| Project Area | HLA polymorphism, disease and evolution |
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| Project/Area Number |
22133009
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyushu University |
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Principal Investigator |
SASAZUKI Takehiko 九州大学, 生体防御医学研究所, 特別主幹教授 (50014121)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMURA Tadashi 独立行政法人国立国際医療研究センター, 研究所, 室長 (00333790)
TANAKA Yoshihiko 福岡歯科大学, 歯学部, 教授 (00398083)
KISHIKAWA Reiko 独立行政法人国立病院機構福岡病院(臨床研究部), アレルギー科, 医長 (50450945)
MORI Akio 独立行政法人国立病院機構(相模原病院臨床研究センター), 先端技術開発研究部, 部長 (80251247)
OKAMURA Ken 九州大学, 医学研究院, 名誉教授 (90150432)
YOSHIKAI Yasunobu 九州大学, 生体防御医学研究所, 教授 (90158402)
NODA Mitsuhiko 独立行政法人国立国際医療研究センター, 糖尿病研究部, 部長 (90237850)
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| Research Collaborator |
ITO Kouichi
YOSHIMURA Hiroshi
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥207,740,000 (Direct Cost: ¥159,800,000、Indirect Cost: ¥47,940,000)
Fiscal Year 2014: ¥38,740,000 (Direct Cost: ¥29,800,000、Indirect Cost: ¥8,940,000)
Fiscal Year 2013: ¥40,690,000 (Direct Cost: ¥31,300,000、Indirect Cost: ¥9,390,000)
Fiscal Year 2012: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2011: ¥42,250,000 (Direct Cost: ¥32,500,000、Indirect Cost: ¥9,750,000)
Fiscal Year 2010: ¥43,420,000 (Direct Cost: ¥33,400,000、Indirect Cost: ¥10,020,000)
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| Keywords | ＨＬＡ－ＤＰ５ / ＨＬＡ－ＤＲ５３ / グレーブス病 / 橋本病 / スギ花粉症 / ＨＬＡ立体構造 / エピスターシス / ゲノム解析 / ＨＬＡ / 立体構造 / ＶＡＶ３ / HLA / 自己免疫性甲状腺炎 / DP5 / HLA-DP5 / HLA-DR53 / 花粉症 |
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| Outline of Final Research Achievements |
We identified Graves disease-specific susceptible HLA alleles, HLA-DR14:03 and DPB1*05:01, and protective alleles, HLA-DRB1*13:02, DRB1*15:02 and B*07:02 by association analysis for HLA-A, B, C, DRB1, DQB1 and DPB1 loci. In addition, we elucidated the epistatic role of protective HLA-DRB1*13:02 allele to susceptible HLA alleles in the incidence of Graves disease. We revealed a crystal structure of the CryJ-1-derived peptide, a major allergen of cedar pollinosis, and HLA-DP5 complex, which would contribute to development of a chemical compound capable of regulating the allergic reaction.
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