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Neuroendocrine control of empathetic systems

Planned Research

Project AreaEmpathic system
Project/Area Number 25118008
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionJichi Medical University

Principal Investigator

Onaka Tatsushi  自治医科大学, 医学部, 教授 (90177254)

Co-Investigator(Kenkyū-buntansha) 高柳 友紀  自治医科大学, 医学部, 講師 (10418890)
吉田 匡秀  自治医科大学, 医学部, 助教 (30533955)
Co-Investigator(Renkei-kenkyūsha) NAGASAWA Miho  麻布大学, 獣医学部, 講師 (70533082)
Project Period (FY) 2013-06-28 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥102,960,000 (Direct Cost: ¥79,200,000、Indirect Cost: ¥23,760,000)
Fiscal Year 2017: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2016: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2015: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2014: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2013: ¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
Keywords共感 / オキシトシン / 超音波発声 / バゾプレシン / 情動伝染 / 共感性
Outline of Final Research Achievements

Roles of oxytocin-oxytocin receptor systems in the control of empathetic behaviors were investigated. We found that supraoptic oxytocin neurons extend their dendrites into the medial amygdala and that this dendritic oxytocin system mediates social recognition. We also found that distinct oxytocin systems facilitate both expression of social defeat postures and consolidation-like behaviors. Affective touches or playing behaviors were also found to activate oxytocin neurons in the hypothalamus, and to modulate development of social behaviors. We also found that oxytocin facilitates bonding between humans and dogs.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (36 results)

All 2018 2017 2016 2015 2014 2013 Other

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 4 results) Presentation (23 results) (of which Int'l Joint Research: 3 results,  Invited: 17 results)

  • [Journal Article] Oxytocin-Oxytocin Receptor Systems Facilitate Social Defeat Posture in Male Mice2017

    • Author(s)
      Nasanbuyan Naranbat、Yoshida Masahide、Takayanagi Yuki、Inutsuka Ayumu、Nishimori Katsuhiko、Yamanaka Akihiro、Onaka Tatsushi
    • Journal Title

      Endocrinology

      Volume: 159 Issue: 2 Pages: 763-775

    • DOI

      10.1210/en.2017-00606

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] オキシトシンと妊娠・出産・育児の関係―その古典的な機能と新しい機能2016

    • Author(s)
      尾仲達史
    • Journal Title

      助産雑誌

      Volume: 70 Pages: 709-714

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Activation of supraoptic oxytocin neurons by secretin facilitates social recognition.2015

    • Author(s)
      Takayanagi Y, Yoshida M, Takashima A, Takanami K, Yoshida S, Nishimori K, Nishijima I, Sakamoto H, Yamagata T, Onaka T
    • Journal Title

      Biological Psychiatry

      Volume: in press Issue: 3 Pages: 243-251

    • DOI

      10.1016/j.biopsych.2015.11.021

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Activation of hypothalamic oxytocin neurons following tactile stimuli in rats.2015

    • Author(s)
      Okabe S, Yoshida M, Takayanagi Y, Onaka T
    • Journal Title

      Neuroscience Letters

      Volume: 600 Pages: 22-27

    • DOI

      10.1016/j.neulet.2015.05.055

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Noxious or Non-Noxious Inputs to Oxytocin Neurons: Possible Roles in the Control of Behaviors.2015

    • Author(s)
      Onaka T, Okabe S, Takayanagi Y, Yoshida M
    • Journal Title

      Interdisciplinary Information Sciences

      Volume: 21 Issue: 3 Pages: 189-195

    • DOI

      10.4036/iis.2015.b.03

    • NAID

      110009966527

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Social evolution. Oxytocin-gaze positive loop and the coevolution of human-dog bonds.2015

    • Author(s)
      Nagasawa M, Mitsui S, En S, Ohtani N, Ohta M, Sakuma Y, Onaka T, Mogi K, Kikusui T.
    • Journal Title

      Science

      Volume: 348 Issue: 6232 Pages: 333-336

    • DOI

      10.1126/science.1261022

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] エイジングとホルモン(4)―オキシトシン2015

    • Author(s)
      尾仲達史
    • Journal Title

      Hormone Frontier in Gynecology

      Volume: 22 Pages: 131-139

    • Related Report
      2015 Annual Research Report
  • [Journal Article] オキシトシンと社会的行動2015

    • Author(s)
      尾仲達史
    • Journal Title

      Clinical Neuroscience

      Volume: 33 Pages: 177-181

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 不安・恐怖とオキシトシン2015

    • Author(s)
      尾仲達史、吉田匡秀、高柳友紀
    • Journal Title

      アンチエイジング医学

      Volume: 11 Pages: 24-33

    • Related Report
      2014 Annual Research Report
  • [Journal Article] The medial amygdala - medullary PrRP-synthesizing neuron pathway mediates neuroendocrine responses to contextual conditioned fear in male rodents.2014

    • Author(s)
      Yoshida M, Takayanagi Y, Onaka T
    • Journal Title

      Endocrinology

      Volume: 155 Issue: 8 Pages: 2996-3004

    • DOI

      10.1210/en.2013-1411

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] オキシトシンの働きと老化2014

    • Author(s)
      尾仲達史
    • Journal Title

      最新医学

      Volume: 69 Pages: 1021-1031

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
  • [Journal Article] ストレス・摂食・社会行動の相互作用:オキシトシンの働き2014

    • Author(s)
      尾仲達史
    • Journal Title

      心身医学

      Volume: 54 Pages: 643-656

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
  • [Journal Article] ストレスと摂食2014

    • Author(s)
      尾仲達史
    • Journal Title

      ストレスアンドヘルスケア

      Volume: 210 Pages: 1-4

    • Related Report
      2013 Annual Research Report
  • [Presentation] 異種間における親和的関係性構築のメカニズム解明に向けてーラットを用いた研究ー2018

    • Author(s)
      岡部祥太, 高柳友紀, 吉田匡秀, 尾仲達史
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 相互注視とオキシトシン神経系を介したヒトとイヌとの絆形成2018

    • Author(s)
      永澤美保, 小川美里, 圓史緒理, 尾仲達史, 佐久間康夫, 茂木一孝, 菊水健史
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Roles of Oxytocin- Oxytocin Receptor Systems in the Control of Stress Responses2018

    • Author(s)
      Onaka T
    • Organizer
      The Social Brain: Social Neural Networks
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 中枢神経系におけるオキシトシン投射線維とオキシトシン受容体の分布:新規の社会行動関連神経回路とその機能2018

    • Author(s)
      吉田匡秀、Naranbat Nasanbuyan、高柳友紀、犬束歩、尾仲達史
    • Organizer
      第28回バゾプレシン研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] オキシトシンとストレス、エネルギー代謝、社会行動.2017

    • Author(s)
      尾仲達史
    • Organizer
      第90回日本内分泌学会学術総会
    • Place of Presentation
      ロームシアター京都・京都勧業館みやこめっせ(京都府京都市)
    • Year and Date
      2017-04-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 社会行動におけるオキシトシンの働き2017

    • Author(s)
      高柳友紀
    • Organizer
      第122回日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎大学坂本キャンパス(長崎県長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 遺伝子改変動物とウィルスベクターを用いたオキシトシンシステム特異的な機能調節.2017

    • Author(s)
      吉田匡秀
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] オキシトシンと母性行動・社会行動2017

    • Author(s)
      尾仲達史
    • Organizer
      第32回東京母性衛生学会学術セミナー
    • Place of Presentation
      帝京科学大学千住キャンパス(東京都足立区)
    • Year and Date
      2017-02-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ストレス反応と下垂体後葉ホルモン2017

    • Author(s)
      尾仲達史
    • Organizer
      日本臨床麻酔学会第37回大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Stroking stimuli form an affiliative relationship between humans and rats2017

    • Author(s)
      Okabe S, Takayanagi Y, Yoshida M, Onaka T
    • Organizer
      行動2017(Koudou2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Activation of oxytocin neurons in response to secretin administration and social defeat stress2017

    • Author(s)
      Onaka T, Takayanagi Y, Nasanbuyan N, Yoshida M, Inutsuka A
    • Organizer
      The 12th World Congress on Neurohypophysial Hormones
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Do stroking stimuli induce a pleasant sensation in rats.2016

    • Author(s)
      Okabe S
    • Organizer
      日本動物心理学会第76回大会
    • Place of Presentation
      北海道大学 学術交流会館(北海道札幌市)
    • Year and Date
      2016-11-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Neuroendocrine and behavioral responses to fear-related or affiliative stimuli: roles of oxytocin.2016

    • Author(s)
      Onaka T, Takayanagi Y, Yoshida M, Okabe S
    • Organizer
      The 93rd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Sapporo
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 接触刺激に対するラット視床下部オキシトシン産生細胞の活性化と超音波発声2015

    • Author(s)
      岡部祥太、吉田匡秀、高柳友紀、尾仲達史
    • Organizer
      第42回日本神経内分泌学会 第23回日本神経行動内分泌研究会 合同学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Noxious or Non-Noxious Inputs to Oxytocin Neurons: Possible Roles in the Control of Behaviors.2015

    • Author(s)
      Onaka T, Takayanagi Y, Yoshida M, Okabe S
    • Organizer
      Parvo- and Magnocellular Symposium in Sendai
    • Place of Presentation
      Sendai
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オキシトシンによる情動・社会行動の制御.2015

    • Author(s)
      高柳友紀、吉田匡秀、尾仲達史
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸(神戸国際会議場・展示場)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 条件恐怖ストレスの神経内分泌反応における内側扁桃体の働き2015

    • Author(s)
      尾仲達史、吉田匡秀、高柳友紀
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸(神戸国際会議場・展示場)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Lesions of vasopressin neurons by use of vasopressin-DTR transgenic rats.2014

    • Author(s)
      Onaka T, Yoshida M, Takayanagi Y
    • Organizer
      Satellite meeting of ICN 2014 in Sydney“Recent and Future Trends in Neuroendocrinology-from Asia and Oceania to Global-”
    • Place of Presentation
      Novotel Sydney Manly Pacific, Sydney
    • Year and Date
      2014-08-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 社会的記憶の制御におけるセクレチンーオキシトシンシステムの役割2014

    • Author(s)
      高柳友紀、尾仲達史
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 下垂体後葉ホルモンとストレス・摂食・社会行動2013

    • Author(s)
      尾仲達史、高柳友紀、吉田匡秀
    • Organizer
      創薬薬理フォーラム第21回シンポジウム
    • Place of Presentation
      日本薬学会長井記念館(東京都渋谷区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The medial amygdala-medullary prolactin-releasing peptide neuron pathway mediates neuroendocrine responses to conditioned fear stimuli2013

    • Author(s)
      Yoshida M, Takayanagi Y, Onaka T
    • Organizer
      10th World Congress on Neurohpophysial Hormones(WCNH2013)
    • Place of Presentation
      St Georges, Bristol, UK
    • Related Report
      2013 Annual Research Report
  • [Presentation] Stress and energy metabolisms: roles of PrRP and oxytocin2013

    • Author(s)
      Onaka T, Takayanagi Y, Yoshida M
    • Organizer
      The 36th Naito Conference on“Molecular Aspects of Energy Balance and Feeding Behavior”
    • Place of Presentation
      Gateaux Kingdom SAPPORO, Sapporo, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 心身ストレスとその機序

    • Author(s)
      尾仲達史
    • Organizer
      生体機能の理解にもとづく災害ストレス支援の推進事業第1回シンポジウム
    • Place of Presentation
      野村総合研究所(東京都千代田区)
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2013-07-10   Modified: 2019-07-29  

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