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The genetic changes of colorectal tumors on relation to histological grades of atypia

Research Project

Project/Area Number 05671083
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionJICHI MEDICAL SCHOOL

Principal Investigator

KONISHI Fumio  Jichi Medical School, Medical College Associate Professor, 医学部, 助教授 (20142242)

Co-Investigator(Kenkyū-buntansha) TSUCHIYA Issei  Jichi Medical School, Medical College Instructor, 医学部, 助手 (90217331)
KASHIWAGI Hiroshi  Jichi Medical School, Medical College Instructor, 医学部, 助手 (30204382)
YAMASHITA Keisuke  Jichi Medical School, Medical College Lecturer, 医学部, 講師 (90239963)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1993: ¥500,000 (Direct Cost: ¥500,000)
KeywordsColo rectal cancer / Adenoma-carcinoma sequence / De novo carcinogenesis / Ki-Ras gene / P-53 / Superficial type early colorectal cancer / 早期大腸癌 / 表面型大腸腫瘍 / Ki-RAS mutation / Adenoma-Carcinoma Sequence / 大腸癌 / 大腸腺腫瘍 / Ki-RAS point mutaion
Research Abstract

In order to analyze the pathways of carcinogenesis in the colon and rectum, we analyzed rates of Ki-ras codon 12 mutations and positive p53 immunostaining in 23 small polypoid type cancers, 20 superficial type cancers, both confined to the mucosa or to the submucosa, and 39 advenced cancers. The frequency of Ki-ras mutations in superficial type cancers was 10% (2/20), which was significantly lower than 43% (10/23) in small polypoid cancers and 38% (15/39) in advenced cancers. This data suggest that another pathway of colorectal carcinogenesis which does not involve Ki-ras point mutation might exist. In small polypoid type cancers, 2 out of the 10 showed mutation present only in the adenomatous areas but not in cancerous areas. This data suggest that cancer does not always develop from pre-existing adenoma with Ki-ras point mutation. Positive staining for the p53 protein of colorectal superficial cancers and small polypoid cancers was detected in 25% (5/20) and 35% (8/23) respectively. Positive staining for the p53 protein was detected only in carcinomatous ares and not in adenomatous areas. There was not distinction between superficial type cancers and small polypoid type cancers.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 小島 正幸 他: "大腸腫瘍におけるC-KiRAS 2遺伝子の点突然変異についての解析" 日本大腸肛門病学会雑誌. 47(8). 769- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 小西 文雄 他: "早期大腸癌の発生過程-内視鏡的および分子生物学的検討" 日本大腸肛門病学会雑誌. 48(8). 691- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 山下 圭輔 他: "表面型大腸腫瘍におけるC-KiRAS 2遺伝子の点突然変異についての解析(進行癌との比較)" 日本大腸肛門病学会雑誌. 48(10). 1200 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kojima M et al.: "Mutations in C Ki-RAS gene codon 12 in colorectal tumors" Journal of Japan Society of Coloproctology. 47 (8). 922 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Konishi F et al.: "Developmental pathways of early colorectal carcinoma" Journal of Japan Society of Coloproctology. 48 (8). 886 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 小西文雄: "大腸腫瘍性病変の発育進展とその遺伝子学的解析に関する研究(厚生省がん研究助成金による研究 平成5年度研究報告)" 東京大学医学部第一外科 主任研究者 武藤 徹一郎, 58 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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