| Budget Amount *help |
¥116,610,000 (Direct Cost: ¥89,700,000、Indirect Cost: ¥26,910,000)
Fiscal Year 2016: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2015: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2014: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
Fiscal Year 2013: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2012: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
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| Outline of Final Research Achievements |
Retention of BRCA1 at sites of DNA damage through interaction with K63-linked polyubiquitin chains is important for homologous recombination repair of DNA breaks. In this study, we revealed that K-63 chains are rather required for non-homologous end-joining and the BRCA1 complex that executes the homologous recombination is retained at DSB sites through interaction of BARD1 with HP1γ, which subsequently interacts with Lys9-dimethylated histone H3 (H3K9me2) in an ATM-dependent manner. We also found a novel ligand-dependent non-genomic action of ER that stimulates the activity of UBE3C E3 ligase during mitosis and enhances cell proliferation. In addition we discovered a novel role of HERC2 E3 ligase activity on chromosome stability.
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