Neuroendocrine control of empathetic systems

• Project Area: Empathic system
• Project/Area Number: 25118008
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Jichi Medical University
• Principal Investigator: Onaka Tatsushi 自治医科大学, 医学部, 教授 (90177254)
• Co-Investigator(Kenkyū-buntansha): 高柳 友紀 自治医科大学, 医学部, 講師 (10418890) ; 吉田 匡秀 自治医科大学, 医学部, 助教 (30533955)
• Co-Investigator(Renkei-kenkyūsha): NAGASAWA Miho 麻布大学, 獣医学部, 講師 (70533082)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥102,960,000 (Direct Cost: ¥79,200,000、Indirect Cost: ¥23,760,000); Fiscal Year 2017: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2016: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000); Fiscal Year 2015: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2014: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000); Fiscal Year 2013: ¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
• Keywords: 共感 / オキシトシン / 超音波発声 / バゾプレシン / 情動伝染 / 共感性

Outline of Final Research Achievements

Roles of oxytocin-oxytocin receptor systems in the control of empathetic behaviors were investigated. We found that supraoptic oxytocin neurons extend their dendrites into the medial amygdala and that this dendritic oxytocin system mediates social recognition. We also found that distinct oxytocin systems facilitate both expression of social defeat postures and consolidation-like behaviors. Affective touches or playing behaviors were also found to activate oxytocin neurons in the hypothalamus, and to modulate development of social behaviors. We also found that oxytocin facilitates bonding between humans and dogs.

Research Products

• [Journal Article] Oxytocin-Oxytocin Receptor Systems Facilitate Social Defeat Posture in Male Mice (2017)
  • Author(s): Nasanbuyan Naranbat、Yoshida Masahide、Takayanagi Yuki、Inutsuka Ayumu、Nishimori Katsuhiko、Yamanaka Akihiro、Onaka Tatsushi
  • Journal Title: Endocrinology Volume: 159 Issue: 2 Pages: 763-775
  • DOI: 10.1210/en.2017-00606
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] オキシトシンと妊娠・出産・育児の関係―その古典的な機能と新しい機能 (2016)
  • Author(s): 尾仲達史
  • Journal Title: 助産雑誌 Volume: 70 Pages: 709-714
• [Journal Article] Activation of supraoptic oxytocin neurons by secretin facilitates social recognition. (2015)
  • Author(s): Takayanagi Y, Yoshida M, Takashima A, Takanami K, Yoshida S, Nishimori K, Nishijima I, Sakamoto H, Yamagata T, Onaka T
  • Journal Title: Biological Psychiatry Volume: in press Issue: 3 Pages: 243-251
  • DOI: 10.1016/j.biopsych.2015.11.021
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Activation of hypothalamic oxytocin neurons following tactile stimuli in rats. (2015)
  • Author(s): Okabe S, Yoshida M, Takayanagi Y, Onaka T
  • Journal Title: Neuroscience Letters Volume: 600 Pages: 22-27
  • DOI: 10.1016/j.neulet.2015.05.055
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Noxious or Non-Noxious Inputs to Oxytocin Neurons: Possible Roles in the Control of Behaviors. (2015)
  • Author(s): Onaka T, Okabe S, Takayanagi Y, Yoshida M
  • Journal Title: Interdisciplinary Information Sciences Volume: 21 Issue: 3 Pages: 189-195
  • DOI: 10.4036/iis.2015.b.03
  • NAID: 110009966527
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Social evolution. Oxytocin-gaze positive loop and the coevolution of human-dog bonds. (2015)
  • Author(s): Nagasawa M, Mitsui S, En S, Ohtani N, Ohta M, Sakuma Y, Onaka T, Mogi K, Kikusui T.
  • Journal Title: Science Volume: 348 Issue: 6232 Pages: 333-336
  • DOI: 10.1126/science.1261022
  • Peer Reviewed / Open Access
• [Journal Article] エイジングとホルモン(4)―オキシトシン (2015)
  • Author(s): 尾仲達史
  • Journal Title: Hormone Frontier in Gynecology Volume: 22 Pages: 131-139
• [Journal Article] オキシトシンと社会的行動 (2015)
  • Author(s): 尾仲達史
  • Journal Title: Clinical Neuroscience Volume: 33 Pages: 177-181
• [Journal Article] 不安・恐怖とオキシトシン (2015)
  • Author(s): 尾仲達史、吉田匡秀、高柳友紀
  • Journal Title: アンチエイジング医学 Volume: 11 Pages: 24-33
• [Journal Article] The medial amygdala - medullary PrRP-synthesizing neuron pathway mediates neuroendocrine responses to contextual conditioned fear in male rodents. (2014)
  • Author(s): Yoshida M, Takayanagi Y, Onaka T
  • Journal Title: Endocrinology Volume: 155 Issue: 8 Pages: 2996-3004
  • DOI: 10.1210/en.2013-1411
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] オキシトシンの働きと老化 (2014)
  • Author(s): 尾仲達史
  • Journal Title: 最新医学 Volume: 69 Pages: 1021-1031
• [Journal Article] ストレス・摂食・社会行動の相互作用：オキシトシンの働き (2014)
  • Author(s): 尾仲達史
  • Journal Title: 心身医学 Volume: 54 Pages: 643-656
• [Journal Article] ストレスと摂食 (2014)
  • Author(s): 尾仲達史
  • Journal Title: ストレスアンドヘルスケア Volume: 210 Pages: 1-4
• [Presentation] 異種間における親和的関係性構築のメカニズム解明に向けてーラットを用いた研究ー (2018)
  • Author(s): 岡部祥太, 高柳友紀, 吉田匡秀, 尾仲達史
  • Organizer: 第95回日本生理学会大会
  • Invited
• [Presentation] 相互注視とオキシトシン神経系を介したヒトとイヌとの絆形成 (2018)
  • Author(s): 永澤美保, 小川美里, 圓史緒理, 尾仲達史, 佐久間康夫, 茂木一孝, 菊水健史
  • Organizer: 第95回日本生理学会大会
  • Invited
• [Presentation] Roles of Oxytocin- Oxytocin Receptor Systems in the Control of Stress Responses (2018)
  • Author(s): Onaka T
  • Organizer: The Social Brain: Social Neural Networks
  • Int'l Joint Research / Invited
• [Presentation] 中枢神経系におけるオキシトシン投射線維とオキシトシン受容体の分布：新規の社会行動関連神経回路とその機能 (2018)
  • Author(s): 吉田匡秀、Naranbat Nasanbuyan、高柳友紀、犬束歩、尾仲達史
  • Organizer: 第28回バゾプレシン研究会
• [Presentation] オキシトシンとストレス、エネルギー代謝、社会行動. (2017)
  • Author(s): 尾仲達史
  • Organizer: 第90回日本内分泌学会学術総会
  • Place of Presentation: ロームシアター京都・京都勧業館みやこめっせ（京都府京都市）
  • Year and Date: 2017-04-20
  • Invited
• [Presentation] 社会行動におけるオキシトシンの働き (2017)
  • Author(s): 高柳友紀
  • Organizer: 第122回日本解剖学会総会・全国学術集会
  • Place of Presentation: 長崎大学坂本キャンパス（長崎県長崎市）
  • Year and Date: 2017-03-28
  • Invited
• [Presentation] 遺伝子改変動物とウィルスベクターを用いたオキシトシンシステム特異的な機能調節. (2017)
  • Author(s): 吉田匡秀
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松（静岡県浜松市）
  • Year and Date: 2017-03-28
  • Invited
• [Presentation] オキシトシンと母性行動・社会行動 (2017)
  • Author(s): 尾仲達史
  • Organizer: 第32回東京母性衛生学会学術セミナー
  • Place of Presentation: 帝京科学大学千住キャンパス（東京都足立区）
  • Year and Date: 2017-02-25
  • Invited
• [Presentation] ストレス反応と下垂体後葉ホルモン (2017)
  • Author(s): 尾仲達史
  • Organizer: 日本臨床麻酔学会第37回大会
  • Invited
• [Presentation] Stroking stimuli form an affiliative relationship between humans and rats (2017)
  • Author(s): Okabe S, Takayanagi Y, Yoshida M, Onaka T
  • Organizer: 行動2017（Koudou2017）
• [Presentation] Activation of oxytocin neurons in response to secretin administration and social defeat stress (2017)
  • Author(s): Onaka T, Takayanagi Y, Nasanbuyan N, Yoshida M, Inutsuka A
  • Organizer: The 12th World Congress on Neurohypophysial Hormones
  • Int'l Joint Research / Invited
• [Presentation] Do stroking stimuli induce a pleasant sensation in rats. (2016)
  • Author(s): Okabe S
  • Organizer: 日本動物心理学会第76回大会
  • Place of Presentation: 北海道大学 学術交流会館（北海道札幌市）
  • Year and Date: 2016-11-23
• [Presentation] Neuroendocrine and behavioral responses to fear-related or affiliative stimuli: roles of oxytocin. (2016)
  • Author(s): Onaka T, Takayanagi Y, Yoshida M, Okabe S
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Sapporo
  • Year and Date: 2016-03-22
• [Presentation] 接触刺激に対するラット視床下部オキシトシン産生細胞の活性化と超音波発声 (2015)
  • Author(s): 岡部祥太、吉田匡秀、高柳友紀、尾仲達史
  • Organizer: 第42回日本神経内分泌学会 第23回日本神経行動内分泌研究会 合同学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2015-09-18
• [Presentation] Noxious or Non-Noxious Inputs to Oxytocin Neurons: Possible Roles in the Control of Behaviors. (2015)
  • Author(s): Onaka T, Takayanagi Y, Yoshida M, Okabe S
  • Organizer: Parvo- and Magnocellular Symposium in Sendai
  • Place of Presentation: Sendai
  • Year and Date: 2015-09-17
  • Int'l Joint Research / Invited
• [Presentation] オキシトシンによる情動・社会行動の制御. (2015)
  • Author(s): 高柳友紀、吉田匡秀、尾仲達史
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸（神戸国際会議場・展示場）
  • Year and Date: 2015-03-21 – 2015-03-23
  • Invited
• [Presentation] 条件恐怖ストレスの神経内分泌反応における内側扁桃体の働き (2015)
  • Author(s): 尾仲達史、吉田匡秀、高柳友紀
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸（神戸国際会議場・展示場）
  • Year and Date: 2015-03-21 – 2015-03-23
  • Invited
• [Presentation] Lesions of vasopressin neurons by use of vasopressin-DTR transgenic rats. (2014)
  • Author(s): Onaka T, Yoshida M, Takayanagi Y
  • Organizer: Satellite meeting of ICN 2014 in Sydney“Recent and Future Trends in Neuroendocrinology-from Asia and Oceania to Global-”
  • Place of Presentation: Novotel Sydney Manly Pacific, Sydney
  • Year and Date: 2014-08-16
  • Invited
• [Presentation] 社会的記憶の制御におけるセクレチンーオキシトシンシステムの役割 (2014)
  • Author(s): 高柳友紀、尾仲達史
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島市）
  • Invited
• [Presentation] 下垂体後葉ホルモンとストレス・摂食・社会行動 (2013)
  • Author(s): 尾仲達史、高柳友紀、吉田匡秀
  • Organizer: 創薬薬理フォーラム第21回シンポジウム
  • Place of Presentation: 日本薬学会長井記念館（東京都渋谷区）
  • Invited
• [Presentation] The medial amygdala-medullary prolactin-releasing peptide neuron pathway mediates neuroendocrine responses to conditioned fear stimuli (2013)
  • Author(s): Yoshida M, Takayanagi Y, Onaka T
  • Organizer: 10th World Congress on Neurohpophysial Hormones（WCNH2013）
  • Place of Presentation: St Georges, Bristol, UK
• [Presentation] Stress and energy metabolisms: roles of PrRP and oxytocin (2013)
  • Author(s): Onaka T, Takayanagi Y, Yoshida M
  • Organizer: The 36th Naito Conference on“Molecular Aspects of Energy Balance and Feeding Behavior”
  • Place of Presentation: Gateaux Kingdom SAPPORO, Sapporo, Japan
  • Invited
• [Presentation] 心身ストレスとその機序
  • Author(s): 尾仲達史
  • Organizer: 生体機能の理解にもとづく災害ストレス支援の推進事業第1回シンポジウム
  • Place of Presentation: 野村総合研究所（東京都千代田区）
  • Invited