| Budget Amount *help |
¥116,610,000 (Direct Cost: ¥89,700,000、Indirect Cost: ¥26,910,000)
Fiscal Year 2016: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2015: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2014: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
Fiscal Year 2013: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2012: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
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| Outline of Final Research Achievements |
Ubiquitin modification controls various cellular processes, such as cell cycle control and protein quality control. This modification provides countless possibilities to assemble a specific polymer. Ubiquitin modification pathway is regulated by a variety of proteins including ubiquitin binding proteins, ubiquitin ligases and deubiquitinating enzymes. To elucidate the molecular mechanisms of ubiquitination pathway, we determined the crystal structures of ubiquitin binding protein, BAG6 and ubiquitin ligases, FBG3, HOIP and Keap1. Moreover, we have determined the structures of bacterial effectors, OspI and IpaH9.8 that manipulate the host ubiquitin pathway. These structures provide the substrate recognition and functional mechanisms.
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