| Project/Area Number |
09670085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
YOSHIOKA Mitsuhiro School of Medicine, Hokkaido University Professor, 医学部, 教授 (40182729)
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| Co-Investigator(Kenkyū-buntansha) |
NAGASHIMA Masafumi School of Medicine, Hokkaido University Assistant Professor, 医学部, 講師 (40241319)
MATSUMOTO Machiko School of Medicine, Hokkaido University Instructor, 医学部, 助手 (70229574)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1998: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1997: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | serotonin / dopamine / noradrenaline / cross-talk / heteroreceptor / autoreceptor / モノアミン / 系統発生学 / シナプス |
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| Research Abstract |
Mono-aminergic neurons extend multiple-branched and divergent connections to many target cells, almost all of which lie outside the brain region in which the neurons are located. Among these neurons there is some cross-talk systems exists via heteroreceptors. The aim of the present study is to elucidate the mechanism of heteroreceptor development and the function.
Noradrenaline-mediated regulation in serotonin release exists in the rat hippocampus. Alpha2-adrenoceptor mRNA was observed in the dorsal raphe nucleus. This result indicates that alpha2-adorenoceptors develops at the serotonergic nerve terminals and confirms that alpha2-adorenoceptors regulate serotonin release in the serotonergic nerve terminals. In addition, dopamine release regulation system via 5-HT6 and 5-HT1B receptors might exist in the prefrontal cortex where serotonergic nerve terminals are projected from the dorsal raphe nucleus. Namely, fluoxetine-induced dopamine release is reduced by the treatment with 5-HT6 receptor mRNA antisense nucleotides and a 5-HT1B receptor antagonist.
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