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ESTABLISHMENT OF IMMUNOSUPPRRESIVE METHOD FOR CLINICAL DISCORDANT XENOGENEIC CARDIAC TRANSPLANTATION

Research Project

Project/Area Number 14370412
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionOsaka University

Principal Investigator

FUKUSHIMA Norihide  Osaka University, Graduate School of Medicine, Lecturer, 医学系研究科, 講師 (30263247)

Co-Investigator(Kenkyū-buntansha) SAWA Yoshiki  Osaka University, Hospital, Associate Professor, 医学部附属病院, 助教授 (00243220)
MATSUMIYA Goro  Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (20314312)
SHIRAKURA Ryota  Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (00116047)
MIYAGAWA Shuji  Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (90273648)
TAKANO Hiroshi  Osaka University, Graduate School of Medicine, Lecturer, 医学系研究科, 講師 (70346196)
宮本 裕治  大阪大学, 医学系研究科, 講師 (80229898)
市川 肇  大阪大学, 医学系研究科, 助手 (60303939)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥13,900,000 (Direct Cost: ¥13,900,000)
Fiscal Year 2003: ¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 2002: ¥7,100,000 (Direct Cost: ¥7,100,000)
KeywordsXenografts / Rhesus Monkey / Transgenic Pig / Hyper Acute Rejection / DAF / Immunoabsorption / 異種移植 / ブタ / 遺伝導入 / 補体制御因子 / decay accelerating factor / 臓器灌流 / 心臓移植 / 遺伝子導入 / decay acclerating factor / N-acetylglucosamiltransferase
Research Abstract

The hearts of transgenic pig (human DAF) and normal pig were transplanted orthotopically into rhesus monkey. No monkeys transplanted with normal pigs could weaned from cardiopulmonary bypass (CPB) and the grafts showed high grade hyperacute rejection (HAR). Mokeys transplanted with transgenic DAF pig hearts could be weaned from CPB and grafts did not show HAR, however all animals died within 7 hours after reperfusion. These data suggested DAF may extend xenograft survival, but not enough to make animal survive more that a day.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (17 results)

All 2004 2003 2002 Other

All Journal Article (11 results) Publications (6 results)

  • [Journal Article] Early result of heart transplantation in Japan : Osaka University experience.2004

    • Author(s)
      Fukushima N, Miyamoto Y, et al.
    • Journal Title

      Asian Cardiovasc Thorac Ann 12

      Pages: 54-158

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 異種心臓移植モデル ブタ-ヒヒ(又はアカゲザル)2003

    • Author(s)
      福嶌教偉, 白倉良太
    • Journal Title

      大動物臓器移植実験マニュアル2003

      Pages: 44-49

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 心移植モデル ヒヒ又はアカゲザル2003

    • Author(s)
      福嶌教偉, 松田 暉
    • Journal Title

      大動物臓器移植実験マニュアル2003

      Pages: 2-11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Model of cardiac xenograft from pig to monkey2003

    • Author(s)
      N Fukushima, R Shirakura
    • Journal Title

      Mannual of Large Animal Transplant Experiments

      Pages: 44-49

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Model of cardiac tranplantation using baboons or rhesus monkeys2003

    • Author(s)
      N Fukushima, R Shirakura
    • Journal Title

      Mannual of Large Animal Transplant Experiments

      Pages: 2-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Studies of multiorgan procurement system from non heart beating donor2002

    • Author(s)
      Fukushima N, Shirakura R, et al.
    • Journal Title

      Transplantation Proceedings 34

      Pages: 2612-2614

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The effects of exogenous adrenaline on the number of the β adrenergic receptors after brain death in human2002

    • Author(s)
      Fukushima N, Sakagoshi N, et al.
    • Journal Title

      Transplantation Proceedings 34

      Pages: 2571-2574

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The effects of donor age in graft coronary atherscrelosis after cardiac transplantation2002

    • Author(s)
      Kobayashi Y, Fukushima N, et al.
    • Journal Title

      Transplantation Proceedings 34

      Pages: 2587-2588

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Studies of multiorgan procurement system form non heart beating donor2002

    • Author(s)
      Fukushima N, Shirakura R, et al.
    • Journal Title

      Transplant Proc 34

      Pages: 2612-2614

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The effects of exogenous adrenaline on the number of the β adrenergic receptors after brain death in human2002

    • Author(s)
      Fukushima N, Sakagoshi N, et al.
    • Journal Title

      Transplant Proc 34

      Pages: 2571-2574

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The effects of donor age in graft coronary atherscrelosis after cardiac transplantation2002

    • Author(s)
      Kobayashi Y, Fukushima N et al.
    • Journal Title

      Transplantation Proceedings 34

      Pages: 2587-2588

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 福嶌 教偉: "大動物臓器移植マニュアル"異種心臓移植モデル ブターヒヒ (又はアカゲザル). 44-49 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 福嶌 教偉: "大動物臓器移植マニュアル"心移植モデル ヒヒ又はアカゲザル. 2-11 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 松田 暉, 福嶌教偉: "脳死臓器移植の現状"Medicina. 39・3. 472-474 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 福嶌教偉, 松田 暉: "心臓移植"日本外科学会雑誌. 103・9. 623-626 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] N Fukushima, et al.: "Effects of exogenous adrenaline on the number of the beta-adrenergic receptors after brain death in humans"Trasnplantation Proceedings. 34・7. 2571-2574 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] N Fukushima, et al.: "Studies of multiorgan procurement system from non-heart beating donor"Trasnplantation Proceedings. 34・7. 2612-2614 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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