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Analysis of gene expression of matrix metalloproteinases cluring the metastasis of gastrointestinal tract cancer

Research Project

Project/Area Number 06671227
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionKeio University

Principal Investigator

OTANI Yoshihide  Keio Univ.School of Med, Dept of Surgeny, 医学部・外科学教室, 助手 (20168983)

Co-Investigator(Kenkyū-buntansha) SAKURAI Yoshiko  Keio Univ, School of Med., Dept of Surgeny, 医学部・外科学教室, 助手 (90245514)
KAMEYAMA Kaori  Keio Univ, School of Med., Dept of Pathology, 医学部・病理学教室, 助手 (10245467)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥900,000 (Direct Cost: ¥900,000)
KeywordsGI tract cancer / metastasis / MMP / collagenase / mesenchymal cell / extracellular matrix / collagen / in situ hybridization / colldgenase / colldgen / collagenase / collagen
Research Abstract

During cancer invasion and metastasis, anscer cells must degradate extracellular matrix around cancer nests. We have already reported that proteolytic enzyme activity correlated to the degree of malignancy of the cancer (Keio J.Med.39 : 159-167,1990).
In this study, we tried to analize which cells produce these enzymes (matrix metalloproteinases : MMPs) and how they are regulated in the local region. For this purpose, in situ hybridization using cDNA probe for MMP-1 was carried out in GI tract cancer tissues.
We have recealed that stromal cells and blood cells, especially eosinophiles, produce MMP-1 and could play impotant roles in cancer invasion and metastasis.
In conclusion, not only cancer cells but host cells such as fibroblasts and eosinophiles are regulating the steps of degradation of extracellular matrix during cancer invasion and metastasis.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Y. OTANI et al.: "Gene expression of in tenstitial collagenase cmatrix metalloproteinase 1) in gastrointes tinal tract cancens" J. Gastroenterology. 29. 391-394 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大谷吉秀他: "癌組織マトリックスと接着分子" G. I. Research. 2. 195-205 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y. Sakurai et al.: "Interstitial Collagenase (matrix metallopvoteinasel)and 92 KD gelatinase cmatrix metallopvoteinase a)are expressecl in stvowal cells in gastric cancer In 1st International gestic dancel Cangress ced. by M. Nishi. H. Sugano, T. Takahashi)" Monduzzi Eclitore Bologna-Italy, 1810(969-971) (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yoshihide Otani, et al: "Gene expression of interstitial collagenase (matrix metallo-proteinase 1) in gastrointestinal tract cancers" J.Gastroenterology. 29. 391-394 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yoshihide Otani, et al: "Extracelluar matrix in cancer tissue and adhesion molecule." G.I.Research. 2. 195-205 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yoshihiko Sakurai, et al: "Interstitial collagenase (matrix metalloproteinase 1) and 92 kD gelatinase (matrix metalloproteinase 9) are expressed in stromal cells in gastric cancer." In 1st International Gastric Cancer Congress (ed.by M.Nishi, H.Sugano and T.Takahashi). 969-971 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Y. Otani et. al.: "Gene oxpreesion of interstitical colldgenase cwatrix urecaltoproteinase-1) in gestrointestinal tract coucaus" J. Gastro evtevology. 29. 391-394 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 大谷吉秀 他: "癌組織マトリックスと接着分子" G. I. Research. 2. 195-205 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y. Sakurai et al.: "Interstitial Colldgenase (matrix urecdlcoproteinase 1) and 92 kD gelatinase (matrix meedlloproteinase a) are oxpressed in seromal cells in gasas caucen." Ict International Gastric Caucau Congress. (ed. by. M. Nishi H. Sugano, T. Takahashi) Monduzzi Editore, Bologna-Italy, 1810 (969-971) (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Y.Otani,et,al: "Gene expression of interstitial collagenase (matrix metalloproteinase 1) in gastro intestinal tract cancers" Journal of Gastroeuterology. 29. 391-394 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大谷 吉秀,他: "癌組織マトリックスと接着分子" G.I.Reseacch. 2. 195-205 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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