| Project/Area Number |
01480319
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
OHI Ryoji Tohoku University, Professor, 医学部, 教授 (50004734)
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| Co-Investigator(Kenkyū-buntansha) |
CHIBA Toshio Tohoku University, Lecturer, 医学部, 助手 (20171944)
MATSUMOTO Yuutaro Tohoku University, Lecturer, 医学部附属病院, 助手 (80190544)
HAYASHI Yutaka Tohoku University, Assistant prof., 医学部附属病院, 講師 (40125638)
CHIBA Tsuneo Tohoku University, Associate Prof., 医学部, 助教授 (70110658)
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| Project Period (FY) |
1989 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1990: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1989: ¥4,000,000 (Direct Cost: ¥4,000,000)
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| Keywords | Biliary atresia / Hepatic portoenterostomy / Ascending cholangitis / Biliary reconstruction / Manometric study / Intestinal valve / Spur valve / 胆道閉鎖症 / Spur valve / 胆道間鎖症 / 胆門部腸物合術 / 消化管内圧検査 / Spur-valve |
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| Research Abstract |
We conducted this study to establish the best method for construction of intestinal antireflux spur valve which could be beneficial in prevention of ascending cholangitis in cases treated by hepatic portoenterostomy and similar conditions.
Materials and Methods :
Fourteen Mongrel dogs of both sexes weighing from 10-20Kg were used, among which 2 dogs served as control. For all dogs, a spur valve was constructed by denuding the seromuscular layer of one side of the distal end of the jejunal conduit and then suturing the boundries of the denuded area to the duodenum. The size of the valves was 2cm in 6 dogs, 5cm in 6 dogs and no valve was constructed in the remaining 2 control dogs. Manometric studies, barium studies and histopathological studies were performed.
Results :
Results were expressed as poor, fair and good. In control dogs there was no valve action and reflux could be observed easily. In dogs with 2cm sized valve 4 out of 6 showed good results and 2 fair. While in dogs with 5cm sized valve 3 out of 6 were good, 2 poor and 1 fair. Opening pressure in fair and good cases ranged from 11 to 20 cmH20. The efficacy of the valve for anti-reflux mechanism was better in later examinations than in earlier ones and it was due to the initial mild inflammatory process within the valve.
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