| Budget Amount *help |
¥45,760,000 (Direct Cost: ¥35,200,000、Indirect Cost: ¥10,560,000)
Fiscal Year 2014: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2013: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2012: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
|
|---|
| Outline of Final Research Achievements |
Sleep disorder Narcolepsy is caused by the specific degeneration of orexin-producing neurons in the hypothalamus. This suggests that orexin neurons play an important role in the regulation of sleep/wakefulness, especially in the maintenance of wakefulness. To study development mechanism of narcolepsy in mice, we generated new narcolepsy model mice which enable ablate orexin neurons with timing-controlled manner. Using these mice, we revealed the relationship between remaining number of orexin neurons and development of narcoleptic symptoms.
|
