| Project/Area Number |
11670397
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Fukuoka University |
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Principal Investigator |
TSUCHIYA Yoshihiro School of Medicine,TSUCHIYA,Yoshihiro Research Assistant, 医学部, 助手 (80312156)
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| Co-Investigator(Kenkyū-buntansha) |
TASHIRO Eiichiro School of Medicine,TSUCHIYA,Yoshihiro Research Assistant, 医学部, 助手 (20271439)
URATA Hidenori B School of Medicine,TSUCHIYA,Yoshihiro Lecturer, 医学部, 講師 (30289524)
IDEISHI Munehito School of Medicine,TSUCHIYA,Yoshihiro Professor, 医学部, 教授 (20131807)
KIYONAGA Akira Faculty of Sports and Health Science,TSUCHIYA,Yoshihiro Prof., スポーツ科学部, 教授 (70177955)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Exercise training / essential hypertension / glucose metabolism / insulin sensitivity / cardiovascular disease |
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| Research Abstract |
The main purpose of the present study was to examine degree of dependency for abnormal glucose metabolism of hypertensive patients on insulin-dependent or -independent glucose uptake, which was determined by an intravenous glucose tolerance test (IVGTT) before and after a 10-week mild exercise training (corresponding approximately 50% of maximum oxygen uptake). Simultaneously, other factors including body mass index, waist-hip ratio, %fat and I biochemical parameters such as total, LDL and HDL cholesterol, triglyceride were determined. After a 10-week exercise training, both insulin-dependent and -independent glucose uptakes were significantly improved and this was accompanied with an improvement of insulin secretion. There was a decrease tendency in waist-hip ratio, %fat, LDL i cholesterol and triglyceride, but no change in body mass index, total cholesterol and free fatty acid. In addition, there was no particular correlation between the improvement of insulin-dependent or -independent glucose uptake and the changes of examined biochemical and physiological factors. This was probably due to relatively small number of patient group. Association study between gene polymorphisms of ACE, angiotensinogen and ATI receptor and the degree of improvement of glucose uptake is currently on going. These results will be reported all together.
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