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2003 Fiscal Year Final Research Report Summary

ESTABLISHMENT OF IMMUNOSUPPRRESIVE METHOD FOR CLINICAL DISCORDANT XENOGENEIC CARDIAC TRANSPLANTATION

Research Project

Project/Area Number 14370412
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionOsaka University

Principal Investigator

FUKUSHIMA Norihide  Osaka University, Graduate School of Medicine, Lecturer, 医学系研究科, 講師 (30263247)

Co-Investigator(Kenkyū-buntansha) SAWA Yoshiki  Osaka University, Hospital, Associate Professor, 医学部附属病院, 助教授 (00243220)
MATSUMIYA Goro  Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (20314312)
SHIRAKURA Ryota  Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (00116047)
MIYAGAWA Shuji  Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (90273648)
TAKANO Hiroshi  Osaka University, Graduate School of Medicine, Lecturer, 医学系研究科, 講師 (70346196)
Project Period (FY) 2002 – 2003
KeywordsXenografts / Rhesus Monkey / Transgenic Pig / Hyper Acute Rejection / DAF / Immunoabsorption
Research Abstract

The hearts of transgenic pig (human DAF) and normal pig were transplanted orthotopically into rhesus monkey. No monkeys transplanted with normal pigs could weaned from cardiopulmonary bypass (CPB) and the grafts showed high grade hyperacute rejection (HAR). Mokeys transplanted with transgenic DAF pig hearts could be weaned from CPB and grafts did not show HAR, however all animals died within 7 hours after reperfusion. These data suggested DAF may extend xenograft survival, but not enough to make animal survive more that a day.

  • Research Products

    (11 results)

All 2004 2003 2002

All Journal Article (11 results)

  • [Journal Article] Early result of heart transplantation in Japan : Osaka University experience.2004

    • Author(s)
      Fukushima N, Miyamoto Y, et al.
    • Journal Title

      Asian Cardiovasc Thorac Ann 12

      Pages: 54-158

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 異種心臓移植モデル ブタ-ヒヒ(又はアカゲザル)2003

    • Author(s)
      福嶌教偉, 白倉良太
    • Journal Title

      大動物臓器移植実験マニュアル2003

      Pages: 44-49

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 心移植モデル ヒヒ又はアカゲザル2003

    • Author(s)
      福嶌教偉, 松田 暉
    • Journal Title

      大動物臓器移植実験マニュアル2003

      Pages: 2-11

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Model of cardiac xenograft from pig to monkey2003

    • Author(s)
      N Fukushima, R Shirakura
    • Journal Title

      Mannual of Large Animal Transplant Experiments

      Pages: 44-49

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Model of cardiac tranplantation using baboons or rhesus monkeys2003

    • Author(s)
      N Fukushima, R Shirakura
    • Journal Title

      Mannual of Large Animal Transplant Experiments

      Pages: 2-11

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Studies of multiorgan procurement system from non heart beating donor2002

    • Author(s)
      Fukushima N, Shirakura R, et al.
    • Journal Title

      Transplantation Proceedings 34

      Pages: 2612-2614

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The effects of exogenous adrenaline on the number of the β adrenergic receptors after brain death in human2002

    • Author(s)
      Fukushima N, Sakagoshi N, et al.
    • Journal Title

      Transplantation Proceedings 34

      Pages: 2571-2574

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The effects of donor age in graft coronary atherscrelosis after cardiac transplantation2002

    • Author(s)
      Kobayashi Y, Fukushima N, et al.
    • Journal Title

      Transplantation Proceedings 34

      Pages: 2587-2588

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Studies of multiorgan procurement system form non heart beating donor2002

    • Author(s)
      Fukushima N, Shirakura R, et al.
    • Journal Title

      Transplant Proc 34

      Pages: 2612-2614

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The effects of exogenous adrenaline on the number of the β adrenergic receptors after brain death in human2002

    • Author(s)
      Fukushima N, Sakagoshi N, et al.
    • Journal Title

      Transplant Proc 34

      Pages: 2571-2574

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The effects of donor age in graft coronary atherscrelosis after cardiac transplantation2002

    • Author(s)
      Kobayashi Y, Fukushima N et al.
    • Journal Title

      Transplantation Proceedings 34

      Pages: 2587-2588

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2006-07-11  

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