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Novel Mitochondrial fatty Acid Oxidation Enzymes

Research Project

Project/Area Number 02454144
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionShinshu University

Principal Investigator

HASHIMOTO Takashi  Shinshu University, Sch. of Med., Professor, 医学部, 教授 (80009935)

Co-Investigator(Kenkyū-buntansha) FURUTA Shuichi  Shinshu University, Sch. of Med., Assistant, 医学部, 助手 (80126705)
MIYAZAWA Shoko  Shinshu University, Sch. of Med., Assistant, 医学部, 助手 (20020745)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1991: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsmitochondria / fatty acid oxidation enzymes / inborn errors of metabolism / 脂肪酸酸化酵素
Research Abstract

1. We found two novel fatty acid oxidation enzymes in rat liver mitochondria, and purified. We named very long-chain acyl-CoA dehydrogenase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolise trifunctional protein, respectively. The molecular and catalytic properties of these enzymes are quite different from those of the known enzymes. The latter enzyme has been called as long-chain 3-hydroxyacyl-CoA dehydrogenase.
2. We have obtained human and rat EDNA clones for these two enzymes.
3. We have first described the presence long-chain 3-hvdroxyacyl-CoA dehydrogenase (trifunctional protein) deficiency.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Kaoru Izai他: "Novel Fatty Acid βーOxidation Enzymes in Rat Liver Mitochondria.I.Purification and properties of veryーlongーchain acylーCoA dehydrogenase." Journal of Biological Chemistry.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yasushi Uchida他: "Novel Fatty Acid βーOxidation Enzymes in Rat Liver Mitochondria.II.Purification and properties of enoylーcoenzyme A (CoA) hydratase/3ーhydroxyacylーCoA dehydrogenase/3ーketoacylーCoA thiolase trifunctional protein." Journal of Biological Chemistry.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kaoru Izai: "Novel Fatty Acid beta-Oxidation Enzymes in Rat Liver Mitochondria I. Purification and Properties of Very-Long-Chain Acyl-Coenzyme a Dehydrogenase." Journal of Biological Chemistry.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yasushi Uchida: "Novel Fatty Acid beta-Oxidation Enzymes in Rat Liver Mitochondria II. Purification and Properties of Enoyl-Coenzyme a (CoA) Hydratase/3-Hydroxyacyl-CoA dehydrogenase/3-Ketoacyl-CoA Thiolase Trifunctional Protein." Journal of Biological Chemistry.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kaori Izai 他: "Novel Fatty Acid βーOxidation Enzymes in Rat Liver Mitochondria.I.Purification and properties of Veryーlongーchain acyl CoA dehydrogenase." Journal of Bilogical Chemisty.

    • Related Report
      1991 Annual Research Report
  • [Publications] Yasushi Uchida 他: "Novel Fatty Acid βーOxidation Enzymes in Rat Liver Mitochondria.II.Purification and properties of enoylーcoenzyme A(CoA)hydratase/3ーhydroxyacyーCoA dehydrogenase/3ーketoacylーCoA thiolase trifunctional protein." Journal of Biological Chemistry.

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Izai,他: "Novel Fatty Acid βーOxidation Enzymes in Rat Liver Mitochondria.I.Purification and properties of very longーchain acylーCoA dehydrogenase." Journal of Biological Chemistry.

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Uchida,他: "Novel Fatty Acid βーOxidation Enzymes in Rat Liver Mitochondria.II.Purification and properties of enoylーCoA hydratase/3ーhydroxyacylーCoA dehydrogenase/3ーketoacylーCoA thiobse trifunctional protein." Journal of Biological Chemistry.

    • Related Report
      1990 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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