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Experimental Study on Pulmonary Hypoplasia in Congenital Diaphragmatic Hernia

Research Project

Project/Area Number 01570717
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionNagoya City Univeristy Medical School

Principal Investigator

SASAKI Shingi (1991)  Nagoya City University Medical School, Lecturer, 医学部, 助手 (20189690)

佐々木 信義 (1989-1990)  名古屋市立大学, 医学部, 講師 (10080136)

Co-Investigator(Kenkyū-buntansha) YAMAKAWA Yosuke  Nagoya City University Medical School, Lecturer, 医学部, 講師 (40148284)
MASAOKA Akira  Nagoya City University Medical School, Professor, 医学部, 教授 (10028326)
HARA Fujio  Nagoya City University Medical School, Assistant (20189690)
SHIBATA Kazuo  Nagoya City University Medical School, Assistant (20145733)
NIWA Hiroshi  Nagoya City University Medical School, Assistant (30228267)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1989: ¥700,000 (Direct Cost: ¥700,000)
Keywordscongenital diaphragmatic hernia / experimental fetal surgery / Nitrofen (NIP) / lung hypoplasia / phospholipids in lung tissue / dysplasia of diaphragma / 実験脂仔手術 / 家兎胎仔手術 / Nitrofen
Research Abstract

The purpose of this study is to make clear the pathological characteristics of hypoplastic lung in congenital diaphragmatic hernia.
Two groups were made.
Group I was "operation models". Fetal rabbits were operated in utero, and congenital diaphragmatic hernia models were obtained after gestational period.
Group II was "Nitrofen treated group". Maternal rabbits were bred with nitrofen (NIP ; 1000, 2000, 3000 ppm) in their gestational period. (But only "non-CDH models with lung damage were obtained)
RESULTS ; compared with "Control Group"
1) Lung weight : low leveled in, Group I, and normo leveled in Group II.
2) Phospholipids in lung tissue : Severely low leveled in Group II, and low leveled in Group I.
3) Microscopical findings : Only atelectasis was found in Group I, but in Group II atelectasis with emphysema were found and the retardation of the alveolar maturation were remarked.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 江口 武史: "先天性横隔膜ヘルニアにおける肺の低形成に関する実験的研究" 名古屋市立大学 医学会雑誌. 40. 731-741 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takeshi Eguchi: "Experimental Study on Pulmonary Hyporplasia in Congenital Diaphragmatic Hernia." Nagoya Medical Journal. 40. 731-741 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 江口 武史: "先天性横隔膜ヘルニアにおける肺の低形成に関する実験的研究" 名古屋市立大学医学会雑誌. 40. 731-741 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] 江口 武史: "先天性横隔膜ヘルニアにおける肺の低形成に関する実験的研究" 名古屋市立大学医学会雑誌. 40. 731-741 (1989)

    • Related Report
      1990 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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