Altered function and structure of immune system in ageing and diseases

• Project Area: Analysis and synthesis of multi-dimensional immune organ network
• Project/Area Number: 24111008
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: Minato Nagahiro 京都大学, 医学研究科, 理事 (40137716)
• Project Period (FY): 2012-06-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥159,900,000 (Direct Cost: ¥123,000,000、Indirect Cost: ¥36,900,000); Fiscal Year 2016: ¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000); Fiscal Year 2015: ¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000); Fiscal Year 2014: ¥30,680,000 (Direct Cost: ¥23,600,000、Indirect Cost: ¥7,080,000); Fiscal Year 2013: ¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000); Fiscal Year 2012: ¥37,700,000 (Direct Cost: ¥29,000,000、Indirect Cost: ¥8,700,000)
• Keywords: T細胞 / 細胞老化 / 免疫老化 / 恒常性増殖 / 老化関連疾患 / 自己免疫病 / 慢性炎症 / Ｔ細胞老化 / 濾胞Ｔ細胞 / 全身性エリテマトーデス / 糖尿病 / 加齢関連疾患

Outline of Final Research Achievements

We have identified a CD4+ T-cell population that exhibits cellular senescence features and increases with age (SA-T cells). The SA-T cells expressed senescence-related genes with SA-secretory phenotype (SASP) and showed a potent inflammatogenic activity with self-reactivity. The SA-T cells are generated after extensive cell divisions in homeostatic proliferation with age. Besides ageing, the SA-T cells are also increased robustly at the lupus-prone background and various tissue stresses and initiate autoimmunity and tissue inflammation such as high fat diet-induced adiposity and insulin-resistance. Current results have revealed that the SA-T cells underlie the systemic autoimmunity and age-related chronic inflammatory disorders.

Research Products

• [Journal Article] Expansion of human γδ T cells for adoptive immunotherapy using a bisphosphonate prodrug (2018)
  • Author(s): Tanaka Yoshimasa、Murata-Hirai Kaoru、Iwasaki Masashi、Matsumoto Kenji、Hayashi Kosuke、Kumagai Asuka、Nada Mohanad H.、Wang Hong、Kobayashi Hirohito、Kamitakahara Hiroshi、Okamura Haruki、Sugie Tomoharu、Minato Nagahiro、Toi Masakazu、Morita Craig T.
  • Journal Title: Cancer Science Volume: 109 Issue: 3 Pages: 587-599
  • DOI: 10.1111/cas.13491
  • NAID: 120006454669
  • Peer Reviewed / Open Access
• [Journal Article] Combined effects of neoadjuvant letrozole and zoledronic acid on γδT cells in postmenopausal women with early-stage breast cancer (2018)
  • Author(s): Sugie Tomoharu、Suzuki Eiji、Yamauchi Akira、Yamagami Kazuhiko、Masuda Norikazu、Gondo Naomi、Sumi Eriko、Ikeda Takafumi、Tada Harue、Uozumi Ryuji、Kanao Shotaro、Tanaka Yoshimasa、Hamazaki Yoko、Minato Nagahiro、Toi Masakazu
  • Journal Title: Breast Volume: 38 Pages: 114-119
  • DOI: 10.1016/j.breast.2017.12.017
  • Peer Reviewed / Open Access
• [Journal Article] Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells (2018)
  • Author(s): Xu Yan、Ikeda Satoshi、Sumida Kentaro、Yamamoto Ryusuke、Tanaka Hiroki、Minato Nagahiro
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 914-914
  • DOI: 10.1038/s41467-018-03307-8
  • NAID: 120006406847
  • Peer Reviewed / Open Access
• [Journal Article] Sipa1deficiency?induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm (2018)
  • Author(s): Xiao Pingnan、Dolinska Monika、Sandhow Lakshmi、Kondo Makoto、Johansson Anne-Sofie、Bouderlique Thibault、Zhao Ying、Li Xidan、Dimitriou Marios、Rassidakis George Z.、Hellstr?m-Lindberg Eva、Minato Nagahiro、Walfridsson Julian、Scadden David T.、Sigvardsson Mikael、Qian Hong
  • Journal Title: Blood Advances Volume: 2 Issue: 5 Pages: 534-548
  • DOI: 10.1182/bloodadvances.2017013599
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Frontline Science: IL-18 primes murine NK cells for proliferation by promoting protein synthesis, survival, and autophagy (2018)
  • Author(s): El-Darawish Yosif、Li Wen、Yamanishi Kyosuke、Pencheva Magdalena、Oka Naoto、Yamanishi Hiromichi、Matsuyama Tomohiro、Tanaka Yoshimasa、Minato Nagahiro、Okamura Haruki
  • Journal Title: Journal of Leukocyte Biology Volume: in press Issue: 2 Pages: 1-12
  • DOI: 10.1002/jlb.1hi1017-396rr
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine. (2017)
  • Author(s): Ito K, Nakajima A1, Fukushima Y1, Suzuki K1, Sakamoto K, Hamazaki Y, Ogasawara K, Minato N, and Hattori M.
  • Journal Title: PLoS One. Volume: 12 Issue: 3 Pages: e0173629-e0173629
  • DOI: 10.1371/journal.pone.0173629
  • NAID: 120006488574
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production (2017)
  • Author(s): Ohigashi I, Ohte Y, Setoh K, Nakase H, Maekawa A, Kiyonari H, Hamazaki Y, Sekai M, Sudo T, Tabara Y, Sawai H, Omae Y, Yuliwulandari R, Tanaka Y, Mizokami M, Inoue H, Kasahara M, Minato N, Tokunaga K, Tanaka K, Matsuda F, Murata S, Takahama Y.
  • Journal Title: JCI Insight Volume: 2 Issue: 10 Pages: 1-14
  • DOI: 10.1172/jci.insight.93664
  • NAID: 120006733720
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4+T Cells (2017)
  • Author(s): Sato Kyosuke、Kato Aiko、Sekai Miho、Hamazaki Yoko、Minato Nagahiro
  • Journal Title: The Journal of Immunology Volume: 199 Issue: 1 Pages: 138-148
  • DOI: 10.4049/jimmunol.1602005
  • Peer Reviewed / Open Access
• [Journal Article] Anti-Tumor Activity and Immunotherapeutic Potential of a Bisphosphonate Prodrug (2017)
  • Author(s): Tanaka, Y.; Iwasaki, M.; Murata-Hirai, K.; Matsumoto, K.; Hayashi, K.; Okamura, H.; Sugie, T.; Minato, N.; Morita, C. T.; Toi, M.
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 5987-5987
  • DOI: 10.1038/s41598-017-05553-0
  • NAID: 120006366782
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Bone Marrow Endothelial Cells Induce Immature and Mature B Cell Egress in Response to Erythropoietin (2017)
  • Author(s): Ito Takeshi、Hamazaki Yoko、Takaori-Kondo Akifumi、Minato Nagahiro
  • Journal Title: Cell Structure and Function Volume: 42 Issue: 2 Pages: 149-157
  • DOI: 10.1247/csf.17018
  • NAID: 130006251709
  • ISSN: 0386-7196, 1347-3700
  • Peer Reviewed / Open Access
• [Journal Article] A human PSMB11 variant affects molecular processing of thymoproteasome and thymic production of CD8+ T cells. (2017)
  • Author(s): Ohigashi, I, Ohte, Y, Setoh, K, Nakase, H, Maekawa, A, Kiyonari, H, Hamazaki, Y, Sekai, M, Sudo, T, Tabara, Y, Sawai, H, Omae, Y, Yuliwulandari, R, Tanaka, Y, Mizokami, M, Inoue, H, Kasahara, M, Minato, N, Tokunaga, K, Tanaka, K, Matsuda, F, Murata, S, and Takahama, Y.
  • Journal Title: J. Clin. Invest. Insight. Volume: 印刷中
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Medullary thymic epithelial stem cells: role in thymic epithelial cell maintenance and thymic involution (2016)
  • Author(s): Hamazaki Y, Sekai M, Minato N
  • Journal Title: Immunol Rev. Volume: 271 Issue: 1 Pages: 38-55
  • DOI: 10.1111/imr.12412
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Involvement of activation-induced cytidine deaminase in skin cancer development. (2016)
  • Author(s): Nonaka, T., Toda, Y., Hiai, H., Uemura, M., Nakamura, M., Yamamoto, N., Asato, R., Hattori, Y., Bessho, K., Minato, N., Kinoshita, K.
  • Journal Title: J. Clini. Invest. Volume: 126 Issue: 4 Pages: 1367-1382
  • DOI: 10.1172/jci81522
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Aberrant PD-L1 expression via 3’-UTR disruption in multiple cancers. (2016)
  • Author(s): K.Kataoka, (27名) N. Minato, K.Kashiwase, K. Izutsu, A. Takaori-Kondo, Y. Miyazaki, S. Takahashi, T. Shibata, H. Kawamoto, Y. Akatsuka, K. Shimoda, K. Takeuchi, T. Seya, S. Miyano, S. Ogawa.
  • Journal Title: Nature Volume: 534 Issue: 7607 Pages: 402-406
  • DOI: 10.1038/nature18294
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney (2016)
  • Author(s): Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, and Yanagita M.
  • Journal Title: JCI. Insight. Volume: 1 Issue: 11
  • DOI: 10.1172/jci.insight.87680
  • NAID: 120005820865
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Osteopontin in spontaneous germinal centers inhibits apoptotic cell engulfment and promotes autoantibody production in lupus mice. (2016)
  • Author(s): Sakamoto、K., Fukushima、Y., Itoh、K., Matsuda, M., Nagata, S., Minato, N., and Hattori, M.
  • Journal Title: J. Immunol. Volume: 197 Issue: 6 Pages: 2177-2186
  • DOI: 10.4049/jimmunol.1600987
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Obesity accelerates T-cell senescence in visceral adipose tissue (2016)
  • Author(s): Shirakawa K, Yan X, Shinmura K, Endo J, Kataoka M, Katsumata Y, Yamamoto T, Anzai A, Isobe S, Yoshida N, Itoh H, Manabe I, Sekai M, Hamazaki Y, Fukuda K, Minato N, and Sano M.
  • Journal Title: J Clin Invest. Volume: 126 Issue: 12 Pages: 4626-4639
  • DOI: 10.1172/jci88606
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway (2016)
  • Author(s): Robles Ana I.、（他６名）、Minato Nagahiro、Anders Robert A.、B?rresen-Dale Anne-Lise、Zhou Jianwei、S?trom P?l、Nielsen Boye Schnack、Kirschner Michaela B.、Krokan Hans E.、Papadimitrakopoulou Vassiliki、Tsamardinos Ioannis、R?e Oluf D.
  • Journal Title: Journal of Translational Medicine Volume: 14 Issue: 1 Pages: 295-310
  • DOI: 10.1186/s12967-016-1059-6
  • Peer Reviewed / Open Access
• [Journal Article] Targeting Lymphoma and Myeloid Leukemia Cells with Bisphosphonate Prodrugs. (2016)
  • Author(s): Matsumoto, K, Hayashi, K, Murata-Hirai, K., Iwasaki, M., Okamura, H., Minato, N., Morita, CT., and Tanaka, Y.
  • Journal Title: Chem.Med.Chem. Volume: 11 Issue: 24 Pages: 2656-2663
  • DOI: 10.1002/cmdc.201600465
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Excerpts from the 1st International NTNU Symposium on Current and Future Clinical Biomarkers of Cancer: Innovation and Implementation. (2016)
  • Author(s): A.I. Robles, K.S. Olsen, D. Tsui, V.Georgoulias, J. Creaney, K. Dobra, M. Vyberg, N. Minato, R. A. Anders, A-L. Børresen-Dale, J.Zhou, P.I. Sætrom, B.S. Nielsen1 M. B Kirschner, H. E. Krokan, V.Papadimitrakopoulou, I. Tsamardinos, and O.D. Røe.
  • Journal Title: J Transl. Med. Volume: 14 Pages: 295-295
  • Int'l Joint Research
• [Journal Article] Nuclear SIPA1 activates integrin β1 promoter and promotes invasion of breast cancer cells. (2015)
  • Author(s): Zhang, Y, Gong, Y, Hu, D, Zhu, P, Wang, N, Zhang, Q, Wang, M, Aldeewan, A, Xia, H, Qu, X, Ring, B.Z, Minato, N, and Su, L.
  • Journal Title: Oncogene Volume: 34 Issue: 11 Pages: 1451-1462
  • DOI: 10.1038/onc.2014.36
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-κB Inhibitor DHMEQ in Mast Cells (2015)
  • Author(s): Noma N, Asagiri M, Takeiri M, Ohmae S, Takemoto K, Iwaisako K, Minato N, Maeda-Yamamoto M, Simizu S, Umezawa K
  • Journal Title: Int Arch Allergy Immunol Volume: 166 Issue: 2 Pages: 84-90
  • DOI: 10.1159/000371419
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia. (2015)
  • Author(s): Doi K, Imai T, Kressler C, Yagita H, Agata Y, Vooijs M, Hamazaki Y, Inoue J, Minato N.
  • Journal Title: Sci Rep. Volume: 5 Issue: 1 Pages: 7978-7985
  • DOI: 10.1038/srep07978
  • NAID: 120005555511
  • Peer Reviewed / Open Access
• [Journal Article] A CD153+CD4+ T follicular cell population with cell-senescence features plays a crucial role in lupus pathogenesis via osteopontin production. (2015)
  • Author(s): 1.Tahir S, Fukushima Y, Sakamoto K, Sato K, Fujita H, Inoue J, Uede T, Hamazaki Y, Hattori M, Minato N.
  • Journal Title: The Journal of Immunology Volume: 194 Issue: 12 Pages: 5725-5735
  • DOI: 10.4049/jimmunol.1500319
  • Peer Reviewed / Open Access
• [Journal Article] A G protein-coupled receptor promotes its own surface expression by recruiting a Rap1-dependent signaling cascade. (2015)
  • Author(s): Zhang, Z., Zhang, W., Huang, S., Sun,Q., Wang, Y., Hu, Y., Zhang, Y., Minato, N., Pin, J-P., Su, L., and Liu, J.
  • Journal Title: J. Cell Sci. Volume: 128 Issue: 12 Pages: 2302-2313
  • DOI: 10.1242/jcs.167056
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Adult thymic medullary epithelium is maintained and regenerated by lineage-restricted cells rather than bipotent progenitors (2015)
  • Author(s): Ohigashi I, Zuklys S, Sakata M, Mayer CE, Hamazaki Y, Minato N, Hollander GA, Takahama Y.
  • Journal Title: Cell Rep. Volume: 13 Issue: 7 Pages: 1432-43
  • DOI: 10.1016/j.celrep.2015.10.012
  • NAID: 120006727050
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Modification of Gene Expression, Proliferation, and Function of OP9 Stroma Cells by Bcr-Abl-Expressing Leukemia Cells (2015)
  • Author(s): Supper E, Tahir S, Imai T, Inoue J, Minato N.
  • Journal Title: PLoS One Volume: 10(7) Issue: 7 Pages: e0134026-e0134026
  • DOI: 10.1371/journal.pone.0134026
  • NAID: 120005678188
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] γδ T cells and their potential for immunotherapy. (2014)
  • Author(s): Wu YL, Ding YP, Tanaka Y, Shen LW, Wei CH, Minato N, Zhang W.
  • Journal Title: Int J Biol Sci. Volume: 10(2): Issue: 2 Pages: 119-35
  • DOI: 10.7150/ijbs.7823
  • Peer Reviewed / Open Access
• [Journal Article] Enteroendocrine cells are specifically marked by cell surface expression of claudin-4 in mouse small intestine (2014)
  • Author(s): Nagatake T, Fujita H, Minato N, Hamazaki Y.
  • Journal Title: PLoS One Volume: 9 Issue: 3 Pages: e90638-e90638
  • DOI: 10.1371/journal.pone.0090638
  • Peer Reviewed / Open Access
• [Journal Article] Medullary thymic epithelial stem cells maintain a functional thymus to ensure lifelong central T cell tolerance. (2014)
  • Author(s): Sekai M, Hamazaki Y, Minato N.
  • Journal Title: Immunity. Volume: 41 Issue: 5 Pages: 753-761
  • DOI: 10.1016/j.immuni.2014.10.011
  • Peer Reviewed / Open Access
• [Journal Article] Effects of zoledronic acid and the association between its efficacy and \gamma\delta T cells in postmenopausal women with breast cancer treated with preoperative hormonal therapy: a study protocol (2014)
  • Author(s): Sumi E, Sugie T, Yoshimura K, Tada H, Ikeda T, Suzuki E, Tanaka Y, Teramukai S, Shimizu A, Toi M, Minato N
  • Journal Title: Journal of Translational Medicine Volume: 12 Issue: 1 Pages: 310-310
  • DOI: 10.1186/s12967-014-0310-2
  • Peer Reviewed / Open Access
• [Journal Article] Zoledronic acid-induced expansion of γ δT cells from early-stage breast cancer patients : effect of IL-18 on helper NK cells (2013)
  • Author(s): Sugie, T., Murata-Hirai, K., Iwasaki, M., Morita, C. T., Li, W., Okamura, H., Minato, N., Toi, M., Tanaka, Y.
  • Journal Title: Cancer Immunol. Immunoth Volume: (印刷中) Issue: 4 Pages: 677-87
  • DOI: 10.1007/s00262-012-1368-4
  • Peer Reviewed
• [Journal Article] Comparative analysis of gamma-delta T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid (2013)
  • Author(s): Idrees, AM., Sugie, T., Inoue, C., Murata-Hirai, K., Okamura, H., Morita, CT. Minato, N., Toi, M., Tanaka, Y
  • Journal Title: Cancer Science Volume: (印刷中) Issue: 5 Pages: 536-542
  • DOI: 10.1111/cas.12124
  • Peer Reviewed
• [Journal Article] Role of Rap signal in normal and disordered hematopoiesis (Review article) Exp (2013)
  • Author(s): Minato, N
  • Journal Title: Cell. Res Volume: (Epub ahead of print) Issue: 15 Pages: 2323-8
  • DOI: 10.1016/j.yexcr.2013.04.009
  • Peer Reviewed
• [Journal Article] Claudin-4 deficiency results in urothelial hyperplasia and lethal hydronephrosis. (2012)
  • Author(s): Fujita, H., Hamazaki, Y. , Noda, Y., Oshima, M., Minato, N.
  • Journal Title: PLoS One Volume: 7 Issue: 12 Pages: e52272-e52272
  • DOI: 10.1371/journal.pone.0052272
  • Peer Reviewed
• [Journal Article] PD-1 expressing T cells in leukemia (2012)
  • Author(s): Nakashima Y, Minato N.
  • Journal Title: Rinsho Ketsueki. Volume: 53(5): Pages: 515-20
  • NAID: 130004501674
• [Journal Article] Immunosenescence and diseases: follicular T cell response in germinal center. (2012)
  • Author(s): Minato N.
  • Journal Title: Seikagaku. Volume: 84(3): Pages: 203-8
• [Journal Article] Synthesis and analysis of multi-dimentional immune organ network. (2012)
  • Author(s): Takahama Y, Minato N.
  • Journal Title: Seikagaku. Volume: 84(3): Pages: 161-2
• [Journal Article] E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin | locus. (2012)
  • Author(s): Sakamoto, S., ffakae, K., Anzai, Y., Murai, K., Tamaki, N., Miyazaki, M., Miyazaki, K., Romanow, W. J., Ikawa, T., Kitamura, D., Yanagihira, I., Minato, N., Murre, C., Agata, Y
  • Journal Title: J. Immunol Volume: 188 Issue: 11 Pages: 5547-5560
  • DOI: 10.4049/jimmunol.1002346
  • Peer Reviewed
• [Presentation] .A new Horizon of Cancer Immunotherapy. (2018)
  • Author(s): Nagahiro Minato
  • Organizer: Senri Life Science International Symposium
  • Int'l Joint Research / Invited
• [Presentation] Aging of Immunity and Immunity in Aging. (2017)
  • Author(s): Nagahiro Minato
  • Organizer: 7th International workshop of Kyoto T cell conference
  • Place of Presentation: 京都大学紫蘭会館
  • Year and Date: 2017-03-13
  • Int'l Joint Research / Invited
• [Presentation] Aging of Immunity and Immunity in Aging. (2017)
  • Author(s): Nagahiro Minato
  • Organizer: KTCC International Symposium
  • Int'l Joint Research / Invited
• [Presentation] Immune checkpoint therapy. (2017)
  • Author(s): Nagahiro Minato
  • Organizer: The 8th Meeting of Asian Cellular Therapy Organization
  • Int'l Joint Research / Invited
• [Presentation] PD-1 and immune checkpoint cancer immunotherapy. (2017)
  • Author(s): Nagahiro Minato
  • Organizer: The 5th Annual Meeting of the International Cytokine and Interferon Society
  • Int'l Joint Research / Invited
• [Presentation] Aging of Immunity and Immunity in Aging. (2016)
  • Author(s): Nagahiro Minato,
  • Organizer: Cellular Senescence and Aging in Cancer and Diseases France-Japan Collaborative Seminar 2016
  • Place of Presentation: 京都
  • Year and Date: 2016-10-31
  • Int'l Joint Research / Invited
• [Presentation] History of PD-1 and perspectives of PD-1 checkpoint blockadecancer Immunotherapy (2016)
  • Author(s): Nagahiro Minato,
  • Organizer: 12th JSH Single Topic Conference
  • Place of Presentation: 金沢
  • Year and Date: 2016-09-22
  • Int'l Joint Research / Invited
• [Presentation] Checkpoint Cancer Immunotherapy (2016)
  • Author(s): Nagahiro Minato
  • Organizer: 1st NTNU Symposium on Current and Future Clinical Biomarkers of Cancer
  • Place of Presentation: Trondheim, Norway
  • Year and Date: 2016-06-16
  • Int'l Joint Research / Invited
• [Presentation] Checkpoint Cancer Immunotherapy (2016)
  • Author(s): Nagahiro Minato
  • Organizer: 1st NTNU Symposium on Current and Future Clinical Biomarkers of Cancer.
  • Int'l Joint Research / Invited
• [Presentation] History of PD-1 and perspectives of PD-1 checkpoint blockade cancer Immunotherapy (2016)
  • Author(s): Nagahiro Minato
  • Organizer: 12th JSH Single Topic Conference.
  • Int'l Joint Research / Invited
• [Presentation] Aging of Immunity and Immunity in Aging. (2016)
  • Author(s): Nagahiro Minato
  • Organizer: Cellular Senescence and Aging in Cancer and Diseases France-Japan Collaborative Seminar
  • Int'l Joint Research / Invited
• [Presentation] PD-1 blockade cancer Immunotherapy (2016)
  • Author(s): Nagahiro Minato
  • Organizer: St Lukes-MDA Cancer Symposium
  • Int'l Joint Research / Invited
• [Presentation] Checkpoint blockade cancer immunotherapy. (2016)
  • Author(s): Nagahiro Minato
  • Organizer: CLS Bohring Seminar.
  • Int'l Joint Research / Invited
• [Presentation] Immunosenescence and autoimmunity. (2015)
  • Author(s): Nagahiro Minato
  • Organizer: IFOM-Kyoto Joint Symposium.
  • Place of Presentation: 京都
  • Year and Date: 2015-10-06
  • Int'l Joint Research / Invited
• [Presentation] Immunosenescence and autoimmunity. (2015)
  • Author(s): Nagahiro Minato.
  • Organizer: IFOM-Kyoto Joint Symposium.
  • Place of Presentation: Kyoto
  • Year and Date: 2015-10-06
  • Int'l Joint Research / Invited
• [Presentation] New aspect of cancer immunotherapy. (2015)
  • Author(s): Nagahiro Minato
  • Organizer: Avison Biomedical Symposium.
  • Place of Presentation: Seoul
  • Year and Date: 2015-08-21
  • Int'l Joint Research / Invited
• [Presentation] Checkpoint blockade cancer immunotherapy. (2015)
  • Author(s): Nagahiro Minato
  • Organizer: CLS Bohring Seminar.
  • Place of Presentation: 京都
  • Year and Date: 2015-04-23
  • Int'l Joint Research / Invited
• [Presentation] Immunosenescence and autoimmunity. (2014)
  • Author(s): Nagahiro Minato.
  • Organizer: International Symposium of Japan Immunology Society
  • Place of Presentation: Kyoto
  • Year and Date: 2014-12-11
  • Int'l Joint Research / Invited
• [Presentation] Immunosenescence and autoimmunity (2014)
  • Author(s): Minato N
  • Organizer: International Symposium of Japanese Immunology Society
  • Place of Presentation: Kyoto International Conference Center (Kyoto)
  • Year and Date: 2014-12-10
  • Invited
• [Presentation] Immunosurveillance and cancer immunity. (2014)
  • Author(s): Nagahiro Minato.
  • Organizer: WRII international Symposium.
  • Place of Presentation: Seoul
  • Year and Date: 2014-10-08
  • Int'l Joint Research / Invited
• [Presentation] 免疫学の進展と医療への貢献 (2014)
  • Author(s): 湊 長博
  • Organizer: 日本医学会特別シンポジウム
  • Place of Presentation: グランフロント大阪（大阪）
  • Year and Date: 2014-07-10
  • Invited
• [Presentation] Recent advances in immunology. (2014)
  • Author(s): Nagahiro Minato.
  • Organizer: Symposium of Japan Medical Society
  • Place of Presentation: Osaka
  • Year and Date: 2014-07-07
  • Invited
• [Presentation] Immunosenescence and systemic autoimmunity. (2014)
  • Author(s): Nagahiro Minato.
  • Organizer: Uehara Memorial Symposium
  • Place of Presentation: Tokyo
  • Year and Date: 2014-06-16
  • Invited
• [Presentation] Immunosenescence and diseases (2014)
  • Author(s): Minato N
  • Organizer: Uehara Memorial Foundation Symposium
  • Place of Presentation: Fiatt Hotel (Tokyo)
  • Year and Date: 2014-06-15
  • Invited
• [Presentation] Immunosenescence and systemic autoimmunity. (2014)
  • Author(s): Nagahiro Minato.
  • Organizer: International Symposium of Japanese Allergy Society
  • Place of Presentation: Kyoto
  • Year and Date: 2014-05-10
  • Invited
• [Presentation] 免疫老化と自己免疫病 (2014)
  • Author(s): 湊 長博
  • Organizer: 日本アレルギー学会
  • Place of Presentation: 京都国際会館（京都）
  • Year and Date: 2014-05-08
  • Invited
• [Presentation] Checkpoint blockade cancer immunotherapy. (2014)
  • Author(s): Nagahiro Minato.
  • Organizer: CLS Bohring Seminar.
  • Place of Presentation: Kyoto
  • Year and Date: 2014-04-23
  • Int'l Joint Research / Invited
• [Presentation] Immunosenescence and diseases (2014)
  • Author(s): Nagahiro Minaｔo
  • Organizer: Uehara Memorial Foundation Symposium
  • Place of Presentation: Hiatt Regency Tokyo
  • Invited
• [Presentation] Immunosenescence and cancer (2013)
  • Author(s): Minato N
  • Organizer: Taiwan-Kyoto International Symposum
  • Place of Presentation: Taipei University (Taipei, Taiwan)
  • Year and Date: 2013-12-18
  • Invited
• [Presentation] Immunosenescence and autoimmunity (2013)
  • Author(s): Minato N
  • Organizer: Japan-Germany Immunology Conference
  • Place of Presentation: Nihondaira Hotel (Shizuoka)
  • Year and Date: 2013-12-11
  • Invited
• [Presentation] Gamma-delta T cells and cancer immunotherapy (2013)
  • Author(s): Minato N
  • Organizer: International Conference on Cell Therapy
  • Place of Presentation: Seoul National University (Seoul, Korea)
  • Year and Date: 2013-10-23
  • Invited
• [Presentation] Immunosenescence and immune surveillance (2013)
  • Author(s): Minato N
  • Organizer: KTCC International Symposium
  • Place of Presentation: Kyoto University (Kyoto)
  • Year and Date: 2013-06-03
  • Invited
• [Presentation] Rap G protein signaling in T cell leukemia (2012)
  • Author(s): Nagahiro Minato
  • Organizer: IFOM-Kyoto International Symposium
  • Place of Presentation: IFOM Institute (Milan, Italy)
  • Invited
• [Presentation] 免疫学の進展と医療への貢献
  • Author(s): 湊 長博
  • Organizer: 日本医学会特別シンポジウム
  • Place of Presentation: グランフロント大阪（大阪）.
  • Invited
• [Presentation] Identification of thymic epithelial stem cells ensuring lifelong central T-cell tolerance
  • Author(s): Ｍｉｈｏ Sekai, Yoko Hamazaki, Nagahiｒo Minato
  • Organizer: 第４２回日本免疫学会総会
  • Place of Presentation: 千葉 幕張メッセ
• [Presentation] Identification of thymic epithelial stem cells ensuring lifelong central T-cell tolerance
  • Author(s): Miho Sekai, Yoko Hamazaki, Nagahiro Minato
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: MiCo Milano Congressi （イタリア ミラノ）
• [Presentation] Claudin-4ノックアウトマウスにおける尿路過形成と水腎症
  • Author(s): 藤田春美、濱崎洋子、野田裕美、大島正信、湊長博
  • Organizer: 第６５回 日本細胞生物学会大会
  • Place of Presentation: ウインクあいち（名古屋）
• [Presentation] Medullary thymic epithelial stem cells ensuring lifelong central T-cell tolerance
  • Author(s): Yoko Hamazaki, Miho Sekai and Nagahiro Minato
  • Organizer: 6th International Workshop of Kyoto T Cell Conference (KTCC2013)
  • Place of Presentation: 京都
• [Presentation] Claudin-4 deficiency results in urothelial hyperplasia and lethal hydronephrosis
  • Author(s): 藤田春美、濵﨑洋子、野田裕美、大島正伸、湊長博
  • Organizer: 第３５回日本分子生物学会総会
  • Place of Presentation: マリンメッセ福岡 （福岡県）
• [Presentation] Identification of thymic epithelial stem cells ensuring lifelong central T-cell tolerance
  • Author(s): Miho Sekai, Yoko Hamazaki, Nagahiro Minato
  • Organizer: 第４１回日本免疫学会総会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] Claudin-5 is a Crucial Component of Blood-thymus Barrier by Regulating Vascular Permeability
  • Author(s): Takahiro Nagatake, Yan-Chun Zhao, Yoko Hamazaki and Nagahiro Minato
  • Organizer: 第４１回日本免疫学会総会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] Claudin-5 plays a role in establishing specific thymic microenvironment by regulating vascular permeability.
  • Author(s): Takahiro Nagatake, Yan-Chun Zhao, Nagahiro Minato and Yoko Hamazaki
  • Organizer: ThymUS international conference 2012
  • Place of Presentation: Trump International Beach Resort、マイアミ（アメリカ）
• [Presentation] PD-1+ memory phenotype CD4+ Th1 like cells underlie T cell immunodepression in senescence.
  • Author(s): Yuhko Suzuki, Joe Inoue, Nagahiro Minato
  • Organizer: 第４２回日本免疫学会総会
  • Place of Presentation: 千葉 幕張メッセ
• [Presentation] Critucal roles of Spa-1 in chemokine-induced rap-1 activation
  • Author(s): Haruka Shimizu, Sayaka Ishihara, Joe Inoue, Nagahiro Minato, Tatsuo Kinashi, Koko Katagiri
  • Organizer: 第４１回日本免疫学会総会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] T細胞性急性白血病における低分子量G蛋白質Rap1の役割
  • Author(s): 土井恵子、湊長博
  • Organizer: Kyoto T Cell Conference
  • Place of Presentation: 京都
• [Presentation] Rap G protein signal is essential for Notch activation in T-ALL
  • Author(s): Keiko Doi, Takahiko Imai, Joe Inoue, Hideo Yagita, Marc Vooijs, Yasutoshi Agata, Nagahiro Minato
  • Organizer: Notch Meeting VII
  • Place of Presentation: The Benaki Museum, Athens, Greece
• [Book] The Vaccine Book, Second Edition （Editors: Barry R. Bloom Paul-Henri Lambert）Chapter 29 Cancer immunotherapy by checkpoint blockade. (2016)
  • Author(s): Minato, N. and Honjo, T.
  • Total Pages: 20
  • Publisher: Academic Press
  • ISBN: 9780128021743
• [Book] The Vaccine Book, Chapter 29 ed. B.R. Bloom and P-H. Lambert (2016)
  • Author(s): Minato, N. and Honjo, T.
  • Total Pages: 19
  • Publisher: Academic Press
• [Book] T-cell senescence and autoimmunity. In “Innovative Medicine” (2015)
  • Author(s): Minato, N.
  • Total Pages: 11
  • Publisher: Springer Press.
• [Book] T-cell senescence and autoimmunity. In “Innovative Medicine” ed. (2014)
  • Author(s): Nakao, K., Minato, N., and Uemoto, S
  • Total Pages: 11
  • Publisher: Springer Press.