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Functional analysis of mesoscopic neural network involved in generation of wakefulness

Planned Research

Project AreaMesoscopic neurocircuitry: towards understanding of the functional and structural basis of brain information processing
Project/Area Number 23115103
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNagoya University (2012-2014)
National Institute for Physiological Sciences (2011)

Principal Investigator

YAMANAKA Akihiro  名古屋大学, 環境医学研究所, 教授 (60323292)

Co-Investigator(Kenkyū-buntansha) MORI Takuma  生理学研究所, 助教 (70545798)
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥45,760,000 (Direct Cost: ¥35,200,000、Indirect Cost: ¥10,560,000)
Fiscal Year 2014: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2013: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2012: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Keywords視床下部 / ペプチド作動性神経 / パッチクランプ / 光遺伝学 / 神経活動操作 / 運命制御 / 時期特異的脱落 / 睡眠覚醒 / ナルコレプシー / 病態モデルマウス / 脱力発作 / 神経脱落 / 遺伝子改変マウス / オレキシン / 神経回路 / オプトジェネティクス / チャネルロドプシン / ハロロドプシン
Outline of Final Research Achievements

Sleep disorder Narcolepsy is caused by the specific degeneration of orexin-producing neurons in the hypothalamus. This suggests that orexin neurons play an important role in the regulation of sleep/wakefulness, especially in the maintenance of wakefulness. To study development mechanism of narcolepsy in mice, we generated new narcolepsy model mice which enable ablate orexin neurons with timing-controlled manner. Using these mice, we revealed the relationship between remaining number of orexin neurons and development of narcoleptic symptoms.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (102 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (26 results) (of which Peer Reviewed: 26 results,  Open Access: 7 results,  Acknowledgement Compliant: 1 results) Presentation (64 results) (of which Invited: 55 results) Book (3 results) Remarks (7 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1.2014

    • Author(s)
      Takayama Y, Shibasaki K, Suzuki Y, Yamanaka A, Tominaga M
    • Journal Title

      FASEB J

      Volume: 28 Issue: 5 Pages: 2238-2248

    • DOI

      10.1096/fj.13-243436

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy.2014

    • Author(s)
      Black SW, Morairty SR, Chen TM, Leung AK, Wisor JP, Yamanaka A, Kilduff TS
    • Journal Title

      J Neurosci

      Volume: 34 Issue: 19 Pages: 6485-6494

    • DOI

      10.1523/jneurosci.0080-14.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Conditional ablation of orexin/hypocretin neurons : A new mouse model for the study of narcolepsy and orexin system function.2014

    • Author(s)
      Tabuchi S, Tsunematsu T, Black SW, Tominaga M, Maruyama M, Takagi K, Minokoshi Y, Sakurai T, Kilduff TS, Yamanaka A
    • Journal Title

      The Joumal of Neuroscience

      Volume: (in press) Issue: 19 Pages: 6495-6509

    • DOI

      10.1523/jneurosci.0073-14.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optogenetic manipulation of activity and temporally controlled cell-specific ablation reveal a role for MCH neurons in sleep/wake regulation.2014

    • Author(s)
      Tsunematsu T, Ueno T, Tabuchi S, Inutsuka A, Tanaka KF, Hasuwa H, Kilduff TS, Terao A, Yamanaka A.
    • Journal Title

      Journal of Neuroscience

      Volume: 34 Issue: 20 Pages: 6896-6909

    • DOI

      10.1523/jneurosci.5344-13.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optogenetic activation of dorsal raphe serotonin neurons enhances patience for future rewards.2014

    • Author(s)
      Miyazaki KW, Miyazaki K, Tanaka KF, Yamanaka A, Takahashi A, Tabuchi S, Doya K
    • Journal Title

      Curr Biol

      Volume: 24 Issue: 17 Pages: 2033-2040

    • DOI

      10.1016/j.cub.2014.07.041

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Concurrent and robust regulation of feeding behavions and metabolism by orexin neurons.2014

    • Author(s)
      Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M.
    • Journal Title

      Neuropharmacology

      Volume: 85 Pages: 451-460

    • DOI

      10.1016/j.neuropharm.2014.06.015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optogenetic activation of serotonergic neurons enhances anxiety-like behavior in mice.2014

    • Author(s)
      Ohmura Y, Tanaka KF, Tsunematsu T, Yamanaka A,Yoshioka M
    • Journal Title

      Int J Neuropsychopharmacology

      Volume: 17 Issue: 11 Pages: 1777-1783

    • DOI

      10.1017/s1461145714000637

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optogenetic manipulation of activity and temporally-controlled cell-specific ablation reveal a role for MCH neurons in sleep/wake regulation2014

    • Author(s)
      Tsunematsu T,Ueno T, Tabuchi S, Inutsuka A,Tanaka KF, Hasuwa H, Kilduff TS, Terao A, Yamanaka A
    • Journal Title

      J Neurosci

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conditional ablation of orexin/hypocretin neurons: A new mouse model for the study of narcolepsy and orexin system function2014

    • Author(s)
      Tabuchi S, Tsunematsu T, Black SW, Tominaga M, Maruyama M, Takagi K, Minokoshi Y, Sakurai T, Kilduff TS, Yamanaka A
    • Journal Title

      J Neurosci

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy2014

    • Author(s)
      Black SW, Morairty SR, Chen TM, Leung AK, Wisor JP, Yamanaka A, Kilduff TS
    • Journal Title

      J Neurosci

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optogenetic activation of serotonergic neurons enhances anxiety-like behavior in mice2014

    • Author(s)
      Ohmura Y, Tanaka KF, Tsunematsu T, Yamanaka A,Yoshioka M,
    • Journal Title

      Int J Neuropsychopharmacology

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 12014

    • Author(s)
      Takayama Y, Shibasaki K, Suzuki Y, Yamanaka A, Tominaga M
    • Journal Title

      FASEB J

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optogenetic countering of glial acidosis suppresses glial glutamate release and ischemic brain damage2014

    • Author(s)
      Beppu K, Sasaki T, Tanaka K F, Yamanaka A, Fukazawa Y, Shigemoto R, Matsui K
    • Journal Title

      Neuron

      Volume: 81(2) Issue: 2 Pages: 314-320

    • DOI

      10.1016/j.neuron.2013.11.011

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Greatly increased numbers of histamine cells in human narcolepsy with cataplexy2013

    • Author(s)
      John J, Thannickal TC, McGregor R, Ramanathan L, Ohtsu H, Nishino S, Sakai N, Yamanaka A, Stone C, Cornford M, Siegel JM
    • Journal Title

      Ann Neurol

      Volume: 74 Issue: 6 Pages: 786-793

    • DOI

      10.1002/ana.23968

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic alterations in monoaminergic cells in the locus coeruleus in orexin neuron-ablated narcoleptic mice2013

    • Author(s)
      Tsujino N, Tsunematsu T,Uchigashima M, Konno K,Yamanaka A, Kobayashi K, Watanabe M, Koyama Y, Sakurai T
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 7 Pages: e70012-e70012

    • DOI

      10.1371/journal.pone.0070012

    • NAID

      120005328803

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of inhibitory serotonergic inputs to orexin/hypocretin neurons on the diurnal rhythm of sleep and wakefulness.2013

    • Author(s)
      Tabuchi S, Tsunematsu T, Kilduff TS, Sugio S, Tanaka KF, Takahashi S, Tominaga M, Yamanaka A
    • Journal Title

      Sleep

      Volume: 36(9) Issue: 9 Pages: 1391-1404

    • DOI

      10.5665/sleep.2972

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-lasting silencing of orexin/hypocretin neurons using archaerhodopsin induces slow-wave sleep in mice.2013

    • Author(s)
      Tsunematsu T, Tabuchi S, Tanaka KF, Boyden ES, Tominaga M, Yamanaka A
    • Journal Title

      Behavioural Brain Research

      Volume: 255 Pages: 64-74

    • DOI

      10.1016/j.bbr.2013.05.021

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nociception originating from the crural fascia in rats2013

    • Author(s)
      Taguchi T, Yasui M, Kubo A, Abe M, Kiyama H, Yamanaka A, Mizumura K
    • Journal Title

      Pain

      Volume: 154 Issue: 7 Pages: 1103-1114

    • DOI

      10.1016/j.pain.2013.03.017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ectopic expression of melanopsin in orexin/hypocretin neurons enables control of wakefulness of mice in vivo by blue light2013

    • Author(s)
      Tsunematsu T, Tanaka KF, Yamanaka A, Koizumi A
    • Journal Title

      Neurosci Res

      Volume: 75(1) Issue: 1 Pages: 23-28

    • DOI

      10.1016/j.neures.2012.07.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The manipulation of neural and cellular activities by ectopic expression of melanopsin.2013

    • Author(s)
      Koizumi A, Tanaka KF, Yamanaka A
    • Journal Title

      Neuroscience Research

      Volume: 75(1) Issue: 1 Pages: 3-5

    • DOI

      10.1016/j.neures.2012.07.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions2013

    • Author(s)
      Inutsuka A, Yamanaka A
    • Journal Title

      Frontiers in Endocrinology

      Volume: -

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The regulation of sleep and wakefulness by the hypotalamic neuropeptide orexin/hypocretin2013

    • Author(s)
      Inutsuka A, Yamanaka A
    • Journal Title

      Nagoya Journal of Medical Science

      Volume: 75 Pages: 29-36

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Light-induced silencing of neural activity in Rosa26 knock-in mice conditionally expressing the microbial halorhodopsin eNpHR2.02012

    • Author(s)
      I.Imayoshi, S.Tabuchi, K.Hirano, M.Sakamoto, S.Kitano, H.Miyachi, A.Yamanaka, R.Kageyama, R.
    • Journal Title

      Neuroscience Research

      Volume: (掲載確定)(印刷中) Issue: 1 Pages: 85-91

    • DOI

      10.1016/j.neures.2012.03.008

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system2012

    • Author(s)
      K. Tanaka, K. Matsui, T. Sasaki. H. Sano, S. Sugio, K. Fan, K. Ikenaka, R. Hen, J. Nakai, Y. Yanagawa, H. Hasuwa, K. Deisseroth, A. Yamanaka
    • Journal Title

      Cell Reports

      Volume: 2 Issue: 2 Pages: 397-406

    • DOI

      10.1016/j.celrep.2012.06.011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Role of Orexin/Hypocretin in the Central Nervous System and Peripheral Tissues.2012

    • Author(s)
      Tsunematsu T, Yamanaka A
    • Journal Title

      Vitamin and Hormones

      Volume: 89 Pages: 19-33

    • DOI

      10.1016/b978-0-12-394623-2.00002-0

    • ISBN
      9780123946232
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice2011

    • Author(s)
      Tsunematsu T, Kilduff TS, Boyden ES, Takahashi S, Tominaga M, Yamanaka A
    • Journal Title

      J Neurosci

      Volume: 31(29) Issue: 29 Pages: 10529-10539

    • DOI

      10.1523/jneurosci.0784-11.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] リズムと本能行動調節のメカニズム2015

    • Author(s)
      山中章弘
    • Organizer
      第92回日本生理学会大会 シンポジウム:流れる時と繰り返す時間の解剖生理学
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] オレキシンの基礎的なメカニズム2015

    • Author(s)
      山中章弘
    • Organizer
      第88回日本薬理学会年会 ランチョンセミナー
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 特定神経活動操作による神経回路機能の解明2015

    • Author(s)
      山中章弘、犬束 歩、山下 哲
    • Organizer
      第88回日本薬理学会年会 シンポジウム「特定細胞ネットワーク活性制御システムの脳機能/脳疾患解析への応用:脳細胞のシングルセルアナリシスへの挑戦」
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Development of new tools for multiple selected gene expression control for specific neural pathway labeling in vivo using trans synaptic Cre recombinase.2015

    • Author(s)
      Yamanaka A
    • Organizer
      SRI International Seminar
    • Place of Presentation
      Menlo Park, CA, U.S.A.
    • Year and Date
      2015-02-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 光遺伝学を用いた精神神経薬理研究2014

    • Author(s)
      山中章弘
    • Organizer
      第44回日本神経精神薬理学会 教育セミナー
    • Place of Presentation
      名古屋
    • Year and Date
      2014-11-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Regulatory mechanism of sleep/wakefulness revealed by using optogenetics.2014

    • Author(s)
      Yamanaka A
    • Organizer
      16th International Conference on Retinal Proteins
    • Place of Presentation
      Nagahama, Japan
    • Year and Date
      2014-10-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Neural regulatory mechanism of state transitions: wakefulness, non-REM and REM sleep.2014

    • Author(s)
      山中章弘
    • Organizer
      藤原セミナー
    • Place of Presentation
      伊豆
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 覚醒ーノンレム睡眠ーレム睡眠調節における視床下部メラニン凝集ホルモン産生神経の役割2014

    • Author(s)
      山中章弘、犬束 歩、常松 友美
    • Organizer
      第37回日本神経科学大会 シンポジウム 光遺伝学や科学遺伝学を用いた神経回路機能操作と行動制御
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Orexin/hypocretin and its physiological roles.2014

    • Author(s)
      Yamanaka A
    • Organizer
      5th International Symposium on the Physiology and Pharmacology of Temperature Regulation (PPTR)
    • Place of Presentation
      Skukuza, South Africa
    • Year and Date
      2014-09-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Activity control or fate control of melanin concentrating hormone (MCH)-containing neurons.2014

    • Author(s)
      Yamanaka A, Tsunematsu T, Inutsuka A
    • Organizer
      Korean Association for Laboratory Animal Science 2014 International Symposium
    • Place of Presentation
      Yeosu, Korea
    • Year and Date
      2014-08-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Behavior control by activity manipulatino of hypothalamic neurons using optogenetics.2014

    • Author(s)
      Yamanaka A
    • Organizer
      University of Strathclyde Seminar
    • Place of Presentation
      Glasgow, UK
    • Year and Date
      2014-07-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Manipulation of neural activity and behavior control.2014

    • Author(s)
      山中章弘
    • Organizer
      第37回内藤コンファレンス
    • Place of Presentation
      ニセコ
    • Year and Date
      2014-07-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 睡眠覚醒調節におけるオレキシン神経の役割2014

    • Author(s)
      山中章弘
    • Organizer
      日本睡眠学会第39回定期学術集会 シンポジウム:オレキシンの基礎から臨床
    • Place of Presentation
      徳島
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Behavior Control by Activity Manipulation of Hypothalamic Neurons Using Optogenetics.2014

    • Author(s)
      Yamanaka A
    • Organizer
      iCeMS International Symposium
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2014-06-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] オレキシン神経活動操作と運命制御による睡眠覚醒調節機構の解明2013

    • Author(s)
      山中章弘、常松友美、田淵紗和子
    • Organizer
      第155回日本獣医学会学術集会 生理学・生化学分科会 シンポジウム「睡眠研究の新展開」
    • Place of Presentation
      東京
    • Year and Date
      2013-03-28
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オレキシン神経の時期特異的運命制御を用いた新規ナルコレプシーモデルマウスの解析2013

    • Author(s)
      田淵紗和子、常松友美、富永真琴、山中章弘
    • Organizer
      第90回日本生理学会大会 シンポジウム 睡眠・覚醒の包括的な理解を目指した若手研究者による新しいアプローチ
    • Place of Presentation
      東京
    • Year and Date
      2013-03-27
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 視床下部神経細胞の機能操作と運命制御による分子病態解析2013

    • Author(s)
      山中章弘、常松友美、田淵紗和子
    • Organizer
      第86回日本薬理学会年会 シンポジウム「脳神経疾患の分子病態解析のための最新アイデアと新技術」
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-21
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オプトジェネティクスを用いた神経活動操作と行制御による本能発現機構の解析2013

    • Author(s)
      山中章弘
    • Organizer
      大阪学蛋白質研究所セミナー 中枢神経研究を拓く新しい潮流
    • Place of Presentation
      大阪
    • Year and Date
      2013-03-08
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オプトジェネティクスを用いた神経活動操作と本能行動制御2013

    • Author(s)
      山中章弘
    • Organizer
      第90回日本生理学会大会 シンポジウム インビボサイエンスに迫る最新研究
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 睡眠覚醒の脳科学~睡眠と覚醒を調節する脳の仕組み~2013

    • Author(s)
      山中章弘
    • Organizer
      名古屋大学予防早期医療創成センター 第3回ワークショップ
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Perturbation using optogenetics affects autonomic regulation of sleep/wakefulness cycle2012

    • Author(s)
      Yamanaka A
    • Organizer
      The 13th RIES-Hokudai International Symposium "律" Joined with The 1st International Symposium of Nano-Macro Materials, Devices, and System Research Alliance Project
    • Place of Presentation
      札幌
    • Year and Date
      2012-12-13
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Optogenetical approach to reveal the regulatory mechanism of instinctive behaviors by the hypothalamic neurons2012

    • Author(s)
      Yamanaka A, Tsunematsu T
    • Organizer
      Sydney 2012 Joint AuPS/PSNZ/ASB Meeting Symposia: Brain dysfunction and translational neurophysiology
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2012-12-02
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Optogenetic manipulation of orexin neuronal activity affects sleep/wakefulness state in mice2012

    • Author(s)
      Tsunematsu, Boyden Edward S, Yamanaka A
    • Organizer
      The 7th Asian Sleep Research Society Congress Symposium "Neuroendocrines on Sleep”
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2012-11-30
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オプトジェネティクスを用いた神経活動操作と行動制御2012

    • Author(s)
      山中章弘、常松友美
    • Organizer
      「細胞を創る」研究会 5.0
    • Place of Presentation
      横浜
    • Year and Date
      2012-11-21
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Timing controlled ablation of orexin/hypocretin neurons reveals the mechanism of narcolepsy2012

    • Author(s)
      Yamanaka A
    • Organizer
      Neuroscience 2012: Symposium "Dissection of CNS Circuitry Regulating Sleep and Arousal: Conditional Transgenics and Genetically Engineered Receptor-Channel Systems."
    • Place of Presentation
      New Orleans, LA, U.S.A.
    • Year and Date
      2012-10-13
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 光遺伝学を用いた視床下部神経による本能制御機構の解明2012

    • Author(s)
      山中章弘
    • Organizer
      神経化学大会公開シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2012-09-30
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 光遺伝学を用いた視床下部神経による本能制御機構の解明2012

    • Author(s)
      山中章弘
    • Organizer
      日本遺伝学会第84回大会 ワークショップ マウス遺伝学が支える生命科学 part 2
    • Place of Presentation
      福岡
    • Year and Date
      2012-09-24
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オプトジェネティクスを用いた睡眠覚醒調節に関わる神経回路の動作原理解明2012

    • Author(s)
      山中章弘
    • Organizer
      第50回日本生物物理学会年会 シンポジウム レチナール蛋白質と光遺伝学
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-22
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オプトジェネティクスを用いたマウス本能#12175;動制御2012

    • Author(s)
      山中章弘、常松友美
    • Organizer
      第35回日本神経科学会大会 シンポジウム 「光操作で探る神経回路の作動原理」
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-18
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オプトジェネティクスと生物リズム2012

    • Author(s)
      山中章弘
    • Organizer
      生物リズム若手研究者の集い2012
    • Place of Presentation
      筑波
    • Year and Date
      2012-08-04
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 様々な神経細胞の活動制御と行動発現2012

    • Author(s)
      山中章弘
    • Organizer
      2012年包括型脳科学研究推進支援ネットワーク夏のワークショップ 新学術領域研究「大脳新皮質構築」「メゾ神経回路」合同ワークショップ
    • Place of Presentation
      仙台
    • Year and Date
      2012-07-24
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オレキシン神経活動操作と運命制御による睡眠覚醒調節機構の解明2012

    • Author(s)
      山中章弘
    • Organizer
      第2回睡眠研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-07-05
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] セロトニン神経からオレキシン神経への抑制性入力の睡眠覚醒調節における役割2012

    • Author(s)
      田淵紗和子、常松友美、杉尾翔太、田中謙二、富永真琴、山中章弘
    • Organizer
      日本睡眠学会第37回定期学術集会 若手シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-28
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オレキシン神経の運命制御を用いた睡眠覚醒調節機構の解明2012

    • Author(s)
      山中章弘、常松友美、田淵紗和子
    • Organizer
      日本睡眠学会第37回定期学術集会 若手シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-28
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オプトジェネティクスを用いた長時間神経活動操作と睡眠覚醒制御2012

    • Author(s)
      常松友美、山中章弘
    • Organizer
      日本睡眠学会第37回定期学術集会 若手シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-28
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オプトジェネティクスを用いた行動制御2012

    • Author(s)
      山中章弘、常松友美、田淵紗和子
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(北海道大学)(招待講演)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] オプトジェネティクスを用いたオレキシン神経活動抑制は徐波睡眠を誘導する2012

    • Author(s)
      山中章弘
    • Organizer
      第117回日本解剖学会総会
    • Place of Presentation
      山梨大学(山梨県)(招待講演)
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] あなたの知らない睡眠の世界(睡眠科学研究の最前線)2012

    • Author(s)
      山中章弘
    • Organizer
      静薬学友会東海支部 第36回薬剤師セミナー
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オプトジェネティクスによる睡眠覚醒制御2012

    • Author(s)
      常松友美、山中章弘
    • Organizer
      第7回NIBBバイオイメージングフォーラム
    • Place of Presentation
      岡崎
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 本能行動を司る視床下部神経回路の機能操作による動作原理解明2012

    • Author(s)
      山中章弘
    • Organizer
      群馬大学生体調節研究所 名古屋大学環境医学研究所 第9回合同シンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Timing controlled ablation of orexin/hypocretin neurons reveals the mechanism of narcolepsy2012

    • Author(s)
      Yamanaka A
    • Organizer
      SRI International Symposium
    • Place of Presentation
      MenloPark, CA, U.S.A.
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 脳を育む:『睡眠覚醒の脳科学』2012

    • Author(s)
      山中章弘
    • Organizer
      第20回 脳の世紀シンポジウム 若手研究者によるパネルディスカッション「脳科学研究これからの20年」
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Control of instinctive behaviors by manipulating the activity of hypothalamic neurons using optogenetics2011

    • Author(s)
      Akihiro Yamanaka
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)(招待講演)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Sleep/wakefulness control using optogenetics in mice2011

    • Author(s)
      Akihiro Yamanaka
    • Organizer
      Japan-Germany Frontiers of Science Symposium
    • Place of Presentation
      ホテルニューオークラ(東京都)(招待講演)
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Optogenetical approach to study regulatory mechanisms of sleep/wakefulness using transgenic mice2011

    • Author(s)
      Akihiro Yamanaka
    • Organizer
      The 6^<th> World Congress of the World Sleep Federation
    • Place of Presentation
      京都国際会館(京都府)(招待講演)
    • Year and Date
      2011-10-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Positive regulation of between orexin/hypocretin neurons2011

    • Author(s)
      田淵紗和子、常松友美、深澤有吾、富永真琴、山中章弘
    • Organizer
      日本睡眠学会第36回定期学術集会
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Optogenetics reveals physiological role of orexin neurons in sleep/wakefulness regulation2011

    • Author(s)
      山中章弘
    • Organizer
      第23回韓国分子細胞生物学会
    • Place of Presentation
      COEX(韓国・ソウル市)(招待講演)
    • Year and Date
      2011-10-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] オプトジェネティクスを用いた睡眠覚醒制御2011

    • Author(s)
      山中章弘
    • Organizer
      第63回細胞生物学会大会
    • Place of Presentation
      北海道大学(北海道)(招待講演)
    • Year and Date
      2011-06-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] The transcriptome profiling of orexin/hypocretin neurons using microarray2011

    • Author(s)
      常松友美、富永真琴、山中章弘
    • Organizer
      日本睡眠学会第36回定期学術集会
    • Place of Presentation
      京都国際会館(京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] オプトジェネティクスを用いた本能行動調節機構の解明

    • Author(s)
      山中章弘、常松友美
    • Organizer
      Neuro 2013 シンポジウム 光による神経細胞機能制御
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 光遺伝学はじめの一歩

    • Author(s)
      山中章弘
    • Organizer
      Neuro 2013 教育講演 Optogeneticsの原理と実際
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] New model mice for narcolepsy revealed the mechanism of symptoms

    • Author(s)
      山中章弘
    • Organizer
      11th World Congress of Biological Psychiatry: Symposium: Rodent models targeting specific neural circuits for the study of psychiatric disorders
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] オレキシン神経の時期特異的除去を用いた新規ナルコレプシーモデルマウス

    • Author(s)
      山中章弘、田口紗和子、常松友美
    • Organizer
      日本睡眠学会第38回定期学術集会 シンポジウム: 睡眠覚醒基礎研究における動物モデルの必要性
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] オレキシンの基礎研究の手法と成果

    • Author(s)
      山中章弘
    • Organizer
      日本睡眠学会 第17回睡眠科学研究講座
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 睡眠覚醒調節における視床下部オレキシン神経の役割~加齢に伴う睡眠覚醒調節障害との関係~

    • Author(s)
      山中章弘、田淵紗和子、常松友美
    • Organizer
      第13回日本抗加齢医学会総会 シンポジウム:生活の基盤となる体内時計機構~分子から生体まで~
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Optogenetical approach to reveal the regulatory mechanism of instinctive behaviors by the hypothalamic neurons

    • Author(s)
      山中章弘、常松友美
    • Organizer
      IUPS 2013 Research Symposia: Shedding light in the neurophysiological black box
    • Place of Presentation
      Birmingham, UK
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 睡眠-覚醒を調節する神経回路

    • Author(s)
      山中章弘
    • Organizer
      創薬薬理フォーラム第21回シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] New model mice for narcolepsy

    • Author(s)
      山中章弘、田淵紗和子、常松友美
    • Organizer
      International Conference of the Korean Society for Molecular and Cellular Biology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ノンレム睡眠とレム睡眠の調節メカニズム

    • Author(s)
      山中章弘
    • Organizer
      第20回日本時間生物学会学術大会
    • Place of Presentation
      東大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] オプトジェネティクスを用いた神経活動操作による本能行動制御メカニズムの解明

    • Author(s)
      山中章弘
    • Organizer
      第16回神経科学領域における分子モニタリングシンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The physiological role of orexin/hypocretin neurons on sleep/wakefulness regulation

    • Author(s)
      山中章弘、常松友美、田淵紗和子、犬束歩
    • Organizer
      2014 Meeting of the Australasian Neuroscience Society
    • Place of Presentation
      Adelaide, Australia
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 光遺伝学を用いた視床下部神経活動の操作による睡眠覚醒の制御

    • Author(s)
      山中章弘
    • Organizer
      International Workshop on Animal Instinctive and Intelligent Behaviors
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 光遺伝学・薬理遺伝学を用いた神経活動操作と行動制御

    • Author(s)
      山中章弘
    • Organizer
      第91回日本生理学会大会 教育講演
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 神経活動操作を用いた睡眠覚醒調節に関わる神経回路の動作原理

    • Author(s)
      山中章弘
    • Organizer
      第87回日本薬理学会年会 シンポジウム2:最先端技術による神経回路網の多次元解析と脳内微小環境構造の可視化;脳疾患の原因解明を目指して
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 細胞工学 Vol.33 オプトジェネティクスを用いた神経機能操作の現在地-光で行動をコントロールする2014

    • Author(s)
      山中章弘
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2013 Annual Research Report
  • [Book] オプトジェネティクス-光工学と遺伝学による行動制御技術の最前線-2013

    • Author(s)
      山中章弘
    • Publisher
      株式会社エヌ・ティー・エス
    • Related Report
      2013 Annual Research Report
  • [Book] アンチ・エイジング医学 9(2)2013

    • Author(s)
      山中章弘
    • Total Pages
      175
    • Publisher
      メディカルレビュー社
    • Related Report
      2013 Annual Research Report
  • [Remarks] Int J Neuropsychopharmacolに掲載されました

    • URL

      http://www.riem.nagoya-u.ac.jp/4/drof1/nr/files/kaisetsu20140523.pdf

    • Related Report
      2014 Annual Research Report
  • [Remarks] 常松友美の論文がJ Neurosciに掲載されました

    • URL

      http://www.riem.nagoya-u.ac.jp/4/drof1/nr/files/kaisetsu20140515.pdf

    • Related Report
      2014 Annual Research Report
  • [Remarks] 田淵紗和子の論文がJ Neurosciに掲載されました

    • URL

      http://www.riem.nagoya-u.ac.jp/4/drof1/nr/files/kaisetsu20140508.pdf

    • Related Report
      2014 Annual Research Report
  • [Remarks] 山中章弘とSRI Dr. Kilduffとの共同研究がJ Neurosciに掲載されました。

    • URL

      http://www.riem.nagoya-u.ac.jp/4/drof1/nr/files/kaisetsu20140508.pdf

    • Related Report
      2014 Annual Research Report
  • [Remarks] 名古屋大学NU Researchのハイライト論文に掲載されました

    • URL

      http://www.aip.nagoya-u.ac.jp/public/nu_research_ja/highlights/detail/0001386.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 名古屋大学環境医学研究所 神経系分野II 山中章弘研究室

    • URL

      http://www.riem.nagoya-u.ac.jp/4/drof1/nr/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/contents/release/entry/2011/07/post-183.html

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] テトラサイクリン遺伝子発現誘導システムにおける発現量を増幅させ る遺伝子座とノックインによる増幅の効果2014

    • Inventor(s)
      山中章弘、田中謙二
    • Industrial Property Rights Holder
      山中章弘、田中謙二
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2011-193680
    • Filing Date
      2014-03-25
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] テトラサイクリン遺伝子発現誘導システムにおける発現量を増幅させる遺伝子座とノックインによる増幅の効果2011

    • Inventor(s)
      山中章弘, 田中謙二
    • Industrial Property Rights Holder
      山中章弘, 田中謙二
    • Industrial Property Number
      2011-193680
    • Filing Date
      2011-09-06
    • Related Report
      2011 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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