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A LYNKAGE ANALYSYS ON AUTISM

Research Project

Project/Area Number 14570911
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionNAGOYA UNIVERSITY

Principal Investigator

HASHIMOTO Ohiko  NAGOYA UNIVERSITY, UNIVERSITY HOSPITAL, ASSOCIATE PROFESSOR, 医学部附属病院, 助教授 (90292911)

Co-Investigator(Kenkyū-buntansha) NOMURA Kenji  NAGOYA UNIVERSITY, UNIVERSITY HOSPITAL, RESEARCH ASSOCIATE, 医学部附属病院, 助手 (50345899)
MURASE Satomi  NAGOYA UNIVERSITY, CENTER FOR DEVELOPMENTAL CLINICAL PSYCHOLOGY AND PSYCHIATRY, ASSOCIATE PROFESSOR, 発達心理精神科学教育研究センター, 助教授 (30335020)
HONJO Syuji  NAGOYA UNIVERSITY, CENTER FOR DEVELOPMENTAL CLINICAL PSYCHOLOGY AND PSYCHIATRY, PROFESSOR, 発達心理精神科学教育研究センター, 教授 (90181544)
石島 路子  東京大学, 医学部附属病院, 助手 (70359602)
渡辺 慶一郎  東京大学, 医学部附属病院, 助手 (10323586)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2003: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsautism / molecular biology / GRPR / polymorphism / linkage study
Research Abstract

The reports on a linkage analysis of autism have been increasing in number in these years. Most of them found some linkage between autism and alleles/genes, while all of them failed in finding concrete promised genes/alleles. Among the candidate, chromosome 7 is the most promised. In 7p32, specially, is found imprinting gene which will be analyzed an association with autism.
The whole genome linkage studies of autism have been done by Schao et.al. (2002, 99family, 352allele), Alarcon et.al. (2002, 152family, 335allele), Auranen et.al. (2002, 38family, 369allele), Buxbaum et.al. (200 1, 95family, 382allele), IMGSAC(2001,152pair, 394allele), Liu et.al. (2001, 110family, 335allele), Risch et.al (1999, 139familiy, 519allele). Some other groups also reported the result of the linkage study by less alleles. While it is difficult to find a strong candidate allele/gene, there exist common results that some chromosomes may have a linkage with autism
Some groups are trying to extract a probable genetically homogeneous subgroup from their subjects. For example, Shao et.al. (2002) reported a linkage between 2q and the autism with speech-onset delay. They also used an Ordered-Subset Analysis and found a subgroup with strong sameness. Because autism is a behavioral syndrome and consists of genetically heterogeneous subgroups, a trial to find subgroups genetically homogeneous will be done in a several years from now on. In order to get a better result from linkage study, which of the family member should be included as an carrier with minor symptom must be considered.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] Marui T, Hashimoto O, Nanba E, et al.: "Gastrin-releasing peptide receptor (GRPR) locus in Japanese subjects with autism"Brain Dev. 26・1. 5-7 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Marui T, Hashimoto O, Nanba E, et al.: "Gastrin-releasing peptide receptor (GRPR) locus in Japanese subjects with autism"Brain Dev. 26(1)・1. 5-7 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Marui T, Hashimoto O, Nanba E, et al.: "Gastrin-releasing peptide receptor (CRPR) locus in Japanese subjects with autism"Brain Dev. 26・1. 5-7 (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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