| Budget Amount *help |
¥184,600,000 (Direct Cost: ¥142,000,000、Indirect Cost: ¥42,600,000)
Fiscal Year 2015: ¥40,820,000 (Direct Cost: ¥31,400,000、Indirect Cost: ¥9,420,000)
Fiscal Year 2014: ¥40,820,000 (Direct Cost: ¥31,400,000、Indirect Cost: ¥9,420,000)
Fiscal Year 2013: ¥43,030,000 (Direct Cost: ¥33,100,000、Indirect Cost: ¥9,930,000)
Fiscal Year 2012: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2011: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
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| Outline of Final Research Achievements |
Chromosomal functional domains such as centromeres and telomeres are consist of non-coding DNAs (ncDNAs), and higher-order chromatin structure, called heterochromatin plays a pivotal role in faithful propagation of chromosomes. Although specific histone methylation and HP1 proteins have been implicated in heterochromatin assembly, the relationship between ncDNAs and heterochromatin formation has not been fully understood. In this study, we focused on HP1 and demonstrated that a series of posttranslational modifications of HP1 regulates its chromatin binding. We further demonstrated that interactions between different types of repetitive DNAs are involved in dynamic chromatin reorganization in nucleus.
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