Delopment mechanisum and cousal factor of non-aropic asthma in schoolchildren

Research Project

Project/Area Number	09670400
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Public health/Health science
Research Institution	Miyazaki Medical College
Principal Investigator	MAEHARA Masanori (1997, 1999) Miyazaki Medical College, Public Health, 医学部, 助手 (50244215) 山田隆司 (1998) 宮崎医科大学, 医学部, 助手 (40274807)
Co-Investigator(Kenkyū-buntansha)	YAMADA Ryuji Miyazaki Medical College, Public Health (40108585) TSUNETOSHI Yshizo Miyazaki Medical College, Public Health (40274807) 前原正法宮崎医科大学, 医学部, 助手 (50244215)
Project Period (FY)	1997 – 1999
Project Status	Completed (Fiscal Year 1999)
Budget Amount *help	¥2,500,000 (Direct Cost: ¥2,500,000) Fiscal Year 1999: ¥300,000 (Direct Cost: ¥300,000) Fiscal Year 1998: ¥500,000 (Direct Cost: ¥500,000) Fiscal Year 1997: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords	Asthma / Allergy / Air Pollution / Epidemyology / School children / IgE / IgG / Asthma(喘息) / allergy(アレルギー) / Air Pollution(大気汚染) / School Children(学童)
Research Abstract	To investigate the delopment mechanism and causal factor of non-aropic asthma in schoolchildren. We determined serum concentration of inmmuno guloblin(IgE, IgA, IgM, IgG)in 230 schoolchildren who lived in 4 communities with different level air pollution in Japan. Level of IgG were higher in schoolchildren who had symptom of asthma and wheeze than who had not respiratory symptoms. Level of IgG4 and IgG1 in positive group of IgE were higher than in normal group of IgE. Level of IgG were higher in schoolchildren who lived in Osaka city. Which had a high level of air pollution, than in children who lived in area of low air pollution, the relationship was not significant. These findings suggest that IgG were maker of development of asthma caused by air pollution.