| Project/Area Number |
15300124
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kanazawa University |
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Principal Investigator |
HIGASHIDA Haruhiro Kanazawa University, Dept.of Biophysical Genetics, Professor, 医学系研究科, 教授 (30093066)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA S. Kanazawa University, Dept.of Biophysical Genetics, Associate Professor, 医学系研究科, 助教授 (00210633)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2005: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2004: ¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 2003: ¥5,800,000 (Direct Cost: ¥5,800,000)
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| Keywords | Cyclic ADP-ribose / CD38 / NAD^+ / NG108-15 cells / Striatum / Dopamine / Dopamine receptor |
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| Research Abstract |
We examined the role of cyclic ADP-ribose (cADPR) as a second messenger downstream of receptors in the striatal cortex and NG108-15 cells. To address this question, ADP-ribosyl cyclase activity was measured in a crude membrane fraction of rat striatum and NG108-15 cells transfected with CD38. Dopamine (DA) stimulated the cyclase activity. The cyclase activity in overexpressed cells had various effects on neuronal function. The following two reports are the summary of the cADPR function written in a review form (7-2) and research report on CD38 transfection (7-3)
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