| Project/Area Number |
12557132
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | SHINSHU UNIVERSITY (2001-2002)
Kumamoto University (2000) |
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Principal Investigator |
OKAMOTO Kazufumi SHINSHU UNIV., SCHOOL OF MEDICINE, PROFESSOR, 医学部, 教授 (60093994)
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Takayuki SHINSHU UNIV., SCHOOL OF MEDICINE, ASSO. PROFESSOR, 医学部, 助教授 (80238815)
OKUDERA Hiroshi SHINSHU UNIV., SCHOOL OF MEDICINE, ASSO. PROFESSOR, 医学部, 助教授 (50252101)
AKIYAMA Hidenori KUMAMOTO UNIV., TECHNICAL DEPT, PROFESSOR, 工学部, 教授 (50126827)
SHINOHARA Kennji SHINSHU UNIV., SCHOOL OF MEDICINE, ASSISTANT, 医学部附属病院, 助手 (80293504)
久木田 一朗 熊本大学, 医学部・附属病院, 講師 (60253746)
猪山 賢一 熊本大学, 医学部・附属病院, 助教授 (10040536)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 2002: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | INHALED NITRIC OXIDE / PULSED POWER / ACUTE RESPIRATORY FAILURE / RESPIRATORY DISTRESS SYNDROME OF THE NEONATE / VENTILATOR / 呼吸不全 / 人工呼吸 / 二酸化窒素 / 一酸化窒素 / 肺高血圧 |
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| Research Abstract |
THE GOAL OF THE PRESENT STUDY WAS TO DEVELOPE A NOVEL DEVICE OF NITRIC OXIDE PRODUCTION USING PULSED DISCHARGES FOR INHALED NITRIC OXIDE THERAPY. A BRASS ELECTRODE WAS USED FOR DISCHARGE. ABOUT 400-500 PPM OF NITRIC OXIDE WAS PRODUCED. THE CONCENTRATION OF NITROGEN DIOXIDE WAS REDUCED USING MOLYBDENUM. BY USING CHARCOAL, THE CONCENTRATION OF NITROGEN DIOXIDE WAS MAINTAINED AT 0 PPM. SMALL AMOUNT OF NITROUS OXIDE WAS ALSO DETECTED. THE DEVICE LASTED 3 MONTHS WITHOUT ANY TROUBLE ALTHOUGH THE ABRASION OF THE ELECTRODE ffAS DETECTED. AN ELECTROMAGNETIC WAVE AND NOISE WERE WITHIN A PERMISSIBLE RANGE. FOR CLINICAL USE, WE HAVE TO CHECK MOREOVER IN DETAIL WHETHER ANYOTHER ABNORMAL GASES ARE NOT PRODUCED BY THE ELECTRICAL DISCHRGES. THE DEVICE CAN BE MINIATURIZED TO LOAD ON A VENTILATOR. INHALED NITRIC OXIDE THERAPY IS OFTEN USED FOR A NEONATE WITH HYPOXEMIC RESPIRATORY FAILURE. THE ANIMAL EXPERIMENT IS REQUIRED TO DETERMINE WHETHER INHALED NITRIC OXIDE THERAPY BY THE DEVICE DO NOT PRODUCE THE PATHOL OGICAL CHANGES OF THE LUNGS IN NEONATE ANIMALS.
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