| Project/Area Number |
07671002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | KOBE UNIVERSITY |
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Principal Investigator |
HIROTA Shozo Kobe University School of Medicine, Division of Central Radiology, associate professor, 医学部附属病院, 助教授 (20181216)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Sinichi Kobe University School of Medicine, Department of Radiology, assistant, 医学部附属病院, 助手 (10229552)
ITOUJI Eiichiro Kobe University School of Medicine, Department of Radiology, lecturer, 医学部附属病院, 講師 (90243302)
SAKO Masao Kobe University School of Medicine, Division of Medical Information, professor, 医学部附属病院, 助教授 (60030970)
KONO Michio Kobe University School of Medicine, Department of Radiology, professor, 医学部, 教授 (60030938)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1995: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | angiogenesis inhibitor / TNP 470 / liver metastasis / implantable port / intermittent injection / intraportal injection / rabbit / 門脈内間欠反復注入 / ウサギ(家兎) / 悪性腫瘍 / 門脈内注入 / 抗癌剤 |
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| Research Abstract |
TNP-470 is expected as a new type of anticancer drug which prevents tumor neovascularization by acting as angiogenesis inhibitor. We attempted to evaluate anticancer effect of intermittent repetitive intraportal injection of TNP-470 for metastatic hepatic tumor models using VX2-carcinoma and considered usefulness and role of TNP-470.
We used 25 Japanese white rabbits with metastatic hepatic tumors made by intraportal injection of tumor cells, and divided into five groups ; group A was control group, group B was treated by repetitive subcutaneous injection of TNP-470 and group C,D,E was treated by repetitive intraportal injection of TNP-470, adriamycin, TNP-470+adriamycin respectively 5 times at 2 or 3 days interval after tumor inoculation using portal reservoir systems. After 2 weeks, we examined anticancer effect of TNP-470 pathologically.
In the number of grown tumors, there was no remarkable difference among five groups statisitically. But mean tumor size of each group is smaller in order of group E,D,C,B,A and the differences were significant (P<0.05) except between E and D group. And intratumoral neovascularization tended to be less in group B,C,E than in group A,D pathologically.
We consider that intermittent repetitive injection of TNP-470 via reservoir system is more useful than systemic administration for liver metastasis.
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