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Effects of centrally administered agents on ischemia induced brain damage

Research Project

Project/Area Number 05671268
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionEhime University

Principal Investigator

ARARI Tatsuru  Ehime University, School of Medicine, Professor, 医学部, 教授 (50033436)

Co-Investigator(Kenkyū-buntansha) DOTE Kentaro  Ehime University, School of Medicine, Assistant Professor, 医学部・附属病院, 講師 (00172239)
AMAKAWA Kazuhiko  Ehime University, School of Medicine, Assistant Instructor, 医学部・附属病院, 助手 (50136313)
足立 尚澄 (足立 尚登)  愛媛大学, 医学部・附属病院, 助手 (50253315)
井上 裕昭  愛媛大学, 医学部, 助手 (60263927)
藤谷 太郎  愛媛大学, 医学部・附属病院, 助手 (20229016)
Project Period (FY) 1993 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1995: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1994: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1993: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsCerebral ischemia / Lidocaine / Amino acids / Hippocampus / Microdialysis / Mongolian gerbils / Direct current potential / Anoxic depolarization / 海馬CA1領域 / グルタミン酸 / 脳室内投与 / ナトリウムチャンネル遮断薬 / プロカインアミド / ダントロレン
Research Abstract

Extracellular levels of amino acids in the hippocampal CA1 region of the gerbil were analyzed by a microdialysis-HPLC procedure. Transient forebrain ischemia produced significant increase in aspartate, glutamate, glycine and taurine (760%, 1070%, 190% and 1210%, respectively), and neuronal blockade by perfusion with a lidocaine (4 mmol/L) -containing medium resulted in 67%, 79%, 58% and 59% reduction in the peak values of each amino acid, respectively. Centrally administered lidocaine (4.0 mu mol) produced a 140% prolongation of its onset latency of anoxic depolarization. On the other hand, an intracerebroventricular administration of lidocaine, 0.8 mu mol or more, produced a protective effect against delayd damage of hippocampal CA1 pyramidal cells, which was caused by bilateral carotid artery occlusion for 4 min. The results suggest that lidocaine may protect neurons against ischemic damage, by preventing the ischemia-induced rise of extracellular concentration of excitatory amino acid.

Report

(4 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • 1993 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Taro Fujitani: "Lidocaine rotects hippocampal neurons against ischemic damage by preventing increase of extracellular excitatory amino acids : a microdialysis study in Mongolian gerbils" Neuroscience Letters. 179. 91-94 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 足立尚登: "スナネズミ海馬CA1領域における遅発性神経細胞壊死に及ぼすリドカイン脳室内投与の影響" 脳循環代謝. 6. 50 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 藤谷太郎: "スナネズミ前脳虚血モデルにおける細胞外アミノ酸に及ぼすリドカインの影響" 脳循環代謝. 6. 151 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 宮崎博文: "12分間完全脳虚血に対する塩酸ベニジピンの影響" 蘇生. 12. 69 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 宮崎博文: "虚血後脳機能回復に及ぼす塩酸ベニジピンの影響" ICUとCCU. 19. 131-138 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Taro Fujitani, Naoto Adachi, Hirofumi Miyazaki, Keyue Liu, Yoichi Nakamura, Kiyoshi Kataoka and Tatsuru Arai: "Lidocaine protects hippocampal neurons against ischemic damage by preventing increase of exatracellular excitatory amino acids : a microdialysis study in Mongolian Gerbils" Neuroscience Letters. 179. 91-94 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hirofumi Miyazaki, Keizo Ikemune, Taro Fujitani, Yasushi Ando, Kentaro Dote and Tatsuru Arai: "The effects of Benidipine on the recovery of neurological functions after 12mintotal cerebral ischemia in beagle dogs" ICU & CCU. 19 (2). 131-138 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 宮崎 博文: "虚血後脳機能回復に及ぼす塩酸ベニジピンの影響" ICUとCCU. 19. 131-138 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Taro Fujitani: "Lidocaine protects hippocampal neurons against ischemic damage by preventing increase of extracellular excitatory amino acids: a microdialysis study in Mongolian gerbils" Neuroscience Letters. 179. 91-94 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 足立尚登: "スナネズミ海馬CA1領域における遅発性神経細胞壊死に及ぼすリドカイン脳室内投与の影響" 脳循環代謝. 6. 50- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 藤谷太郎: "スナネズミ前脳虚血モデルにおける細胞外アミノ酸に及ぼすリドカインの影響" 脳循環代謝. 6. 151- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 宮崎博文: "12分間完全脳虚血に対する塩酸ベニジピンの影響" 蘇生. 12. 69- (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1993-04-01   Modified: 2016-04-21  

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