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Intracellular signal-transduction in oxidized LDL-induced macrophage growth in arterial wall.

Research Project

Project/Area Number 09671065
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 内分泌・代謝学
Research InstitutionKumamoto University

Principal Investigator

SHICHIRI Motoaki  Kumamoto Univ.School of Med., Professor and Director, 医学部, 教授 (00028515)

Co-Investigator(Kenkyū-buntansha) TOYONAGA Tetsushi  Kumamoto Univ.School of Med., Assistant Professor, 医学部, 助手 (60295128)
SHIROTANI Tetsuya  Kumamoto Univ.School of Med., Assistant Professor, 医学部・附属病院, 助手 (30274715)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsMacrophage / Foam Cell / Cell proliferation / Atherosclerosis / Scavenger receptor / Oxidized low density lipoprotein / GM-CSF / Protein kinase C / lysophohsphatidylcholine
Research Abstract

In this project, we demonstrated following findings ;
(1) Endocytic uptake of lysophosphatidylcholine through the scavenger receptor A-I/A-II plays an essential role in oxidized LDL-induced macrophage proliferation.
(2) Rise in intracellular calcium and subsequent activation of protein kinase C by oxidized LDL are involved in oxidized LDL-induced macrophageproliferation.
(3) Induction of GM-CSF by oxidized LDL induces macrophage proliferation in autocrine or paracrine fashion.
(4) HMG-CoA reductase inhibitors inhibit oxidized LDL-induced macrophage proliferation.
(5) Glucocorticoids suppress oxidized LDL-induced macrophage proliferation.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Matsumura T. et al.: "Two intracellular signaling pathways for activation of protein kinase C are involved in oxidized low-density lipoprotein-induced macrophage growth" Arterioscler Thromb Vasc Biol. 17. 3013-3020 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sakai M. et al.: "HMG-CoA reductase inhibitors suppress macrophage growth induced by oxidized low density lipoprotein." Atherosclerosis. 133. 51-59 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yano T. et al.: "β-very low density lipoprotein induces triglyceride accumlation through receptor mediated endocytic pathway in 3T3-L1 adipocytes" Atherosclerosis. 135. 57-64 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Anami Y. et al.: "Human β-migrating very low density lipoprotein induces foam cell formation in human mesangial cells." Atherosclerosis. 135. 225-234 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sakai M. et al.: "Role of macrophage scavenger receptor for internalization of lysophosphatidylcholine in oxidized low density lipoprotein-induced macrophage growth" Ann NY Acad Sci. 811. 378-383 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kobori S. et al.: "Induction of macrophage growth by lipoprotein(a)" Advances of Diabetes Mellitus. 187-190 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsumura T.et al.: "Two intracellular signaling pathways for activation of protein kinase C are involved in oxidized low-density lipoprotein-induced macrophage growth" Arterioscler Thromb Vasc Biol. 17. 3013-3020 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sakai M.et al.: "HMG-CoA reductase inhibitors suppress macrophage growth induced by oxidized low density lipoprotein" Atherosclerosis. 133. 51-59 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yano T.et al.: "beta-very low density lipoprotein induces triglyceride accumulation through receptor mediated endocytic pathway in 3T3-L1 adipocytes" Atherosclerosis. 135. 57-64 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Anami Y.et al.: "Human beta-migrating very low density lipoprotein induces foam cell formation in human mesangial cells" Atherosclerosis. 135. 225-234 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sakai M.et al.: "Role macrophage scavenger receptor for internalization of lysophosphatidylcholine in oxidized low density lipoprotein-induced macrophage growth" Ann NY Acad Sci. 811. 378-385 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kobori S.et al.: "Induction of macrophage growth by lipoprotein (a)" Advances of Diabetes Mellitus. 187-190 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sakai M.et al.: "Endocytosed lysophosphatidylcholine, through the scavenger receptor, plays an essential role in oxidized low-density lipoprotein-induced macrophage proliferation" Trends Cardiovasc Med. 8. 119-124 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Biwa T.et al.: "Inducution of murine macrophage growth by oxidized low density lipoprotein is mediated by granulocyte macrophage colony-stimulating factor" J Biol Chem. 273. 28305-28313 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsumura T.et al.: "The activation of PKC is involved in Ox-LDL-induced macrophage growth" Recent Advances on the Pathogenesis and Management of Diabetes Mellitus. 242-247 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sakai M.et al.: "Glucocorticoid suppresses oxidized low density lipoprotein-induced macrophage proliferation" Arterioscler Thromb Vasc Biol. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kobori S.et al.: "Induction of macrophage growth by lipoprotein(a)" Advances of Diabetes Mellitus. 187-190 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Biwa T.et al.: "Induction of murine macrophage growth by oxidized low density lipoprotein is mediated by granulocyte macrophage colony-stimulating factor" J Biol Chem. 273. 28305-28313 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsumura T.et al.: "The activation of PKC is involved in Ox-LDL-induced macrophage growth" Recent Advences on the Pathogenesis and Management of Diabetes Mellitus. 242-247 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sakai M.et al.: "Glucocorticoid suppresses oxidized low density lipoprotein-induced macrophage proliferation" Arterioscler Thromb Vasc Biol. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 堺 政和、他: "泡沫細胞の生成と増殖に関する受容体" The Lipid. 8. 200-205 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 堺 政和、他: "糖尿病性大血管障害に対する酸化LDLの影響-酸化LDLによるマクロファージ増殖-" 糖尿病性合併症. 10. 78-85 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sakai, M.: "Role of the macrophage scavenger receptor for internalization of lysophosphatidylcholine in oxidized low density lipoprotein-induced macrophage growth." Ann. N. Y. Acad. Sci.811. 387-384 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sakai, M.: "HMG-CoA reductase inhibitors suppress macrophage growth induced by oxidized low density lipoprotein." Atherosclerosis. 133. 51-59 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yano, T.: "β-very low density lipoprotein induces Triglyceride-accumulation through receptor-mediated endocytic pathway in 3Tз-L1 adipocytes" Atherosclerosis. 135. 57-64 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Anami, Y.: "Human β-migrating very low density lipoprotein induces foam cell formation in human mesangial cells" Atherosclerosis. 135. 225-234 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumura, T.: "Two intracellular signaling pathways for activation of protein kinase C are involved in oxidized low density lipoprotein-induced macrophage growth." Arterioscler. Thromb. Vasc. Biol.17. 3013-3020 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sakai, M.: "Endocytosed lysophosphatidylcholine through the scavenger receptor plays an essential role in oxidized low density lipoprotein-induced macrophage growth." Trend Cardiovasc. Med.(in press).

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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