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Protective Effect of New Enteral Nutritional Formula including Whey Protein Hydrolysate against Indomethacin-Induced Ulceration in Rats

Research Project

Project/Area Number 11470264
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionTokai University

Principal Investigator

NAKASAKI Hisao  Tokai Univ.School of Medicine, Associate Prof., 医学部, 助教授 (10056145)

Co-Investigator(Kenkyū-buntansha) KATAYAMA Tokitaka  Tokai Univ.School of Medicine, Assistant Researcher, 医学部, 助手 (40214332)
TSUDA Michio  Tokai Univ.School of Medicine, Associate Prof., 医学部, 助教授 (00102848)
長坂 義秀  テルモ株式会社, 開発研究所, 研究員
上田 善継  テルモ株式会社, 開発研究所, 研究員
米倉 政実  茨城大学, 農学部, 助教授 (40134168)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥10,800,000 (Direct Cost: ¥10,800,000)
Fiscal Year 2000: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1999: ¥8,200,000 (Direct Cost: ¥8,200,000)
Keywordswhey protein hydrolysate / enteral nutrition / rats / indomethacin-induced ulcers / anti-ulcer properties / 潰瘍性大腸炎 / アミノ酸栄養剤 / 経腸栄養 / 乳清ペプチド / 脂肪酸
Research Abstract

A new enteral nutritional formula containing whey protein hydrolysate (WPH) was evaluated its suppressive effect on indomethacin-induced ulcers. The first experiment resulted less intestinal ulcers appearance (1/7) in Sprague-Dawley male rats which received subcutaneous indomethacin administration or WPH formula feeding period than in those fed the formulas containing amino acids(4/6) and intact protein (6/7) as nitrogen source. In the second experiment, rats were cross-fed on different formulas, less intestinal ulcers appeared in rats pre-fed WPH formula. (1/7 in pre WPH- post WPH, 1/8 in WPH-AA, 6/7 in AA-WPH, 5/7 in AA-AA). Similar results were also shown in cecum ulcers. These results suggest that the WPH formula would have some property suppressing indomethacin-induced ulcers.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] 上田善継 他: "乳清タンパク質加水分解物を用いた経腸栄養剤のラットにおけるインドメタシン潰瘍予防効果"日本栄養・食糧学会誌に. (発表予定).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Protective Effect of New Enteral Nutritional Formula including Whey Protein Hydrolysate against Indomethacin-Induced Ulceration in Rats. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 上田善継 他: "乳清タンパク質加水分解物を用いた経腸栄養剤のラットにおけるインドメタシン潰瘍予防効果"日本栄養・食糧学会誌. (発表予定).

    • Related Report
      2000 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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