: in press Issue: 2 Pages: 505-510

    • DOI

      10.1002/ajmg.a.36284

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of Yp inversion in PRKX/PRKY-mediated Xp;Yp translocation in a patient with 45,X testicular disorder of sex development.2013

    • Author(s)
      Nakashima S, Watanabe Y, Okada J, Ono H, Nagata E, Fukami M, Ogata T*
    • Journal Title

      Endocr J

      Volume: 60 Pages: 1329-1334

    • NAID

      130004770409

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long term follow up study for a patient with Floating-Harbor syndrome due to a hotspot SRCAP mutation.2013

    • Author(s)
      Nagasaki K*, Asami T, Sato H, Ogawa Y, Kikuchi T, Saitoh A, Ogata T, Fukami M
    • Journal Title

      Am J Med Genet A,

      Volume: 164 Issue: 3 Pages: 731-735

    • DOI

      10.1002/ajmg.a.36314

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of AP2S1 Mutation and Effects of Low Calcium Formula in an Infant with Hypercalcemia and Hypercalciuria.2013

    • Author(s)
      Fujisawa Y*, Yamaguchi R, Satake E, Ohtaka K, Nakanishi T, Ozono K, Ogata T
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 98 Issue: 12 Pages: E2022-E2027

    • DOI

      10.1210/jc.2013-2571

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The lipid fraction of human milk initiates adipocyte differentiation in 3T3-L1 cells.2013

    • Author(s)
      Fujisawa Y*, Yamaguchi R, Nagata E, Satake E, Sano S, Matsushita R, Kitsuta K, Nakashima S, Nakanishi T, Nakagawa Y, Ogata T
    • Journal Title

      Early Hum Dev

      Volume: Epub ahead of print Issue: 9 Pages: 713-719

    • DOI

      10.1016/j.earlhumdev.2013.05.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A 68-year-old phenotypically male patient with 21-hydroxylase deficiency and concomitant adrenocortical neoplasm producing testosterone and cortisol.2013

    • Author(s)
      Hayashi M*, Kataoka Y, Sugimura Y, Kato F, Fukami M, Ogata T, Homma K, Hasegawa T, Oiso Y, Sasano H, Tanaka H
    • Journal Title

      Tohoku J Exp Med

      Volume: 231 Pages: 75-84

    • NAID

      130004720753

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cryptic genomic rearrangements in three patients with 46,XY disorders of sex development.2013

    • Author(s)
      Igarashi M, Dung VC, Suzuki E, Ida S, Nakacho M, Nakabayashi K, Mizuno K, Hayashi Y, Kohri K, Kojima Y, Ogata T, Fukami M*
    • Journal Title

      PLoS One

      Volume: 8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gain-of-function mutations in RIT1 cause Noonan syndrome, a RAS/MAPK pathway syndrome.2013

    • Author(s)
      Aoki Y*, Niihori T, Banjo T, Okamoto N, Mizuno S, Kurosawa K, Ogata T, Takada F, Yano M, Ando T, Hoshika T, Barnett C, Ohashi H, Kawame H, Hasegawa T, Okutani T, Nagashima T, Hasegawa S, Funayama R, Nagashima T, Nakayama K, Inoue S, Watanabe Y, Ogura T, Matsubara Y
    • Journal Title

      Am J Hum Genet

      Volume: 93 Pages: 173-180

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glucose-6-phosphate dehydrogenase deficiency and adrenal hemorrhage in a Filipino neonate with hyperbilirubinemia.2013

    • Author(s)
      Ohishi A*, Ueno D, Ogata T
    • Journal Title

      AJP Rep

      Volume: 3 Issue: 01 Pages: 5-8

    • DOI

      10.1055/s-0032-1329125

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MLL2 and KDM6A mutations in patients with Kabuki syndrome.2013

    • Author(s)
      Miyake N*, Koshimizu E, Okamoto N, Mizuno S, Ogata T,at all
    • Journal Title

      Am J Med Genet A

      Volume: 161 Issue: 9 Pages: 2234-2243

    • DOI

      10.1002/ajmg.a.36072

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis.2013

    • Author(s)
      Matsumura T, Imamichi Y, Mizutani T, Ju Y, Yazawa T, Kawabe S, Kanno M, Ayabe T, Katsumata N, Fukami M, Inatani M, Akagi Y, Umezawa A, Ogata T, Miyamoto K
    • Journal Title

      FASEB J

      Volume: 27 Issue: 8 Pages: 3198-3208

    • DOI

      10.1096/fj.12-222745

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Submicroscopic deletion involving the fibroblast growth factor receptor 1 gene in a patient with combined pituitary hormone deficiency.2013

    • Author(s)
      Fukami M*, Iso M, Sato N, Igarashi M, Seo M, Kazukawa I, Kinoshita E, Dateki S, Ogata T
    • Journal Title

      Endocr J

      Volume: 60 Pages: 1013-1020

    • NAID

      10031195771

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel homozygous mutation of the nicotinamide nucleotide transhydrogenase gene in a Japanese patient with familial glucocorticoid deficiency.2013

    • Author(s)
      Yamaguchi R, Kato F, Hasegawa T, Katsumata N, Fukami M, Matsui T, Nagasaki K, Ogata T
    • Journal Title

      Endocr J

      Volume: 60 Pages: 855-859

    • NAID

      10031195753

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Birth seasonality in Prader-Willi syndrome resulting from chromosome 15 microdeletion.2013

    • Author(s)
      Ayabe T, Matsubara K, Ogata T, Ayabe A, Murakami N, Nagai T, Fukami M*
    • Journal Title

      Am J Med Genet A

      Volume: 161 Issue: 6 Pages: 1495-1497

    • DOI

      10.1002/ajmg.a.35893

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and clinical studies in 138 Japanese patients with Silver-Russell syndrome.2013

    • Author(s)
      Fuke T, Mizuno S, Nagai T, Hasegawa T, Horikawa R, Miyoshi Y, Muroya K, Kondoh T, Numakura C, Sato S, Nakabayashi K, Tayama C, Hata K, Sano S, Matsubara K, Kagami M, Yamazawa K, Ogata T*
    • Journal Title

      PLoS One

      Volume: 8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuromuscular symptoms in a patient with familial pseudohypoparathyroidism type Ib diagnosed by methylation-specific multiplex ligation-dependent probe amplification.2013

    • Author(s)
      Nagasaki K*, Tsuchuya S, Saitoh A, Ogata T, Fukami M
    • Journal Title

      Endocr J

      Volume: 60 Pages: 231-236

    • NAID

      10031156746

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A report of two novel NR5A1 mutation families: possible clinical phenotype of psychiatric symptoms of anxiety and/or depression.2013

    • Author(s)
      Suzuki-Suwanai A, Ishii T, Haruna H, Yamataka A, Narumi S, Fukuzawa R, Ogata T, Hasegawa T*
    • Journal Title

      Clin Endocrinol

      Volume: 78 Issue: 6 Pages: 957-965

    • DOI

      10.1111/cen.12054

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 性分化疾患の性自認に関する調査研究2013

    • Author(s)
      大山建司,深見真紀,緒方勤
    • Journal Title

      日小児会誌

      Volume: 117 Pages: 1403-1409

    • NAID

      10031195068

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新規男性ホルモン産生経路:正常性分化および性分化疾患発症における役割2013

    • Author(s)
      深見真紀,緒方勤
    • Journal Title

      細胞工学(特集:性決定分化の制御システム)

      Volume: 32 Pages: 193-198

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 性分化疾患の検査の進め方2013

    • Author(s)
      緒方勤
    • Journal Title

      小児内科(特集:負荷試験の実際)

      Volume: 45 Pages: 815-820

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aromatase excess syndrome: a rare autosomal dominant disorder leading to pre- or peri-pubertal onset gynecomastia.2013

    • Author(s)
      Fukami M*, Miyado M, Nagasaki K, Shozu M, Ogata T
    • Journal Title

      Pediatr Endocr Rev

      Volume: 11 Pages: 298-305

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advanced maternal age at childbirth and the development of uniparental disomy. A commentary on the proportion of uniparental disomy is increased in Prader-Willi syndrome due to an advanced maternal childbearing age in Korea.2013

    • Author(s)
      Matsubara K, Ogata T*
    • Journal Title

      J Hum Genet

      Volume: 58 Issue: 3 Pages: 118-119

    • DOI

      10.1038/jhg.2013.4

    • NAID

      10031164067

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of de novo synthesis of Gas proteins to 1-methyladenine production in starfish ovarian follicle cells stimulated by relaxin-like gonad-stimulating substance2013

    • Author(s)
      Masatoshi Mita, Shogo Haraguchi, Haruka Uzawa, Kazutoshi Tsutsui
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 440 Issue: 4 Pages: 798-801

    • DOI

      10.1016/j.bbrc.2013.10.038

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular evolution of Kiss2 genes and peptides in vertebrates2013

    • Author(s)
      T. Osugi, N. Ohtaki, Y. Sunakawa, Y. L. Son, M. Ohkubo, M. Iigo, M. Amano, K. Tsutsui
    • Journal Title

      Endocrinology

      Volume: VOL.154 Issue: 11 Pages: 4270-4280

    • DOI

      10.1210/en.2012-2267

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone reduces sexual motivation but not lordosis behavior in female Syrian hamsters (Mesocricetus auratus)2013

    • Author(s)
      D. J. Piekarski, S. Zhao, K. J. Jennings, T. Iwasa, S. J. Legan, J. D. Mikkelsen, K. Tsutsui, L. J. Kriegsfeld
    • Journal Title

      Horm. Behav

      Volume: 64 Issue: 3 Pages: 501-510

    • DOI

      10.1016/j.yhbeh.2013.06.006

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genetically female brain is required for a regular reproductive cycle in chicken brain chimeras2013

    • Author(s)
      Fumihiko Maekawa
    • Journal Title

      Nature Communications

      Volume: 4 Issue: 1 Pages: 1372-1372

    • DOI

      10.1038/ncomms2372

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes2013

    • Author(s)
      Y. Shima, K. Miyabayashi, S. Haraguchi, T. Arakawa, H, Otake, T. Baba, S. Matsuzaki, Y. Shishido, H. Akiyama, T. Tachibana, K. Tsutsui, K. Morohashi
    • Journal Title

      Mol. Endocrinol

      Volume: 27 Pages: 63-67

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthesis and biological actions of pineal neurosteroids in domestic birds, [Selected for Issue Cover]2013

    • Author(s)
      K. Tsutsui, S. Haraguchi, M. Hatori, T. Hirota, Y. Fukada, Review
    • Journal Title

      Neuroendocrinology

      Volume: 98 Issue: 2 Pages: 97-105

    • DOI

      10.1159/000353782

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New biosynthesis and biological actions of avian neurosteroids2013

    • Author(s)
      K. Tsutsui, S. Haraguchi, K. Inoue, H. Miyabara, T. Ubuka, M. Hatori, T. Hirota, Y. Fukada, Review
    • Journal Title

      J. Exp. Neurosci

      Volume: 7 Pages: 15-29

    • DOI

      10.4137/jen.s11148

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 10th International Symposium on Avian Endocrinology2013

    • Author(s)
      K. Tsutsui, P. J. Sharp, R. M. Dores, Review
    • Journal Title

      Gen. Comp. Endocrinol

      Volume: 190 Pages: 1-2

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory mechanisms of gonadotropin-inhibitory hormone (GnIH) synthesis and release in photoperiodic animals2013

    • Author(s)
      K. Tsutsui, T. Ubuka, G. E. Bentley, L. Kriegsfeld, Review
    • Journal Title

      Front. Neurosci

      Volume: 7 Pages: 1-11

    • DOI

      10.3389/fnins.2013.00060

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroendocrine regulation of gonadotropin secretion in seasonally breeding birds2013

    • Author(s)
      T. Ubuka, G. E. Bentley, K. Tsutsui, Review
    • Journal Title

      Front. Neurosci

      Volume: 7 Pages: 1-17

    • DOI

      10.3389/fnins.2013.00038

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain and pineal 7α-hydroxypregnenolone stimulating locomotor activity : Identification, mode of action and regulation of biosynthesis2013

    • Author(s)
      Kazuyoshi Tsutsui, Shogo Haraguchi, Yoshitaka Fukada, Hubert Vaudry
    • Journal Title

      Frontiers in Neuroendocrinology

      Volume: 34 Issue: 3 Pages: 179-189

    • DOI

      10.1016/j.yfrne.2013.05.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] dentification, localization and function of a novel neuropeptide, 26RFa, and its cognate receptor, GPR103 in the avian hypothalamus2013

    • Author(s)
      K. Ukena, T. Tachibana, Y. Tobari, J. Leprince, H. Vaudry, K. Tsutsui, Review
    • Journal Title

      Gen. Comp. Endocrinol

      Volume: 190 Pages: 42-46

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Gonadotropin-inhibitory hormone (GnIH), GnIH receptor and cell signaling2013

    • Author(s)
      T. Ubuka, Y. L. Son, G. E. Bentley, R. P. Millar, K. Tsutsui
    • Journal Title

      Gen. Comp. Endocrinol.

      Volume: VOL.190 Pages: 10-17

    • DOI

      10.1016/j.ygcen.2013.02.030

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA interference of gonadotropin-inhibitory hormone gene induces aggressive and sexual behaviors in birds2013

    • Author(s)
      T. Ubuka, T. Mizuno, Y. Fukuda, G. E. Bentley, J. C. Wingfield, K. Tsutsui, Review
    • Journal Title

      Gen. Comp. Endocrinol

      Volume: 181 Pages: 179-186

    • DOI

      10.1016/j.ygcen.2012.09.010

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin stimulates the synthesis and release of gonadotropin-inhibitory hormone in birds2013

    • Author(s)
      V. S. Chowdhury, T. Ubuka, K. Tsutsui, Review
    • Journal Title

      Gen. Comp. Endocrinol

      Volume: 181 Pages: 175-178

    • DOI

      10.1016/j.ygcen.2012.08.005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Create new research directions in comparative endocrinology from Asia and Oceania2013

    • Author(s)
      K. Tsutsui, Review
    • Journal Title

      Gen. Comp. Endocrinol

      Volume: 181 Pages: 192-196

    • DOI

      10.1016/j.ygcen.2012.04.015

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ハムスターのGnIHの同定及び発現制御と生理機能の解析2013

    • Author(s)
      産賀崇由、井上和彦、筒井和義、総説
    • Journal Title

      生殖内分泌学会雑誌

      Volume: 18 Pages: 27-33

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] :松果体で合成・放出されたアロプレグナノロンは発達期の小脳プルキンエ細胞の生存に不可欠である2013

    • Author(s)
      原口省吾、原桜子、産賀崇由、三田雅敏、筒井和義、総説
    • Journal Title

      比較内分泌学

      Volume: 39 Pages: 44-48

    • NAID

      130004952311

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 46, XY gonadal dysgenesis : new SRY point mutation in two siblings with paternal germ line mosaicism2012

    • Author(s)
      Stoppa-Vaucher S, Ogata T, et al
    • Journal Title

      Clin Genet

      Volume: (in press)(Epub ahead of print) Issue: 6 Pages: 505-513

    • DOI

      10.1111/j.1399-0004.2011.01832.x

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two-step biochemical differential diagnosis of classic 21-hydroxylase deficiency and coytochrome P450 oxidoreductase deficiency in Japanese infants by GC-MS measurement2012

    • Author(s)
      Y.Koyama, K.Homma, M.Fukami, M.Miwa, K.Ikeda, T.Ogata, et al
    • Journal Title

      Clin.Chem.

      Volume: 58 Issue: 4 Pages: 741-747

    • DOI

      10.1373/clinchem.2011.173286

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening of MAMLD1 mutations in 70 Children with 46,XY DSD: Identification and functional analysis of two new mutations.2012

    • Author(s)
      N. Kalfa, M. Fukami, P. Philibert, F. Audran, C. Pienkowski, G. Weill, C. Pinto, S. Manouvrier, M. Polak, T. Ogata, C. Sultan.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 3 Pages: e32505-e32505

    • DOI

      10.1371/journal.pone.0032505

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel low-dose bisphenol A targets in human foreskin fibroblast cells derived from hypospadias patients.2012

    • Author(s)
      Qin X-Y, Miyado M, Kojima Y, Zaha H Akanuma H, Zeng Q, Yoshinaga J, Yonemoto J, Fukami M, Ogata T, Sone H*
    • Journal Title

      PLoS ONE

      Volume: 7 (5)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complex genomic rearrangements in the SOX9 5' region in a patient with Pierre Robin sequence and hypoplastic left scapula.2012

    • Author(s)
      M. Fukami, T. Tsuchiya, S. Takada, A. Kanbara, H. Asahara, A. Igarashi, Y. Kamiyama, G. Nishimura, T. Ogata.
    • Journal Title

      Am. J. Med. Genet. A.

      Volume: 158A Issue: 7 Pages: 1529-1534

    • DOI

      10.1002/ajmg.a.35308

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutations in PRRT2 responsible for paroxysmal kinesigenic dyskinesias also cause benign familialinfantile convulsions.2012

    • Author(s)
      Ono S, Yoshiura K , KinoshitaA, Kikuchi T, Nakane Y, Kato N,Sadamatsu M , Konishi T , Nagamitsu S , Matsuura M, Yasuda A, KomineM, Kanai K , Inoue T , Osamura T , Saito K , Hirose S, Koide H, Tomita H , Ozawa H , Niikawa N and Kurotaki N.
    • Journal Title

      J Hum Genet

      Volume: 57 Issue: 5 Pages: 1-4

    • DOI

      10.1038/jhg.2012.23

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadias.2012

    • Author(s)
      X.Y. Qin, Y. Kojima, K. Mizuno, K. Ueoka, F. Massart, C. Spinelli, H. Zaha, M. Okura, J. Yoshinaga, J. Yonemoto, K. Kohri, Y. Hayashi, T. Ogata, H. Sone.
    • Journal Title

      J. Hum. Genet.

      Volume: 57 Issue: 7 Pages: 434-441

    • DOI

      10.1038/jhg.2012.48

    • NAID

      10030965639

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PRKAR1A mutation affecting cAMP-mediated G-protein-coupled receptor signaling in a patient with acrodysostosis and hormone resistance.2012

    • Author(s)
      Nagasaki K, Iida T, Sato H, Ogawa Y, Kikuchi T, Saitoh A, Ogata T*, Fukami M
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 97 (9)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Individual variation of the genetic response to low-dose bisphenol A in human foreskin fibroblast cells derived from cryptorchidism and hypospadias patients.2012

    • Author(s)
      Qin XY, Sone H*, Kojima Y, Ueoka K, Muroya K, Miyado M, Zaha H, Fukuda T, Yoshinaga J, Yonemoto J, Fukami M, Ogata T
    • Journal Title

      PLoS One

      Volume: 7 (12)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal Leydig cells but permits normal genital and reproductive development.2012

    • Author(s)
      Miyado M, Nakamura M, Miyado K, Morohashi K, Sano S, Nagata E, Fukami M, , Ogata T*
    • Journal Title

      Endocrinology

      Volume: accepted

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation and deletion of fibroblast growth factor receptor 1 gene in two patients with combined pituitary hormone deficiency.2012

    • Author(s)
      Fukami M*, Iso M, Sato N, Igarashi M, Seo M, Kazukawa I, Kinoshita E, Dateki S, Ogata T
    • Journal Title

      Endocr J

      Volume: accepted

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Molecular bases and phenotypic determinants of aromatase excess syndrome2012

    • Author(s)
      M.Fukami, M.Shozu, T.Ogata, et al
    • Journal Title

      Int.J.Endocrinol.

      Volume: (印刷中)(in~press) Pages: 584807-584807

    • DOI

      10.1155/2012/584807

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review: MAMLD1 and 46,XY disorders of sex development.2012

    • Author(s)
      T. Ogata, S. Sano, E. Nagata, F. Kato, M. Fukami.
    • Journal Title

      Semi. Reprod. Med.

      Volume: 30 Issue: 05 Pages: 410-416

    • DOI

      10.1055/s-0032-1324725

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 性分化疾患2012

    • Author(s)
      緒方勤
    • Journal Title

      臨床と研究(特集:小児診療のピットフォールII)

      Volume: 89 (5) Pages: 53-58

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 性分化疾患2012

    • Author(s)
      緒方勤
    • Journal Title

      小児科(小児疾患の診断治療基準)

      Volume: 44 (増刊号) Pages: 218-219

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 子どもの健康と環境ホルモン:男児外陰部異常をモデルとして2012

    • Author(s)
      緒方勤
    • Journal Title

      小児科臨床

      Volume: 65 (増刊号:小児の中毒) Pages: 1565-1572

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 原発性性線機能低下症.大関武彦,古川漸,横田俊一郎,水口雅2012

    • Author(s)
      緒方勤
    • Journal Title

      今日の小児治療指針

      Volume: 15版 Pages: 244-245

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 心血管病変発症の性差とY染色体2012

    • Author(s)
      緒方勤
    • Journal Title

      MMJ

      Volume: 8 (4) Pages: 190-191

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Identification of a novel mutation in the exon 2 splice donor site of the POU1F1/PIT-1 gene in Japanese identical twins with mild combined pituitary hormone deficiency2012

    • Author(s)
      Inoue H, Ogata T, et al
    • Journal Title

      Clin Endocrinol

      Volume: 76(1) Pages: 78-87

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic characteristics on HLA-cass IT and class I among Japanese type 1A and type 1B diabetic children and their families2012

    • Author(s)
      Sugihara S, Ogata T, et al
    • Journal Title

      Pediatr Diabetes

      Volume: 13(1) Pages: 33-44

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relative frequency of underlying genetic causes for the development of UPD(14)pat-like phenotype2012

    • Author(s)
      Kagami M, Ogata T, et al
    • Journal Title

      Eur J Hum Genet

      Volume: (accepted)(Epub ahead of print) Issue: 9 Pages: 928-932

    • DOI

      10.1038/ejhg.2012.26

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mosaic upd(7)mat in a patient with Silver-Russell syndrome : correlation between phenotype and mosaic ratio in the body and the placenta2012

    • Author(s)
      Fuke-Sato T, Ogata T, et al
    • Journal Title

      Am J Med Genet A

      Volume: 158A(2) Pages: 465-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and clinical features of Costello syndrome and cardio-facio-cutaneous syndrome in Japan2012

    • Author(s)
      Abe Y, Aoki Y, Ogata T, et al
    • Journal Title

      Am J Med Genet A

      Volume: (accepted)(Epub ahead of print) Issue: 5 Pages: 1083-1094

    • DOI

      10.1002/ajmg.a.35292

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two-step biochemical differential diagnosis of classical 21-hydroxylase deficiency and cytochrome P450 oxidoreductase deficiency in Japanese infants using uUrinary Pregnanetriolone/Tetrahydroxycortisone Ratio and 11β-hydroxyandrosterone by Gas chromatography-mass spectrometry2012

    • Author(s)
      Koyama Y, Ogata T, et al
    • Journal Title

      Clin Chem

      Volume: 58(4) Pages: 741-7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening of MAMLD1 mutations in 70 children with 46,XY DSD : Identification and functional analysis of 2 new mutations2012

    • Author(s)
      Kalfa N, Ogata T, et al
    • Journal Title

      PLoS ONE

      Volume: 7(3)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification, expression, and physiological functions of Siberian hamster gonadotropin-inhibitory hormone2012

    • Author(s)
      T.Ubuka, K.Tsutsui, et al
    • Journal Title

      Endocrinology

      Volume: 153 Issue: 1 Pages: 373-385

    • DOI

      10.1210/en.2011-1110

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute stress increases the synthesis of 7α-hydroxypregnenolone, a new key neurosteroid stimulating locomotor activity, through corticosterone action2012

    • Author(s)
      S.Haraguchi, K.Tsutsui, et al
    • Journal Title

      Endocrinology

      Volume: 153 Issue: 2 Pages: 794-805

    • DOI

      10.1210/en.2011-1422

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA interference of gonadotropin-inhibitory hormone gene induces arousal in songbirds2012

    • Author(s)
      T.Ubuka, K.Tsutsui, et al
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 1 Pages: e30202-e30202

    • DOI

      10.1371/journal.pone.0030202

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: class FormattedString { value: An implicative role of SIRT1 in the ovary }2012

    • Author(s)
      Y.Morita, K.Tsutsui, et al
    • Journal Title

      Reprod.Biol.Endocrinbl.

      Volume: 10 Issue: 1 Pages: 14-24

    • DOI

      10.1186/1477-7827-10-14

    • URL

      https://localhost/en/publications/a97f2630-e3b5-40c8-894e-fa987b90bada

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mollusc gonadotropin-releasing hormone directly regulates gonadal functions : A primitive endocrine system controlling reproduction2012

    • Author(s)
      N.Treen, K.Tsutsui, et al
    • Journal Title

      Gen.Comp.Endocrinol.

      Volume: (in press) Issue: 2 Pages: 167-172

    • DOI

      10.1016/j.ygcen.2012.01.008

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothalamic gonadotropin-inhibitory hormone precursor mRNA is increased during depressed food intake in heat-exposed chicks2012

    • Author(s)
      V.S.Chowdhury, K.Tsutsui, et al
    • Journal Title

      Comp.Biol.Physiol.

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological activity of novel lamprey RFamide peptides, specifically PQRFamide and their related peptides2012

    • Author(s)
      D.Daukss, K.Tsutsui, et al
    • Journal Title

      Gen.Comp.Endocrinol.

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-Inhibitory Hormone Inhibits Gonadotropin-Releasing Hormone-Induced Gonadotropin Synthesis Mediated by Adenylate Cyclase/cAMP/PKA-dependent ERK Pathway in LβT2 Gonadotrope Cells2012

    • Author(s)
      Y.L.Son, K.Tsutsui, et al
    • Journal Title

      Endocrinology

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary origin of the structure and function of gonadotropin-inhibitory hormone : Insights from lampreys2012

    • Author(s)
      T.Osugi, K.Tsutsui, et al
    • Journal Title

      Endocrinology

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides2012

    • Author(s)
      J.L.Do Rego, K.Tsutsui, et al
    • Journal Title

      Front.Endocrin

      Volume: 3:article 4 Pages: 1-15

    • DOI

      10.3389/fendo.2012.00004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 7α-Hydroxypregnenolone, a new key regulator of amphibian locomotion: discovery, progress and prospect2012

    • Author(s)
      Kazuyoshi Tsutsui
    • Journal Title

      General and compaitive endocrinology

      Volume: 176 Issue: 3 Pages: 440-447

    • DOI

      10.1016/j.ygcen.2011.11.020

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Control of circadian activity of birds by the interaction of melatonin with 7α-hydroxypregnenolone, a newly discovered neurosteroid stimulating locomotion2012

    • Author(s)
      K.Tsutsui, S.Haraguchi, et al
    • Journal Title

      J.Ornitol.

      Volume: (in press) Issue: S1 Pages: 235-243

    • DOI

      10.1007/s10336-011-0795-x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurosteroid biosynthesis and action during cerebellar development2012

    • Author(s)
      K.Tsutsui
    • Journal Title

      Cerebellum

      Volume: (in press) Issue: 2 Pages: 414-415

    • DOI

      10.1007/s12311-011-0341-7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Gonadotropin-inhibitory hormone (GnIH) : discovery, progress and prospect2012

    • Author(s)
      K.Tsutsui, T.Ubuka, et al
    • Journal Title

      Gen.Comp.Endocrinol.

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and functional analysis of novel human growth hormone-releasing hormone receptor (GHRHR) gene mutations in Japanese subjects with short stature2011

    • Author(s)
      Inoue H, Ogata T, et al
    • Journal Title

      Clin Endocrinol

      Volume: 74(2) Pages: 223-233

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Androgenetic/biparental mosaicism in a girl with Beckwith-Wiedemann syndrome-like and upd (14) pat-like phenotypes2011

    • Author(s)
      Yamazawa K, Ogata T, et al
    • Journal Title

      J Hum Genet

      Volume: 56(1) Pages: 91-93

    • NAID

      10030657597

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and functional analysis of novel human growth hormone secretagogue receptor (GHSR) gene mutations in Japanese subjects with short stature2011

    • Author(s)
      Inoue H, Ogata T, et al
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 96(2)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GATA3 abnormalities in six patients with HDR syndrome2011

    • Author(s)
      Fukami M, Ogata T, et al
    • Journal Title

      Endocr J

      Volume: 58(2) Pages: 117-121

    • NAID

      10029587700

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of chromosome 15q terminal deletion with telomere sequences and its bearing on genotype-phenotype analysis2011

    • Author(s)
      Dateki S, Ogata T, et al
    • Journal Title

      Endocr J

      Volume: 58(3) Pages: 155-159

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MAMLD1 (Mastermind-Like Domain Containing 1) Homozygous Gain-of-Function Missense Mutation Causing 46,XX Disorder of Sex Development in a Virilized Female2011

    • Author(s)
      Brandao MP, Ogata T, et al
    • Journal Title

      Adv Exp Med Biol

      Volume: 707(10) Pages: 129-31

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiological evaluation of dysmorphic thorax in paternal uniparental disomy for chromosome 142011

    • Author(s)
      Miyazaki O, Ogata T, et al
    • Journal Title

      Ped Radiol

      Volume: 41(8) Pages: 1013-1019

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aromatase excess syndrome : identification of cryptic duplications and deletions leading to gain-of-function of CYP19A1 and assessment of phenotypic determinants2011

    • Author(s)
      Fukami, M, Ogata T, et al
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 96(6)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Steroid 5α-reductase-2 deficiency and fertility2011

    • Author(s)
      Ogata T, Matsubara K
    • Journal Title

      Fertil Steril

      Volume: 95(7)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mamldl knockdown reduces testosterone production and Cyp17al expression in mouse Leydig tumor cells2011

    • Author(s)
      Nakamura M, Ogata T, et al
    • Journal Title

      PLoS ONE

      Volume: 6(4)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maternal age effect on the development of Prader-Willi syndrome resulting from upd (15) mat through meiosis 1 errors2011

    • Author(s)
      Matsubara K, Ogata T, et al
    • Journal Title

      J Hum Genet

      Volume: 56(8) Pages: 566-71

    • NAID

      10030660380

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylation screening of reciprocal genome-wide UPDs identifies novel human specific imprinted genes2011

    • Author(s)
      Nakabayashi K, Ogata T, et al
    • Journal Title

      Hum Mol Genet

      Volume: 20(16) Pages: 3188-97

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of expression and structure of the rat GH secretagogue/ghrelin receptor (Ghsr) gene : roles of epigenetic modifications in transcriptional regulation2011

    • Author(s)
      Inoue H, Ogata T, et al
    • Journal Title

      Mol Cell Endocrinol

      Volume: 345 Pages: 1-15

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proximal promoter of the cytochrome P450 oxidoreductase gene : identification of microdeletions involving the untranslated exon 1 and critical function of the SP1 binding site2011

    • Author(s)
      Soneda S, Ogata T, et al
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 96(11)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Number of CGG repeats in the FMR1 gene of Japanese patients with primary ovanan insufficiency2011

    • Author(s)
      Ishizuka B, Ogata T, et al
    • Journal Title

      Fertil Steril

      Volume: 96(5) Pages: 1170-1174

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of primary ovarian insufficiency with a specific HLA haplotype (A^*24:02-C^*03:03-B^*35:01) in Japanese patients2011

    • Author(s)
      Ayabe T, Ogata T, et al
    • Journal Title

      Sex Dev

      Volume: 5(5) Pages: 235-240

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphisms of MAMLD1 gene in hypospadias2011

    • Author(s)
      Kalfa N, Ogata T, et al
    • Journal Title

      J Pediatr Urol

      Volume: 7(6) Pages: 585-591

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advanced maternal age and the development of Prader-Willi syndrome resulting from upd (15) mat through non-disjunction at meiosis 12011

    • Author(s)
      Ogata T, Matsubara K, et al
    • Journal Title

      J Mamm Ova Res

      Volume: 28(3) Pages: 96-102

    • NAID

      10029898301

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synchronised expressions of LPXRFamide peptide and its receptor genes : seasonal, diurnal and circadian changes during spawning period in grasspuffer2011

    • Author(s)
      M.Shahjahan, K.Tsutsui, et al
    • Journal Title

      J.Endocrinol.

      Volume: 23 Issue: 1 Pages: 39-51

    • DOI

      10.1111/j.1365-2826.2010.02081.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen biosynthesis in the gonad of the frog Rana rugosa2011

    • Author(s)
      T.Isomura, K.Tsutsui, et al
    • Journal Title

      Gen.Comp.Endocrinol.

      Volume: 170 Issue: 1 Pages: 207-212

    • DOI

      10.1016/j.ygcen.2010.10.015

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of cytochrome P450 side-chain cleavage enzyme mRNA and production of pregnenolone in the brain of the red-bellied newt Cynops pyrrhogaster2011

    • Author(s)
      M.Takase, K.Tsutsui, et al
    • Journal Title

      Gen.Comp.Endocrinol.

      Volume: 170 Issue: 3 Pages: 468-474

    • DOI

      10.1016/j.ygcen.2010.10.019

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of gonadotropin-inhibitory hormone on folliculogenesis and steroidogenesis of cyclic mice2011

    • Author(s)
      P.Singh, K.Tsutsui, et al
    • Journal Title

      Fertil.Steril.

      Volume: 95 Issue: 4 Pages: 1397-1404

    • DOI

      10.1016/j.fertnstert.2010.03.052

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification, localization and expression of LPXRFamide peptides, and melatonin-dependent induction of their precursor mRNA in the newt brain2011

    • Author(s)
      V.S.Chowdhury, K.Tsutsui, et al
    • Journal Title

      J.Endocrinol.

      Volume: 209 Issue: 2 Pages: 1-12

    • DOI

      10.1530/joe-10-0494

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] (*equalcontribution) Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1 and heat shock factor pathways2011

    • Author(s)
      Hatori,M.*, Hirota,T., Fukada,Y.
    • Journal Title

      Proc. Natl. Acad. Sci. USA.

      Volume: 108 Issue: 12 Pages: 4864-4869

    • DOI

      10.1073/pnas.1015959108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification, Localisation and Functional Implication of 26RFa Orthologue Peptide in the Brain of Zebra Finch (Taeniopygia guttata)2011

    • Author(s)
      Y.Tobari, K.Tsutsui, et al
    • Journal Title

      J.Neuroendocrinol.

      Volume: 23 Issue: 9 Pages: 791

    • DOI

      10.1111/j.1365-2826.2011.02179.x

    • URL

      https://pure.teikyo.jp/en/publications/70eda0c3-6213-4976-a722-9876ed8e2497

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of GnRH and RFamide-related peptide-3 during estrous cycle of mouse : Their potential role in the ovarian activity2011

    • Author(s)
      P.Singh, K.Tsutsui, et al
    • Journal Title

      J.Mol.Histol.

      Volume: 42 Issue: 5 Pages: 371-81

    • DOI

      10.1007/s10735-011-9340-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of novel RFamide peptides in the central nervous system of the brown hagfish : isolation, localization, and functional analysis2011

    • Author(s)
      T.Osugi, K.Tsutsui, et al
    • Journal Title

      Endocrinology

      Volume: 152 Pages: 4252-4264

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hagfish, genome duplications, and RFamide neuropeptide evolution2011

    • Author(s)
      T.Osugi, K.Tsutsui, et al
    • Journal Title

      Endocrinology

      Volume: 152 Issue: 11 Pages: 4010-4013

    • DOI

      10.1210/en.2011-1375

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developmental changes in the mammalian gonadotropin-inhibitory hormone(GnIH) ortholog RFamide-related peptide(RFRP) and its cognate receptor GPR147 in the rat hypothalamus.2011

    • Author(s)
      Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Osugi T, Gereltsetseg G, Yoshida S, Irahara M, Tsutsui K.
    • Journal Title

      Int J Dev Neurosci

      Volume: 30(1) Issue: 1 Pages: 31-37

    • DOI

      10.1016/j.ijdevneu.2011.10.003

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mini-review : Molecular evolution and functional characterization of the orexigenic peptide 26RFa and its receptor in vertebrates : Discovery and comparative aspects2011

    • Author(s)
      K.Ukena, K.Tsutsui, et al
    • Journal Title

      Cell Tissue Res

      Volume: 343 Issue: 3 Pages: 475-481

    • DOI

      10.1007/s00441-010-1116-z

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Historical view of development of comparative endocrinology in Japan2011

    • Author(s)
      Kikuyama S, Tsutsui K
    • Journal Title

      Gen Comp Endocrinol

      Volume: 171 Issue: 2 Pages: 117-123

    • DOI

      10.1016/j.ygcen.2011.02.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mode of action and functional significance of 7α-hydroxypregnenolone stimulating locomotor activity2011

    • Author(s)
      Shogo Haraguchi
    • Journal Title

      Frontiers in Endocrinology

      Volume: 2 Pages: 1-8

    • DOI

      10.3389/fendo.2011.00023

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Neurosteroid biosynthesis and function in the brain of domestic birds2011

    • Author(s)
      K.Tsutsui
    • Journal Title

      Front.Endocrin.

      Volume: 2:article 37 Pages: 1-14

    • DOI

      10.3389/fendo.2011.00037

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthesis, mode of action and functional significance of neurosteroids in the Purkinje cell2011

    • Author(s)
      Kazuyoshi Tsutsui
    • Journal Title

      Frontiers in Endocrinology

      Volume: 2 Pages: 1-9

    • DOI

      10.3389/fendo.2011.00061

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Neurosteroid biosynthesis in the brain of amphibians2011

    • Author(s)
      H.Vaudry, K.Tsutsui, et al
    • Journal Title

      Front.Endocrin

      Volume: 2:article 79 Pages: 1-9

    • DOI

      10.3389/fendo.2011.00079

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estradiol promotes Purkinje dendritic growth, spinogenesis and synaptogenesis during neonatal life by inducing the expression of BDNF2011

    • Author(s)
      Shogo Haraguchi
    • Journal Title

      The Cerebellum

      Volume: (in press) Issue: 2 Pages: 416-417

    • DOI

      10.1007/s12311-011-0342-6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Light-dependent and circadian clock-regulated activation of SREBP, XBP1 and HSF pathways2011

    • Author(s)
      M.Hatori, T.K.Tsutsui, 他
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 108 Pages: 4864-4869

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synchronised expressions of LPXRFamide peptide and its receptor genes : seasonal, diurnal and circadian changes during spawning period in grass puffer2011

    • Author(s)
      M.Shahjahan, K.Tsutsui, 他
    • Journal Title

      J.Neuroendocrinol.

      Volume: 23 Pages: 39-51

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Historical view of development of comparative endocrinology in Japan2011

    • Author(s)
      S.Kikuyama, K.Tsutsui
    • Journal Title

      Gen.Comp.Endocrinol.

      Volume: 171 Pages: 117-123

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GnIHの発見とGnIH研究の進展・展望-鳥類から哺乳類、ヒトへの展開2011

    • Author(s)
      筒井和義
    • Journal Title

      比較内分泌学

      Volume: 37 Pages: 21-28

    • NAID

      10027947486

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterozygous OTX2 mutations are associated with variable pituitary phenotype2010

    • Author(s)
      Dateki S, Fukami M, Ogata T, 他
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 95(2) Pages: 756-764

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothalamic dysfunction in a female with isolated hypogonadotropic hypogonadism and compound heterozygous TACR3 mutations and clinical manifestation in her heterozygous mother2010

    • Author(s)
      Fukami M, Ogata T, 他
    • Journal Title

      Horm Res Peadiatr

      Volume: 73(6) Pages: 477-481

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency : identification of a single patient with LHX4 deletion2010

    • Author(s)
      Dateki S, Fukami M, Ogata T, 他
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 95(8) Pages: 4043-4047

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anorectal and urinary anomalies and aberrant retinoic acid metabolism in cytochrome P450 oxidoreductase deficiency2010

    • Author(s)
      Fukami M, Nagai T, Mochizuki H, Muroya K, Yamada G, Takitani K, Ogata T
    • Journal Title

      Mol Genet Metab

      Volume: 100(3) Pages: 269-273

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel loss of function mutation in OTX2 is associated with phenotypically variable anophthalmia and isolated growth hormone deficiency2010

    • Author(s)
      Ashkenazi-Hoffnung L, Ogata T, 他
    • Journal Title

      Hum Genet

      Volume: 127(6) Pages: 721-729

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Semen analysis and successful paternity by intracytoplasmic sperm injection in a man with steroid 5α-reductase-2 deficiency2010

    • Author(s)
      Matsubara K, Iwamoto H, Yoshida A, Ogata T
    • Journal Title

      Fertil Steril

      Volume: 94(7)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of chromosome 15q terminal deletion with telomere sequences and its bearing on genotype-phenotype analysis2010

    • Author(s)
      Dateki S, Fukami M, Ogata T, 他
    • Journal Title

      Endocr J

      Volume: (accepted)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exonic polymorphisms of MAMLD1 (CXorf6) are associated with hypospadias2010

    • Author(s)
      Kalfa N, Fukami M, Ogata T, 他
    • Journal Title

      J Urol

      Volume: (accepted)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aromatase excess syndrome : identification of cryptic duplications and deletions leading to gain-of-function of CYP19A1 and assessment of phenotypic determinants2010

    • Author(s)
      Fukami M, Ogata T, 他
    • Journal Title

      J Clin Endocrinol Metab

      Volume: (accepted)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中枢性性腺機能低下症2010

    • Author(s)
      深見真紀, 伊達木澄人, 緒方勤
    • Journal Title

      Horm Front Gynecol

      Volume: 17(2) Pages: 4-8

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Prokineticin signaling pathwayとKallmann症候群2010

    • Author(s)
      佐藤直子, 緒方勤
    • Journal Title

      医のあゆみ

      Volume: 233(9) Pages: 934-938

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-dependent variation in the RFRP-3 neurons is inversely correlated with gonadal activity of mice2010

    • Author(s)
      S.Sethi, K.Tsutsui, C.M.Chaturvedi
    • Journal Title

      Gen.Comp.Endocrinol.

      Volume: 168 Pages: 326-332

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photoperiod and reproductive condition are associated with changes in RFamide-related peptide (RFRP) expression in Syrian hamsters (Mesocricetus auratus)2010

    • Author(s)
      A.O.Mason, K.Tsutsui, 他
    • Journal Title

      J.Biol.Rhythm.

      Volume: 25 Pages: 176-85

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification, localization and function of a novel avian hypothalamic neuropeptide, 26RFa, and its cognate receptor, GPR1032010

    • Author(s)
      K.Ukena, K.Tsutsui, 他
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 2255-2264

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolactin increases the synthesis of 7□-hydroxypregnenolone, a key factor for induction of locomotor activity, in breeding male newts2010

    • Author(s)
      S.Haraguchi, K.Tsutsui, 他
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 2211-2222

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of gonadotropin-inhibitory hormone in the zebra finch(Taeniopygia guttata) : peptide isolation, cDNA cloning and brain distribution2010

    • Author(s)
      Y.Tobari, N.K.Tsutsui, 他
    • Journal Title

      Peptides

      Volume: 31 Pages: 816-826

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b62010

    • Author(s)
      M.Doi, K.Tsutsui, 他
    • Journal Title

      Nature Medicine

      Volume: 16 Pages: 67-74

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RFamide-related peptide (RFRP) and mRNA expression in mammaliantestis : Association with the spermatogenic cycle2010

    • Author(s)
      S.Zhao, K.Tsutsui, 他
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 617-627

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin stimulates the release of gonadotropin-inhibitory hormone by the avian hypothalamus2010

    • Author(s)
      V.S.Chowdhury, K.Tsutsui, 他
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 271-280

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal phase relation of circadian neural oscillations alters RFamide-related peptide-3 (RFRP-3), a mammalian gonadotropin-inhibitory hormone (GnIH) homolog, and testicular function in the mouse (Mus musculus)2010

    • Author(s)
      S.Sethi, K.Tsutsui, C.M.Chaturvedi
    • Journal Title

      Neuroendocrinology

      Volume: 91 Pages: 189-199

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular evolution and functional characterization of the orexigenic peptide 26RFa and its receptor in vertebrates : Discovery and comparative aspects2010

    • Author(s)
      K.Ukena, H.Vaudry, J.Leprince, K.Tsutsui
    • Journal Title

      Cell Tissue Res.

      Volume: 343 Pages: 475-481

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 7□-Hydroxypregnenolone, a new key regulator of locomotor activity of vertebrates : Identification, mode of action and functional significance2010

    • Author(s)
      K.Tsutsui, 他
    • Journal Title

      Front.Endocrin.

      Volume: 1 Pages: 1-13

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent studies of Gonadotropin-Inhibitory Hormone (GnIH) in the mammalian hypothalamus, pituitary and gonads2010

    • Author(s)
      G.E.Bentley, K.Tsutsui, L.J.Kriegsfeld
    • Journal Title

      Brain Res.

      Volume: 1364 Pages: 62-71

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of 7□-hydroxypregnenolone, a novel bioactive amphibian neurosteroid stimulating locomotor activity, and its physiological roles in the regulation of locomotion2010

    • Author(s)
      K.Tsutsui, 他
    • Journal Title

      Gen.Comp.Endocrinol.

      Volume: 168 Pages: 275-279

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery and Evolutionary History of GnIH and Kisspeptin : New Key Neuropeptides Controlling Reproduction2010

    • Author(s)
      K.Tsutsui, 他
    • Journal Title

      J.Neuroendocrinol

      Volume: 22 Pages: 716-727

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The roles of RFamide-related peptide-3 (RFRP-3) in mammalian reproductive function and behaviour2010

    • Author(s)
      L.J.Kriegsfeld, K.Tsutsui, 他
    • Journal Title

      J.Neuroendocrinol

      Volume: 22 Pages: 692-700

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone (GnIH) and its control of central and peripheral reproductive function2010

    • Author(s)
      K.Tsutsui, 他
    • Journal Title

      Front.Neuroendocrinol.

      Volume: 31 Pages: 284-295

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phylogenetic aspects of gonadotropin-inhibitory hormone (GnIH)and its homologs in vertebrates2010

    • Author(s)
      K.Tsutsui
    • Journal Title

      Ann.N.Y.Acad.Sci.

      Volume: 1200 Pages: 75-84

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 性周期とニューロペプチド2010

    • Author(s)
      筒井和義・産賀崇由
    • Journal Title

      Hormone Frontier in Gynecology

      Volume: 17 Pages: 25-29

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GnIHによるゴナドトロピン分泌制御.特集/生殖機能調節の新しい視点2010

    • Author(s)
      筒井和義
    • Journal Title

      産科と婦人科

      Volume: 77 Pages: 252-258

    • NAID

      40017005894

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between fetal myocardial tissue Doppler indices before birth and gestational age-specific birth weight in low-risk term pregnancies

    • Author(s)
      Sekii K, Ogata T, et al
    • Journal Title

      Ultrasound Obstet Gynecol

      Volume: (accepted)(Epub ahead of print)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complex genomic rearrangements in the SOX9 5' region in a patient with Pierre Robin sequence and hypoplastic left scapula

    • Author(s)
      Fukami M, Ogata T, et al
    • Journal Title

      Am J Med Genet A

      Volume: (accepted)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Haplotype analysis of ESR2 in Japanese patients with spermatogenic failure : Implications for genetic susceptibility to estrogenic environmental endocrine disruptors

    • Author(s)
      Ogata T, Fukami M, et al
    • Journal Title

      Int J Androl

      Volume: (accepted)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular bases and phenotypic determinants of aromatase excess syndrome

    • Author(s)
      Fukami M, Shozu M, Ogata T
    • Journal Title

      Int J Endocrinol

      Volume: (accepted)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MAMLD1 and 46,XY disorders of sex development

    • Author(s)
      Ogata T, Sano S, et al
    • Journal Title

      Seminars in Reproductive Medicine

      Volume: (accepted)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 性分化疾患における性同一性障害:性差構築からみる性同一性障害の治療戦略2015

    • Author(s)
      緒方勤
    • Organizer
      GID(性同一性障害)学会 第17回研究大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-03-21 – 2015-03-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Environmental Impacts on Male Sexual Differentiation.2014

    • Author(s)
      Ogata T
    • Organizer
      16th International Congress of Endocrinology & the Endocrine Society’s 96th Annual Meeting & Expo
    • Place of Presentation
      シカゴ(米国)
    • Year and Date
      2014-06-21 – 2014-06-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 精子形成障害と内分泌撹乱化学物質感受性.2014

    • Author(s)
      緒方勤
    • Organizer
      第33回アンドロロジー学会
    • Place of Presentation
      軽井沢
    • Year and Date
      2014-06-12 – 2014-06-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] わかりやすい臨床遺伝学2014

    • Author(s)
      緒方勤
    • Organizer
      第9回日本小児耳鼻咽喉科学会
    • Place of Presentation
      浜松
    • Year and Date
      2014-06-06 – 2014-06-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] インプリンティング疾患発症機序について2014

    • Author(s)
      緒方勤
    • Organizer
      第56回日本小児神経学会
    • Place of Presentation
      浜松
    • Year and Date
      2014-05-29 – 2014-05-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Genetics of DSD (Disorders of sex development)2014

    • Author(s)
      Ogata T
    • Organizer
      PAS/ASPR (Pediatric Academic Societies and Asian Society for Pediatric Research) 2014.
    • Place of Presentation
      バンクーバー(カナダ)
    • Year and Date
      2014-05-03 – 2014-05-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] インプリンティング機構と胎児・胎盤の成長2014

    • Author(s)
      緒方勤
    • Organizer
      第87回日本内分泌学会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 四肢形成不全の分子遺伝学:裂手裂足症およびその関連疾患の発症機序 2014年4月17–18日,那覇.2014

    • Author(s)
      緒方勤
    • Organizer
      第57回日本手外科学会学術集会
    • Place of Presentation
      那覇
    • Year and Date
      2014-04-17 – 2014-04-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 内分泌撹乱環境化学物質と男児外性器異常2014

    • Author(s)
      緒方勤
    • Organizer
      第117回日本小児科学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-04-11 – 2014-04-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Progress in comparative endocrinology by discovering novel neuropeptides and neurosteroids2014

    • Author(s)
      K. Tsutsui
    • Organizer
      The 7th Intercongress symposium of the Asia and Oceania Society for the Comparative Endocrinology (AOSCE)
    • Place of Presentation
      National Taiwan Ocean University, Keelung, Taiwan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ineal allopregnanolone saves purkinje cells from apoptosis in the cerebellum.2014

    • Author(s)
      S. Haraguchi, S. Hara, T. Ubuka, K. Tsutsui
    • Organizer
      The 7th Intercongress symposium of the AOSCE
    • Place of Presentation
      National Taiwan Ocean University, Keelung, Taiwan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Transcriptional activation of gonadotropin-inhibitory hormone by corticosterone2014

    • Author(s)
      Y. L. Son, T. Ubuka, M. Narihiro, Y. Fukuda, I. Hasunuma, K. Yamamoto, D. D. Belsham, K. Tsutsui
    • Organizer
      The 7th Intercongress symposium of the AOSCE
    • Place of Presentation
      National Taiwan Ocean University, Keelung, Taiwan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Genetics of Combined Pituitary Hormone Deficiency. In: Symposium, Neuroendocrinology, Novel Players in Pituitary Disorders. 2013 Seoul International Congress of Endocrinology and Metabolism;2013

    • Author(s)
      Ogata T
    • Organizer
      In conjunction with the 32nd Annual Meeting of the Korean Endocrine Society
    • Place of Presentation
      Seoul, South Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Genetic advances in DSD2013

    • Author(s)
      Ogata T
    • Organizer
      The Joint Summer School for Pediatric Endocrinology.
    • Place of Presentation
      Lake Maggiore, Italy
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 脳の性分化に関する最近の知見2013

    • Author(s)
      緒方勤
    • Organizer
      第22回日本小児泌尿器科学会教育講演
    • Place of Presentation
      東京ビックサイトTFTホール(東京都江東区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 性分化疾患の発症機序:最新の知見2013

    • Author(s)
      緒方勤
    • Organizer
      日本アンドロロジー学会第32回学術大会・第19回精子形成・精巣毒性研究会共同開催学会特別講演
    • Place of Presentation
      グランキューブ大阪(大阪府大阪市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 生殖補助医療と小児医療の接点2013

    • Author(s)
      緒方勤
    • Organizer
      オーバービュー.第116回日本小児科学会学術集会:生殖補助医療と小児医療の接点
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 先天性副腎ステロイド合成異常症2013

    • Author(s)
      緒方勤
    • Organizer
      シンポジウム:ステロイドホルモン研究Update.第86回日本内分泌学会学術集会.
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] インプリンティング疾患の遺伝子診断2013

    • Author(s)
      緒方勤
    • Organizer
      第14染色体父性ダイソミー表現型をモデルとして.シンポジウム:単因子疾患の遺伝子診療.第20回日本遺伝子診療学会
    • Place of Presentation
      浜松
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 生殖補助医療とインプリンティング疾患発症2013

    • Author(s)
      緒方勤
    • Organizer
      シンポジウム:疾患から見たARTとエピゲノム.第31回日本受精着床学会学術集会
    • Place of Presentation
      別府
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Gonadotropin-inhibitory hormone (GnIH), a new key neurohormone regulating reproduction: Discovery, progress and perspective2013

    • Author(s)
      K. Tsutsui
    • Organizer
      The International Conference on Comparative Endocrinology and Physiology (ICCEP-2013)
    • Place of Presentation
      RTM Nagpur University, Nagpur, India
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Breakthrough in neuroendocrinology by discovering novel neuropeptides and neurosteroids (特別講演: Bargmann-Scharrer Lecture)2013

    • Author(s)
      K. Tsutsui
    • Organizer
      The 17th International Congress of Comparative Endocrinology (ICCE),
    • Place of Presentation
      University of Barcelona, Barcelona, Spain
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Pineal allopregnanolone saves cerebellar Purkinje cells from apoptosis2013

    • Author(s)
      S. Haraguchi, S. Hara, T. Ubuka, M. Mita, K. Tsutsui
    • Organizer
      The 17th ICCE
    • Place of Presentation
      University of Barcelona, Barcelona, Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] Female presence increases gonadotropin-inhibitory hormone gene expression by decreasing norepinephrine in the male quail brain (招待講演)2013

    • Author(s)
      Y. Tobari, Y. L. Son, Y. Hasegawa, K. Tsutsui
    • Organizer
      The 17th ICCE
    • Place of Presentation
      University of Barcelona, Barcelona, Spain
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Gonadotropin-inhibitory hormone inhibits AC/cAMP/PKA-mediated signaling pathway in gonadotropes and GnRH neurons2013

    • Author(s)
      Y. L. Son, T. Ubuka, R. P. Millar, K. Tsutsui
    • Organizer
      The 17th ICCE
    • Place of Presentation
      University of Barcelona, Barcelona, Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gonadotropin-inhibitory hormone inhibits aggressive behavior by increasing estrogen synthesis in the brain beyond its optimum concentration2013

    • Author(s)
      T. Ubuka, S. Haraguchi, N. Harada, K. Tsutsui
    • Organizer
      The 17th ICCE
    • Place of Presentation
      University of Barcelona, Barcelona, Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生殖を抑制する新規脳ホルモンの発見と研究進展:鳥類から哺乳類への展開2013

    • Author(s)
      筒井和義
    • Organizer
      第2回実験動物科学シンポジウム-新たなライフサイエンス研究の展開-鳥類リソースの整備と活用に向けて
    • Place of Presentation
      名古屋大学野依記念学術交流館(名古屋市千種区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The signaling pathway mediating the inhibitory effect of gonadotropin-inhibitory hormone (GnIH) in gonadotropes and GnRH neurons2013

    • Author(s)
      Y. L. Son, T. Ubuka, K. Tsutsui
    • Organizer
      第18回日本生殖内分泌学会学術集会
    • Place of Presentation
      シェーンバッハ・サボー(東京都千代田区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Biosynthesis and biological action of pineal neurosteroids in birds2013

    • Author(s)
      K. Tsutsui, S. Haraguch
    • Organizer
      第37回鳥類内分泌研究会
    • Place of Presentation
      アソシエート(熊本県阿蘇郡)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neuroendocrine mechanisms translating social stimuli into reproductive physiology and behavior2013

    • Author(s)
      Y. Tobari, Y. L. Son, T. Ubuka, Y. Hasegawa, K. Tsutsui
    • Organizer
      第37回鳥類内分泌研究会
    • Place of Presentation
      アソシエート(熊本県阿蘇郡)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 視床下部ホルモンの比較内分泌学2013

    • Author(s)
      筒井和義
    • Organizer
      第38回日本比較内分泌学会大会・小林英司先生記念シンポジウム
    • Place of Presentation
      宮崎市民プラザ(宮崎県宮崎市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] サケの遡上行動を促進する7alpha-ヒドロキシプレグネノロンの作用機構2013

    • Author(s)
      鈴木悠子、原口省吾、山本雄三、張雋螢、小山鉄平、三田雅敏、上田宏、筒井和義
    • Organizer
      第38回日本比較内分泌学会大会・小林英司先生記念シンポジウム
    • Place of Presentation
      宮崎市民プラザ(宮崎県宮崎市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 精巣由来アンドロゲンによる脳内7alpha-ヒドロキシプレグネノロン合成制御2013

    • Author(s)
      原口省吾、鈴木悠子、田代渓一郎、三田雅敏、筒井和義
    • Organizer
      第38回日本比較内分泌学会大会・小林英司先生記念シンポジウム
    • Place of Presentation
      宮崎市民プラザ(宮崎県宮崎市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] サケの遡上行動を促進する7alpha-ヒドロキシプレグネノロンの作用機構2013

    • Author(s)
      鈴木悠子、原口省吾、山本雄三、張雋螢、小山鉄平、三田雅敏、上田宏、筒井和義
    • Organizer
      第84回日本動物学会大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山県岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 松果体で合成されたアロプレグナノロンは小脳プルキンエ細胞の細胞死を防ぐ2013

    • Author(s)
      原口省吾、原桜子、産賀崇由、三田雅敏、筒井和義
    • Organizer
      第84回日本動物学会大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山県岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] GnIHによるGnRHニューロン内シグナリング抑制機構2013

    • Author(s)
      孫ユリ、産賀崇由、筒井和義
    • Organizer
      第84回日本動物学会大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山県岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] GnIH はニューロエストロゲン合成を促進して攻撃行動を抑制する2013

    • Author(s)
      産賀崇由、原口省吾、原田信弘、筒井和義
    • Organizer
      第84回日本動物学会大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山県岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生殖生理と生殖行動を変化させる社会的刺激の脳内機構2013

    • Author(s)
      戸張靖子、孫ユリ、産賀崇由、長谷川喜久、筒井和義
    • Organizer
      第84回日本動物学会大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山県岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Kiss2の分子進化に関する研究2013

    • Author(s)
      大杉知裕、大滝直仁、砂川裕哉、孫ユリ、大久保誠、飯郷雅之、天野勝文、筒井和義
    • Organizer
      第84回日本動物学会大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山県岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] GnIHによる視床下部P450arom活性の制御と性差2013

    • Author(s)
      産賀崇由、筒井和義
    • Organizer
      新学術領域研究「性差構築の分子基盤」第5回領域会議
    • Place of Presentation
      国民宿舎虹の松原ホテル(佐賀県唐津市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 視床下部ホルモンの発見と比較内分泌学の進展2013

    • Author(s)
      筒井和義
    • Organizer
      東京大学大気海洋研究所共同利用研究集会-海洋生物のさまざまな適応戦略
    • Place of Presentation
      東京大学大気海洋研究所(千葉県柏市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 脳におけるprogesteroneとallopregnanoloneの生合成と生理作用2013

    • Author(s)
      筒井和義
    • Organizer
      第2回プロゲストーゲン研究会
    • Place of Presentation
      第一ホテル東京(東京都港区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] バックドア経路:テストステロンを経由しないジヒドロテストステロン産生経路2012

    • Author(s)
      緒方勤
    • Organizer
      第35回日本分子生物学会学術集会ワークショップ 哺乳類の性分化・性成熟の新知見 性腺機能を制御する遺伝子ネットワークとその破綻による疾患
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Aromatase Excess Syndrome as a Model for Genomic Disorder: Identification of Molecular Bases and Phenotypic Determinants.2012

    • Author(s)
      Ogata T, Shozu M, Fukami M
    • Organizer
      Kaichi Kida Session. The 7th Asia Pacific Paediatric Endocrine Society Meeting.
    • Place of Presentation
      Bali, Indonesia.
    • Year and Date
      2012-11-14
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Genetics of DSD (Disorders of sex development).2012

    • Author(s)
      Ogata T
    • Organizer
      Disorders of sex development. The 15th International and 14th European Congress of Endocrinology (ICE/ECE).
    • Place of Presentation
      Florence, Italy.
    • Year and Date
      2012-05-05
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Cytochrome P450 Oxidoreductase Deficiency: A Unique Disease Leading to Disorders of Sex Development in Both 46,XY and 46,XX Patients. Invited Lecture.2012

    • Author(s)
      Ogata T
    • Organizer
      The 6th International Symposium on the Biology of Vertebrate Sex Determination.
    • Place of Presentation
      Kona Hawaii, USA.
    • Year and Date
      2012-04-23
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 胎児期における環境化学物質と先天奇形の発症2012

    • Author(s)
      緒方勤
    • Organizer
      第115回日本小児科学会学術集会:子どもの健康と環境に関する全国調査(エコチル調査)と小児内分泌代謝疾患
    • Place of Presentation
      福岡
    • Year and Date
      2012-04-20
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 性の分化・発達と小児医療2012

    • Author(s)
      緒方勤
    • Organizer
      第188回浜松市小児科医会研究会
    • Place of Presentation
      浜松
    • Year and Date
      2012-03-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mollusc gonadotropin-releasing hormone directly regulates gonadal functions : A primitive endocrine system controlling reproduction2012

    • Author(s)
      N.Treen, K.Tsutsui, et al
    • Organizer
      The 7th Congress of the Asia and Oceania Society for Comparative Endocrinology
    • Place of Presentation
      Sunway Resort Hotel, Kuala Lumpur, Malaysia
    • Year and Date
      2012-03-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evolutionary origin of the structure and function of gonadotropin-inhibitory hormone (GnIH)2012

    • Author(s)
      T.Osugi, K.Tsutsui, et al
    • Organizer
      The 7th Congress of the Asia and Oceania Society for Comparative Endocrinology
    • Place of Presentation
      Sunway Resort Hotel, Kuala Lumpur, Malaysia
    • Year and Date
      2012-03-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Acute stress increases the synthesis of 7alpha-hydroxypregnenolone, a new key neurosteroid stimulating locomotor activity, through corticosteroneaction2012

    • Author(s)
      S.Haraguchi, K.Tsutsui, et al
    • Organizer
      The 7th Congress of the Asia and Oceania Society for Comparative Endocrinology
    • Place of Presentation
      Sunway Resort Hotel, Kuala Lumpur, Malaysia
    • Year and Date
      2012-03-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification and distribution of gonadotropin-inhibitory hormone (GnIH) in the brain of Zebra finch2012

    • Author(s)
      Y.Tobari, K.Tsutsui, et al
    • Organizer
      The 7th Congress of the Asia and Oceania Society for Comparative Endocrinology
    • Place of Presentation
      Sunway Resort Hotel, Kuala Lumpur, Malaysia
    • Year and Date
      2012-03-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 性分化疾患の基礎と臨床2012

    • Author(s)
      緒方勤
    • Organizer
      第58回愛媛県小児科医会特別講演
    • Place of Presentation
      松山
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 性分化疾患とゲノム異常2012

    • Author(s)
      緒方勤
    • Organizer
      第15回宮崎代謝内分泌研究会
    • Place of Presentation
      宮崎
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 環境ホルモン物質の子どもへの影響2012

    • Author(s)
      緒方勤
    • Organizer
      松葉のダイオキシン調査実行委員会研修会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Create new research directions in comparative endocrinology from Asia and Oceania2012

    • Author(s)
      K.Tsutsui
    • Organizer
      The 7th Congress of the Asia and Oceania Society for Comparative Endocrinology
    • Place of Presentation
      Sunway Resort Hotel, Kuala Lumpur, Malaysia
    • Related Report
      2011 Annual Research Report
  • [Presentation] Melatonin stimulates the synthes's and release of gonadotropin-inhibitory hormone in birds2012

    • Author(s)
      V.S.Chowdhury, T.Ubuka, K.Tsutsui
    • Organizer
      The 7th Congress of the Asia and Oceania Society for Comparative Endocrinology
    • Place of Presentation
      Sunway Resort Hotel, Kuala Lumpur, Malaysia
    • Related Report
      2011 Annual Research Report
  • [Presentation] RNA interference of gonadotropin-inhibitory hormone gene induces aggressive and sexual behaviors in birds2012

    • Author(s)
      T.Ubuka, K.Tsutsui
    • Organizer
      The 7th Congress of the Asia and Oceania Society for Comparative Endocrinology
    • Place of Presentation
      Sunway Resort Hotel, Kuala Lumpur, Malaysia
    • Related Report
      2011 Annual Research Report
  • [Presentation] 「システム生命科学による医・理・工学の先端研究」生体機能を調節する脳ホルモンの発見と理解の到達点2011

    • Author(s)
      筒井和義
    • Organizer
      ハイテクジョイントシンポジウム
    • Place of Presentation
      早稲田大学理工学部50号館・東京
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] ターナー症候群を招く分子基盤2011

    • Author(s)
      緒方勤
    • Organizer
      第7回北関東遺伝診療フォーラム
    • Place of Presentation
      大宮
    • Year and Date
      2011-12-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] キンカチョウの脳における生殖線刺激ホルモン放出抑制ホルモン(GnIH)の同定と脳内分布2011

    • Author(s)
      戸張靖子、筒井和義, 他
    • Organizer
      第36回日本比較内分泌学会大会
    • Place of Presentation
      都道府県会館・東京
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] ハムスターの生殖腺刺激ホルモン放出抑制ホルモン(GnIH)の同定、発現制御および生理作用2011

    • Author(s)
      産賀崇由、筒井和義, 他
    • Organizer
      第36回日本比較内分泌学会大会
    • Place of Presentation
      都道府県会館・東京
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] ウシガエルの脳におけるneuropeptide FF cDNAのクローニングと内因性リガンドの同定2011

    • Author(s)
      大杉知裕、筒井和義, 他
    • Organizer
      第36回日本比較内分泌学会大会
    • Place of Presentation
      都道府県会館・東京
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] メダカ脳におけるgonadotropin-inhibitory hormone (GnIH) cDNAのクローニング2011

    • Author(s)
      岡村友貴、筒井和義, 他
    • Organizer
      第36回日本比較内分泌学会大会
    • Place of Presentation
      都道府県会館・東京
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] The mammalian GnIH ortholog RFRP inhibits gonadotropin gene expression by inhibiting AC/cAMP/PKA-mediated ERK activation2011

    • Author(s)
      Kazuyoshi Tsutsui, et al
    • Organizer
      第36回日本比較内分泌学会大会
    • Place of Presentation
      都道府県会館・東京
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] ストレスが誘導する脳内7alpha-ヒドロキシプレグネノロン合成の変動とその制御機構2011

    • Author(s)
      原口省吾、筒井和義, 他
    • Organizer
      第36回日本比較内分泌学会大会
    • Place of Presentation
      都道府県会館・東京
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 遡上中のサケの脳内では7alpha-ヒドロキシプレグネノロンの合成が高まる2011

    • Author(s)
      チャンジュンヒョン、筒井和義, 他
    • Organizer
      第36回日本比較内分泌学会大会
    • Place of Presentation
      都道府県会館・東京
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 無脊椎動物の脳におけるニューロステロイド合成:棘皮動物ヒトデの解析2011

    • Author(s)
      市丸修子、筒井和義, 他
    • Organizer
      第36回日本比較内分泌学会大会
    • Place of Presentation
      都道府県会館・東京
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 無脊椎動物の脳におけるニューロステロイド合成:頭足類マダコの解析2011

    • Author(s)
      喜多悠斗、筒井和義, 他
    • Organizer
      第36回日本比較内分泌学会大会
    • Place of Presentation
      都道府県会館・東京
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] ステロイド性の雌イモリ誘引フェロモン2011

    • Author(s)
      豊田ふみよ、筒井和義, 他
    • Organizer
      第36回日本比較内分泌学会大会
    • Place of Presentation
      都道府県会館・東京
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Bivalve mollusc gonadotropin-releasing hormone2011

    • Author(s)
      Kazuyoshi Tsutsui, et al
    • Organizer
      第36回日本比較内分泌学会大会
    • Place of Presentation
      都道府県会館・東京
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生殖を制御する新規脳ホルモンGnIHの起源と分子進化2011

    • Author(s)
      筒井和義
    • Organizer
      第36回日本比較内分泌学会大会シンポジウム
    • Place of Presentation
      都道府県会館・東京
    • Year and Date
      2011-11-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 性分化疾患の分子基盤と臨床的対応2011

    • Author(s)
      緒方勤
    • Organizer
      第117回日本小児科学会甲信地方会
    • Place of Presentation
      甲府
    • Year and Date
      2011-11-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子どもを取り巻く環境と小児の健康2011

    • Author(s)
      緒方勤
    • Organizer
      第40回Medical Photonics Seminar
    • Place of Presentation
      浜松
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] キンカチョウの脳における26RFaペプチドの同定と機能解析2011

    • Author(s)
      戸張靖子、筒井和義, 他
    • Organizer
      第82回日本動物学会大会
    • Place of Presentation
      大雪アリーナ旭川
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] メダカの脳における生殖腺刺激ホルモン放出抑制ホルモン(GnIH)cDNAのクローニング2011

    • Author(s)
      岡村友貴、筒井和義, 他
    • Organizer
      第82回日本動物学会大会
    • Place of Presentation
      大雪アリーナ旭川
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヤツメウナギの脳におけるLPXRFamideペプチドの同定と機能解析2011

    • Author(s)
      大杉知裕、筒井和義, 他
    • Organizer
      第82回日本動物学会大会
    • Place of Presentation
      大雪アリーナ旭川
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] GnHはAC/cAMP/PKAシグナリングによりゴナドトロピン発現を抑制する2011

    • Author(s)
      ソン ユリ、筒井和義, 他
    • Organizer
      第82回日本動物学会大会
    • Place of Presentation
      大雪アリーナ旭川
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] ストレスは生殖腺刺激ホルモン放出抑制ホルモン(GnIH)とその受容体の発現を増加させる2011

    • Author(s)
      福田裕治郎、筒井和義, 他
    • Organizer
      第82回日本動物学会大会
    • Place of Presentation
      大雪アリーナ旭川
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] ストレスによる脳内7alpha-ヒドロキシプレグネノロン合成の変動とその生理作用2011

    • Author(s)
      原口省吾、筒井和義, 他
    • Organizer
      第82回日本動物学会大会
    • Place of Presentation
      大雪アリーナ旭川
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] テストステロンによる生殖腺刺激ホルモン放出抑制ホルモン(GnIH)受容体の発現制御機構2011

    • Author(s)
      水野貴信、筒井和義, 他
    • Organizer
      第82回日本動物学会大会
    • Place of Presentation
      大雪アリーナ旭川
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 雄イモリ腹腺由来ステロイドの雌誘引作用2011

    • Author(s)
      豊田ふみよ、筒井和義, 他
    • Organizer
      第82回日本動物学会大会
    • Place of Presentation
      大雪アリーナ旭川
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 遡上中のサケの脳では活動性を高める7alpha-ヒドロキシプレグネノロンの合成が高まる2011

    • Author(s)
      チャンジュンヒヨン、筒井和義, 他
    • Organizer
      第82回日本動物学会大会
    • Place of Presentation
      大雪アリーナ旭川
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] プルキンエ細胞における7alpha-ヒドロキシプレグネノロン合成の変動とその制御機構2011

    • Author(s)
      奥山真一郎、筒井和義, 他
    • Organizer
      第82回日本動物学会大会
    • Place of Presentation
      大雪アリーナ旭川
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neurosteroid biosynthesis and action during cerebellar development2011

    • Author(s)
      K.Tsutsui
    • Organizer
      The 4th International Symposium : Society for Research on the Cerebellum
    • Place of Presentation
      University of Tokyo, Tokyo, Japan
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 性分化疾患の分子基盤:update2011

    • Author(s)
      緒方勤
    • Organizer
      第12回山陰内分泌研究会
    • Place of Presentation
      米子
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 性分化疾患の分子基盤2011

    • Author(s)
      緒方勤
    • Organizer
      第3回岐阜小児内分泌学術講演会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 性分化疾患研究の進歩2011

    • Author(s)
      緒方勤
    • Organizer
      第81回京都内分泌同好会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヌーナン症候群とGH治療2011

    • Author(s)
      緒方勤
    • Organizer
      ヌーナン症候群勉強会
    • Place of Presentation
      東京
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子どもを取り巻く環境と健康2011

    • Author(s)
      緒方勤
    • Organizer
      浜松小児科医会
    • Place of Presentation
      浜松
    • Year and Date
      2011-07-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 乳幼児期および思春期の性について2011

    • Author(s)
      緒方勤
    • Organizer
      第1回乳幼児発達指導研究会
    • Place of Presentation
      浜松
    • Year and Date
      2011-07-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] SHOX遺伝子異常症2011

    • Author(s)
      緒方勤
    • Organizer
      Update.Forum on Turner syndrome in Osaka
    • Place of Presentation
      大阪
    • Year and Date
      2011-07-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Melatonin regulates diurnal changes in locomotor activity by regulating 7alpha-hydroxypregnenolone synthesis in newts2011

    • Author(s)
      K.Tsutsui, et al
    • Organizer
      The inaugural meeting of the North American Society for Comparative Endocrinology (NASCE 2011)
    • Place of Presentation
      Michigan
    • Year and Date
      2011-07-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification, mode of action and functional significance of 7alpha-hydroxypregnenolone, a new key regulator of amphibian locomotion2011

    • Author(s)
      K.Tsutsui, H.Vaudry
    • Organizer
      The 7th International Symposium on Amphibian and Reptilian Endocrinology and Neurobiology
    • Place of Presentation
      University of Michigan, Ann Arbor, USA
    • Year and Date
      2011-07-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 7alpha-Hydroxypregnenolone acts as a serotonin-inducing factor to increase locomotor activity via corticosterone action under stress2011

    • Author(s)
      S.Haraguchi, K.Tsutsui, et al
    • Organizer
      The 7th International Symposium on Amphibian and Reptilian Endocrinology and Neurobiology (ISAREN)
    • Place of Presentation
      Michigan
    • Year and Date
      2011-07-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genetic susceptibility to endocrine disrupters : Estrogen receptor polymorphisms2011

    • Author(s)
      Ogata T
    • Organizer
      In : Hamamatsu DOHaD Conference
    • Place of Presentation
      Hamamatsu, Japan
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子どもの成長と成熟2011

    • Author(s)
      緒方勤
    • Organizer
      国際医療福祉大学熱海病院学術講演会
    • Place of Presentation
      熱海
    • Year and Date
      2011-07-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 中枢性性線機能低下症の基礎と臨床2011

    • Author(s)
      緒方勤
    • Organizer
      静岡産科婦人科学会春季学術集会
    • Place of Presentation
      静岡
    • Year and Date
      2011-06-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Discovery and evolutionary history of gonadotropin-inhibitory hormone (GnIH), a new key neuropeptide controlling reproduction2011

    • Author(s)
      K.Tsutsui
    • Organizer
      The 8th International Congress of Comparative Physiology and Biochemistry (ICCPB2011)
    • Place of Presentation
      Nagoya Congress Center, Nagoya, Japan
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] ニューロステロイドの生合成とオーガナイジング作用2011

    • Author(s)
      筒井和義
    • Organizer
      第84回日本内分泌学会学術総会教育講演
    • Place of Presentation
      神戸国際会議場・神戸
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生殖腺刺激ホルモン放出抑制ホルモン(GnIH)とリプロダクション:GnIHの発見と研究の進展、展望2011

    • Author(s)
      筒井和義
    • Organizer
      第1回沖縄生殖内分泌セミナー(第4回 沖縄リプロダクション研究会)
    • Place of Presentation
      沖縄
    • Year and Date
      2011-02-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生体機能を調節する脳ホルモンの発見と理解の到達点2011

    • Author(s)
      筒井和義
    • Organizer
      新教育課程(生物)と最新の生物学セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2011-02-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Disorders of Sex Development : Recent Progress. Plenary Lecture2011

    • Author(s)
      Ogata T
    • Organizer
      In : The 13th European Congress of Endocrinology (ECE 2011)
    • Place of Presentation
      Rotterdam Netherlands
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genetic susceptibility to endocrine disrupters : Estrogen receptor polymorphisms2011

    • Author(s)
      Ogata T
    • Organizer
      Plenary Lecture. In : 6^<th> Copenhagen Workshop on Endocrine Disrupters (COW 2011)
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2011 Annual Research Report
  • [Presentation] 性ホルモン産生異常と性分化2011

    • Author(s)
      緒方勤
    • Organizer
      第84回日本内分泌学会学術総会教育講演
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] ターナー症候群を招く分子基盤2011

    • Author(s)
      緒方勤
    • Organizer
      日本人類遺伝学会第56回大会共催セミナー
    • Place of Presentation
      千葉
    • Related Report
      2011 Annual Research Report
  • [Presentation] 性分化疾患の臨床像と新規遺伝子MAMLD1の同定2011

    • Author(s)
      緒方勤
    • Organizer
      第28回日本医学会総会シンポジウム:内分泌疾患-病態解明と治療の進歩
    • Place of Presentation
      東京(東日本大震災のためDVD収録で配布)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳の性分化に関する最近の知見2011

    • Author(s)
      緒方勤
    • Organizer
      第84回日本内分泌学会学術総会シンポジウム:性分化疾患の診断・治療戦略
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] 性分化疾患の発症機序2011

    • Author(s)
      緒方勤
    • Organizer
      第56回日本未熟児新生児学会学術集会:性分化疾患の新生児期管理
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] Gonadotropin-inhibitory hormone (GnIH), a new key neurohormone controlling vertebrate reproduction : Biosynthesis, mode of action and functional significance2011

    • Author(s)
      K.Tsutsui
    • Organizer
      The 2011 International Biomodulation Symposium on 'Biotechnology for Future Era'
    • Place of Presentation
      Seoul National University, Seoul, Korea
    • Related Report
      2011 Annual Research Report
  • [Presentation] Gonadotropin-inhibitory hormone (GnIH), a new key neurohormone controlling vertebrate reproduction : Biosynthesis, mode of action and functional significance2011

    • Author(s)
      K.Tsutsui
    • Organizer
      The 2011 International Biomodulation Symposium on 'Biomaterials and Biomodelling for Translational Research'. Seoul National University
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2010 Annual Research Report
  • [Presentation] Putting the brakes on reproduction. Implications for conservation? Global climate change?2011

    • Author(s)
      J.C.Wingfield, K.Tsutsui
    • Organizer
      "Howard Bern Lecture" at the Society of Integrative and Comparative Biology (SICB) meeting 2011
    • Place of Presentation
      Salt Lake City, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] GnRHとGnIHによる生殖神経内分泌制御.岡山大学研究開発委員会2010

    • Author(s)
      筒井和義
    • Organizer
      第4回ワーキング主催シンポジウム「分野・領域を超えた内分泌学・生殖内分泌学の研究ネットワーク」
    • Place of Presentation
      岡山
    • Year and Date
      2010-12-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生殖腺刺激ホルモン放出抑制ホルモンGnIHによる生殖機能調節2010

    • Author(s)
      筒井和義
    • Organizer
      第55回日本生殖医学会総会および学術講演会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生殖腺刺激ホルモン放出抑制ホルモンGnIH:発見、研究の進展と展望2010

    • Author(s)
      筒井和義
    • Organizer
      日本動物学会第81回大会 2010比較生理生化学の醍醐味~ICCPB2011国際比較生理生化学会に向けて~
    • Place of Presentation
      東京
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 性分化疾患の発症機序:遺伝-環境相互作用の観点から2010

    • Author(s)
      緒方勤
    • Organizer
      第249回日本小児科学会東海地方会特別講演
    • Place of Presentation
      名古屋
    • Year and Date
      2010-05-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Kallmann syndrome : a one amino-acid insertion mutation of the fibroblast growth factor receptor 1 (FGFR1) acid box may affect neuronal extension in an FGF-dependent manner2010

    • Author(s)
      Sato N, Ogata T, 他
    • Organizer
      The 14th International Congress of Endocrinology
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endocrine Disruptors-the environment and its impact on paediatric endocrinology2010

    • Author(s)
      Ogata T
    • Organizer
      The 6^<th> Bienniel Scientific Meeting of The Asia Pacific Paediatric Endocrinolgy
    • Place of Presentation
      Xi'an, China
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genetic causes of POF2010

    • Author(s)
      Ogata T
    • Organizer
      October 16-17, 2010. Kyoto, Japan
    • Place of Presentation
      Kyoto, Japan.
    • Related Report
      2010 Annual Research Report
  • [Presentation] 性分化疾患研究の最前線2010

    • Author(s)
      緒方勤
    • Organizer
      日本アンドロロジー学会第29回学術大会・第16回精子形成・精巣毒性研究会共同開催学会特別講演
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] エコチル調査における遺伝医学研究2010

    • Author(s)
      緒方勤
    • Organizer
      日本人類遺伝学会第55回大会シンポジウム:小児環境疫学(エコチル)調査と遺伝医学
    • Place of Presentation
      大宮
    • Related Report
      2010 Annual Research Report
  • [Presentation] Novel molecular mechanisms underlying diurnal locomotor rhythms in birds : Coordination of melatonin with 7α-hydroxypregnenolone, a newly discovered avian neurosteroid2010

    • Author(s)
      K.Tsutsui
    • Organizer
      Presenting at the 25th International Ornithological Congress.
    • Place of Presentation
      Campos do Jordao, Brazil
    • Related Report
      2010 Annual Research Report
  • [Presentation] Discovery and evolutionary history of GnIH and kisspeptin, new key neuropeptides controlling reproduction2010

    • Author(s)
      K.Tsutsui
    • Organizer
      The 7th International Congress of Neuroendocrinology
    • Place of Presentation
      Rouen, France
    • Related Report
      2010 Annual Research Report
  • [Presentation] Discovery of GnIH : First Identification in Birds and Conservation in Mammals2010

    • Author(s)
      K.Tsutsui
    • Organizer
      The Symposium "Gonadotropin inhibitory hormone (GnIH) functions in mammals" at The Endocrine Society's 92nd Annual Meeting
    • Place of Presentation
      San Diego, California, USA
    • Related Report
      2010 Annual Research Report
  • [Book] 外性器と脳の性分化のメカニズム.有阪治(編)ビギナーのための小児内分泌診療ガイド2014

    • Author(s)
      緒方勤
    • Total Pages
      10
    • Publisher
      中山書店
    • Related Report
      2013 Annual Research Report
  • [Book] スクエア 最新図説生物(二訂版)高等学校2014

    • Author(s)
      筒井和義
    • Total Pages
      344
    • Publisher
      第一学習社
    • Related Report
      2013 Annual Research Report
  • [Book] Turner症候群.吉川史隆,倉智博久,平松祐司(編)産婦人科疾患最新の治療2013

    • Author(s)
      緒方勤
    • Total Pages
      2
    • Publisher
      南江堂
    • Related Report
      2013 Annual Research Report
  • [Book] 性分化の分子生物学.吉田修(監),小川修、岡田裕作、荒井陽一、寺地敏郎、松田公志、筧義行、羽渕友則(編)ベッドサイド泌尿器科学 改定第4版2013

    • Author(s)
      緒方勤
    • Total Pages
      6
    • Publisher
      南江堂
    • Related Report
      2013 Annual Research Report
  • [Book] ヌーナン症候群.横谷進(編)成長障害のマネジメント 改定第3版2013

    • Author(s)
      緒方勤
    • Total Pages
      8
    • Publisher
      医薬ジャーナル社
    • Related Report
      2013 Annual Research Report
  • [Book] Gen. Comp. Endocrinol2013

    • Author(s)
      K. Tsutsui, P. J. Sharp, R. M. Dores
    • Total Pages
      235
    • Publisher
      Gen. Comp. Endocrinol
    • Related Report
      2013 Annual Research Report
  • [Book] The E-Book of Neurosteroids: Frontiers Research Topic2013

    • Author(s)
      H. Vaudry, K. Tsutsui
    • Total Pages
      476
    • Publisher
      Frontiers in Endocrinology (http://flashbook.frontiersin.org//clients/Frontiers/Neurosteroids/EBook.html)
    • Related Report
      2013 Annual Research Report
  • [Book] Neurosteroids and synaptic formation in the cerebellum. In: Handbook of Cerebellum and Cerebellar Disorders2013

    • Author(s)
      K. Tsutsui
    • Total Pages
      2397
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report
  • [Book] Gonadotropin-inhibitory hormone (GnIH). In: The Handbook of Biologically Active Peptides (2nd edition)2013

    • Author(s)
      K. Tsutsui, T. Ubuka
    • Total Pages
      1943
    • Publisher
      Elsevier publisher
    • Related Report
      2013 Annual Research Report
  • [Book] 26RFa. In: The Handbook of Biologically Active Peptides (2nd edition)2013

    • Author(s)
      J. Leprince, C. Neveu, B. Lefrance, L. Guilhaudis, I. Segalas-Milazzo, J.-C. Do Rego, M. Tena-Sempere, K. Tsutsui, H. Vaudry
    • Total Pages
      1943
    • Publisher
      Elsevier publisher
    • Related Report
      2013 Annual Research Report
  • [Book] 高等学校新生物基礎2012

    • Author(s)
      筒井和義(監修)
    • Total Pages
      176
    • Publisher
      第一学習社
    • Related Report
      2011 Annual Research Report
  • [Book] 高等学校生物基礎2012

    • Author(s)
      筒井和義(監修)
    • Total Pages
      304
    • Publisher
      第一学習社
    • Related Report
      2011 Annual Research Report
  • [Book] Neurosteroids and synaptic formation in the cerebellum2010

    • Author(s)
      K.Tsutsui
    • Publisher
      Springer(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Book] Phylogenetic Aspects of Neuropeptides : From Invertebrates to Humans2010

    • Author(s)
      K.Tsutsui
    • Total Pages
      300
    • Publisher
      Blackwell
    • Related Report
      2010 Annual Research Report
  • [Book] 性分化疾患における遺伝カウンセリング2010

    • Author(s)
      緒方勤
    • Publisher
      メディカルドゥ(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Book] 原発性性腺機能低下2010

    • Author(s)
      緒方勤
    • Publisher
      医学書院(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Book] ターナー症候群2010

    • Author(s)
      緒方勤
    • Publisher
      中山書店(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Book] クラインフェルター症候群2010

    • Author(s)
      緒方勤
    • Publisher
      中山書店(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Remarks] 浜松医大小児科

    • URL

      http://www2.hama-med.ac.jp/w1b/pediatr/patient/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 国立成育医療研究センター分子内分泌研究部

    • URL

      http://www.nch.go.jp/endocrinology/index.htm

    • Related Report
      2013 Annual Research Report
  • [Remarks] 早稲田大学

    • URL

      http://www.f.waseda.jp/k-tsutsui/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 浜松医科大学小児科

    • URL

      http://www2.hama-med.ac.jp/w1b/pediatr/patient/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks] 国立成育医療研究センター研究所分子内分泌研究部

    • URL

      http://www.nch.go.jp/endocrinology/index.htm

    • Related Report
      2012 Annual Research Report
  • [Remarks] 早稲田大学筒井研究室

    • URL

      http://www.f.waseda.jp/k-tsutsui/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www2.hama-med.ac.jp/wlb/pediatr/patient/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.nch.go.jp/endocrinology/index.htm

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.f.waseda.jp/k-tsutsui/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.nch.go.jp/endocrinology/index.htm

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.f.waseda.jp/k-tsutsui/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi