| Project/Area Number |
08671367
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | KOBE UNIVERSITY |
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Principal Investigator |
SUGIMOTO Takaki KOBE UNIVERSITY SCHOOL OF MEDICINE,DEPARTMENT OF SURGERY,DIVISION II,ASSISTANT PROFESSOR, 医学部・附属病院, 助手 (80263375)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Masato KOBE UNIVERSITY SCHOOL OF MEDICINE,DEPARTMENT OF SURGERY,DIVISION II,ASSISTANT P, 医学部, 助手 (70243318)
OKADA Masayoshi KOBE UNIVERSITY SCHOOL OF MEDICINE,DEPARTMENT OF SURGERY,DIVISION II,PROFESSOR, 医学部, 教授 (70030856)
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| Project Period (FY) |
1996 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Occlusive arterial diseases / Color duplex sonography / Endothelin / Nitric oxide / グラフト流量 / 抹消動脈血流 / 分子生物学 |
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| Research Abstract |
The systolic velocities of the dorsalis pedial and the posterior tibial arteries as well as the brachial artery were measured using a color-flow Doppler ultrasonic scanner (7.5MHz). The flow volume, and the ratio of systolic velocities and flow volume of the lower to upper extremitiy (AVI, AFI) were also measured. Furthermore, the blood endothelin (ET-1) and NO levels were measured and the relationship between this value and clinical symptoms was investigated. The value of AVI as well as AFI decreased in order of Fontaine class I, II, m and IV.In 4 limbs with Fontaine class greater than II with a normal ankle pressure index, the values of AVI were low. On the other hand, 3 limbs with normal values of peak-AVI (>0.9) and lower API (<0.75) were in Fontaine class I.The value of the ET-l level was higher in Fontaine class Ill and IV than in class II, and decreased after revascularization along with improvement of clinical symptoms. In the cases with preoperative higher values of NO3, NO3 level showed restorations to the normal ranges after revascularization. However, these values revealed reelevation in accordance with deterioration of the values of AVI and AFT and clinical symptoms in three cases. The new AVI and AFI values showed a better correlation with clinical symptoms than API.The ET-1 level was significantly higher in Fontaine class Ill and IV, and showed marked regression after arterial reconstruction. The ET-l level was significantly higher in Fontaine class III and IV, and showed a remarkable regression after arterial reconstruction. The NO3 level might be a promissing parameter for follow-up after arterial reconstruction.
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