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Noninvasive imaging technique for measuring neural circuit activity

Planned Research

Project AreaMechanisms underlying the functional shift of brain neural circuitry for behavioral adaptation
Project/Area Number 26112003
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University (2018)
Institute of Physical and Chemical Research (2014-2017)

Principal Investigator

onoe hirotaka  京都大学, 医学研究科, 特定准教授 (80214196)

Co-Investigator(Kenkyū-buntansha) 水間 広  国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員 (00382200)
疋島 啓吾  沖縄科学技術大学院大学, 実験動物セクション, MRIスペシャリスト (30420219)
崔 翼龍  国立研究開発法人理化学研究所, 生命機能科学研究センター, ユニットリーダー (60312229)
林 拓也  国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (50372115)
Research Collaborator Komaki Yuji  
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥73,450,000 (Direct Cost: ¥56,500,000、Indirect Cost: ¥16,950,000)
Fiscal Year 2018: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2017: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2016: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2015: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2014: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
KeywordsMRI / PET / 遺伝子改変マウス / 非ヒト霊長類 / 脳機能イメージング / リハビリテーション / 精神神経疾患 / 自閉症 / 無麻酔 / 安静期fMRI / グラフ理論 / 母胎感染モデル / 脳機能画像 / fMRI / 機能イメージング / 機能結合 / atlas / サル / Long Evans / 代謝連結 / fMRI / VBM / DTI / 脳梗塞 / 脊髄損傷 / 標準脳 / MR microscopy / 拡散強調 / 安静時脳機能ネットワーク / 拡散テンソル
Outline of Final Research Achievements

In order to identify the functional structure of the brain from pathological animal models such as non-human primates and genetically modified mice, we developed dedicated coils for animals MRI imaging and also developed new molecular probes in PET. In combination with other technologies, we established a method for delineating the dynamic changes in functional network and its causality. Using this non-invasive imaging methods, we analyzed functional neural networks in genetically modified model mice and non-human primates such as macaques, and not only pathologies, but also neural circuits under the transition in the learning and development stages and functional recovery after the brain and spinal cord injury.

Academic Significance and Societal Importance of the Research Achievements

遺伝子改変モデルマウスから非ヒト霊長類であるマカクサルにおける機能的神経回路網の解析のためのイメージング基盤技術を開発したことで、ヒトの病態のみならず、学習や発達の段階で遷移する神経回路や脳・脊髄損傷後の機能代償に関わる回路を特定することが可能となった。したがって、ヒトにおける脳損傷後のリハビリテーションや発達障害等の病態を、脳構造・機能的ネットワークの神経回路動態変化に基づいて理解することで、効率的で有用な治療法の開発につながることが期待される。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (45 results)

All 2019 2018 2017 2016 2015 2014 Other

All Journal Article (18 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 15 results,  Open Access: 10 results,  Acknowledgement Compliant: 1 results) Presentation (24 results) (of which Int'l Joint Research: 6 results,  Invited: 10 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Dissecting the circuit for blindsight to reveal the critical role of pulvinar and superior colliculus2019

    • Author(s)
      Kinoshita M, Kato R, Isa K, Kobayashi K, Kobayashi K, Onoe H, Isa T
    • Journal Title

      Nat Commun

      Volume: 10 Issue: 1 Pages: 135-135

    • DOI

      10.1038/s41467-018-08058-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A voxel-based analysis of neurobiological mechanisms in placebo analgesia in rats.2018

    • Author(s)
      Zeng Y, Hu D, Yang W, Hayashinaka E, Wada Y, Watanabe Y, Zeng Q. Cui YL
    • Journal Title

      NeuroImage

      Volume: 178 Pages: 602-612

    • DOI

      10.1016/j.neuroimage.2018.06.009

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 3.Kato M, Yokoyama C, Kawasaki A, Takeda C, Koike T, Onoe H, Iriki A, Individual identity and affective valence in marmoset calls: in vivo brain imaging with vocal sound playback.2018

    • Author(s)
      Kato M, Yokoyama C, Kawasaki A, Takeda C, Koike T, Onoe H, Iriki A.
    • Journal Title

      Anim Cogn.

      Volume: 21(3) Issue: 3 Pages: 331-343

    • DOI

      10.1007/s10071-018-1169-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive analysis of area-specific and time-dependent changes in gene expression in the motor cortex of macaque monkeys during recovery from spinal cord injury.2018

    • Author(s)
      Higo N et al.
    • Journal Title

      J Comp Neurol.

      Volume: 526 Issue: 7 Pages: 1110-1130

    • DOI

      10.1002/cne.24396

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Brain/MINDS 3D digital marmoset brain atlas2018

    • Author(s)
      Woodward A, Hashikawa T, Maeda M, Kaneko T, Hikishima K, Iriki A, Okano H, Yamaguchi Y.
    • Journal Title

      Sci Data

      Volume: 5 Issue: 1 Pages: 180009-180009

    • DOI

      10.1038/sdata.2018.9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Developmental trajectories of macroanatomical structures in common marmoset brain2017

    • Author(s)
      Seki Fumiko、Hikishima Keigo、Komaki Yuji、Hata Junichi、Uematsu Akiko、Okahara Norio、Yamamoto Masafumi、Shinohara Haruka、Sasaki Erika、Okano Hideyuki
    • Journal Title

      Neuroscience

      Volume: 364 Pages: 143-156

    • DOI

      10.1016/j.neuroscience.2017.09.021

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2. Development of Neuroimaging Using Preclinical MRI, and the Clinical Application2017

    • Author(s)
      疋島啓吾、藤吉兼浩
    • Journal Title

      Japanese Journal of Radiological Technology

      Volume: 73 Issue: 12 Pages: 1277-1284

    • DOI

      10.6009/jjrt.2017_JSRT_73.12.1277

    • NAID

      130006258038

    • ISSN
      0369-4305, 1881-4883
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Involvement of the Septo-Hippocampal Cholinergic Pathway in Association with Septal Acetylcholinesterase Upregulation in a Mouse Model of Tauopathy.2017

    • Author(s)
      Hara Y, Motoi Y, Hikishima K, Mizuma H, Onoe H, Matsumoto SE, Elahi M, Okano H, Aoki S, Hattori N.
    • Journal Title

      Curr Alzheimer Res

      Volume: 14(1) Issue: 1 Pages: 94-103

    • DOI

      10.2174/1567205013666160602235800

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Functional brain mapping using specific sensory-circuit stimulation and a theoretical graph network analysis in mice with neuropathic allodynia.2016

    • Author(s)
      Komaki Y, Hikishima K, Shibata S, Konomi T, Seki F, Yamada M, Miyasaka N, Fujiyoshi K, Okano HJ, Nakamura M, Okano H.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 37802-37802

    • DOI

      10.1038/srep37802

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Application of q-Space Diffusion MRI for the Visualization of White Matter2016

    • Author(s)
      Fujiyoshi K, Hikishima K, Nakahara J, Tsuji O, Hata J, Konomi T, Nagai T, Shibata S, Kaneko S, Iwanami A, Momoshima S, Takahashi S, Jinzaki M, Suzuki N, Toyama Y, Nakamura M, Okano H.
    • Journal Title

      Journal of Neuroscience

      Volume: 36(9) Issue: 9 Pages: 2796-2808

    • DOI

      10.1523/jneurosci.1770-15.2016

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neural changes in the primate brain correlated with the evolution of complex motor skills.2016

    • Author(s)
      Yamazaki Y, Hikishima K, Saiki M, Inada M, Sasaki E, Lemon RN, Price CJ, Okano H, Iriki A.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 31084-31084

    • DOI

      10.1038/srep31084

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Function of the nucleus accumbens in motor control during recovery after spinal cord injury.2015

    • Author(s)
      Sawada, M., K. Kato, T. Kunieda, N. Mikuni, S. Miyamoto, H. Onoe, T. Isa and Y. Nishimura
    • Journal Title

      Science

      Volume: 350 Issue: 6256 Pages: 98-101

    • DOI

      10.1126/science.aab3825

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Voxel-based morphometry of the marmoset brain: In vivo detection of volume loss in the substantia nigra of the MPTP-treated Parkinson's disease model.2015

    • Author(s)
      Hikishima K, Ando K, Komaki Y, Kawai K, Yano R, Inoue T, Itoh T, Yamada M, Momoshima S, Okano HJ, Okano H
    • Journal Title

      Neuroscience

      Volume: 300 Pages: 585-92

    • DOI

      10.1016/j.neuroscience.2015.05.041

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Murata Y, Higo N, Hayashi T, Nishimura Y, Sugiyama Y, Oishi T, Tsukada H, Isa T, Onoe H2015

    • Author(s)
      Temporal Plasticity Involved in Recovery from Manual Dexterity Deficit after Motor Cortex Lesion in Macaque Monkeys
    • Journal Title

      J Neuroscience

      Volume: 35 Issue: 1 Pages: 84-95

    • DOI

      10.1523/jneurosci.1737-14.2015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Parkinson Disease: Diffusion MR Imaging to Detect Nigrostriatal Pathway Loss in a Marmoset Model Treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.2015

    • Author(s)
      Hikishima K, Ando K, Yano R, Kawai K, Komaki Y, Inoue T, Itoh T, Yamada M, Momoshima S, Okano HJ, Okano H.
    • Journal Title

      Radiology

      Volume: 275(2) Issue: 2 Pages: 430-7

    • DOI

      10.1148/radiol.14140601

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optogenetic Activation of CA1 Pyramidal Neurons at the Dorsal and Ventral Hippocampus Evokes Distinct Brain-Wide Responses Revealed by Mouse fMRI.2015

    • Author(s)
      N, Yoshida K, Komaki Y, Xu M, Sakai Y, Hikishima K, Mimura M, Okano H, Tanaka KF.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 3 Pages: e0121417-e0121417

    • DOI

      10.1371/journal.pone.0121417

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 神経束空間統計Tract-Based Spatial Statistics (TBSS).2014

    • Author(s)
      林 拓也
    • Journal Title

      Clinical Neuroscience

      Volume: 32(5) Pages: 585-87

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 脳のオシレーション、循環代謝と自発的神経活動 Cerebral Oscillation, Blood Flow-Metabolism and Spontaneous Neural Activity.2014

    • Author(s)
      林 拓也
    • Journal Title

      Clinical Neuroscience

      Volume: 32(7) Pages: 762-67

    • Related Report
      2014 Annual Research Report
  • [Presentation] 双方向性神経活動操作で側坐核の役割を探る2019

    • Author(s)
      西村幸男
    • Organizer
      第58回日本定位・機能神経外科学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脳代謝、神経伝達、神経ネットワーク解析における麻酔の影響について:マーモセットなど小動物を用いたPET, MRIによるイメージング研究 「基盤チュートリアル」2019

    • Author(s)
      尾上浩隆
    • Organizer
      第8回マーモセット研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脊髄損傷後の指先巧緻性運動の機能回復には腹側線条体が必要不可欠である2018

    • Author(s)
      鈴木迪諒、尾上嘉代、澤田真寛、村田弓、肥後範行、塚田秀夫、伊佐正、尾上浩隆、西村幸男
    • Organizer
      第12回モーターコントロール研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Role of superior colliculus - pulvinar pathway in blindsight2018

    • Author(s)
      Isa T, Kinoshita M, Kato R, Isa K, Kobayashi K, Onoe H, Kobayashi K.
    • Organizer
      The NIPS-CIN Joint Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] α-synuclein propagation in brains via olfactory pathway in non-human primate model2018

    • Author(s)
      澤村正典, 尾上浩隆, 塚田秀夫, 伊佐かおる, 上村紀仁, 伊佐正, 高橋良輔
    • Organizer
      第59回神経学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] α-synuclein propagation in brains via olfactory pathway in non-human primate model2018

    • Author(s)
      澤村正典, 尾上浩隆, 塚田秀夫, 伊佐かおる, 上村紀仁, 伊佐正, 高橋良輔
    • Organizer
      41th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2018 Annual Research Report
  • [Presentation] -synuclein propagation in brains via olfactory pathway in non-human primate model2018

    • Author(s)
      澤村正典, 尾上浩隆, 塚田秀夫, 伊佐かおる, 上村紀仁, 伊佐正, 高橋良輔
    • Organizer
      International Congress of Parkinson’s Disease and Movement Disorders2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] α-synuclein propagation in brains via olfactory pathway in non-human primate model2018

    • Author(s)
      澤村正典, 尾上浩隆, 塚田秀夫, 伊佐かおる, 上村紀仁, 伊佐正, 高橋良輔
    • Organizer
      16th Asia Aceanian Congress of Neurology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脊髄損傷後の運動機能回復における側坐核の因果的関与:霊長類側坐核損傷モデルを用いて2017

    • Author(s)
      1.鈴木迪諒, 尾上嘉代, 澤田真寛, 村田弓, 肥後範行, 塚田秀夫, 伊佐正, 尾上浩隆, 西村幸男.
    • Organizer
      第52回日本理学療法学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Dynamic shifts of regional brain activation pattern during acquisition of an auditory discrimination task2017

    • Author(s)
      2.Susumu Setogawa, Okauchi Takashi, Di Hu, Mika Shigeta, Emi Hayashinaka, Kayo Onoe, Yasuhiro Wada, Keigo Hikishima, Hirotaka Onoe, Yilong Cui, Kazuto Kobayashi
    • Organizer
      第40回 日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Neural basis of Pavlovian conditioning induced placebo analgesia in rat: A small animal neuroimaging analysis2017

    • Author(s)
      3.Ying Zeng, Qunli Zeng, Di Hu, Emi Hayashinaka, Yasuhiro Wada, Yasuyoshi Watanabe, Yilong Cui
    • Organizer
      第40回 日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A voxel-based analysis of the pain matrix in chronic pain model rats using small-animal neuroimaging method2016

    • Author(s)
      Yilong Cui, Ying Zeng, Emi Hayashinaka, Yasuhiro Wada, Yasuyoshi Watanabe
    • Organizer
      World Congress on Pain 2016
    • Place of Presentation
      National Convention Hall of Yokohama and Yo kahama Gr and Intercontinental, Yokoyama
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of the pain matrix in chronic pain model rats using small-animal neuroimaging method2016

    • Author(s)
      Yilong Cui, Ying Zeng Emi Hayashinaka, Yasuhiro Wada, Yasuyoshi Watanabe
    • Organizer
      FENS2016
    • Place of Presentation
      Cophehagen(Denmark)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マーモセット神経疾患モデルのMRI2016

    • Author(s)
      疋島啓吾
    • Organizer
      第63回日本実験動物学会
    • Place of Presentation
      ミューザ川崎シンフォニーホール(川崎・神奈川)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] High-resolution diffusion and structural MRI brain atlas of rhesus macaques.2015

    • Author(s)
      Hayashi T et al.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] High-resolution diffusion and structural MRI brain atlas of rhesus macaques.2015

    • Author(s)
      Hayashi T et al
    • Organizer
      Organization for Human Brain Mapping
    • Place of Presentation
      Honolulu, Hawaii (USA)
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 霊長類動物脳内ネットワーク動態解明のための技術基盤の構築2015

    • Author(s)
      林 拓也
    • Organizer
      第3回霊長類認知ゲノミクスワークショップ
    • Place of Presentation
      東京大学医学部、東京都
    • Year and Date
      2015-03-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 拡散強調MRI画像の定量化と動態解析による脳再生のイメージング2015

    • Author(s)
      林 拓也
    • Organizer
      第14回日本再生医療学会シンポジウム
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2015-03-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] MRIを用いた可塑性の神経科学と治療法の開発2015

    • Author(s)
      林 拓也
    • Organizer
      東レ医薬研究所講演会
    • Place of Presentation
      東レ医薬研究所、鎌倉市
    • Year and Date
      2015-03-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 可塑性の神経機構をさぐる水分子イメージング2015

    • Author(s)
      林 拓也
    • Organizer
      第2回「水シグナリングの分子動態から病態へ」研究会
    • Place of Presentation
      AOSSA、福井市
    • Year and Date
      2015-03-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 損傷脳研究における機能局在化と機能回復機構解明の矛盾-NODDIによる解明2014

    • Author(s)
      林 拓也
    • Organizer
      京都大学大学院精神神経科セミナー
    • Place of Presentation
      京都大学大学院、京都市
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 脳ネットワークイメージングと神経可塑性の解明~臨床応用を目指して~2014

    • Author(s)
      林 拓也
    • Organizer
      徳島神経病学学術講演会
    • Place of Presentation
      ザ・グランドパレス徳島、徳島市
    • Year and Date
      2014-10-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 脳損傷後の機能脱落と回復に関わるネットワーク解明2014

    • Author(s)
      林 拓也
    • Organizer
      第3回充実生活を実現する技術のための脳と心と身体のメカニズムワークショップ―脳の回復メカニズムとリハビリテーション―
    • Place of Presentation
      産業技術総合研究所、つくば市
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] MRIに神経連絡の解析2014

    • Author(s)
      疋島啓吾
    • Organizer
      第6回光操作研究会
    • Place of Presentation
      東北大学艮陵会館、仙台市
    • Year and Date
      2014-08-21 – 2014-08-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] The 3-Dimensional Atlas of the Marmoset Brain2018

    • Author(s)
      Hikishima K
    • Total Pages
      388
    • Publisher
      Springer
    • ISBN
      9784431566106
    • Related Report
      2018 Annual Research Report
  • [Remarks] 「期待感」は痛みを和らげる-プラセボ効果の神経生物学的な基盤の解明-

    • URL

      http://www.aist.go.jp/aist_j/press_release/pr2015/pr20150107/pr20150107.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] リハビリテーションによる運動機能回復には側坐核の働きが大切

    • URL

      http://www2.clst.riken.jp/bfi/content.html

    • Related Report
      2015 Annual Research Report

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Published: 2014-11-20   Modified: 2020-03-30  

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