| Project/Area Number |
12671299
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Chiba University |
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Principal Investigator |
SEKINE Yasuo Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (70312957)
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| Co-Investigator(Kenkyū-buntansha) |
FUJISAWA Takehiko Chiba University, Graduate School of Medicine, Professor, 大学院・医学研究院, 教授 (80110328)
SAITOH Yukio Chiba University, Graduate School of Medicine, Lecturer, 大学院・医学研究院, 講師 (60261905)
馬場 雅行 千葉大学, 大学院・医学研究院, 助教授 (00143305)
佐藤 二郎 千葉大学, 大学院・医学研究院, 助教授 (90187203)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | emphysema / lung volume reduction / transbronchial / heat probe |
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| Research Abstract |
(1) Irradiation effect on pulmonary parenchyma by a heat probe (indigo 830)
Under general anesthesia and unilateral ventilation, transbronchial irradiation by a heat probe was performed. Under the condition of 80 degree centigrade for 5 minutes, coagulation area was 25 by 10 mm, which was equivalent to that under 90 and 100 degrees for 5 minutes. However, Under 90 and 100 degrees, a part of the lung was changed necrosis, static compliance was decreased from 21.2 to 7.1 ml/cmH2O (33.5% reduction).
(2) The best condition of pulmonary coagulation for lung volume reduction
Under the three conditions as follows, irradiation was performed and the best condition for volume reduction was evaluated. 1) Under spontaneous ventilation with lung expansion, 2) no ventilation with lung expansion and 3) no ventilation with lung collapse by thoracotomy. No heat elevation was observed under the condition #1. A small coagulation was observed under the condition #2. Well coagulation was observed under the condition #3.
(3) Lung emphysema model
One month after inhalation of 40 mg/kg of papain to a mini pig, lung mechanics (intra-bronchial air pressure, flow volume, airway resistance and compliance) was measured. Static compliance elevated from 23 +/- 3.5 ml/H2O before inhalation to 33.3 +/- 4.6 ml/H2O after inhalation(n=3). Pathologically, lung emphysema was confirmed.
(4) The effect of laser irradiation on emphysema lung
The static compliance was reduced from 21.2 +/- 3.7 ml/H2O to 7.1 +/- 2.5 ml/H2O (33% reduction) after papain inhalation. After irradiation, that was re-elevation to 13.8 ml/H2O.
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