| Project/Area Number |
11670903
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Miyazaki Medical College |
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Principal Investigator |
TAMURA Shozo Miyazaki Medical College, professor, 医学部, 教授 (60150439)
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| Co-Investigator(Kenkyū-buntansha) |
ASADA Yujiro Miyazaki Medical College, professor, 医学部, 教授 (70202588)
ASATO Mikio Miyazaki Medical College, assisstant professor, 医学部, 助手 (10284829)
木佐貫 篤 宮崎医科大学, 医学部, 助手 (70253846)
結城 康弘 宮崎医科大学, 医学部, 助手 (30284855)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2000: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1999: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Intravascular ultrasound / Atherosclerosis / Proteoglycan / intravascular ultrasound / animal model / atherosclerosis / rabbit |
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| Research Abstract |
PURPOSE : To examine the correlation between the echogenicity and the components of atherosclerotic plaques in rabbit.
MATERIALS AND METHOD : We have stimulated atherosclerotic plaque formation in the abdominal aortas of hyperlipidemic or normolipidemic rabbits by inserting polyethylene tubing. Intravascular ultrasound (30-MHz, 4.5 F catheter) investigation was performed at locations in the vessel where a two or three-layered images was obtained. The intravascular ultrasound images of the plaques were evaluated and compared with the histological findings.
RESULS : Ultrasound images delineated areas showing strongly (hyperechoic) or weakly (hypoechoic) reflecting ultrasound beams in the plaques. Histological studies revealed that the hyperechoic areas were closely associated with a dense fibrous extracellular matrix with proliferation of smooth muscle cells, whereas the hypoechoic areas corresponded to lesions showing a marked accumulation of foamy macrophages or proteoglycan-rich loose myxoid extracellular matrix with smooth muscle cell proliferation.
CONCLUSION : A good correlation between ultrasound images and histological features was observed. These results suggest that intravascular ultrasound imaging could provide useful information for assessing the tissue characteristics of atherosclerotic lesions.
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