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Evaluation of Liver Function Prior to Hepatectomy by 31P-MRS

Research Project

Project/Area Number 01480323
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionGifu University

Principal Investigator

HAYASHI Masatomo (1990)  Gifu University School of Medicine assistant professor, 医学部 (80144020)

鬼束 惇義 (1989)  岐阜大学, 医学部, 助教授 (00092924)

Co-Investigator(Kenkyū-buntansha) SENGA Shoshi  Gifu University Hospital instructor, 医学部・附属病院, 助手 (20226690)
尾関 豊  岐阜大学, 医学部附属病院, 助手 (40185591)
日野 晃紹  岐阜大学, 医学部附属病院, 助手 (60189793)
林 勝知  岐阜大学, 医学部附属病院, 講師 (80144020)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1990: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1989: ¥5,500,000 (Direct Cost: ¥5,500,000)
KeywordsHepatectomy / Liver chirrosis / MRI / 31p-MRS / 肝癌 / 肝予備能 / 肝硬変症 / 31P-NMR
Research Abstract

31P-MRS by whole body magnetic resonance imaging (MRI) systems was used to assess the liver function of chirrotic patients.
The patients who were diagnosed as chirrosis clinically were divided into three groups, 1) LC-1 (n=9) ; the patients who had chirrosis, 2) HCC (n=6) ; cancerous part of the liver of the patients whom were diagnosed as hepatocellular carcinoma clinically and 3) LC-2 (n=6) ; acancerous part of the liver of the HCC group. And we added 4) control (n=6) ; the patients who were diagnosed as having normal liver function. High energy phosphates were measured in these four groups.
In the control group, Six major peaks were detected spectrographically. From high frequency zone, these were indentified as phosphomonoesters(PM), inorganic phosphate (PI), phosphodiester(PD), gamma-ATP, alpha-ATP, beta-ATP, Signal intensity was measured by height of the peaks. The ratio of means of PM/beta-ATP was 0.67<plus-minus>0.16 and that of Pi/beta-ATP was 0.90<plus-minus>0
In the LC-1 group, … More six major peaks were detected as well as control group. The ratio of means of PM/beta-ATP was 1.06<plus-minus>0.21, which was significantly higher(p<0.05) than in the control group. Pi/beta-ATP ratio of means was 1.12<plus-minus>0.25 and there was no difference as compared with the control gr
In the HCC group, PM/betaーATP ratio of means was 1.18<plus-minus>0.33, which was significantly higher(p<0.05) than in the control group. The ratio of means of Pi/beta-ATP was 0.90<plus-minus>0.39, which was not significantly different as compared to the control gr
In the LC-2 group, the ratios of means of PM/beta-ATP, Pi/beta-ATP were 1.03<plus-minus>0.34, 0.74<plus-minus>0.26 respectively. There was no significant differe
Conclusion. 1) In the LC-1 and the HCC group, phosphomonoesters was significantly higher than the control group. 2) As high energy phosphates could be measured both in the cancerous part and the acancerous part of the liver, in future 31P-MRS may play some role in the pre-oparative assessment of patients who have chirrosis. Less

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report

Research Products

(8 results)

All Other

All Publications (8 results)

  • [Publications] H.Matsunami,H.Hirose,A.Onitsuka,S.V.Lynch,G.A.Balderson,and R.W.Strson、and R.W.Strong: "^<31>PーMagnetic Rosonance Spectroscopy in Evating Hepatic Function:A Possible Application in Donor Assessment Prior to Liver Transplantation" TranspLantation Proceedings. 22. 2146-2148 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 松波 英寿,鬼束惇義,広瀬 一: "MRSによる術前肝機能評価" モダンメディシン. 18. 66-69 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 村川 真司,鬼束 惇義,森 義雄,渡辺 敬,松波 英寿,千賀 省始,広瀬 一: "^<31>PーNMR法を用いた肝虚血障害時のリン化合物の変動の検討ーLーSOD、verapamil虚血肝に及ぼす影響一" Cytoーprotection & biology. 8. 255-262 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Matsunami, H. Hirose, A. Onitsuka, S. V. Lynch, G. A. Balderson, and R. W. Strong: "31P-Maqnetic Resonance Spectroscopy in Evaluating Hepatic Function : A Possible Application in Donor Assessment Prior to Liver Transplantation" Transplantation Proceedings. 22 :. 2146-2148, (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Matsunami, A. Onitsuka and H. Hirose: "Pre-operative assessment of liver function by MRS." Modern Medicine. 18 :. 66-69, (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Murakawa, A. Onitsuka, Y. Mori, K. Watanabe, H. Matsunami, S. Senga and H. Hirose: "31P-NMR in evaluating changes in high energy phosphates of ischemic liver." Cyto-Protection & biology. 8 :. 255-262, (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 村川 真司,鬼束 惇義,森 義雄,渡辺 敬,松波 英寿,千賀 省始,広瀬 一: " ^<31>PーNMR法を用いた肝虚血障害時のリン化合物の変動の検討 ーLーSOD,verapamilの虚血肝に及ぼす影響ー" Cytoーprotection & biology. 8. 255-262 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 鬼束惇義ほか: "MRSによる術前肝機能評価" モダンメディシン. 18(12). 66-69 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-03-31   Modified: 2016-04-21  

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