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Comperative study in the viability of the liver graft harvested from cadaver and living donor, evaluated by assessment of tissue oxygenation in sinusoid and oxidation of hepatocyte

Research Project

Project/Area Number 06044127
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

YAMAOKA Yoshio  Professor, Kyoto University, 医学研究科, 教授 (90089102)

Co-Investigator(Kenkyū-buntansha) ウオニカイト クルト  ハノーファー医科大学, 教授
ピッケルマイヤー ルドル  ハノーファー医科大学, 教授
IKAI Iwao  Assistant, Kyoto University, 医学研究科, 助手 (60263084)
OZAKI Nobuhiro  Assistant, Kyoto University, 医学研究科, 助手 (50211818)
UEMOTO Shinji  Assistant, Kyoto University, 医学研究科, 助手 (40252449)
INOMATA Yukihiro  Assistant Professor, Kyoto University, 医学研究科, 講師 (50193628)
TANAKA Akira  Assistant Professor, Kyoto University, 医学研究科, 講師 (00240820)
INAMOTO Takashi  Professor, Kyoto University, College of Medical Technology and Nursing, 医療技術短期大学部, 教授 (10135577)
TANAKA Koichi  Associate Professor, Kyoto University, 医学研究科, 助教授 (20115877)
WONIGEIT Kurt  Professor
PICHLMAYR Rudorf  Professor
本田 和男  京都大学, 医学部, 講師 (00209321)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥23,600,000 (Direct Cost: ¥23,600,000)
Fiscal Year 1995: ¥11,700,000 (Direct Cost: ¥11,700,000)
Fiscal Year 1994: ¥11,900,000 (Direct Cost: ¥11,900,000)
KeywordsLiver TRASPLANTATION / REGECTION / Near infra-red spectroscopy / micro circulation / hepaticsinusoid / oxygen satulation / primary-nonfunction / 近赤外光分析 / 生体部分肝移植 / 脳死肝移植
Research Abstract

As hemoglobin can be used as an optical parameter of microcirculation, oxygen saturation and content of hemoglobin of red cells in the liver sinusoids can be evaluated with tissue near-infrared spectroscopy. Using this novel method, we have studied relationship between the circulation status and post-transplantation pathophisiology. Grafts that presented aspiration cytology scores of 2 or more at 1 week after operation (groupI, n=14) were associated with a higher heterogeneity than grafts with no or very mild intragraft immune activation (group II,n=33). Group I was also accompanied by higher postoperative peak GOT level and higher donor age. Heterogenous reperfusion, higher peak GOT level and higher donor age were also associated with clinical rejection at 1week, but not with later-onset rejection.

Report

(2 results)
  • 1995 Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] N.Yanabu: "Evaluation of circulation status tissue near-infrared spectroscopy in living related liver transplantation across ABO blood groups." Transprantation Proceedings. 27(1). 1160-1163 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Kiuchi: "Background of early intragraft immune activation and rejection in liver transplant recipients." Transplantation. 60(1). 49-55 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Kiuchi: "Implications of host pancreatic hormones in the restart of grafted liver." Hepatology. 21(6). 1561-1567 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Shirakata: "Inhibitory effect of plasma FKBP12 on immunosuppressive activity of FK506." Transplantation. 60(12). 1582-1587 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Inomoto: "Experiences of 120 microsurgical reconstructions of hepatic artwry in living related liver transplantation." Surgery. (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Tanaka: "Graft size-matching in living related partial liver transplantation on relation.to tissue oxygenation and metabolic capacity." Transplantation International. 9. 15-22 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] N.Yanabu: "Evaluation of circulation status tissue near-infrared spectroscopy in living related liver transplantation across ABO blood groups." Transprantation Proceedings. 27 (1). 1160-1163 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Kiuchi: "Background of early intragraft immune activation and rejection in liver transplant recipients." Transplantation. 60 (1). 49-55 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Kiuchi: "Implications of host pancreatic hormones in the restart of grafted liver." Hepatology. 21 (6). 1561-1567 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Shirakata: "Inhibitory effect of plasma FKBP12 on immunosuppressive activity of FK506." Transplantation.60 (12). 1582-1587 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Inomoto: "Experiences of 120 microsurgical reconstructions of hepatic artwry in living related liver transplantation." Surgery. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Tanaka: "Graft size-matching in living related partial liver transplantation on relation to tissue oxygenation and metabolic capacity." Transplantation International. 9. 15-22 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y.Yamaoka: "Liver transplantation using a right lobe graft from a living related donor." Transplantation. 57. 1127-1130 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Tanaka: "Living related liver transplantation in children." The American Journal of Surgery. 168. 41-48 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Kato: "Spontaneous proliferation of peripheral blood mononuclear cells as an indicator for insufficient plasma level of FK506 in the early phase after transplantation." Transplant.Proc.26. 893-895 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Tanaka: "Living-related liver transplantation for fulminant hepatic failure in children" Transplant.Proc.7(Suppl 1). S108-S110 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Y Yamaoka: "Safety of the donor in living related liver transplantation-Analysis of 100 parental donors." Transplantation. 59. 224-226 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] M.Ueda: "Classifications and surgical trearment of hepatocellular carcinoma(HCC) with bile duct thrombi" Hepato-Gastroenterol. 41. 349-354 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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