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Association between antlhypertensive effect and glucose intolerance with mild exercise therapy in patients with essential hypertension.

Research Project

Project/Area Number 11670397
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionFukuoka University

Principal Investigator

TSUCHIYA Yoshihiro  School of Medicine,TSUCHIYA,Yoshihiro Research Assistant, 医学部, 助手 (80312156)

Co-Investigator(Kenkyū-buntansha) TASHIRO Eiichiro  School of Medicine,TSUCHIYA,Yoshihiro Research Assistant, 医学部, 助手 (20271439)
URATA Hidenori  B School of Medicine,TSUCHIYA,Yoshihiro Lecturer, 医学部, 講師 (30289524)
IDEISHI Munehito  School of Medicine,TSUCHIYA,Yoshihiro Professor, 医学部, 教授 (20131807)
KIYONAGA Akira  Faculty of Sports and Health Science,TSUCHIYA,Yoshihiro Prof., スポーツ科学部, 教授 (70177955)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsExercise training / essential hypertension / glucose metabolism / insulin sensitivity / cardiovascular disease
Research Abstract

The main purpose of the present study was to examine degree of dependency for abnormal glucose metabolism of hypertensive patients on insulin-dependent or -independent glucose uptake, which was determined by an intravenous glucose tolerance test (IVGTT) before and after a 10-week mild exercise training (corresponding approximately 50% of maximum oxygen uptake). Simultaneously, other factors including body mass index, waist-hip ratio, %fat and I biochemical parameters such as total, LDL and HDL cholesterol, triglyceride were determined. After a 10-week exercise training, both insulin-dependent and -independent glucose uptakes were significantly improved and this was accompanied with an improvement of insulin secretion. There was a decrease tendency in waist-hip ratio, %fat, LDL i cholesterol and triglyceride, but no change in body mass index, total cholesterol and free fatty acid. In addition, there was no particular correlation between the improvement of insulin-dependent or -independent glucose uptake and the changes of examined biochemical and physiological factors. This was probably due to relatively small number of patient group. Association study between gene polymorphisms of ACE, angiotensinogen and ATI receptor and the degree of improvement of glucose uptake is currently on going. These results will be reported all together.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Shono et al.: "Effects of low intensity aerobic training on skeltal muscle capillary and blood lipoprotein profiles"J Atheroscler Thromb. 9. 78-85 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sakamoto et al.: "Influence of mild exercise at the lactate threshold on glucose effectiveness"J Appl Physiol. 87. 2305-2310 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shono et al.: "Decreased skeltal muscle capillarization is related to higher serum levels of LDL cholesterol and apolipoprotein B in men"Methabolism. 48. 1-6 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Motoyama et al.: "Blood pressure lowering effect of low intensity aerobic training in elderly hypertensive patient"Med Sci Sports Exerc. 30. 818-823 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sakai et al.: "Mild exercise activates renal dopamine system in mild hypertensives"J Hum Hypertens. 12. 355-362 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujitani et al.: "Intravenous glucose tolerance test-derived glucose effectiveness in strength-trained humans"Metabolism. 47. 874-877 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shono, et al.: "Effects of low intensity aerobic training on skeltal muscle capillary and blood lipoprotein profiles"J Atheroscler Thromb. 9. 78-85 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sakamoto, et al.: "Influence of mild exercise at the lactate threshold on glucose effecti ve ness"J Appl Physiol. 87. 2305-2310 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shono, et al.: "Decreased skeltal muscle capillarization is related to higher serum levels of LDL cholesterol and apolipoprotein B in men"Methabolism. 48. 1-6 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Motoyama, et al.: "Blood pressure lowering effect of low intensity aerobic training in elderly hypertensive patient"Med Sci Sports Exerc. 30. 818-823 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sakai, et al.: "Mild exercise activates renal dopamine system in mild hypertensives"J Hum Hypertens. 12. 355-362 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujitani, et al.: "Intravenous glucose tolerance test-derived glucose effectiveness in strength-trained humans"Metabolism. 47. 874-877 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tsuchiya, et al.: "Parasympathetic tone affects el ectro cardiogr aphic preconditioning during right coronary angioplasty"Cardiology. 90. 122-126 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tanaka, et al.: "Double product response is accelerated above the blood lactate threshold"Med Sci Sports Exerc. 29. 503-508 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shono et al.: "Effects of low intensity aerobic training on skeltal muscle capillary and blood lipoprotein profiles"J Atheroscler Thromb. 9. 78-85 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sakamoto et al.: "Influence of mild exercise at the lactate threshold on glucose effectiveness"J Appl Physiol. 87. 2305-2310 (1999)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shono et al.: "Decreased skeltal muscle capillarization is related to higher serum levels of LDL cholesterol and apolipoprotein B in men"Methabolism. 48. 1-6 (1999)

    • Related Report
      2001 Annual Research Report
  • [Publications] Motoyama et al.: "Blood pressure lowering effect of low intensity aerobic training in elderly hypertensive patient"Med Sci Sports Exerc. 30. 818-823 (1998)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sakai et al.: "Mild exercise activates renal dopamine system in mild hypertensives"J Hum Hypertens. 12. 355-362 (1998)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tanaka et al.: "Double product response is accelerated above the blood lactate threshold"Med Sci Sports Exerc. 29. 503-508 (1997)

    • Related Report
      2001 Annual Research Report
  • [Publications] Motoyama et al.: "Blood pressure lowering effect of low intensity aerobic training in elderly hypertensive patient."Med Sci Sports Exerc. 30. 818-823 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sakai et al.: "Mild exercise activates renal dopamine system in mild hypertensives"J Hum Hypertens. 12. 355-362 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fujitani et al.: "Intravenous glucose tolerance test-derived glucose effectiveness in strength-trained humans"Metabolism. 47. 874-877 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tanaka et al.: "Double product response is accelerated above the blood lactate threshold"Med Sci Sports Exerc. 29. 503-508 (1997)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tanaka et al.: "Double product response is accelerated above the blood lactate threshold"Med Sci Sports Exerc. 29. 503-508 (1997)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sakai et al.: "Mild exercise activates renal dopamine system in mild hypertensives"J Hum Hypertens. 12. 355-362 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fujitani et al.: "Intravenous glucose tolerance test-derived glucose effectiveness in strength-trained humans"Metabolism. 47. 874-877 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Motoyama et al.: "Blood pressure lowering effect of low intensity aerobic training in elderly hypertensive patient"Med Sci Sports Exerc. 30. 818-823 (1998)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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