Protective Effect of New Enteral Nutritional Formula including Whey Protein Hydrolysate against Indomethacin-Induced Ulceration in Rats
| Project/Area Number |
11470264
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokai University |
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Principal Investigator |
NAKASAKI Hisao Tokai Univ.School of Medicine, Associate Prof., 医学部, 助教授 (10056145)
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| Co-Investigator(Kenkyū-buntansha) |
KATAYAMA Tokitaka Tokai Univ.School of Medicine, Assistant Researcher, 医学部, 助手 (40214332)
TSUDA Michio Tokai Univ.School of Medicine, Associate Prof., 医学部, 助教授 (00102848)
長坂 義秀 テルモ株式会社, 開発研究所, 研究員
上田 善継 テルモ株式会社, 開発研究所, 研究員
米倉 政実 茨城大学, 農学部, 助教授 (40134168)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥10,800,000 (Direct Cost: ¥10,800,000)
Fiscal Year 2000: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1999: ¥8,200,000 (Direct Cost: ¥8,200,000)
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| Keywords | whey protein hydrolysate / enteral nutrition / rats / indomethacin-induced ulcers / anti-ulcer properties / 潰瘍性大腸炎 / アミノ酸栄養剤 / 経腸栄養 / 乳清ペプチド / 脂肪酸 |
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| Research Abstract |
A new enteral nutritional formula containing whey protein hydrolysate (WPH) was evaluated its suppressive effect on indomethacin-induced ulcers. The first experiment resulted less intestinal ulcers appearance (1/7) in Sprague-Dawley male rats which received subcutaneous indomethacin administration or WPH formula feeding period than in those fed the formulas containing amino acids(4/6) and intact protein (6/7) as nitrogen source. In the second experiment, rats were cross-fed on different formulas, less intestinal ulcers appeared in rats pre-fed WPH formula. (1/7 in pre WPH- post WPH, 1/8 in WPH-AA, 6/7 in AA-WPH, 5/7 in AA-AA). Similar results were also shown in cecum ulcers. These results suggest that the WPH formula would have some property suppressing indomethacin-induced ulcers.
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Report
(3 results)
Research Products
(3 results)
