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Induction of anti- Porphyromanas gingivalis antibody by tonsillar application

Research Project

Project/Area Number 10671704
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionKyushu Dental College

Principal Investigator

TSUJISAWA Toshiyuki (1999)  Kyushu Dental College, School of Dentistry, Research Associate, 歯学部, 助手 (60265006)

内山 長司 (1998)  九州歯科大学, 歯学部, 教授 (70047786)

Co-Investigator(Kenkyū-buntansha) FUKIIZUMI Takaki  Kyushu Dental College, School of Dentistry, Assistant Professor, 歯学部, 講師 (50275442)
INOUE Hiromasa  Kyushu Dental College, School of Dentistry, Associate Professor, 歯学部, 助教授 (20137326)
辻澤 利行  九州歯科大学, 歯学部, 助手 (60265006)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordstonsillar application / salivary IgA / Porphyromonas gingivlis / adult periodontitis / prevation / Porphyromonas gingivalis / Porpyromnas gingivalis
Research Abstract

Tonsillar application is a new immunization method for inducing a specific antibody against antigen in saliva and blood plasma. We tonsillarly applied formalin-killed cells of Porphyromonas gingivaris (P.gingivalis), a periodontopathic bacteria, and obtained following results.
1. Tosillar application of killed P. gingivalis induced anti-P. gingivalis IgA in saliva and anti-P. gingivalis IgG in blood plasma.
2. A number of anti-P. gingivalis IgA produsing cells increased in the tissue surrounding parotid gland by tonsillar application.
3. Induced salivary IgA reacted against P. gingivalis both the applied strain and other several kind of the different strain. The reactions to Prevotella intermedia, Fusobacterium nucleatum, and Streptococcus sanguis were very low level.
4. Induced salivary IgA inhibited the adherence of P. gingivalis to the cloned cells of gingival epithelial cell in vitro.
These results shows that tonsillar application by killed cell of P. gingivalis induced antigen specific antibody in saliva. Since the induced antibody inhibited the adherence of P. gingivalis to gingival epithelial cells, it is suggested that tonsillar application of the periodontpathic bacterial cells is possible to prevent periodontal disease.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] 長濱宗一郎: "Porphromonas gingivalisの扁桃投与による特異的唾液IgAの誘導"九州歯会誌. 52. 557-566 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Soichiro Nagahama: "Specific IgA induction in saliva by tonsillar application of Porphyromonas gingivalis"J. Kyushu Dent. Soc. 52 (2). 557-566 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 長濱宗一郎,福泉 隆喜: "Porphyromonas gingivalisの扁桃投与による特異的唾液IgAの誘導" 九州歯会誌. 52(5). 557-566 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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