Project/Area Number |
06671562
|
Research Category |
Grant-in-Aid for General Scientific Research (C)
|
Allocation Type | Single-year Grants |
Research Field |
Urology
|
Research Institution | HOKKAIDO UNIVERSITY |
Principal Investigator |
SEKI Toshimori Hokkaido Univ., Dept. of Urol., Assistant Professor, 医学部附属病院, 講師 (70196947)
|
Co-Investigator(Kenkyū-buntansha) |
TANDA Katsutoshi Hokkaido Univ., Dept. of Urol., Instructor, 医学部, 助手 (90250430)
CHIKARAISHI Tatsuya Hokkaido Univ., Dept. of Urol., Instructor, 医学部附属病院, 助手 (80261303)
|
Project Period (FY) |
1994 – 1995
|
Project Status |
Completed (Fiscal Year 1995)
|
Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1995: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1994: ¥800,000 (Direct Cost: ¥800,000)
|
Keywords | RENAL TRANSPLANTATION / XENOTRANSPLANTATION / ALLOTRANSPANTATION / 15-DEOXYSPERGUALIN |
Research Abstract |
Xeno renal transplantation is very difficult for us, so we investigate the immunological mechanisms in rat allotransplantation. Purpose and Methods : The effect of short term administration of 15-deoxyspergual in (DSG), 5mg. /kg. /day from postoperative days 4 to 7, on rat renal transplantation was studied. Results : Although allografts treated with DSG survived longer than nontreated ones, cellular infiltration in both grafts did not differ. However, renal tubular cells of DSG-treated grafts proliferated well and escaped apoptotic cell death. A donor-specific tolerance 2 weeks after transplantation was developed, and cells with in vitro suppressor function were induced in such animals. Conclusions : Treatment with DSG appears to prevent lethal atteck of effector cells on tubular cells in situ and to generate suppressor cells in the maintenance phase of graft enhancement.
|