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Study on the influence of periapical lesions on systemic health

Research Project

Project/Area Number 12307044
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionMeikai University

Principal Investigator

ISHIHARA Sachiyo  Meikai University, School of Dentistry, Department of Operative Dentistry, Lecturer, 歯学部, 講師 (10223017)

Co-Investigator(Kenkyū-buntansha) KAWASHIMA Nobuyuki  Tokyo Mediacal and Dental School, Department of Endodontics, Research Associate, 歯学部, 助手 (60272605)
NOIRI Yuichiro  Osaka University Dental School, Department of Operative Dentistry and Endodontics, Research Associate, 歯学部, 助手 (50218286)
TAKAHASHI Keiso  Meikai University, School of Dentistry, Department of Endodontics, Lecturer, 歯学部, 講師 (70243475)
HASEGAWA Masako  Tsurumi University School of Dentistry, Department of Endodontics, Research Associate, 歯学部, 助手 (00217803)
HAYASHI Yoshihiko  Nagasaki University Dental School, Department of Endodontics, Professor, 歯学部, 教授 (20150477)
山本 宏治  朝日大学, 歯学部, 教授 (60182622)
松下 健二  鹿児島大学, 歯学部, 助手 (90253898)
高柴 正悟  岡山大学, 歯学部, 助教授 (50226768)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥34,980,000 (Direct Cost: ¥30,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2002: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2001: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2000: ¥16,000,000 (Direct Cost: ¥16,000,000)
Keywordsbiofilm / bactermia / E. faecalis / cytokine / polymerase chain reaction / geriatric hospital / E. faecalis / 生体反応 / recQ遺伝子 / 根尖病巣 / 感染根管 / 細菌検査 / 易罹染性宿主 / 掌蹠膿琺疱症 / 全身疾患
Research Abstract

Anaero bic bacteria in infected root canals and the biofilm produced by the bacteria have been analyzed biochemically and micro morphologically. The activity forming the biofilm differed among bacteria examined and glycocalyx-like concentration has been found outside the biofilm. We have established the methodology of isolation and identification for E. faecalis by chair-side anaerobic culture system. In addition, a novel identification method for bacteria in infected root canals by polymerase chain reaction has been developed. Relationship between systemic diseases and periapical lesions has been investigated on various types of compromised hosts, such as non-Hodgkin's, hepatitis C, refractory skin diseases and the aged patients over 70 years old. No significant relationship of the changes of CRP values after infected root canal treatment was found. We have investigated the influence of oral infection in the pathogenesis of Pustulosis Palmartis et Plantaris (PPP), by measuring the ser … More um titer of Interleukin-8 (IL-8). Although the titer of IL-8 in PPP patients accompanied with periodontal and/or periapical lesions was not significantly higher than that in healthy subjects, the adult atopic dermatitis patients accompanied with the legions, up-regulation of serum IL-8 was induced by endodontic or periodontal treatments which would cause bacteriemia in PPP patients. Improvement of clinical symptoms of PPP was obvious after the treatments. These results indicated that the serum IL-8 was susceptible to bacterial infection in the PPP patients, and overproduction of IL-8 might modify the initiation and progress of PPP. Most of aged person tended to suffer from periodontal disease in addition to periapical lesions and then we need to collect the subjects whom we can evaluate the influence of periapical lesions alone. We have performed root canal therapy to the patient who has 20 infected root canals and shows compromised according to using adrenocortical hormones. The degree of CRP in the serum of this patient decreased to normal levels, although tic therapy did not. Less

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (57 results)

All Other

All Publications (57 results)

  • [Publications] Takahashi K, et al.: "A Pilot Study on Anti-Plaque Effects of Mastic Chewing Gum in the Oral Cavity"J.Periodontol.. 74. 507-511 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Walker KF, Lappin DF, Takahashi K, et al.: "Cytokine expression in periapical granulation tissue as assessed by immunohistochemistry"Eur J Oral Sci. 108(3). 104-111 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi K, et al.: "Subgingival Microflora and Antibody Responses against Periodontal Bacteria of young Japanese Patients with Type 1 Diabetes Mellitus"J.Int.Acad.Periodontol.. 3/4. 104-111 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ikeda T, Yanagiguchi K, Viloria IL, Hayashi Y: "Relationship between lysozyme and clinical symptoms following the application of chitin-chitosan in endodontic treatment"Chitosan per os. 275-292 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yanagiguchi K, Ikeda T, Takai F, Ogawa K, Hayashi Y: "Wound Healing Following Direct Pulp Capping with Chitosan-Ascorbic Acid Complex in Rat Incisors"Chitin and Chitosan in Life Science. 240-243 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 池田 毅, 柳口嘉治郎, 林 善彦: "歯科領域への応用-う蝕・歯槽骨治療を中心として-"バイオインダストリー. 19(4). 22-30 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 柳口嘉治郎, 山口慶治, 大原直子, 林 義彦: "根管治療時の臨床症状と根管内滲出液中の起炎性サイトカイン(IL-1β)濃度との関連性"日本歯科保存学雑誌. 第45巻第2号. 344-348 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Noiri Y, Ehara A, Kawahara T, Takemura T, Ebisu S: "Participation of bacterial biofilm in refractory and chronic periapical periodontitis"J.Endodon.. 28(10). 679-683 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 河西裕美, 川島伸之, 鈴木規元, 須田英明, 高木実: "実験的ラット歯髄炎におけるiNOs発現"日本歯科保存学雑誌. 第45巻第3号. 532-539 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 深沢宗主, 高橋慶壮, 本平一志: "マスティックガムは抗プラーク剤として有用である"日本歯周病学会会誌. 第44巻第2号. 213-219 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 高橋慶壮, 鈴木一成, 中村有良: "外科的歯内療法における吸収性膜の臨床応用"日本歯内療法学会雑誌. 第23巻2号. 115-122 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 本平 一志, 高橋 慶壮: "Bisphenol Aが卵巣摘出ラットの骨代謝に及ぼす影響に関する研究"明海大学歯学雑誌. 31(2). 178-183 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 新井 英雄, 高柴正悟: "コンピューターグラフィックスを応用した歯周・歯内病態の生物学的な教育"日本歯科保存学雑誌. 第45巻第5号. 808-818 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.KAWASHITA, S.TSUNEYAMA, F.MIYAJI, et al.: "Antibacterial silver-containing silica glass prepared by sol-gel method"Biomaterials. 21. 393-398 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.OHASHI, Y.YAMAMOTO: "Development of Anticarious Composite Resin Dental Materials-Antibacterial Activity of Ag-Silica Glass as Filler Particles"Cariology Today 2000. 第45巻第3号. 532-539 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y.DOI, Y.SHIMIZU, Y.MORIWAKI, et al.: "Development of a new calcium phosphate cement that contains sodium calcium phosphate"Biomaterials. 22. 847-854 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H.TAKEUCHI, K.YAMAMOTO: "Ultrastructural analysis of structural framework in dental plaque developing on synthetic carbonate apatite applied to human tooth surfaces"Eur J Oral Sci. 109. 249-259 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 石原祥世, 中鉢智彦, 村井宏隆: "老人病院入院患者の口腔内と全身疾患について"明海大歯誌. 30. 120-123 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi K, et al.: "A Pilot Study on Anti-Plaque Effects of Mastic Chewing Gum in the Oral Cavity"J. Periodontol.. 74. 507-511 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Walker KF, Lappin DF, Takahashi K, et al.: "Cytokine expression in periapical granulation tissue as assessed by immunohistochemistry"Eur J Oral Sci 74. 108. 104-111 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi K, et al.: "Subgingival Microflora and Antibody Responses against Periodontal Bacteria of young Japanese Patients with Type I Diabetes Mellitus"J. Int. Acad. Periodontol.. 3/4. 104-111 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ikeda T, Yanagiuchi K, Viloria IL, Hayashi Y: "Relationship between lysozyme and clinical symptoms following the application of chitin-chitosan in endodontic treatment"Chitosan per os. 275-292 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yanagiuchi K, Ikeda T, Takai F, Ogawa K, Hayashi Y: "Wound Healing Following Direct Pulp Capping with Chitosan-Ascorbic Acid Complex in Rat Incisors"Chitin and Chitosan in Life Science. 240-243 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Noiri Y, Ehara A, Kawahara T, Takemura T, Ebisu U: "Participation of bacterial biofilm in refractory and chronic periapical periodontitis"J. Endodon.. 28(10). 679-683 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M. KWASHITA, S. TSUNEYAMA, F. MIYAJI, et al.: "Antibacterial silver-containing silica glass prepared by sol-gel method"Biomaterials. 21. 393-398 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S. OHASHI, Y. YAMAMOTO: "Development of Anticarious Composite Resin Dental Materials - Antibacterial Activity of Ag-Silica Glass as Filler Particles"Cariology Today 2000. 532-539 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y. DOI, Y. SHIMIZU, Y. MORIWAKI, et al.: "Development of a new calcium phosphate cement that contains sodium calcium phosphate"Biomaterials. 22. 847-854 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H. TAKEUCHI, K. YAMAMOTO: "Ultrastructural analysis of structural framework in dental plaque developing on synthetic carbonate apatite applied to human tooth surfaces"Eur J Oral Sci. 109. 249-259 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takahashi K, et al.: "A pilot Study on Anti-Plaque Effects of Mastic Chewing Gum in the Oral Cavity"J. Periodontol.. 74. 507-511 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Walker KF, Lappin DF, Takahashi K, et al.: "Cytokine expression in periapical granulation tissue as assessed by immunohistochemistry"Eur J Oral Sci. 108(3). 104-111 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takahashi K, et al.: "Subgingival Microflora and Antibody Responses against Periodontal Bacteria of young Japanese Patients with Type 1 Diabetes Mellitus"J. Int. Acad. Periodontol.. 3/4. 104-111 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ikeda T, Yanagiguchi K, Viloria IL, Hayashi Y: "Relationship between lysozyme and clinical symptoms following the application of chitin-chitosan in endodontic treatment"Chitosan per os. 275-292 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yanagiguchi K, Ikeda T, Takai F, Ogawa K, Hayashi Y: "Wound Healing Following Direct Pulp Capping with Chitosan-Ascorbic Acid Complex in Rat Incisors"Chitin and Chitosan in Life Science. 240-243 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 池田 毅, 柳口嘉治郎, 林 善彦: "歯科領域への応用-う蝕・歯槽骨治療を中心として-"バイオインダストリー. 19(4). 22-30 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 柳口嘉治郎, 山口慶治, 大原直子, 林 義彦: "根管治療時の臨床症状と根管内滲出液中の起炎性サイトカイン(IL-1β)濃度との関連性"日本歯科保存学雑誌. 第45巻第2号. 344-348 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Noiri Y, Ehara A, Kawahara T, Takemura T, Ebisu S: "Participation of bacterial biofilm in refractory and chronic periapical periodontitis"J. Endodon.. 28(10). 679-683 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 河西裕美, 川島伸之, 鈴木規元, 須田英明, 高木実: "実験的ラット歯髄炎におけるiNOS発現"日本歯科保存学雑誌. 第45巻第3号. 532-539 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 深沢宗主, 高橋慶壮, 本平一志: "マスティックガムは抗プラーク剤として有用である"日本歯周病学会会誌. 第44巻第2号. 213-219 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 高橋慶壮, 鈴木一成, 中村有良: "外科的歯内療法における吸収性膜の臨床応用"日本歯内療法学会雑誌. 第23巻2号. 115-122 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 本平 一志, 高橋 慶壮: "Bisphenol Aが卵巣摘出ラットの骨代謝に及ぼす影響に関する研究"明海大学歯学雑誌. 31(2). 178-183 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 新井 英雄, 高柴正悟: "コンピューターグラフィックスを応用した歯周・歯内病態の生物学的な教育"日本歯科保存学雑誌. 第45巻第5号. 808-818 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.KAWASHITA, S.TSUNEYAMA, F.MIYAJI, et al.: "Antibacterial silver-containing silica glass prepared by sol-gel method"Biomaterials. 21. 393-398 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.OHASHI, Y.YAMAMOTO: "Development of Anticarious Composite Resin Dental Materials-Antibacterial Activity of Ag-Silica Glass as Filler Particles"Cariology Today 2000. 第45巻第3号. 532-539 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.DOI, Y.SHIMIZU, Y.MORIWAKI, et al.: "Development of a new calcium phosphate cement that contains sodium calcium phosphate"Biomaterials. 22. 847-854 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] H.TAKEUCHI, K.YAMAMOTO: "Ultrastructural analysis of structural framework in dental plaque developing on synthetic carbonate apatite applied to human tooth surfaces"Eur J Oral Sci. 109. 249-259 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 石原祥世, 中鉢智彦, 村井宏隆: "老人病院入院患者の口腔内と全身疾患について"明海大歯誌. 30. 120-123 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takahashi K, Nishimura F, Kurihara M, Iwamoto Y, Takashiba S, Miyata T, Muravama Y: "Subgingival Microflora and Antibody Responses against Periodontal Bacteria of young Japanese Patients with Type 1 Diabetes Mellitus"Journal of the International Academy of Periodontology. 3/4. 104-111 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Noiri Y, Ehara A, Kawahara T, Takemura N, Ebisu S: "Participation of bacterial biofilm in refractory and chronic periapical periodontitis"Journal of Endodontics. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kawahara T, Murakami S, Noiri Y, Takemura N, Ehara A, Furukawa S, Ebisu S: "Effects of Cyclosporin A-induced immunosuppression on rat chronic periapical lesions"Journal of Dental Research. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takemura N, Noiri Y, Kawahara T, Ehara A, Noguchi N, Ebisu S: "Correlation between extraradicular biofilm and systemic disorder-a preliminary study"Journal of Dental Research. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] H.Takeda, K.Takahashi, H.Motohira, T.Azuma, H.Nishida, M.Fukazawa., T.Miyata: "Microbiological Test for Early-Onset Periodontitis Patients"Journal of Dental Research special issue abstract # 1232. 80. 680 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] H.Motohira, K.Takahashi, S.Yokose, H.Tajima, T.Katayama, T.Miyata: "Effects of Bisphenol A on the Bone Metabolism of Ovariectomized Rats"Journal of Dental Research special issue abstract # 1665. 80. 735 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takahashi K, H.Takeda, K.Motohira, K.Shin, T.Miyata: "Aggressive Periodontitis Associated with Palmoplantar Pustulos"Journal of Dental Research special issue # 0424. 80. 579 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 山口慶次, 戸田一雄, 池田直樹, 林善彦: "レンジャー訓練によるストレス鎮痛"第46回防衛衛生学会抄録集. 98 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 石原祥世, 中鉢智彦, 村井宏隆, 薄井真美, 佐々木博美, 木下直人, 岩崎覚, 片山直: "老人病院入院患者の全身疾患と口腔内状況について"明海大雑誌. 30. 120-123 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ikeda T, Yanagiguchi K, Viloria IL, Hayashi Y: "Relationship between lysozyme and clinical symptoms following the application of chitin-chitosan in endodontic treatment"Chitosan per os, Muzzarelli RAA (ed.), Atec, Grottammare. 275-292 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 野杁由一郎 ら: "根尖性歯周組織疾患の難治化・慢性化に伴う細菌バイオフィルムの関与"Bacterial adherence研究会会誌. 15(印刷中). (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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