| Project Area | Plasma medical innovation |
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| Project/Area Number |
24108009
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Kyushu University |
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Principal Investigator |
Tanaka Akiyo 九州大学, 医学研究院, 講師 (10136484)
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| Co-Investigator(Kenkyū-buntansha) |
後藤 昌昭 佐賀大学, その他部局等, 教授 (10145211)
平田 美由紀 九州大学, 医学(系)研究科(研究院), 助教 (30156674)
柳生 義人 佐世保工業高等専門学校, その他部局等, 准教授 (40435483)
米須 章 琉球大学, 工学部, 教授 (90220764)
古閑 一憲 九州大学, システム情報科学研究科(研究院, 准教授 (90315127)
北崎 訓 福岡工業大学, 工学部, 助教 (70713147)
林 信哉 九州大学, 総合理工学研究科(研究院), 准教授 (40295019)
板垣 奈穂 九州大学, システム情報科学研究科(研究院, 准教授 (60579100)
山下 佳雄 佐賀大学, 医学部, 教授 (50322300)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUZUKI Teruhisa 九州大学, 医学研究院, 教授 (40155429)
SAKUDO Akikazu 琉球大学, 医学部, 准教授 (10397672)
UCHIDA Giichiro 大阪大学, 接合科学研究所, 准教授 (90422435)
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| Project Period (FY) |
2012-06-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥126,750,000 (Direct Cost: ¥97,500,000、Indirect Cost: ¥29,250,000)
Fiscal Year 2016: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
Fiscal Year 2015: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2014: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Fiscal Year 2013: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2012: ¥32,370,000 (Direct Cost: ¥24,900,000、Indirect Cost: ¥7,470,000)
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| Keywords | プラズマ / ナノマテリアル / 健康影響評価 / 体内動態 / 医療科学 / プラズマ照射水 |
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| Outline of Final Research Achievements |
We evaluated the health effects of plasma irradiation on the skin of normal hairless mice, Saccharomyces cerevisiae, silkworm, oral cancer cell or plasma-activated medium (PAM) when administered to mice via repeated intraperitoneal injections. In vivo kinetics of nanoparticles synthesized by discharge plasmas in water was analyzed. Clear dose-response relations were not observed by irradiation to Saccharomyces cerevisiae, silkworm, and oral cancer cell. From the histopathological changes in the mice skin after plasma irradiation, slight to mild skin lesions in the epidermis were seen just after irradiation until termination of observation periods and the severity of these lesions worsened with the passage of time. Concerning the health effect of PAM, clear lesions were not manifested in the PAM-treated mice. It would seem that a less toxic effect is manifested when PAM is injected intraperitoneally in mice.
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