Functional analysis of mesoscopic neural network involved in generation of wakefulness

• Project Area: Mesoscopic neurocircuitry: towards understanding of the functional and structural basis of brain information processing
• Project/Area Number: 23115103
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Nagoya University (2012-2014); National Institute for Physiological Sciences (2011)
• Principal Investigator: YAMANAKA Akihiro 名古屋大学, 環境医学研究所, 教授 (60323292)
• Co-Investigator(Kenkyū-buntansha): MORI Takuma 生理学研究所, 助教 (70545798)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥45,760,000 (Direct Cost: ¥35,200,000、Indirect Cost: ¥10,560,000); Fiscal Year 2014: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000); Fiscal Year 2013: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000); Fiscal Year 2012: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
• Keywords: 視床下部 / ペプチド作動性神経 / パッチクランプ / 光遺伝学 / 神経活動操作 / 運命制御 / 時期特異的脱落 / 睡眠覚醒 / ナルコレプシー / 病態モデルマウス / 脱力発作 / 神経脱落 / 遺伝子改変マウス / オレキシン / 神経回路 / オプトジェネティクス / チャネルロドプシン / ハロロドプシン

Outline of Final Research Achievements

Sleep disorder Narcolepsy is caused by the specific degeneration of orexin-producing neurons in the hypothalamus. This suggests that orexin neurons play an important role in the regulation of sleep/wakefulness, especially in the maintenance of wakefulness. To study development mechanism of narcolepsy in mice, we generated new narcolepsy model mice which enable ablate orexin neurons with timing-controlled manner. Using these mice, we revealed the relationship between remaining number of orexin neurons and development of narcoleptic symptoms.

Research Products

• [Journal Article] Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1. (2014)
  • Author(s): Takayama Y, Shibasaki K, Suzuki Y, Yamanaka A, Tominaga M
  • Journal Title: FASEB J Volume: 28 Issue: 5 Pages: 2238-2248
  • DOI: 10.1096/fj.13-243436
  • Peer Reviewed / Open Access
• [Journal Article] GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy. (2014)
  • Author(s): Black SW, Morairty SR, Chen TM, Leung AK, Wisor JP, Yamanaka A, Kilduff TS
  • Journal Title: J Neurosci Volume: 34 Issue: 19 Pages: 6485-6494
  • DOI: 10.1523/jneurosci.0080-14.2014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Conditional ablation of orexin/hypocretin neurons : A new mouse model for the study of narcolepsy and orexin system function. (2014)
  • Author(s): Tabuchi S, Tsunematsu T, Black SW, Tominaga M, Maruyama M, Takagi K, Minokoshi Y, Sakurai T, Kilduff TS, Yamanaka A
  • Journal Title: The Joumal of Neuroscience Volume: (in press) Issue: 19 Pages: 6495-6509
  • DOI: 10.1523/jneurosci.0073-14.2014
  • Peer Reviewed / Open Access
• [Journal Article] Optogenetic manipulation of activity and temporally controlled cell-specific ablation reveal a role for MCH neurons in sleep/wake regulation. (2014)
  • Author(s): Tsunematsu T, Ueno T, Tabuchi S, Inutsuka A, Tanaka KF, Hasuwa H, Kilduff TS, Terao A, Yamanaka A.
  • Journal Title: Journal of Neuroscience Volume: 34 Issue: 20 Pages: 6896-6909
  • DOI: 10.1523/jneurosci.5344-13.2014
  • Peer Reviewed / Open Access
• [Journal Article] Optogenetic activation of dorsal raphe serotonin neurons enhances patience for future rewards. (2014)
  • Author(s): Miyazaki KW, Miyazaki K, Tanaka KF, Yamanaka A, Takahashi A, Tabuchi S, Doya K
  • Journal Title: Curr Biol Volume: 24 Issue: 17 Pages: 2033-2040
  • DOI: 10.1016/j.cub.2014.07.041
  • Peer Reviewed / Open Access
• [Journal Article] Concurrent and robust regulation of feeding behavions and metabolism by orexin neurons. (2014)
  • Author(s): Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M.
  • Journal Title: Neuropharmacology Volume: 85 Pages: 451-460
  • DOI: 10.1016/j.neuropharm.2014.06.015
  • Peer Reviewed / Open Access
• [Journal Article] Optogenetic activation of serotonergic neurons enhances anxiety-like behavior in mice. (2014)
  • Author(s): Ohmura Y, Tanaka KF, Tsunematsu T, Yamanaka A,Yoshioka M
  • Journal Title: Int J Neuropsychopharmacology Volume: 17 Issue: 11 Pages: 1777-1783
  • DOI: 10.1017/s1461145714000637
  • Peer Reviewed / Open Access
• [Journal Article] Optogenetic manipulation of activity and temporally-controlled cell-specific ablation reveal a role for MCH neurons in sleep/wake regulation (2014)
  • Author(s): Tsunematsu T,Ueno T, Tabuchi S, Inutsuka A,Tanaka KF, Hasuwa H, Kilduff TS, Terao A, Yamanaka A
  • Journal Title: J Neurosci Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Conditional ablation of orexin/hypocretin neurons: A new mouse model for the study of narcolepsy and orexin system function (2014)
  • Author(s): Tabuchi S, Tsunematsu T, Black SW, Tominaga M, Maruyama M, Takagi K, Minokoshi Y, Sakurai T, Kilduff TS, Yamanaka A
  • Journal Title: J Neurosci Volume: 印刷中
  • Peer Reviewed
• [Journal Article] GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy (2014)
  • Author(s): Black SW, Morairty SR, Chen TM, Leung AK, Wisor JP, Yamanaka A, Kilduff TS
  • Journal Title: J Neurosci Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Optogenetic activation of serotonergic neurons enhances anxiety-like behavior in mice (2014)
  • Author(s): Ohmura Y, Tanaka KF, Tsunematsu T, Yamanaka A,Yoshioka M,
  • Journal Title: Int J Neuropsychopharmacology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1 (2014)
  • Author(s): Takayama Y, Shibasaki K, Suzuki Y, Yamanaka A, Tominaga M
  • Journal Title: FASEB J Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Optogenetic countering of glial acidosis suppresses glial glutamate release and ischemic brain damage (2014)
  • Author(s): Beppu K, Sasaki T, Tanaka K F, Yamanaka A, Fukazawa Y, Shigemoto R, Matsui K
  • Journal Title: Neuron Volume: 81(2) Issue: 2 Pages: 314-320
  • DOI: 10.1016/j.neuron.2013.11.011
  • Peer Reviewed
• [Journal Article] Greatly increased numbers of histamine cells in human narcolepsy with cataplexy (2013)
  • Author(s): John J, Thannickal TC, McGregor R, Ramanathan L, Ohtsu H, Nishino S, Sakai N, Yamanaka A, Stone C, Cornford M, Siegel JM
  • Journal Title: Ann Neurol Volume: 74 Issue: 6 Pages: 786-793
  • DOI: 10.1002/ana.23968
  • Peer Reviewed
• [Journal Article] Chronic alterations in monoaminergic cells in the locus coeruleus in orexin neuron-ablated narcoleptic mice (2013)
  • Author(s): Tsujino N, Tsunematsu T,Uchigashima M, Konno K,Yamanaka A, Kobayashi K, Watanabe M, Koyama Y, Sakurai T
  • Journal Title: PLoS ONE Volume: 8 Issue: 7 Pages: e70012-e70012
  • DOI: 10.1371/journal.pone.0070012
  • NAID: 120005328803
  • Peer Reviewed
• [Journal Article] Influence of inhibitory serotonergic inputs to orexin/hypocretin neurons on the diurnal rhythm of sleep and wakefulness. (2013)
  • Author(s): Tabuchi S, Tsunematsu T, Kilduff TS, Sugio S, Tanaka KF, Takahashi S, Tominaga M, Yamanaka A
  • Journal Title: Sleep Volume: 36(9) Issue: 9 Pages: 1391-1404
  • DOI: 10.5665/sleep.2972
  • Peer Reviewed
• [Journal Article] Long-lasting silencing of orexin/hypocretin neurons using archaerhodopsin induces slow-wave sleep in mice. (2013)
  • Author(s): Tsunematsu T, Tabuchi S, Tanaka KF, Boyden ES, Tominaga M, Yamanaka A
  • Journal Title: Behavioural Brain Research Volume: 255 Pages: 64-74
  • DOI: 10.1016/j.bbr.2013.05.021
  • Peer Reviewed
• [Journal Article] Nociception originating from the crural fascia in rats (2013)
  • Author(s): Taguchi T, Yasui M, Kubo A, Abe M, Kiyama H, Yamanaka A, Mizumura K
  • Journal Title: Pain Volume: 154 Issue: 7 Pages: 1103-1114
  • DOI: 10.1016/j.pain.2013.03.017
  • Peer Reviewed
• [Journal Article] Ectopic expression of melanopsin in orexin/hypocretin neurons enables control of wakefulness of mice in vivo by blue light (2013)
  • Author(s): Tsunematsu T, Tanaka KF, Yamanaka A, Koizumi A
  • Journal Title: Neurosci Res Volume: 75(1) Issue: 1 Pages: 23-28
  • DOI: 10.1016/j.neures.2012.07.005
  • Peer Reviewed
• [Journal Article] The manipulation of neural and cellular activities by ectopic expression of melanopsin. (2013)
  • Author(s): Koizumi A, Tanaka KF, Yamanaka A
  • Journal Title: Neuroscience Research Volume: 75(1) Issue: 1 Pages: 3-5
  • DOI: 10.1016/j.neures.2012.07.010
  • Peer Reviewed
• [Journal Article] The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions (2013)
  • Author(s): Inutsuka A, Yamanaka A
  • Journal Title: Frontiers in Endocrinology Volume: -
  • Peer Reviewed
• [Journal Article] The regulation of sleep and wakefulness by the hypotalamic neuropeptide orexin/hypocretin (2013)
  • Author(s): Inutsuka A, Yamanaka A
  • Journal Title: Nagoya Journal of Medical Science Volume: 75 Pages: 29-36
  • Peer Reviewed
• [Journal Article] Light-induced silencing of neural activity in Rosa26 knock-in mice conditionally expressing the microbial halorhodopsin eNpHR2.0 (2012)
  • Author(s): I.Imayoshi, S.Tabuchi, K.Hirano, M.Sakamoto, S.Kitano, H.Miyachi, A.Yamanaka, R.Kageyama, R.
  • Journal Title: Neuroscience Research Volume: (掲載確定)(印刷中) Issue: 1 Pages: 85-91
  • DOI: 10.1016/j.neures.2012.03.008
  • Peer Reviewed
• [Journal Article] Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system (2012)
  • Author(s): K. Tanaka, K. Matsui, T. Sasaki. H. Sano, S. Sugio, K. Fan, K. Ikenaka, R. Hen, J. Nakai, Y. Yanagawa, H. Hasuwa, K. Deisseroth, A. Yamanaka
  • Journal Title: Cell Reports Volume: 2 Issue: 2 Pages: 397-406
  • DOI: 10.1016/j.celrep.2012.06.011
  • Peer Reviewed
• [Journal Article] The Role of Orexin/Hypocretin in the Central Nervous System and Peripheral Tissues. (2012)
  • Author(s): Tsunematsu T, Yamanaka A
  • Journal Title: Vitamin and Hormones Volume: 89 Pages: 19-33
  • DOI: 10.1016/b978-0-12-394623-2.00002-0
  • Peer Reviewed
• [Journal Article] Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice (2011)
  • Author(s): Tsunematsu T, Kilduff TS, Boyden ES, Takahashi S, Tominaga M, Yamanaka A
  • Journal Title: J Neurosci Volume: 31(29) Issue: 29 Pages: 10529-10539
  • DOI: 10.1523/jneurosci.0784-11.2011
  • Peer Reviewed
• [Presentation] リズムと本能行動調節のメカニズム (2015)
  • Author(s): 山中章弘
  • Organizer: 第92回日本生理学会大会 シンポジウム：流れる時と繰り返す時間の解剖生理学
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-22
  • Invited
• [Presentation] オレキシンの基礎的なメカニズム (2015)
  • Author(s): 山中章弘
  • Organizer: 第88回日本薬理学会年会 ランチョンセミナー
  • Place of Presentation: 名古屋
  • Year and Date: 2015-03-19
  • Invited
• [Presentation] 特定神経活動操作による神経回路機能の解明 (2015)
  • Author(s): 山中章弘、犬束 歩、山下 哲
  • Organizer: 第88回日本薬理学会年会 シンポジウム「特定細胞ネットワーク活性制御システムの脳機能／脳疾患解析への応用：脳細胞のシングルセルアナリシスへの挑戦」
  • Place of Presentation: 名古屋
  • Year and Date: 2015-03-18
  • Invited
• [Presentation] Development of new tools for multiple selected gene expression control for specific neural pathway labeling in vivo using trans synaptic Cre recombinase. (2015)
  • Author(s): Yamanaka A
  • Organizer: SRI International Seminar
  • Place of Presentation: Menlo Park, CA, U.S.A.
  • Year and Date: 2015-02-13
  • Invited
• [Presentation] 光遺伝学を用いた精神神経薬理研究 (2014)
  • Author(s): 山中章弘
  • Organizer: 第44回日本神経精神薬理学会 教育セミナー
  • Place of Presentation: 名古屋
  • Year and Date: 2014-11-21
  • Invited
• [Presentation] Regulatory mechanism of sleep/wakefulness revealed by using optogenetics. (2014)
  • Author(s): Yamanaka A
  • Organizer: 16th International Conference on Retinal Proteins
  • Place of Presentation: Nagahama, Japan
  • Year and Date: 2014-10-09
  • Invited
• [Presentation] Neural regulatory mechanism of state transitions: wakefulness, non-REM and REM sleep. (2014)
  • Author(s): 山中章弘
  • Organizer: 藤原セミナー
  • Place of Presentation: 伊豆
  • Year and Date: 2014-09-27
  • Invited
• [Presentation] 覚醒ーノンレム睡眠ーレム睡眠調節における視床下部メラニン凝集ホルモン産生神経の役割 (2014)
  • Author(s): 山中章弘、犬束 歩、常松 友美
  • Organizer: 第37回日本神経科学大会 シンポジウム 光遺伝学や科学遺伝学を用いた神経回路機能操作と行動制御
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-12
  • Invited
• [Presentation] Orexin/hypocretin and its physiological roles. (2014)
  • Author(s): Yamanaka A
  • Organizer: 5th International Symposium on the Physiology and Pharmacology of Temperature Regulation (PPTR)
  • Place of Presentation: Skukuza, South Africa
  • Year and Date: 2014-09-09
  • Invited
• [Presentation] Activity control or fate control of melanin concentrating hormone (MCH)-containing neurons. (2014)
  • Author(s): Yamanaka A, Tsunematsu T, Inutsuka A
  • Organizer: Korean Association for Laboratory Animal Science 2014 International Symposium
  • Place of Presentation: Yeosu, Korea
  • Year and Date: 2014-08-21
  • Invited
• [Presentation] Behavior control by activity manipulatino of hypothalamic neurons using optogenetics. (2014)
  • Author(s): Yamanaka A
  • Organizer: University of Strathclyde Seminar
  • Place of Presentation: Glasgow, UK
  • Year and Date: 2014-07-23
  • Invited
• [Presentation] Manipulation of neural activity and behavior control. (2014)
  • Author(s): 山中章弘
  • Organizer: 第37回内藤コンファレンス
  • Place of Presentation: ニセコ
  • Year and Date: 2014-07-16
  • Invited
• [Presentation] 睡眠覚醒調節におけるオレキシン神経の役割 (2014)
  • Author(s): 山中章弘
  • Organizer: 日本睡眠学会第39回定期学術集会 シンポジウム：オレキシンの基礎から臨床
  • Place of Presentation: 徳島
  • Year and Date: 2014-07-04
  • Invited
• [Presentation] Behavior Control by Activity Manipulation of Hypothalamic Neurons Using Optogenetics. (2014)
  • Author(s): Yamanaka A
  • Organizer: iCeMS International Symposium
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2014-06-13
  • Invited
• [Presentation] オレキシン神経活動操作と運命制御による睡眠覚醒調節機構の解明 (2013)
  • Author(s): 山中章弘、常松友美、田淵紗和子
  • Organizer: 第155回日本獣医学会学術集会 生理学・生化学分科会 シンポジウム「睡眠研究の新展開」
  • Place of Presentation: 東京
  • Year and Date: 2013-03-28
  • Invited
• [Presentation] オレキシン神経の時期特異的運命制御を用いた新規ナルコレプシーモデルマウスの解析 (2013)
  • Author(s): 田淵紗和子、常松友美、富永真琴、山中章弘
  • Organizer: 第90回日本生理学会大会 シンポジウム 睡眠・覚醒の包括的な理解を目指した若手研究者による新しいアプローチ
  • Place of Presentation: 東京
  • Year and Date: 2013-03-27
  • Invited
• [Presentation] 視床下部神経細胞の機能操作と運命制御による分子病態解析 (2013)
  • Author(s): 山中章弘、常松友美、田淵紗和子
  • Organizer: 第86回日本薬理学会年会 シンポジウム「脳神経疾患の分子病態解析のための最新アイデアと新技術」
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-21
  • Invited
• [Presentation] オプトジェネティクスを用いた神経活動操作と行制御による本能発現機構の解析 (2013)
  • Author(s): 山中章弘
  • Organizer: 大阪学蛋白質研究所セミナー 中枢神経研究を拓く新しい潮流
  • Place of Presentation: 大阪
  • Year and Date: 2013-03-08
  • Invited
• [Presentation] オプトジェネティクスを用いた神経活動操作と本能行動制御 (2013)
  • Author(s): 山中章弘
  • Organizer: 第90回日本生理学会大会 シンポジウム インビボサイエンスに迫る最新研究
  • Place of Presentation: 東京
  • Invited
• [Presentation] 睡眠覚醒の脳科学～睡眠と覚醒を調節する脳の仕組み～ (2013)
  • Author(s): 山中章弘
  • Organizer: 名古屋大学予防早期医療創成センター 第3回ワークショップ
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] Perturbation using optogenetics affects autonomic regulation of sleep/wakefulness cycle (2012)
  • Author(s): Yamanaka A
  • Organizer: The 13th RIES-Hokudai International Symposium "律" Joined with The 1st International Symposium of Nano-Macro Materials, Devices, and System Research Alliance Project
  • Place of Presentation: 札幌
  • Year and Date: 2012-12-13
  • Invited
• [Presentation] Optogenetical approach to reveal the regulatory mechanism of instinctive behaviors by the hypothalamic neurons (2012)
  • Author(s): Yamanaka A, Tsunematsu T
  • Organizer: Sydney 2012 Joint AuPS/PSNZ/ASB Meeting Symposia: Brain dysfunction and translational neurophysiology
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2012-12-02
  • Invited
• [Presentation] Optogenetic manipulation of orexin neuronal activity affects sleep/wakefulness state in mice (2012)
  • Author(s): Tsunematsu, Boyden Edward S, Yamanaka A
  • Organizer: The 7th Asian Sleep Research Society Congress Symposium "Neuroendocrines on Sleep”
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2012-11-30
  • Invited
• [Presentation] オプトジェネティクスを用いた神経活動操作と行動制御 (2012)
  • Author(s): 山中章弘、常松友美
  • Organizer: 「細胞を創る」研究会 5.0
  • Place of Presentation: 横浜
  • Year and Date: 2012-11-21
  • Invited
• [Presentation] Timing controlled ablation of orexin/hypocretin neurons reveals the mechanism of narcolepsy (2012)
  • Author(s): Yamanaka A
  • Organizer: Neuroscience 2012: Symposium "Dissection of CNS Circuitry Regulating Sleep and Arousal: Conditional Transgenics and Genetically Engineered Receptor-Channel Systems."
  • Place of Presentation: New Orleans, LA, U.S.A.
  • Year and Date: 2012-10-13
  • Invited
• [Presentation] 光遺伝学を用いた視床下部神経による本能制御機構の解明 (2012)
  • Author(s): 山中章弘
  • Organizer: 神経化学大会公開シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2012-09-30
  • Invited
• [Presentation] 光遺伝学を用いた視床下部神経による本能制御機構の解明 (2012)
  • Author(s): 山中章弘
  • Organizer: 日本遺伝学会第84回大会 ワークショップ マウス遺伝学が支える生命科学 part 2
  • Place of Presentation: 福岡
  • Year and Date: 2012-09-24
  • Invited
• [Presentation] オプトジェネティクスを用いた睡眠覚醒調節に関わる神経回路の動作原理解明 (2012)
  • Author(s): 山中章弘
  • Organizer: 第50回日本生物物理学会年会 シンポジウム レチナール蛋白質と光遺伝学
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-22
  • Invited
• [Presentation] オプトジェネティクスを用いたマウス本能#12175;動制御 (2012)
  • Author(s): 山中章弘、常松友美
  • Organizer: 第35回日本神経科学会大会 シンポジウム 「光操作で探る神経回路の作動原理」
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-18
  • Invited
• [Presentation] オプトジェネティクスと生物リズム (2012)
  • Author(s): 山中章弘
  • Organizer: 生物リズム若手研究者の集い2012
  • Place of Presentation: 筑波
  • Year and Date: 2012-08-04
  • Invited
• [Presentation] 様々な神経細胞の活動制御と行動発現 (2012)
  • Author(s): 山中章弘
  • Organizer: 2012年包括型脳科学研究推進支援ネットワーク夏のワークショップ 新学術領域研究「大脳新皮質構築」「メゾ神経回路」合同ワークショップ
  • Place of Presentation: 仙台
  • Year and Date: 2012-07-24
  • Invited
• [Presentation] オレキシン神経活動操作と運命制御による睡眠覚醒調節機構の解明 (2012)
  • Author(s): 山中章弘
  • Organizer: 第2回睡眠研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-07-05
  • Invited
• [Presentation] セロトニン神経からオレキシン神経への抑制性入力の睡眠覚醒調節における役割 (2012)
  • Author(s): 田淵紗和子、常松友美、杉尾翔太、田中謙二、富永真琴、山中章弘
  • Organizer: 日本睡眠学会第37回定期学術集会 若手シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-28
  • Invited
• [Presentation] オレキシン神経の運命制御を用いた睡眠覚醒調節機構の解明 (2012)
  • Author(s): 山中章弘、常松友美、田淵紗和子
  • Organizer: 日本睡眠学会第37回定期学術集会 若手シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-28
  • Invited
• [Presentation] オプトジェネティクスを用いた長時間神経活動操作と睡眠覚醒制御 (2012)
  • Author(s): 常松友美、山中章弘
  • Organizer: 日本睡眠学会第37回定期学術集会 若手シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-28
  • Invited
• [Presentation] オプトジェネティクスを用いた行動制御 (2012)
  • Author(s): 山中章弘、常松友美、田淵紗和子
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(北海道大学)(招待講演)
  • Year and Date: 2012-03-30
• [Presentation] オプトジェネティクスを用いたオレキシン神経活動抑制は徐波睡眠を誘導する (2012)
  • Author(s): 山中章弘
  • Organizer: 第117回日本解剖学会総会
  • Place of Presentation: 山梨大学(山梨県)(招待講演)
  • Year and Date: 2012-03-26
• [Presentation] あなたの知らない睡眠の世界（睡眠科学研究の最前線） (2012)
  • Author(s): 山中章弘
  • Organizer: 静薬学友会東海支部 第36回薬剤師セミナー
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] オプトジェネティクスによる睡眠覚醒制御 (2012)
  • Author(s): 常松友美、山中章弘
  • Organizer: 第7回NIBBバイオイメージングフォーラム
  • Place of Presentation: 岡崎
  • Invited
• [Presentation] 本能行動を司る視床下部神経回路の機能操作による動作原理解明 (2012)
  • Author(s): 山中章弘
  • Organizer: 群馬大学生体調節研究所 名古屋大学環境医学研究所 第9回合同シンポジウム
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] Timing controlled ablation of orexin/hypocretin neurons reveals the mechanism of narcolepsy (2012)
  • Author(s): Yamanaka A
  • Organizer: SRI International Symposium
  • Place of Presentation: MenloPark, CA, U.S.A.
  • Invited
• [Presentation] 脳を育む：『睡眠覚醒の脳科学』 (2012)
  • Author(s): 山中章弘
  • Organizer: 第20回 脳の世紀シンポジウム 若手研究者によるパネルディスカッション「脳科学研究これからの20年」
  • Place of Presentation: 東京
  • Invited
• [Presentation] Control of instinctive behaviors by manipulating the activity of hypothalamic neurons using optogenetics (2011)
  • Author(s): Akihiro Yamanaka
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)(招待講演)
  • Year and Date: 2011-12-13
• [Presentation] Sleep/wakefulness control using optogenetics in mice (2011)
  • Author(s): Akihiro Yamanaka
  • Organizer: Japan-Germany Frontiers of Science Symposium
  • Place of Presentation: ホテルニューオークラ(東京都)(招待講演)
  • Year and Date: 2011-10-29
• [Presentation] Optogenetical approach to study regulatory mechanisms of sleep/wakefulness using transgenic mice (2011)
  • Author(s): Akihiro Yamanaka
  • Organizer: The 6^<th> World Congress of the World Sleep Federation
  • Place of Presentation: 京都国際会館(京都府)(招待講演)
  • Year and Date: 2011-10-19
• [Presentation] Positive regulation of between orexin/hypocretin neurons (2011)
  • Author(s): 田淵紗和子、常松友美、深澤有吾、富永真琴、山中章弘
  • Organizer: 日本睡眠学会第36回定期学術集会
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2011-10-15
• [Presentation] Optogenetics reveals physiological role of orexin neurons in sleep/wakefulness regulation (2011)
  • Author(s): 山中章弘
  • Organizer: 第23回韓国分子細胞生物学会
  • Place of Presentation: COEX(韓国・ソウル市)(招待講演)
  • Year and Date: 2011-10-06
• [Presentation] オプトジェネティクスを用いた睡眠覚醒制御 (2011)
  • Author(s): 山中章弘
  • Organizer: 第63回細胞生物学会大会
  • Place of Presentation: 北海道大学(北海道)(招待講演)
  • Year and Date: 2011-06-27
• [Presentation] The transcriptome profiling of orexin/hypocretin neurons using microarray (2011)
  • Author(s): 常松友美、富永真琴、山中章弘
  • Organizer: 日本睡眠学会第36回定期学術集会
  • Place of Presentation: 京都国際会館(京都府)
• [Presentation] オプトジェネティクスを用いた本能行動調節機構の解明
  • Author(s): 山中章弘、常松友美
  • Organizer: Neuro 2013 シンポジウム 光による神経細胞機能制御
  • Place of Presentation: 京都
  • Invited
• [Presentation] 光遺伝学はじめの一歩
  • Author(s): 山中章弘
  • Organizer: Neuro 2013 教育講演 Optogeneticsの原理と実際
  • Place of Presentation: 京都
  • Invited
• [Presentation] New model mice for narcolepsy revealed the mechanism of symptoms
  • Author(s): 山中章弘
  • Organizer: 11th World Congress of Biological Psychiatry: Symposium: Rodent models targeting specific neural circuits for the study of psychiatric disorders
  • Place of Presentation: 京都
  • Invited
• [Presentation] オレキシン神経の時期特異的除去を用いた新規ナルコレプシーモデルマウス
  • Author(s): 山中章弘、田口紗和子、常松友美
  • Organizer: 日本睡眠学会第38回定期学術集会 シンポジウム： 睡眠覚醒基礎研究における動物モデルの必要性
  • Place of Presentation: 秋田
  • Invited
• [Presentation] オレキシンの基礎研究の手法と成果
  • Author(s): 山中章弘
  • Organizer: 日本睡眠学会 第17回睡眠科学研究講座
  • Place of Presentation: 秋田
  • Invited
• [Presentation] 睡眠覚醒調節における視床下部オレキシン神経の役割～加齢に伴う睡眠覚醒調節障害との関係～
  • Author(s): 山中章弘、田淵紗和子、常松友美
  • Organizer: 第13回日本抗加齢医学会総会 シンポジウム：生活の基盤となる体内時計機構～分子から生体まで～
  • Place of Presentation: 横浜
  • Invited
• [Presentation] Optogenetical approach to reveal the regulatory mechanism of instinctive behaviors by the hypothalamic neurons
  • Author(s): 山中章弘、常松友美
  • Organizer: IUPS 2013 Research Symposia: Shedding light in the neurophysiological black box
  • Place of Presentation: Birmingham, UK
  • Invited
• [Presentation] 睡眠－覚醒を調節する神経回路
  • Author(s): 山中章弘
  • Organizer: 創薬薬理フォーラム第21回シンポジウム
  • Place of Presentation: 東京
  • Invited
• [Presentation] New model mice for narcolepsy
  • Author(s): 山中章弘、田淵紗和子、常松友美
  • Organizer: International Conference of the Korean Society for Molecular and Cellular Biology
  • Place of Presentation: Seoul, Korea
  • Invited
• [Presentation] ノンレム睡眠とレム睡眠の調節メカニズム
  • Author(s): 山中章弘
  • Organizer: 第20回日本時間生物学会学術大会
  • Place of Presentation: 東大阪
  • Invited
• [Presentation] オプトジェネティクスを用いた神経活動操作による本能行動制御メカニズムの解明
  • Author(s): 山中章弘
  • Organizer: 第16回神経科学領域における分子モニタリングシンポジウム
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] The physiological role of orexin/hypocretin neurons on sleep/wakefulness regulation
  • Author(s): 山中章弘、常松友美、田淵紗和子、犬束歩
  • Organizer: 2014 Meeting of the Australasian Neuroscience Society
  • Place of Presentation: Adelaide, Australia
  • Invited
• [Presentation] 光遺伝学を用いた視床下部神経活動の操作による睡眠覚醒の制御
  • Author(s): 山中章弘
  • Organizer: International Workshop on Animal Instinctive and Intelligent Behaviors
  • Place of Presentation: 札幌
  • Invited
• [Presentation] 光遺伝学・薬理遺伝学を用いた神経活動操作と行動制御
  • Author(s): 山中章弘
  • Organizer: 第91回日本生理学会大会 教育講演
  • Place of Presentation: 鹿児島
  • Invited
• [Presentation] 神経活動操作を用いた睡眠覚醒調節に関わる神経回路の動作原理
  • Author(s): 山中章弘
  • Organizer: 第87回日本薬理学会年会 シンポジウム2：最先端技術による神経回路網の多次元解析と脳内微小環境構造の可視化；脳疾患の原因解明を目指して
  • Place of Presentation: 仙台
  • Invited
• [Book] 細胞工学 Vol.33 オプトジェネティクスを用いた神経機能操作の現在地-光で行動をコントロールする (2014)
  • Author(s): 山中章弘
  • Publisher: 学研メディカル秀潤社
• [Book] オプトジェネティクス-光工学と遺伝学による行動制御技術の最前線- (2013)
  • Author(s): 山中章弘
  • Publisher: 株式会社エヌ・ティー・エス
• [Book] アンチ・エイジング医学 9(2) (2013)
  • Author(s): 山中章弘
  • Total Pages: 175
  • Publisher: メディカルレビュー社
• [Remarks] Int J Neuropsychopharmacolに掲載されました
  • URL: http://www.riem.nagoya-u.ac.jp/4/drof1/nr/files/kaisetsu20140523.pdf
• [Remarks] 常松友美の論文がJ Neurosciに掲載されました
  • URL: http://www.riem.nagoya-u.ac.jp/4/drof1/nr/files/kaisetsu20140515.pdf
• [Remarks] 田淵紗和子の論文がJ Neurosciに掲載されました
  • URL: http://www.riem.nagoya-u.ac.jp/4/drof1/nr/files/kaisetsu20140508.pdf
• [Remarks] 山中章弘とSRI Dr. Kilduffとの共同研究がJ Neurosciに掲載されました。
  • URL: http://www.riem.nagoya-u.ac.jp/4/drof1/nr/files/kaisetsu20140508.pdf
• [Remarks] 名古屋大学NU Researchのハイライト論文に掲載されました
  • URL: http://www.aip.nagoya-u.ac.jp/public/nu_research_ja/highlights/detail/0001386.html
• [Remarks] 名古屋大学環境医学研究所 神経系分野II 山中章弘研究室
  • URL: http://www.riem.nagoya-u.ac.jp/4/drof1/nr/index.html
• [Remarks]
  • URL: http://www.nips.ac.jp/contents/release/entry/2011/07/post-183.html
• [Patent(Industrial Property Rights)] テトラサイクリン遺伝子発現誘導システムにおける発現量を増幅させ る遺伝子座とノックインによる増幅の効果 (2014)
  • Inventor(s): 山中章弘、田中謙二
  • Industrial Property Rights Holder: 山中章弘、田中謙二
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2011-193680
  • Filing Date: 2014-03-25
• [Patent(Industrial Property Rights)] テトラサイクリン遺伝子発現誘導システムにおける発現量を増幅させる遺伝子座とノックインによる増幅の効果 (2011)
  • Inventor(s): 山中章弘, 田中謙二
  • Industrial Property Rights Holder: 山中章弘, 田中謙二
  • Industrial Property Number: 2011-193680
  • Filing Date: 2011-09-06